The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate DNA repair in the context of oncogene-induced replication stress and elevated transcription. Intertwined roles of repair with replication and transcription are emerging for dynamic complexes acting in genome stability and its loss in cancer. Moreover, the synthetic lethality and essentiality resulting from replication-repair stresses suggest strategies to define and predict pathway selection and damage outcomes as a foundation for advanced therapeutics that target Achilles heels for cancer.
The 4th DNA Repair/Replication Structures & Cancer conference in February 2020 will focus on structural and mechanistic insights into dynamic protein, chromatin, DNA and RNA complexes acting in DNA repair and its interface with DNA replication and transcription events relevant to cancer. This fundamental information will be pivotal for the accurate interpretation of cancer clinical data, design of clinical trials, prognosis, etiology and improving the currently 1/20 low success rate for oncology drug clinical trials. Informative talks and poster sessions along with vibrant discussions will foster productive interactions and collaborations.
All presenters are asked to focus on unpublished work, cutting-edge approaches and novel mechanistic insights that aid prediction of biological outcomes and plans to best apply basic research advances for cancer research and treatment. To include late-breaking advances and innovating new investigators, one or more talks for every session will be selected from submitted abstracts. Meeting attendance is limited. Applicants strongly encouraged to submit applications and abstracts early.
What makes this meeting unique? Professor Ben Van Houten from the University of Pittsburgh says:
‘I can honestly say your meeting, by combining hard core structure-function studies with beautiful biology, hits an important area that many meetings miss; being part of that science is just terrific.’
Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference.
Sessions will include emerging results and breakthrough methods concerning:
- Repair and replication complexes, structures and mechanisms
- RNA damage responses and actions in repair
- Mutational signatures, DNA repair, and cancer
- Intertwined interactions in transcription-replication-repair
- DNA damage signaling, pathway selection & cross-talk
- Targeting synthetic lethality and essentiality for damage responses
- Chromatin structures and dynamics in repair and cancer
- Epigenetics, DNA damage and repair
- PARP, PARG, and metabolic signaling
- Mitochondrial replication/repair and damage signaling
- DNA repair, apoptosis and cancer
Students & Postdocs
To encourage students and fellows to resister and present their work, we offer them the following reduced registration options:
- Register at the student rate. You will receive a reduced rate and be paired with another student or postdoc (or you may specify a room sharer). This saves money and allows you to get to know a colleague.
- Register at the special student rate. Fully paying academics may bring one student or postdoc at a heavily discounted price of $900 from their lab or institute.*
- Register at the academic rate. This entitles you to a single room and a chance of receiving a $150 grant against your registration fees. Chairs will award 10 grants shortly after the oral submission deadline falls (23 Sept 2019). All postdoc and student registrants at the academic rate will be considered.
*Register an academic at the earlybird rate of $1,699 and bring a student for only $900. Both registration packages include; accommodation for the 16, 17, 18, 19 Feb 2020 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 02 Sep 2019. Once registered, please contact Laura Trundle to obtain a special registration link for your student.
Susan Gasser (Friedrich Miescher Institute)
LOSS OF HISTONE H3 K9 METHYLATION AND BRCA-1 DESTABILIZE GENOMES THROUGH R-loop FORMATION
Karl-Peter Hopfner (Ludwig-Maximilians-University Munich)
STRUCTURAL STUDIES OF CHROMATIN REMODELLER
Wei Yang (NIH)
REPLISOME STRUCTURE AND OPERATING PRINCIPLES
*Talk titles are subject to change.
Lorena Beese (Duke University School of Medicine)
DNA MISMATCH REPAIR MACHINES
James Berger (Johns Hopkins University)
(UN?)STRUCTURAL METHODS FOR INITIATING DNA REPLICATION
Walter Chazin (Vanderbilt University)
INTEGRATED APPROACHES TO CHARACTERIZE STRUCTURAL DYNAMICS OF DNA REPLICATION AND REPAIR PROTEINS
Irene Chiolo (University of Southern California)
NUCLEAR AND CHROMATIN DYNAMICS FOR HETEROCHROMATIN REPAIR
Titia de Lange (The Rockefeller University)
THE ROLE OF CST IN PARP1-TREATMENT OF BRCA1 MUTANT CANCERS
Sylvie Doublie (University of Vermont)
SHAPING THE GENOME THROUGH DNA REPAIR
Dorothy Erie (University of North Carolina at Chapel Hill)
SINGLE-MOLECULE FLUORESCENCE AND AFM STUDIES OF DNA MISMATCH REPAIR
Samir Hamdan (KAUST)
STRUCTURAL BASES OF THE HUMAN LAGGING STRAND DNA POLYMERASE HOLOENZYME
Steve Jackson (Gurdon Institute)
FUNCTIONAL INTERACTIONS BETWEEN COMPONENTS OF THE MAMMALIAN DNA-DAMAGE-RESPONSE NETWORK
Caroline Kisker (University of Würzburg)
NUCLEOTIDE EXCISION REPAIR STRUCTURAL BIOCHEMISTRY
Stephen Kowalczykowski (University of California, Davis)
SEEING AND UNDERSTANDING BRCA1, BRCA2, AND RAD51, ONE MOLECULE AT A TIME
Hitoshi Kurumizaka (Waseda University)
CHROMATIN STRUCTURE AND DYNAMICS AS THE PLATFORM FOR DNA REPAIR
Susan Lees-Miller (University of Calgary)
NOVEL ROLES OF DNA-PKcs
Steve Mao (American Association for the Advancement of Science)
OPENING THE BLACK BOX: AN EDITOR’S PERSPECTIVE ON SCIENTIFIC PUBLISHING
Jo Morris (University of Birmingham)
A NEW PATHWAY OF BRCA1-MEDIATED REPLICATION FORK PROTECTION
Mark O'Connor (AstraZeneca)
DEVELOPING INHIBITORS OF THE DNA DAMAGE RESPONSE
Lori Passmore (MRC Laboratory of Molecular Biology)
MECHANISTIC INSIGHTS INTO DNA REPAIR COMPLEXES USING cryo-EM
Susan Rosenberg (Baylor College of Medicine)
TRAPPING DNA REACTION INTERMEDIATES IN LIVING CELLS
Titia Sixma (Netherlands Cancer Institute)
SNAPSHOTS OF MISMATCH REPAIR INITIATION
Terence Strick (CNRS)
NANOMECHANICAL DETECTION OF SINGLE- AND DOUBLE-STRAND BREAK REPAIR
Stephen West (The Francis Crick Institute)
TARGETING THE SMX TRINUCLEASE TO DNA REPLICATION/RECOMBINATION STRUCTURES
Dale Wigley (Imperial College London)
STRUCTURE AND REGULATION OF INO80 FAMILY REMODELLERS
Scott Williams (NIH)
MOLECULAR MECHANISMS OF DNA PROTEIN CROSSLINK REPAIR
*Talk titles are subject to change.
If you're interested in sponsoring this conference please contact us.