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Registration Deadline - Expired

4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Report

The fourth DNA Repair/Replication Structures and Cancer Conference, which took place in Nassau, Bahamas from 16th to 20th February, 2020, focused on developing a mechanistic knowledge of DNA replication and repair responses to stress that were suitable to guide advanced intervention strategies for cancer. The meeting followed three previous successful conferences with organisers, Professor John Tainer (Director, Sibyls Advanced Light Source, Professor and Director of Structural Biology, MD Anderson Cancer Center, Houston, Texas, USA) and Professor Sir Tom Blundell (FRS, FMedSci, Department of Biochemistry, University of Cambridge, UK) joined by Professor Xiaodong Zhang from Imperial College London.

The meeting proved to be a most productive meeting with the focus now further broadening from the core structural biology and mechanisms of the earlier conferences towards understanding the cellular mechanisms of DNA replication, damage responses and cancer as well as therapeutic strategies and approaches based on mechanistic understandings. It featured a formidable group of leading researchers and many excellent PhD students and post-docs from USA, UK, Netherlands, Poland, Germany, Switzerland, Saudi Arabia, Canada, Japan, France, Sweden, Australia, Finland, and Portugal. The meeting attracted 129 participants in total of which 33% were junior investigators. We were also extremely proud to have a strong gender balance with 43% female and 57% male. The quality of the talks was uniformly high, and there was a large amount of high quality unpublished data, which reflected current new developments in basic science that underpin and inform our understanding of cancer. Thus, Titia de Lange (The Rockefeller University) noted in her talk that “the great thing about this meeting is that there is so much unpublished data.” This fact makes the meeting extremely cost effective in providing participants with knowledge and methods months or years before its publication. Indeed, leading and early stage researchers had in depth and specific discussions about controversies and gaps in our knowledge, such as the likely rate limiting steps for repair pathways and the role of damaged RNA as the canary in coal mine, thus providing views and information distinct from those that end up in publications. Other exemplary advanced discussions included the mechanisms of mismatch recognition, the presence and effects of phase transitions, and the importance of RNA damage in cancer methylating agents.

With a solid foundation from prior conferences and the invaluable additional guidance from Xiaodong Zhang, this was probably the most impressive meeting of our series in terms of active participation of both research leaders and early career researchers in the lively and sometimes thought-provoking discussions that followed each of the talks given. As for example, seen by the intense discussion about mismatch repair complexes and how they inform the biology with cancer therapy implications. The conference format with protected discussion times after every talk and informal discussion breaks was great to meet and ask questions during the conference as well as the meals and the afternoon breaks. Many fruitful discussions and planning for collaborations continued at the pool and on the beach. Excitement throughout the sessions was high due to dramatic advances in structures of DNA repair complexes as included in structures were presented of ATM, ATR and DNA-PKcs kinases at the conference. In fact, a timely review comparing all PIKKs is now planned to come from these conference presentations. Tom Blundell presented informative X-ray and EM structures of DNA-pk and its complexes with Ku and Artemis. Furthermore, clever combinations of different approaches provided the means to see the whole elephant for several complexes, rather than part, and moreover at times to see the elephant moving rather than frozen in one position. Science editor Valda Vinson enlightened investigators at all stages by unveiling how to write cover letters and the editor’s considerations in rejecting manuscripts or selecting them for review and then publication. 

Voted by the participants were three junior researchers Noah Bradley (Vanderbilt University), Brittany Ripley (University of Iowa) and Ondrej Belan (The Francis Crick Institute) who were awarded the Junior Investigator Award for their active participation and excellent questions during the meeting. Noah Bradley commented on the extensive student/post-doc involvement saying “the organizers made certain that the junior investigators had the first opportunities to ask questions after each talk. It was very clear that involvement of the younger scientists was a goal for this meeting, and it was achieved.” Apart from the talks, the poster sessions and the one-minute poster bite, when each poster presenter described their poster within one minute, provided opportunities for presentations, engaging discussions and interactions among all the participates. The quality of the posters was exceptionally high, and five posters and their presenters, Noah Bradley (Vanderbilt University), Marijke Jansma (Ludwig-Maximilians-Universität München), Namrata Kumar (University of Pittsburgh), Luke Yates (Imperial College London) and Martin Wilkinson (Imperial College London), were voted to receive the poster awards. A huge achievement considering that there were 51 posters to consider. Thank you to Nucleic Acids Research and Nucleic Acids Research Cancer for supporting two of these awards. The poster sessions definitely contributed greatly to the success of the meeting. Many participates at all career levels joined the dance floor and enjoyed the lively entertainment after the beautiful Gala dinner on the beach.  

We were sorry to lose our Chinese speakers and participants as well as a few others due to the coronavirus epidemic. Yet, we are aware that there are extremely active research teams now developing there, and plan to involve them in the next conference. We are also aware that we need in future to be more proactive in recruiting from other countries in Europe as well as in South America, Africa, India, South East Asia and Australia/New Zealand.  

As in prior meetings of this series, this DNA repair conference focused on mechanisms, and not simply a laundry list of structures and proteins. The speakers sought understanding of how these proteins work in cells, as opposed to providing only a list of what are the proteins involved. Although there was a wide range of techniques applied, the molecular mechanisms for function was a constant theme. Even those participants who were most familiar with the mechanisms of loss of stability through DNA damage to the human genome were impressed by the extensive and deep understanding of new mechanisms presented at this meeting. As noted in our previous conferences, the area of DNA replication is further developing as a complex but fragile process. This and the gene essentiality and synthetic lethality - information that identifies the combination of genes whose deletion inhibits cell growth resulting from the replication-repair stresses underlines a variety of new mechanisms that could be exploited, and in some cases are already being exploited, in the design of advanced therapeutics.  

The meeting started with a Student/Postdoc networking lunch. Each of the four days of meetings focused on new developments with internationally renowned speakers. They ranged through replication instability and cancer to Fanconi Anemia and the repair/replication interface to RNA transcription and repair, as well as DNA double-strand break repair through homologous recombination and non-homologous end joining and chromatin remodeling. There were equally stimulating talks on the broader aspects of cancer biology as well as strategies for intervention and design of therapeutics. The keynote lectures given by Wei Yang and Karl-Peter Hopfner on replisome and Mre11-Rad50 respectively stimulated lively discussions. They provided unpublished data and integrated insights that inspired discussion and set the tone for conference and other talks. For example, Karl-Peter Hopfner’s presentation on structures of MRE11/Rad50 advanced current understanding of how Rad50 regulates the Mre11 endo and exonuclease activities and how the Rad50 coiled coil enforces double-stranded specificity onto the endonuclease activity. Instead of having MRE11 alter the DNA binding surface for a particular specificity, the Mre11-Rad50 complex dramatically swings its nuclease domain to the other side of the protein and thereby positioning it for a completely different substrate specificity. Also remarkable was the control of DNA substrate specificity using the Rad50 coiled coil domains, whereby the full coil-coil extending to the Zn hook zips down all the way to the DNA to fully validate its substrate. 

We went away with new ideas and suggestions for our research team members who were unable to join. It is evident that the meeting will have an impact on international research development through the new ideas generated but most importantly by the establishing and strengthening of many friendships and collaborations. The organisers thank MD Anderson Cancer Center, ThermoFisher Scientific, DNA & Cell Biology, Journal of Cell Biology, Methods in Enzymology, LUMICKS, New England BioLabs, Nucleic Acids Research, Nucleic Acids Research Cancer and Progress in Biophysics and Molecular Biology for their generous enabling financial support. They also thank once again Fusion Conferences Ltd for their excellent organisation, helpful interactions with the organisers and participants both before and during the meeting. The absence of problems in all aspects of the presentations meant all participants could focus on the advanced science and technologies. As before, Fusion was able to choose a site providing an inspiring and relaxed atmosphere for the productive interactions.

“Thank you so much for organizing once again such a spectacular meeting. There was not a dull moment, there was not an awkward moment. The talks were uniformly outstanding. The atmosphere was positive and collegial throughout, from breakfast conversations to coffee breaks to poster sessions to question time. My student James was definitely left starry-eyed. Thanks again for including us. Congratulations on a brilliant job!”

Antonia Kefala Stavridi (University of Cambridge) has very kindly written a blog about her experience at the conference and she shares a very interesting perspective from a student standpoint on why this meeting was so beneficial and valuable to her. Read Tonia’s blog here.

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4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Synopsis

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate DNA repair in the context of oncogene-induced replication stress and elevated transcription. Intertwined roles of repair with replication and transcription are emerging for dynamic complexes acting in genome stability and its loss in cancer. Moreover, the synthetic lethality and essentiality resulting from replication-repair stresses suggest strategies to define and predict pathway selection and damage outcomes as a foundation for advanced therapeutics that target Achilles heels for cancer.

The 4th DNA Repair/Replication Structures & Cancer conference in February 2020 will focus on structural and mechanistic insights into dynamic protein, chromatin, DNA and RNA complexes acting in DNA repair and its interface with DNA replication and transcription events relevant to cancer. This fundamental information will be pivotal for the accurate interpretation of cancer clinical data, design of clinical trials, prognosis, etiology and improving the currently 1/20 low success rate for oncology drug clinical trials. Informative talks and poster sessions along with vibrant discussions will foster productive interactions and collaborations.

All presenters are asked to focus on unpublished work, cutting-edge approaches and novel mechanistic insights that aid prediction of biological outcomes and plans to best apply basic research advances for cancer research and treatment. To include late-breaking advances and innovating new investigators, one or more talks for every session will be selected from submitted abstracts. Meeting attendance is limited. Applicants strongly encouraged to submit applications and abstracts early.

What makes this meeting unique? Professor Ben Van Houten from the University of Pittsburgh says:

‘I can honestly say your meeting, by combining hard core structure-function studies with beautiful biology, hits an important area that many meetings miss; being part of that science is just terrific.’

Key Sessions

Sessions will include emerging results and breakthrough methods concerning:

  • Repair and replication complexes, structures and mechanisms
  • RNA damage responses and actions in repair
  • Mutational signatures, DNA repair, and cancer
  • Intertwined interactions in transcription-replication-repair
  • DNA damage signaling, pathway selection & cross-talk
  • Targeting synthetic lethality and essentiality for damage responses
  • Chromatin structures and dynamics in repair and cancer
  • Epigenetics, DNA damage and repair
  • PARP, PARG, and metabolic signaling
  • Mitochondrial replication/repair and damage signaling
  • DNA repair, apoptosis and cancer

Students & Postdocs

To encourage students and fellows to register and present their work, we offer them the following reduced registration options:

  • Register at the student rate. You will receive a reduced rate and be paired with another student or postdoc (or you may specify a room sharer). This saves money and allows you to get to know a colleague. 
  • Register at the special student rate. Fully paying academics may bring one student or postdoc at a heavily discounted price of $900 from their lab or institute.*
  • Register at the academic rate. This entitles you to a single room and a chance of receiving a $150 grant against your registration fees. Chairs will award 10 grants shortly after the registration deadline falls (16 Dec 2019). All postdoc and student registrants at the academic rate will be considered.

*Fully paying academics can bring a student for only $900. Both registration packages include; accommodation for the 16, 17, 18, 19 Feb 2020 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Laura Trundle to obtain a special registration link for your student.

Confirmed Plenary Speakers

Karl-Peter Hopfner (Ludwig-Maximilians-University Munich)
STRUCTURAL STUDIES OF CHROMATIN REMODELLER
Wei Yang (NIH)
REPLISOME STRUCTURE AND OPERATING PRINCIPLES 

*Talk titles are subject to change.

Confirmed Invited Speakers

Lorena Beese (Duke University School of Medicine)
DNA MISMATCH REPAIR MACHINES
James Berger (Johns Hopkins University)
(UN)STRUCTURAL MECHANISMS FOR INITIATING DNA REPLICATION
Walter Chazin (Vanderbilt University)
STRUCTURE AND MECHANISM OF THE CORE SCAFFOLDING OF NER
Junjie Chen (University of Texas MD Anderson Cancer Center)
TARGETING DNA DAMAGE RESPONSE PATHWAYS IN CANCER THERAPY
Irene Chiolo (University of Southern California)
NUCLEAR AND CHROMATIN DYNAMICS FOR HETEROCHROMATIN REPAIR
Titia de Lange (The Rockefeller University)
THE ROLE OF CST IN PARP1-TREATMENT OF BRCA1 MUTANT CANCERS
Sylvie Doublie (University of Vermont)
SHAPING THE GENOME THROUGH DNA REPAIR
Brandt Eichman (Vanderbilt University)
REPAIR AND TOLERANCE OF REPLICATION STALLING LESIONS
Dorothy Erie (University of North Carolina at Chapel Hill)
SINGLE-MOLECULE FLUORESCENCE AND AFM STUDIES OF DNA MISMATCH REPAIR
Samir Hamdan (KAUST)
STRUCTURAL BASES OF THE HUMAN LAGGING STRAND DNA POLYMERASE HOLOENZYME
Caroline Kisker (University of Würzburg)
THE MULTIFACETED CONTROL OF THE TFIIH HELICASE XPD IN NUCLEOTIDE EXCISION REPAIR AND TRANSCRIPTION
Stephen Kowalczykowski (University of California, Davis)
SEEING AND UNDERSTANDING BRCA1, BRCA2, AND RAD51, ONE MOLECULE AT A TIME
Meindert Lamers (Leiden University Medical Center)
STRUCTURAL FEATURES OF HIGH-FIDELITY DNA REPLICATION
Susan Lees-Miller (University of Calgary)
NOVEL ROLES OF DNA-PKcs
Jo Morris (University of Birmingham)
MECHANISTIC INSIGHTS OF BRCA1 FUNCTION
Mark O'Connor (AstraZeneca)
OVERCOMING PARPINHIBITOR RESISTANCE BY TARGETING THE REPLICATION STRESS RESPONSE
Taiana Oliveira (AstraZeneca)
STRUCTURAL INSIGHTS INTO THE CRITICAL DNA DAMAGE SENSORS DNA-PKCS, ATM AND ATR
Lori Passmore (MRC Laboratory of Molecular Biology)
STRUCTURES OF KEY COMPLEXES IN FANCONI ANEMIA DNA REPAIR
Susan Rosenberg (Baylor College of Medicine)
TRAPPING DNA REACTION INTERMEDIATES IN LIVING CELLS
Katharina Schlacher (University of Texas MD Anderson Cancer Center)
BREAST CANCER AND FANCONI ANEMIA SUPPRESSOR GENE STRUCTURE, MECHANISM AND FUNCTION IN CANCER PREDICTION AND DISEASE MODELING
Titia Sixma (Netherlands Cancer Institute)
ALLOSTERIC REGULATION OF USP1 ACTIVITY
Terence Strick (CNRS)
NANOMECHANICAL DETECTION OF SINGLE- AND DOUBLE-STRAND BREAK REPAIR
Ben Van Houten (University of Pittsburgh) 
WATCHING COOPERATIVE INTERACTIONS BETWEEN BASE AND NUCLEOTIDE EXCISION REPAIR PROTEINS
Valda Vinson (American Association for the Advancement of Science)
OPENING THE BLACK BOX: AN EDITOR’S PERSPECTIVE ON SCIENTIFIC PUBLISHING
Bin Wang (University of Texas MD Anderson Cancer Center)
UBIQUITIN MODIFICATION IN DNA DAMAGE RESPONSE
Stephen West (The Francis Crick Institute)
SENSITISATION OF BRCA-DEFICIENT CANCER CELLS BY TARGETING NUCLEOTIDE METABOLISM
Dale Wigley (Imperial College London)
STRUCTURAL AND MECHANISTIC STUDIES OF THE SWR1 HISTONE EXCHANGE COMPLEX
Scott Williams (NIH)
DOES FIDELITY MATTER IN THE END? MOLECULAR PRINCIPLES OF DNA LIGATION FIDELITY
Rick Wood (University of Texas MD Anderson Cancer Center)
DNA POLYMERASES AND CANCER

*Talk titles are subject to change.

Supported By

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Media Partners
If you're interested in sponsoring this conference please contact us.

4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Speakers

Plenary Speakers

Karl-Peter Hopfner

Professor, Gene Center

Invited Speakers

Junjie Chen

Professor and Chair, The University of Texas MD Anderson Cancer Center

Katharina Schlacher

Assistant Professor, MD Anderson Cancer Center

Caroline Kisker

Professor, University of Wuerzburg

Titia de Lange

Leon Hess Professor, The Rockefeller University

Susan Rosenberg

Professor, Baylor College of Medicine

Dale Wigley

Professor, Imperial College London

Brandt Eichman

Professor, Vanderbilt University

Taiana Maia de Oliveira

Senior Scientist, Astrazeneca

Sylvie DoubliƩ

Professor, University of Vermont

Richard Wood

Professor, The University of Texas MD Anderson Cancer Center

James M. Berger

Professor, Johns Hopkins University School of Medicine

Meindert Lamers

Associate Professor, Leiden University Medical Center

Lorena Beese

Professor, Duke University Medical Center

Bin Wang

Associate Professor, MD Anderson Cancer Center

Irene Chiolo

Assistant Professor, University of Southern California, Los Angeles

Titia Sixma

head of division, Netherlands Cancer Institute

Terence Strick

Professeur, Ecole normale supƩrieure

Valda Vinson

Editor, Science

Supported By

Diamond
Platinum
Silver
Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Programme

 DISCUSSION IS VALUED: 5 MINUTES IS SAVED FOR DISCUSSION AFTER EACH TALK

SUNDAY 16TH FEBRUARY 2020

13:00 – 14:00

Student & Postdoc Networking Lunch

14:00 – 15:00

Registration & Welcome Reception

15:00 – 15:15

Opening Comments by John Tainer, Tom Blundell & Xiaodong Zhang

SUNDAY PM

Replication Mechanisms & Fidelity
Session Chair: John Tainer

15:15 – 15:35

Sylvie Doublie
University of Vermont

SHAPING THE GENOME THROUGH DNA REPAIR

15:40 – 16:00

James Berger
Johns Hopkins University

(UN)STRUCTURAL MECHANISMS FOR INITIATING DNA REPLICATION

16:05 – 16:15

David Jeruzalmi *
City College of New York

HOW THE BACTERIAL REPLICATIVE HELICASE OPENS AND CLOSES

16:20 – 16:40

Meindert Lamers
Leiden University Medical Center

STRUCTURAL FEATURES OF HIGH-FIDELITY DNA REPLICATION

16:45 – 17:15

Meet the Poster Presenters I

17:15 – 18:00

Refreshments

18:00 – 18:30

Meet the Poster Presenters II

18:30 – 18:40

Domi Baretic *
MRC Laboratory of Molecular Biology

THE CRYO-EM STRUCTURE OF A 1.4 MDa EUKARYOTIC REPLISOME COMPLEX AT A DNA FORK

18:45 – 19:05

Samir Hamdan
King Abdullah University of Science and Technology

STRUCTURAL BASES OF THE HUMAN LAGGING STRAND DNA POLYMERASE HOLOENZYME

19:10 – 19:40

Plenary Speaker:
Wei Yang

NIH

REPLISOME STRUCTURE AND OPERATING PRINCIPLES

19:45

Group Dinner

MONDAY 17TH FEBRUARY 2020

07:00 – 08:30

Breakfast at Leisure

MONDAY AM

Replication Instability and Cancer
Session Chair: Sylvie Doublie

08:30 – 08:35

Sylvie Doublie
University of Vermont

Session Introduction

08:35 – 08:55

Mark O'Connor
AstraZeneca

OVERCOMING PARP INHIBITOR RESISTANCE BY TARGETING THE REPLICATION STRESS RESPONSE

09:00 – 09:20

Susan Rosenberg
Baylor College of Medicine

TRAPPING DNA REACTION INTERMEDIATES IN LIVING CELLS

09:25 – 09:35

Jessica Luzwick *
UT MD Anderson Cancer Center

MITOCHONDRIAL DNA REPLICATION FORK PROTECTION BY THE FANCONI ANEMIA PATHWAY SUPPRESSES INFLAMMATION AND DISEASE

09:40 – 10:00

Katharina Schlacher
UT MD Anderson Cancer Center

BREAST CANCER AND FANCONI ANEMIA SUPPRESSOR GENE STRUCTURE, MECHANISM AND FUNCTION IN CANCER PREDICTION AND DISEASE MODELING

10:05 – 11:00

Refreshments & Poster Viewing

11:00 – 11:20

Brandt Eichman
Vanderbilt University

REPAIR AND TOLERANCE OF REPLICATION STALLING LESIONS

11:25 – 11:45

Jo Morris
University of Birmingham

MECHANISTIC INSIGHTS OF BRCA1 FUNCTION

11:50 – 12:00

Sara Martin *
UT MD Anderson Cancer Center

LOSS OF TRANSLESION DNA POLYMERASE ζ INVOKES AN INNATE IMMUNE RESPONSE

12:05 – 12:25

Rick Wood
UT MD Anderson Cancer Center

DNA POLYMERASES AND CANCER

12:30 – 16:30

Lunch at Leisure & Free Time

MONDAY PM

Fanconi Anemia & the Repair/Replication Interface
Session Chair: Katharina Schlacher

16:30 – 16:35

Katharina Schlacher
UT MD Anderson Cancer Center

Session Introduction

16:35 – 16:55

Lori Passmore
MRC Laboratory of Molecular Biology

STRUCTURES OF KEY COMPLEXES IN FANCONI ANEMIA DNA REPAIR

17:00 – 17:10

Martin Cohn *
University of Oxford

REGULATION OF THE FANCONI ANEMIA DNA REPAIR PATHWAY

17:15 – 17:25

Matthew Bochman *
Indiana University

MECHANISM OF FANCONI ANEMIA-INDEPENDENT DNA ICL REPAIR

17:30 – 17:40

Winnie Tan *
St Vincent's Institute of Medical Research

MONOUBIQUITINATION STABILISES FANCI:FANCD2 AS A FILAMENT ON DNA

17:45 – 18:05

Titia Sixma
Netherlands Cancer Institute

ALLOSTERIC REGULATION OF USP1 ACTIVITY

18:10 – 18:30

Scott Williams
NIH

DOES FIDELITY MATTER IN THE END? MOLECULAR PRINCIPLES OF DNA LIGATION FIDELITY

18:35 – 20:30

Poster Session & Refreshments (even poster numbers only)

20:30

Group Dinner

TUESDAY 18TH FEBRUARY 2020

07:00 – 08:30

Breakfast at Leisure

TUESDAY AM

Targeting DNA Damage Responses for Cancer Therapy
Session Chair: Bin Wang

08:30 – 08:35

Bin Wang
UT MD Anderson Cancer Center

Session Introduction

08:35 – 08:55

Junjie Chen
UT MD Anderson Cancer Center

TARGETING DNA DAMAGE RESPONSE PATHWAYS IN CANCER THERAPY

09:00 – 09:20

Steve West
Francis Crick Institute

SENSITISATION OF BRCA-DEFICIENT CANCER CELLS BY TARGETING NUCLEOTIDE METABOLISM

09:25 – 09:35

Stephen Taylor *
Manchester Cancer Research Centre

DNA REPLICATION VULNERABILITIES RENDER OVARIAN CANCER CELLS SENSITIVE TO POLY(ADP-RIBOSE) GLYCOHYDROLASE INHIBITORS

09:40 – 09:50

Joseph Newman *
University of Oxford

TARGETING RECQ HELICASES AS SYNTHETIC LETHAL TARGETS IN CANCER

09:55 – 10:05

Kara Bernstein *
University of Pittsburgh School of Medicine

NOVEL ROLES FOR THE RAD51 PARALOGS IN DNA STRAND SPECIFIC DAMAGE TOLERANCE

10:10 – 10:30

Titia de Lange
The Rockefeller University

THE ROLE OF CST IN PARP1-TREATMENT OF BRCA1 MUTANT CANCERS

10:35 – 11:20

Group Photo, Refreshments & Poster Viewing

TUESDAY AM II

RNA, Transcription and Repair
Session Chair: Petr Cejka

11:20 – 11:25

Petr Cejka
Università della Svizzera Italiana

Session Introduction

11:25 – 11:35

Nima Mosammaparast *
Washington University in St. Louis

ABERRANT RNA METHYLATION TRIGGERS RECRUITMENT OF AN ALKYLATION REPAIR AND TRANSCRIPTIONAL REPRESSOR COMPLEX

11:40 – 12:00

Caroline Kisker
University of Würzburg

THE MULTIFACETED CONTROL OF THE TFIIH HELICASE XPD IN NUCLEOTIDE EXCISION REPAIR AND TRANSCRIPTION

12:05 – 12:15

Ivaylo Ivanov *
Georgia State University

EMERGING UNIFIED DESCRIPTION OF TRANSCRIPTION INITIATION FROM cryo-EM AND INTEGRATIVE COMPUTATIONAL MODELING

12:20 – 12:30

Goran Kokic *
MPI for Biophysical Chemistry

STRUCTURAL BASIS OF TFIIH ACTIVATION FOR NUCLEOTIDE EXCISION REPAIR

12:35 – 12:45

Susan Tsutakawa *
Lawrence Berkeley National Laboratory

DISEASE MUTATIONS IN MULTIFUNCTIONAL DNA REPAIR PROTEINS, XPG AND TFIIH

12:50 – 17:00

Lunch at Leisure & Free Time

TUESDAY PM

Repairing Mismatches and Human Disease
Session Chair: Samir M. Hamdan

17:00 – 17:05

Samir M. Hamdan
King Abdullah University of Science and Technology

Session Introduction

17:05 – 17:25

Lorena Beese
Duke University School of Medicine

DNA MISMATCH REPAIR MACHINES

17:30 – 17:50

Dorothy Erie
University of North Carolina at Chapel Hill

SINGLE-MOLECULE FLUORESCENCE AND AFM STUDIES OF DNA MISMATCH REPAIR

17:55 – 18:05

Christopher E. Pearson *
The Hospital for Sick Children

TOWARDS THERAPEUTICALLY MODULATING DISEASE-ASSOCIATED REPEAT INSTABILITY

18:10 – 18:20

Sheila David *
University of California, Davis

FISHING FOR DNA DAMAGE: STRUCTURAL INSIGHTS INTO MUTYH RECOGNITION OF 8-OXOGUANINE:A MISMATCHES

18:25 – 20:30

Poster Session & Refreshments (odd poster numbers only)

20:30

Group Dinner

WEDNESDAY 19TH FEBRUARY 2020

07:00 – 08:30

Breakfast at Leisure

WEDNESDAY AM

DNA Double-Strand Break Repair: Homologous Recombination and Cancer Biology
Session Chair: Kara Bernstein

08:30 – 08:35

Kara Bernstein
University of Pittsburgh School of Medicine

Session Introduction

08:35 – 08:55

Steve Kowalczykowski
University of California, Davis

SEEING AND UNDERSTANDING BRCA1, BRCA2, AND RAD51, ONE MOLECULE AT A TIME

09:00 – 09:10

Petr Cejka *
Università della Svizzera Italiana

CtIP PROMOTES THE MOTOR ACTIVITY OF DNA2 TO ACCELERATE LONG-RANGE DNA END RESECTION

09:15 – 09:25

Piero Bianco *
University at Buffalo

THE MECHANISM OF SSB-RecG BINDING: IMPLICATIONS FOR SSB INTERACTOME FUNCTION

09:30 – 09:40

Jessica Tyler *
Weill Cornell Medicine

THE DREAM TRANSCRIPTIONAL REPRESSOR COMPLEX PREVENTS THE EXPRESSION OF THE HR MACHINERY AND THE INITIATION OF HR IN G1-PHASE CELLS

09:45 – 10:05

Terence Strick
CNRS

NANOMECHANICAL DETECTION OF SINGLE- AND DOUBLE-STRAND BREAK REPAIR

10:10 – 10:20

Jeff Lengyel *
Thermo Fisher Scientific

THE LATEST AND GREATEST IN CryoEM

10:25 – 11:00

Refreshments & Poster Viewing

WEDNESDAY AM II

DNA Double-Strand Break Repair: NHEJ Machines and Cancer Biology
Session Chair: Martin Cohn

11:00 – 11:05

Martin Cohn
University of Oxford

Session Introduction

11:05 – 11:25

Tom Blundell & Antonia Kefala Stavridi
University of Cambridge

UNDERSTANDING NHEJ THROUGH STRUCTURAL BIOLOGY: NEW DEVELOPMENTS IN cryo-EM FOR DNA-PKcs, Ku AND ARTEMIS INTERACTIONS

11:30 – 11:50

Susan Lees-Miller
University of Calgary

NOVEL ROLES OF DNA-PKcs

11:55 – 12:15

Taiana Oliveira
AstraZeneca

STRUCTURAL INSIGHTS INTO THE CRITICAL DNA DAMAGE SENSORS DNA-PKCS, ATM AND ATR

12:20 – 12:30

Maga Rowicka *
University of Texas Medical Branch at Galveston

DOUBLE-STRAND DNA BREAKS: QUANTITATIVE MAPPING AND COMPUTATIONAL MODELING OF MECHANISMS

12:35 – 12:45

Michal Szymanski *
University of Gdansk and Medical University of Gdansk

INTERPLAY BETWEEN DNA REPLICATION AND REPAIR IN HUMAN MITOCHONDRIA

12:50 – 16:30

Lunch at Leisure & Free Time

WEDNESDAY PM

Chromatin Remodeling
Session Chair: Jessica Tyler

16:30 – 16:35

Jessica Tyler
Weill Cornell Medicine
 

Session Introduction

16:35 – 16:55

Valda Vinson
American Association for the Advancement of Science

OPENING THE BLACK BOX: AN EDITOR’S PERSPECTIVE ON SCIENTIFIC PUBLISHING

17:00 – 17:20

Dale Wigley
Imperial College London

STRUCTURAL AND MECHANISTIC STUDIES OF THE SWR1 HISTONE EXCHANGE COMPLEX

17:25 – 17:45

Irene Chiolo
University of Southern California

NUCLEAR AND CHROMATIN DYNAMICS FOR HETEROCHROMATIN REPAIR

17:50 – 18:00

Yoshimasa Takizawa *
University of Tokyo

CHROMATIN STRUCTURE AND DYNAMICS AS THE PLATFORM FOR DNA REPAIR

18:05 – 18:35

Plenary Speaker:
Karl Peter Hopfner

Ludwig-Maximilians-University Munich

STRUCTURAL STUDIES OF CHROMATIN REMODELLER

18:40 – 20:00

Refreshments & Poster Viewing

20:00 – 23:00

Gala Dinner & Poster Awards

THURSDAY 20TH FEBRUARY 2020

07:00 – 08:35

Breakfast at Leisure

THURSDAY AM

DNA Damage Checkpoint, Repair and Disease
Session Chair: Nima Mosammaparast

08:35 – 08:40

Nima Mosammaparast
Washington University in St. Louis

Session Introduction

08:40 – 09:00

Xiaodong Zhang
Imperial College London

STRUCTURES AND MECHANISMS OF KEY COMPONENTS IN DNA DAMAGE SIGNALLING AND REPAIR

09:05 – 09:25

Walter Chazin
Vanderbilt University

STRUCTURE AND MECHANISM OF THE CORE SCAFFOLDING OF NER

09:30 – 09:40

Bor-Jang Hwang *
University of Maryland

THE ROLE OF CHECKPOINT CLAMP IN DNA REPAIR

09:45 – 10:15

Refreshments

THURSDAY AM II

Damage Sensing and “Canaries in the Coal Mine”
Session Chair: Karl Peter Hopfner

10:15 – 10:20

Karl Peter Hopfner
Ludwig-Maximilians-University Munich

Session Introduction

10:20 – 10:40

Bin Wang
UT MD Anderson Cancer Center

UBIQUITIN MODIFICATION IN DNA DAMAGE RESPONSE

10:45 – 10:55

Katherine Amidon *
Vanderbilt University

PROTECTION OF ABASIC SITES IN DNA BY A NATIVELY-OCCURRING THIAZOLIDINE DNA-PROTEIN CROSSLINK

11:00 – 11:20

Ben Van Houten
University of Pittsburgh

WATCHING COOPERATIVE INTERACTIONS BETWEEN BASE AND NUCLEOTIDE EXCISION REPAIR PROTEINS

11:25 – 11:45

John Tainer
UT MD Anderson Cancer Center

ATPases AT DNA REPLICATION FORKS AND BREAKS

11:50 – 12:00

Closing Comments by Tom Blundell, John Tainer & Xiaodong Zhang


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4th DNA Repair/Replication Structures and Cancer Conference

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16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Prices

Early Bird Full Price Additional Adult Additional Child Extra Night Adult Extra Night Child
Academic $1729 $1829 $862 $351 $321 $88
Industry $1729 $1829 $862 $351 $321 $88
Student $1377 $1477 $862 $351 $321 $88

All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.

What's Included in our Registration Fees?

Our registration fees are inclusive of the following during the conference period only:

- Conference registration 
- 4 nights’ fixed accommodation (16, 17, 18, 19 Feb 2020) on a single basis for academics and industry, on a shared basis for students
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited select brand liquors, wines by the glass, local domestic beer, bottled water and soft drinks
- Gala Dinner (includes an open bar)
- Room service
- Guest room mini bar
- Non motorized water sports equipment
- Complimentary WIFI throughout hotel

What's Included in our Accompanying Adult Fees?

Our accompanying adult fees are inclusive of the following during the conference period only:

- 4 nights’ fixed accommodation (16, 17, 18, 19 Feb 2020) on a shared basis with a conference participant 
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited select brand liquors, wines by the glass, local domestic beer, bottled water and soft drinks
- Gala Dinner (includes an open bar)
- Room service
- Guest room mini bar
- Non motorized water sports equipment
- Complimentary WIFI in throughout hotel

Important Note: Accompanying persons are not permitted access to the conference.

What's Included in our Accompanying Child Fees?

Our accompanying child fees are inclusive of the following during the conference period only:

- 4 nights’ fixed accommodation (16, 17, 18, 19 Feb 2020) on a shared basis with the parent/s
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited bottled water and soft drinks
- Gala Dinner 
- Room service
- Non motorized water sports equipment
- Complimentary WIFI throughout hotel

Important Note: Accompanying child fees are applicable for children aged 2-12 years. Children younger than 2 years stay free of charge with a parent. Children aged 13-17 years will be charged $503 per child. 18 years + will be classified as an adult at this venue (Melia Nassau Beach, Bahamas). Please kindly ensure your child / children are supervised at all times during conference and related events. Childcare services are available at the hotel, please contact Laura for further information.

What's Included in our Extra Night Fees?

- 1 nights’ accommodation for 1 person
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited select brand liquors, wines by the glass, local domestic beer, bottled water and soft drinks
- Room service 
- Guest room mini bar
- Non motorized water sports equipment
- Complimentary WIFI in your guest room

Important Note: Extra night child fees are applicable for children aged 2-12 years. Children younger than 2 years stay free of charge with a parent. Children aged 13-17 years will be charged $126 per night, per child. 18 years + will be classified as an adult at this venue (Melia Nassau Beach, Bahamas).

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4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

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4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

LinkedIn forum

Bringing together the global community of researchers and scientists interested in the study of DNA. Relevant specialties are wide-ranging, reflecting the importance of DNA Research in many aspects of health and disease, including; DNA Repair, DNA Replication, DNA Damage, Cancer, Chromosomal Instability, RNA and Nucleic Acids.

The group is open to all and is intended as a networking forum for past, present and future participants of Fusion Conferences as well as those interested in the related topics.

Join our group

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4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Venue

Melia Nassau Beach All Inclusive

Venue Rating
Currency
US Dollar (USD)
Address
Nassau W Bay St. Nassau Bahamas
Nearest Airport
Lynden Pindling International Airport

Overlooking one of the finest beaches in the world the Meliá Nassau Beach is surrounded by crystal blue waters and white sandy beaches. Located on the stunning Cable Beach, you are just a few minutes walk from the center, shops and restaurants. The beautiful Nassau Botanical Gardens are within easy reach (7km) and Lynden Pindling International Airport is situated only 9km away.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from Cilantro where you can experience the natural textures, aromas and flavors of Mexico, Nikkei, celebrated for its exquisite fusion of Japanese, Cantonese and Peruvian cuisine featuring a sushi bar and Teppanyaki tables, Estavida, an upbeat tapas lounge located in the hotel lobby serving innovative tapas and a wide selection of cocktails, Aqua, an A la carte restaurant specializing in exquisite, rustic Italian cuisine, The Market Place, where you will find an International buffet serving an array of exquisite dishes, O'Grille, an open air restaurant with fabulous views of the sea and pool serving casual beach fare and light bites and finally The Black Angus, a steakhouse featuring hip, contemporary jazz and modern decor, offering guests the finest quality prime cuts and the freshest ingredients.(This restaurant is not included in the all inclusive package, additional charges apply). The Gala Night takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment.  We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

  • 24 hour reception
  • Room service
  • 3 heated outdoor pools
  • Complimentary resort wide Wi-Fi (guest rooms, throughout hotel, beach and conference areas)   
  • 24-hour Fitness Center
  • 7 dining venues
  • 4 bars.
  • non-motorised water sports

The Bahamas is formed by over 700 islands, keys and islets located in the Atlantic Ocean and renowned for its warm sunshine, mild climate, fine, white sandy beaches, turquoise, crystal clear water and friendly people, making this the perfect environment to relax and unwind in your free time during the conference.

Location

The Melia Nassau Beach All-Inclusive is located right on the stunning Cable Beach just a few minutes away from the airport and city center; Nearby in Downtown Nassau you can experience the flavours of new foods at local restaurants, shop 'til you drop at Straw market or take a trip through time at the Pirates Museum. The beautiful Nassau Botanical Gardens are close by and water enthusiasts can enjoy non-motorized water sports right on property.

Nassau is the capital of the Bahamas. It lies on the island of New Providence, with neighboring Paradise Island accessible via Nassau Harbor bridges. The city has a hilly landscape and is known for it's fabulous beaches as well as its offshore coral reefs, popular for diving and snorkeling. It retains many of its typical pastel-colored British colonial buildings, like the pink-hued Government House.

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4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Transportation

The Melia Nassau Beach Resort is located just 9km from Lynden Pindling International Airport, approximately 10-15 minutes journey time. Formerly known as Nassau International Airport, it is the largest airport in the Bahamas and provides an international gateway into the country.

Taxis

There’s no shortage of available taxi cabs at Lynden Pindling International Airport. Taxis are available outside the U.S., International and Domestic terminals. Taxis charge approximately $25 one way to the Melia Nassau Hotel, however charges may increase if there are more than two passengers and/or two large suitcases.

Pre-Booked Airport Transfers

There are various suppliers that offer pre-booked airport transfer services to and from Lynden Pindling Airport. Please find details of a few that we are aware of below. However, should you require further information or would like to make a booking, please contact the company directly. Pre-booked transportation prices range from $70 - $145 one way. 

Simon's Transports Ltd
Contact Name: Jocelyne Casimir
Contact Email: info@simonstransports.com
Website: https://simonstransportsbahamas.com/nassau-airport-transfers/ 

Majestic Tours
Contact Name: Betty Fox
Contact Email: betty@MajesticHolidays.com
Website: http://www.majestictoursbahamas.com/

Cheryl Bahamas Taxi & Tours
Contact Email: cherylfoxferguson@live.com
Website: http://www.cherylbahamastaxiandtours.com/

Black Diamond Transportation (BDT Bahamas)
Website: https://bdtbahamas.com

**Any bookings and transactions made with the above suppliers are the sole responsibility of the individual.

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4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Local Activities

Several free activities are available within the resort and include:

  • Trip to Balmoral Island during your stay; a taxi boat to and from Balmoral Island and access to the VIP Balmoral Beachside is included. Please ask reception for the boat departure/return schedule.
  • Daily fitness activities: gym classes, yoga, zumba, pool aerobics, etc.
  • In the water: paddleboards, glass-bottom kayaks, ocean duo kayaks, reef-board zayaks, cabana floating mats, water hammocks, etc.
  • Workshops: jewellery making, henna tattoo, scent creation, Bahamian crafts, etc.
  • Classes: mixology, scuba diving, dancing, etc.
  • Friendly competitions: beach volleyball, beach soccer, ping pong, darts, water balloon toss, deep dive contest, etc.
  • Free shuttle to Baha Mar and direct access to its spectacular 100,000 sq. ft. casino, Royal Blue™ tournament player’s golf course with special rates for Meliá guests, tennis court, spa, retail outlets and over 30 dining venues and lounges.

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If you're interested in sponsoring this conference please contact us.

4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Group Activities

Unfortunately, due to the recent shark attacks, we will no longer be offering a group snorkelling trip for our conferences in the Bahamas next year.

For those of you who still wish to enjoy tours/excursions outside of the resort during free time, Majestic Tours is a local tour operator offering individual or small group trips which can be pre-booked or organised through their hospitality desk within the hotel. For more information, please contact Majestic Tours directly.

Majestic Tours
Contact Name: Betty Fox
Contact Email: betty@MajesticHolidays.com
Website: http://www.majestictoursbahamas.com/

A number of free activities are also available within the resort, please visit our ‘Local Activities’ tab for more information.

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If you're interested in sponsoring this conference please contact us.

4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Childcare

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4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Oral Presenters

We have several oral opportunities available at this meeting. To be considered for a talk, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

If you are accepted for a talk, we recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference website.

Your Presentation

On the day of your presentation please make yourself known to our AV technician who will be present in the conference room. We advise running through your presentation at least 30minutes prior to your session commencing to ensure your slides and any videos or animations appear as expected. We prefer our speakers to run their presentation from the master PC or Mac, however, if you prefer to use your own laptop then please notify us prior to the session. A HDMI or VGA cable is usually available on the podium.

Our AV technician will apply your microphone and provide a combined slide advancer and laser pointer.

We ask all speakers to adhere to their time slots and respect their fellow presenters. A visual traffic light aide will be available to warn presenters as their time decreases.

Please make sure your presentation adheres to the following guidelines.

Aspect Ratio: On Screen Show (16:9)
File Type: Please save your presentation in PPT, PPTS or Keynote format.

Download Abstract Template

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4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Posters

We have several poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

Please bring your poster to registration and hand this to a member of the Fusion team. They will advise of your poster number and display your poster for you. 

Your poster will remain on display for the duration of the conference, allowing presenters to take advantage of the refreshment breaks and free time for valuable networking opportunities, in addition to the official poster session.

Please check the programme and note the date and time of the poster session(s). Your poster will be judged during the poster session and prizes will be awarded at the Gala Dinner.

Posters will be taken down by the Fusion team and will be ready for collection at the Fusion desk on the final day of the conference.

Download Abstract Template

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4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20


16 Feb 2020 - 20 Feb 2020

Nassau, Bahamas

Chairs

Conference History

12 Feb 2014, 15 Feb 2014

Dynamic Structures in DNA Damage Responses and Cancer

Fiesta Americana Condesa, Cancun, Mexico

Key sessions will include: DNA and RNA complexes Chromatin Remodeling Post-translational modifications - Ub, SUMO kinases The repair interface with Replication Transcription, and Recomb...

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22 Feb 2016, 25 Feb 2016

2nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

Fiesta Americana Condesa, Cancun, Mexico

This conference will focus on insights into dynamic DNA and RNA complexes involved in the damage response and cancer. It will emphasize informal as well as formal discussions together with informative talks and...

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11 Feb 2018, 15 Feb 2018

3rd DNA Replication/Repair Structures and Cancer Conference

Fiesta Americana Condesa, Cancun, Mexico

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a...

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16 Feb 2020, 20 Feb 2020

4th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20

Melia Nassau Beach All Inclusive, Nassau, Bahamas

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate DNA repair in the context of oncogene-induced replication stress and elevated transcription. Intertwined roles of repair with replica...

More Information

Supported By

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If you're interested in sponsoring this conference please contact us.