Registration deadlines
Early Bird - 01 Sep 2023
Talk Submission - 01 Sep 2023
Poster Submission - 10 Jan 2024
Registration Deadline - 10 Jan 2024
Register14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
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Important fundamental breakthroughs in cancer biology have come from the basic research discovery that defects in the tumor suppressor and DNA repair genes BRCA1/2 genes predispose to breast, ovarian, prostate, and pancreatic cancers. Furthermore, the game-changing synthetic lethality concept for defects with inhibitors to Poly-ADP-Ribose Polymerase 1 (PARP1) is transforming clinical cancer therapy and prompting many new clinical trials. Yet, key gaps in our molecular and mechanistic understanding of therapy efficacy limit our ability to fully harness the insights from DNA damage responses gained so far. In this context, striking ongoing advances in methods and results spanning from molecules to cells and organisms are implicating functionally-important molecular communications coupling the DNA damage response, responses to DNA replication fork instability and DNA-based immune response. Future master keys to cancer biology and advanced therapies will benefit from better defining these distinct cellular stress responses, their mechanistic interconnectivity, and their implications for cancer biology and therapeutic outcomes.
The 6th DNA Repair/Replication Structures & Cancer conference on 14-18 February 2024 will focus on molecular structural and mechanistic insights into dynamic complexes acting in DNA repair, replication, and inflammation and their intersections relevant to advanced cancer therapies. This fundamental information will be pivotal for pioneering research on DNA damage responses as well as for the accurate interpretation of cancer clinical data, design of clinical trials, prognosis, etiology and improving the currently low success rate for oncology drug clinical trials. Informative talks and poster sessions along with vibrant discussions will foster productive interactions, collaborations, and insights. In this conference and this area of science basic research is empowering medical advances and clinical data are unveiling basic relationships in ways that are completely changing how research and translation is being done.
To advance understanding, all presenters are asked to focus on unpublished work, cutting-edge approaches and mechanistic insights. The talks and discussions will seek to aid prediction of biological outcomes and plans to best apply basic research advances for cancer research and treatment. To include late-breakthrough advances and innovative new ideas and methodologies, many talks will be selected from submitted abstracts. Poster sessions are vital part of the conference and contribute greatly to the success of the conference with stimulating and in-depth discussions between junior researchers and well-established international leaders in their field. Meeting attendance is limited, and delegates are encouraged to submit applications and abstracts early to avoid disappointment.
What makes this meeting unique? Professor Ben Van Houten from the University of Pittsburgh says: "This conference stands out as the very best due to the amazing science, great speakers, wonderful venue, and Laura and her teams’ attention to every detail." Professor John Tainer from the University of Texas MD Anderson Cancer Centre says: “This conference makes me want to stand up and cheer because most participants contribute unpublished data and useful discussions that together can identify and fill knowledge gaps with potentially game-changing insights.”
Sessions will include emerging results and breakthrough methodologies on core topics including:
We are excited to continue the tradition from the last conference of including a session dedicated to DDR-based cancer therapeutics. This session will highlight new agents and new combined therapies that have recently entered the clinic and the translational potential of emerging mechanistic knowledge at the repair-replication-inflammation axis.
We are joined by the following incredible speakers:
Ranjit S. Bindra (Yale School of Medicine)
Helen Robinson (Artios)
Timothy Yap (MD Anderson Cancer Center)
CLINICAL DEVELOPMENT OF AGENTS TARGETING THE DNA DAMAGE RESPONSE: CURRENT STATE OF PLAY
Michael Zinda (Repare Therapeutics)
Maria Jasin (Memorial Sloan Kettering)
Titia de Lange (Rockefeller University)
STRUCTURE AND FUNCTION OF CST-POLA/PRIMASE, THE SECOND TELOMERE MAINTENANCE MACHINE
Irene Chiolo (University of Southern California)
Ranjit S. Bindra (Yale School of Medicine)
Simon Boulton (Francis Crick Institute)
Cynthia Burrows (University of Utah)
G-QUADRUPLEXES CONNECT BER TO GENE INDUCTION: STRUCTURE & MECHANISM
Junjie Chen (MD Anderson Cancer Center)
REPLICATION STRESS AND CELL CYCLE CHECKPOINT CONTROL
Karlene Cimprich (Stanford University)
Francesca Cole (MD Anderson Cancer Center)
AGE-DEPENDENT ALTERATIONS IN DNA REPAIR CAUSE CHROMOSOME MIS-SEGREGATION IN MEIOSIS
Sylvie Doublié (University of Vermont)
Daniel Durocher (Mount Sinai Hospital)
THE MITOTIC DNA DAMAGE RESPONSE THROUGH THE LENS OF CIP2A
Samir Hamdan (KAUST)
Yuan He (Northwestern University)
STRUCTURAL BASIS OF DNA DOUBLE-STRAND BREAK REPAIR BY NHEJ
Karl Peter Hopfner (Ludwig Maximilian University of Munich)
Ben Van Houten (University of Pittsburgh)
Stephen Kowalczykowski (University of California, Davis)
MOLECULAR MECHANISM OF CHROMOSOME MAINTENANCE BY HOMOLOGOUS RECOMBINATION
Susan Lees-Miller (University of Calgary)
John Pascal (University of Montreal)
PARP ENZYMES IN THE DNA DAMAGE RESPONSE AND PARP INHIBITOR MECHANISMS
Lori Passmore (MRC Laboratory of Molecular Biology)
Tanya Paull (University of Texas at Austin)
MECHANISMS OF DNA DOUBLE-STRAND BREAK REPAIR
Helen Robinson (Artios)
Eli Rothenberg (New York University)
Katharina Schlacher (MD Anderson Cancer Center)
Jessica Tyler (Weill Cornell Medicine)
Johannes Walter (Harvard Medical School)
Dale Wigley (Imperial College London)
Scott Williams (NIH)
Timothy Yap (MD Anderson Cancer Center)
CLINICAL DEVELOPMENT OF AGENTS TARGETING THE DNA DAMAGE RESPONSE: CURRENT STATE OF PLAY
Steve West (Francis Crick Institute)
Wei Yang (NIH)
Xiaolan Zhao (Memorial Sloan Kettering Cancer Center)
STRUCTURAL AND FUNCTIONAL INSIGHT INTO A VERSATILE GENOME PROTECTOR COMPLEX Smc5/6
Michael Zinda (Repare Therapeutics)
Inform basic and clinical researchers on current advances in methodologies, approaches, mechanistic and structural knowledge suitable to understand and predict damage responses and their relationship to cancer. Create optimal formal and informal opportunities to gain new knowledge and to establish fruitful collaborations among key stakeholders in damage responses and cancer research.
This conference will bring together basic and clinical scientists working at the forefront of DNA repair, replication, inflammation, and post-translational modification including PARylation for cancer biology and medicine. Presentations will consider diverse cutting-edge methodologies and integrated approaches to investigate the structures and mechanisms of dynamic protein, chromatin, DNA and RNA complexes. The conference will showcase breakthrough advances and new developments in these areas. It will furthermore provide opportunities for industry and academia to consider and exchange emerging results in this exciting, rapidly advancing arena. The inter-disciplinary nature of the presented work will create strong synergies among participants and outstanding opportunities for exchanging information and developing fruitful collaborations. The cross-disciplinary interactions will be invaluable training for young scientists to work in these and other emerging areas of science.
Academic and industrial researchers (including established and junior principal investigators, postdoctoral fellows and PhD students) interested in DNA damage responses, replication, inflammation, and their intersection with cancer biology and cancer drug discovery. The focus will be the molecular mechanisms of and interfaces controlling damage responses and cancer biology and thereby impacting therapeutic outcomes.
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
Chairs
Irene Chiolo
University of Southern California
Maria Jasin
Memorial Sloan Kettering
Titia de Lange
Rockefeller University
Simon Boulton
Francis Crick Institute
Cynthia Burrows
University of Utah
Karlene Cimprich
Stanford University
Francesca Cole
MD Anderson Cancer Center
Sylvie Doublié
University of Vermont
Daniel Durocher
Mount Sinai Hospital
Samir Hamdan
KAUST
Yuan He
Northwestern University
Karl Peter Hopfner
Ludwig Maximilian University of Munich
Ben Van Houten
University of Pittsburgh
Stephen Kowalczykowski
University of California, Davis
Susan Lees-Miller
University of Calgary
John Pascal
University of Montreal
Lori Passmore
MRC Laboratory of Molecular Biology
Tanya Paull
University of Texas at Austin
Helen Robinson
Artios
Eli Rothenberg
New York University
Katharina Schlacher
MD Anderson Cancer Center
Jessica Tyler
Weill Cornell Medicine
Johannes Walter
Harvard Medical School
Steve West
Francis Crick Institute
Dale Wigley
Imperial College London
Scott Williams
NIH
Wei Yang
NIH
Timothy Yap
MD Anderson Cancer Center
Xiaolan Zhao
Memorial Sloan Kettering Cancer Center
Michael Zinda
Repare Therapeutics
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
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Although the programme has not yet been released, we are able to confirm that the conference should begin no earlier than 14:00 with opening comments on 14th February 2024. The conference will conclude no later than 12:30 on 18th February 2024.
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
Chairs
| Ticket Type | Early Bird | Full Price |
|---|---|---|
|
Single
Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.
|
$2172 | $2368 |
|
Shared
Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.
|
$1849 | $2045 |
|
Student
Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.
|
$1593 | $1694 |
Adult
$987
Child
$291
Adult
$330
Child
$73
Our registration fees are inclusive of the following at the Fiesta Americana Condesa Cancun hotel during the conference period only:
- Conference registration
- 4 nights’ fixed accommodation (14, 15, 16, 17 Feb 2024) on a single or shared basis
- Breakfast, lunch and dinner available at all restaurants according to their operational hours
- Unlimited alcoholic beverages, cocktails and soft drinks available by the glass at all restaurants and bars according to their operational hours
- Gala Dinner
- 24 hour room service
- Guest room mini bar (replenished daily)
- Complimentary WIFI in both conference rooms and your guest room
Our accompanying adult fees are inclusive of the following at the Fiesta Americana Condesa Cancun hotel during the conference period only:
- 4 nights’ fixed accommodation (14, 15, 16, 17 Feb 2024) on a shared basis with a conference participant
- Breakfast, lunch and dinner available at all restaurants according to their operational hours
- Unlimited alcoholic beverages, cocktails and soft drinks available by the glass at all restaurants and bars according to their operational hours
- Gala Dinner
- 24 hour room service
- Guest room mini bar (replenished daily)
- Complimentary WIFI in your guest room
Important Note: Accompanying guests are not permitted access to the conference.
Our accompanying child fees are inclusive of the following at the Fiesta Americana Condesa Cancun hotel during the conference period only:
- 4 nights’ fixed accommodation (14, 15, 16, 17 Feb 2024) on a shared basis with the parent/s
- Breakfast, lunch and dinner available at all restaurants according to their operational hours
- Unlimited soft drinks available by the glass at all restaurants and bars according to their operational hours
- Gala Dinner
- 24 hour room service
- Complimentary WIFI in your guest room
Important Note: Accompanying child fees are applicable for children aged 5-12 years. Children 4 years or younger stay free of charge with a parent. Children aged 13 years and older are classified as an adult at this venue (Fiesta Americana Condesa Cancun).
Please kindly ensure your child / children are supervised at all times during conference and related events. Childcare services are available at the hotel, please contact Laura for further information.
Our extra night fees are inclusive of the following at the Fiesta Americana Condesa Cancun hotel:
- 1 night’s accommodation for 1 person
- Breakfast, lunch and dinner available at all restaurants according to their operational hours
- Unlimited alcoholic beverages, cocktails and soft drinks available by the glass at all restaurants and bars according to their operational hours
- 24 hour room service
- Guest room mini bar (replenished daily)
- Complimentary WIFI in your guest room
Important Note: The extra night price is only applicable 1 night pre/post the conference dates. If you wish to extend your stay further, this is possible to book via Fusion, but please contact Laura for assistance and prices. Extra night child fees are applicable for children aged 5-12 years. Children 4 years or younger stay free of charge with a parent. Children aged 13 years and older are classified as an adult at this venue (Fiesta Americana Condesa Cancun)
Prices and hotel availability are subject to change without notice.
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
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Please see below opportunties for financial support for students, postdocs and early career researchers. If you have any questions, please reach out to the Conference Manager, Laura Trundle.
Take advantage of this fantastic opportunity for students and postdocs! Fully paying academics can bring one student or postdoc for only $1,170. Both registration packages include accommodation for the 14th, 15th, 16th and 17th Feb 2024 (on a shared basis for students/postdocs) and an all inclusive food and beverage package for the conference period. Once registered, please contact Laura Trundle to obtain a special registration link for your student or postdoc.
We have been able to create several ECR awards. Two different award values are available, $500 or $1,000 and these have been set aside for early career researchers. If you are a student, postdoc or junior faculty (within 3 years of your position), you are eligible. To apply please email the conference manager, Laura Trundle. Your application should include your name, organisation, career level, an abstract for talk or poster consideration and a short summary answering the below questions (no more than 50-100 words per question).
Applications will be considered as they are submitted so although there is no application deadline, we recommend applying early to avoid disappointment as we only have a limited number of ECR awards available. If you are interested in presenting a talk, please ensure your abstract and ECR award application are submitted no later than midnight BST on 01 September 2023.
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
Chairs
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
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Bringing together the global community of researchers and scientists interested in the study of DNA. Relevant specialties are wide-ranging, reflecting the importance of DNA Research in many aspects of health and disease, including; DNA Repair, DNA Replication, DNA Damage, Cancer, Chromosomal Instability, RNA and Nucleic Acids.
The group is open to all and is intended as a networking forum for past, present and future participants of Fusion Conferences as well as those interested in the related topics.
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
Chairs
This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
Lagoon Pool
Extensive Health Club and Spa
Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
Venue Rating
Currency
US Dollar (USD)
Address
Fiesta Americana Condesa Cancún All Inclusive Blvd. Kukulcan km 16.5 Zona Hotelera 77500 Cancun Q.R. Mexico
Nearest Airport
Cancun International Airport
Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.
Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
Chairs
Unlike other Airports, Cancun Airport Taxi Services must be pre-arranged. To obtain safe, licensed and bilingual transportation services please ensure you book your ground transportation online with an authorised transportation company prior to your arrival.
If you wish to share a return transfer to the airport then we would suggest waiting and organising this on-site at the hotel. The hotel have registered Taxi's readily available- you simply need to speak to the Concierge/Bellmen on the day of your departure. This will allow attendees to share return transfers where flight times permit.
One way (Cancun Hotel Zone): $24.85+ (USD)
*subject to change, please check the Cancun International Airport website for a more accurate estimation for your trip.
Further information on Taxi services can be found on the Cancun International Airport website (see below link) along with some top tips for travellers from local experts and official authorities.
https://www.cancunairport.com/taxi.html
** Please note that Fusion Conferences is not responsible for any bookings made with any transfer/taxi service as transportation is not included within the registration package **
If you'd prefer to book a private transfer, there are several DMC's operating in the Cancun area who will be able to provide a quotation for your trip. We have not partnered with any companies this year, however, there are a number of well reviewed companies operating in Cancun, such as; USA Transfers, Canada Transfers and Kalido Travel.
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
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Several activities are available within the resort. Timetables vary daily so please check with the hotel for the latest activities program.
There are also many other activities, trips and excursions to consider in and around the local area, depending on the time you have available. Please find a few suggestions below:
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
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14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
Chairs
We have several oral opportunities available at this meeting. To be considered for a talk, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.
Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.
If you are accepted for a talk, we recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference website.
On the day of your presentation please make yourself known to our AV technician who will be present in the conference room. We advise running through your presentation at least 30minutes prior to your session commencing to ensure your slides and any videos or animations appear as expected. We prefer our speakers to run their presentation from the master PC or Mac, however, if you prefer to use your own laptop then please notify us prior to the session. A HDMI or VGA cable is usually available on the podium.
Our AV technician will apply your microphone and provide a combined slide advancer and laser pointer.
We ask all speakers to adhere to their time slots and respect their fellow presenters. A visual traffic light aide will be available to warn presenters as their time decreases.
Please make sure your presentation adheres to the following guidelines.
Aspect Ratio: On Screen Show (16:9)
File Type: Please save your presentation in PPT, PPTS or Keynote format.
14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
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We have several poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.
Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.
Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.
Please bring your poster to registration and hand this to a member of the Fusion team. They will advise of your poster number and display your poster for you.
Your poster will remain on display for the duration of the conference, allowing presenters to take advantage of the refreshment breaks and free time for valuable networking opportunities, in addition to the official poster session.
Please check the programme and note the date and time of the poster session(s). Your poster will be judged during the poster session and prizes will be awarded at the Gala Dinner.
Posters will be taken down by the Fusion team and will be ready for collection at the Fusion desk on the final day of the conference.
Download Abstract Template14 Feb 2024 - 18 Feb 2024
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Cancun, Mexico
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12 Feb 2014, 15 Feb 2014
Fiesta Americana Condesa, Cancun, Mexico
Key sessions will include: DNA and RNA complexes Chromatin Remodeling Post-translational modifications - Ub, SUMO kinases The repair interface with Replication Transcription, and Recomb...
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This conference will focus on insights into dynamic DNA and RNA complexes involved in the damage response and cancer. It will emphasize informal as well as formal discussions together with informative talks and...
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27 Apr 2022, 01 May 2022
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Future master keys to cancer biology and advanced therapies are being forged from mechanistic understanding of the intertwined roles of DNA repair with DNA replication stress, transcription and immune responses. The remarkable stability of the hum...
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14 Feb 2024, 18 Feb 2024
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Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico
Important fundamental breakthroughs in cancer biology have come from the basic research discovery that defects in the tumor suppressor and DNA repair genes BRCA1/2 genes predispose to breast, ovarian, prostate, and pancreatic cancers. Furthermore,...
More Information
If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
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