5 th DNA Repair/Replication Structures and Cancer Conference

Synopsis

Future master keys to cancer biology and advanced therapies are being forged from mechanistic understanding of the intertwined roles of DNA repair with DNA replication stress, transcription and immune responses. The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate DNA repair in the context of oncogene-induced replication stress and elevated transcription. In fact, DNA repair complexes are frequently found at the convergence of multiple processes critical for cancer development, making their elucidation of fundamental biological and medical importance. Moreover, the synthetic lethality and essentiality resulting from repair-replication stresses suggest strategies and tactics for advanced therapeutics that target Achilles heels for cancer. Furthermore, epigenetics, non-coding RNA, phase condensates and microbiome are emerging as increasingly important players/processes in cancer biology and cancer progression, and as potential therapeutic targets.

The 5th DNA Repair/Replication Structures & Cancer conference in May 2022 will focus on structural and mechanistic insights into dynamic complexes acting in DNA repair and its interface with replication, transcription and other cancer-relevant transactions. This fundamental information will be pivotal for the accurate interpretation of cancer clinical data, design of clinical trials, prognosis, etiology and improving the currently 1/20 low success rate for oncology drug clinical trials. Informative talks and poster sessions along with vibrant discussions will foster productive interactions, collaborations, and insights.

To advance understanding, all presenters are asked to focus on unpublished work, cutting-edge approaches and mechanistic insights that aid prediction of biological outcomes and plans to best apply basic research advances for cancer research and treatment. To include late-breaking advances and innovating new investigators, multiple talks will be selected from submitted abstracts. As meeting attendance is limited to ensure effective discussions and interactions, delegates are strongly encouraged to submit applications and abstracts early to avoid disappointment.

What makes this meeting unique? Professor Ben Van Houten from the University of Pittsburgh says:

‘I can honestly say your meeting, by combining hard core structure-function studies with beautiful biology, hits an important area that many meetings miss; being part of that science is just terrific.’

Key Sessions

Sessions will include emerging results and breakthrough methodologies on core topics including:

Repair and replication complexes, structures and mechanisms
Epigenetics and non-coding RNA
Mutational signatures, DNA repair, and cancer
Intertwined repair interactions with transcription and replication stress
Posttranslational modifications, phase condensates, and repair
Links to microbiome, inflammation and immune responses
Targeting synthetic lethality and essentiality for damage responses

Therapeutics Session

This year we are super excited to include a session dedicated to DDR-based cancer therapeutics, highlighting a number of new DDR agents that have recently entered the clinic, alongside more established DDR inhibitors, the use of DDR-based technology that has potential translational science utility both in the lab and the clinic, as well as an overview of the opportunities and challenges associated with developing new DDR-based medicines for cancer patients.

We are joined by the following incredible speakers:

Mark O'Connor, Chief Scientist Oncology R&D, AstraZeneca
Discussing next generation PARP inhibitors.
Helen Robinson, VP of Biology, Artios
Discussing the discovery and development of polymerase theta inhibitors.
Magda Kordon, CEO & Co-Founder, intoDNA
Discussing how DNA STRIDE technology is being used to advance DDR inhibitor drug discovery and development.
Timothy Yap, Medical Director, Institute for Applied Cancer Science, MD Anderson Cancer Center
Discussing what it means to test DDR inhibitors in the clinic.

Student Offer

Take advantage of this fantastic opportunity for students and postdocs! Fully paying academics can bring one student or postdoc for only $900. Both registration packages include accommodation for the 27th, 28th, 29th and 30th April 2022 (on a shared basis for students/postdocs) and a food and beverage package for the conference period. Once registered, please contact Laura Trundle to obtain a special registration link for your student or postdoc.

Confirmed Plenary Speakers

Rising Star Plenary: Yuan He (Northwestern University)
STRUCTURAL BASIS OF DNA DOUBLE-STRAND BREAK REPAIR BY NHEJ
Steve Kowalczykowski (University of California, Davis)
CONTROL AND MECHANISM OF DNA RESECTION
Titia Sixma (Netherlands Cancer Institute)
INITIATION OF DNA MISMATCH REPAIR

Confirmed Invited Speakers

Ivan Ahel (University of Oxford)
ADP-RIBOSYLATION SIGNALLING IN REGULATION OF DNA DAMAGE RESPONSE
Aura Carreira (CBMSO)
INSIGHTS ON BRCA2 FUNCTIONAL DOMAINS FROM BREAST CANCER VARIANTS
Walter Chazin (Vanderbilt University)
EXPLORING NER MISSENSE MUTATIONS AND SENSITIVITY TO PT AGENTS
Junjie Chen (MD Anderson Cancer Center)
TARGETING DNA DAMAGE RESPONSIVE PATHWAYS FOR CANCER THERAPY
Patrick Cramer (Max Planck Institute for Biophysical Chemistry)
STRUCTURAL STUDIES OF EUKARYOTIC TRANSCRIPTION-COUPLED DNA REPAIR
Sylvie Doublie (University of Vermont)
PROBING THE STRUCTURE AND FUNCTION OF POLYMERASE THETA HELICASE-LIKE DOMAIN
Angela Eggleston (Nature)
THE IMPACT OF cryoEM ON OUR UNDERSTANDING OF DNA REPAIR
Dorothy Erie (University of North Carolina at Chapel Hill)
SINGLE-MOLECULE STUDIES OF DNA REPAIR ENZYMES
Yuan He (Northwestern University)
STRUCTURAL BASIS OF DNA DOUBLE-STRAND BREAK REPAIR BY NHEJ
Karl-Peter Hopfner (Ludwig-Maximilians-University Munich)
MECHANISM OF DNA DOUBLE-STRAND BREAK SENSING AND PROCESSING BY THE Mre11-Rad50 COMPLEX
Caroline Kisker (University of Würzburg)
HOW TO LIMIT THE SPEED OF A MOTOR - THE INTRICATE REGULATION OF THE XPB ATPase AND TRANSLOCASE IN TFIIH
Magda Kordon (intoDNA)
DETECTION OF DNA DAMAGE USING STRIDE TECHNOLOGY AS NEW PD BIOMARKER IN LIQUID BIOPSIES AND FFPE TISSUE SECTIONS
Carolyn Larabell (University of California, San Francisco)
LABEL-FREE IMAGING OF NUCLEAR ORGANIZATION WITH SOFT X-RAY TOMOGRAPHY
Susan Lees-Miller (University of Calgary)
STRUCTURAL INSIGHTS INTO NON-HOMOLOGOUS END-JOINING
Mark O'Connor (AstraZeneca)
DEVELOPING A NEXT-GENERATION PARP1-SELECTIVE INHIBITOR TO TREAT CANCER
John Pascal (University of Montreal)
POLY(ADP-ribose) POLYMERASE ENZYMES AS SENSORS OF DNA DAMAGE AND TARGETS FOR CANCER THERAPY
Helen Robinson (Artios)
DNA POLYMERASE THETA INHIBITION FOR CANCER THERAPY
Eli Rothenberg (NYU Langone Health)
MECHANISMS OF REPLICATION FORK REMODELING AND REPAIR VIA SINGLE-MOLECULE IMAGING
Katharina Schlacher (MD Anderson Cancer Center)
NUCLEAR AND MITOCHONDRIAL GENOME INSTABILITY IN DISEASE AND INFLAMMATION
Joann Sweasy (University of Arizona)
BASE EXCISION REPAIR AND HUMAN DISEASE
Ben Van Houten (UPMC Hillman Cancer Center)
THE ROLE OF UV-DDB IN BASE EXCISION REPAIR: FROM SINGLE MOLECULES TO CELLS
Steve West (Francis Crick Institute)
STRUCTURE-FUNCTION STUDIES OF THE TUMOUR SUPPRESSOR COMPLEX RAD51B-RAD51C-RAD51D-XRCC2
Dale Wigley (Imperial College London)
MECHANISM AND REGULATION OF INO80-FAMILY REMODELLERS
Scott Williams (NIH)
MOLECULAR MECHANISMS OF DNA REPAIR FACTORS IMPACTED IN HERITABLE ATAXIA SYNDROMES
Wei Yang (NIH)
THE INS AND OUTS OF V(D)J RECOMBINATION
Timothy Yap (MD Anderson Cancer Center)
DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES TO TARGET THE DNA DAMAGE RESPONSE IN THE CLINIC
Shan Zha (Columbia University Medical Center)
THE FUNCTIONAL IMPACTS OF KU C-terminal DOMAINS IN NON-HOMOLOGOUS END-JOINING AND BEYOND
Xiaolan Zhao (Memorial Sloan Kettering Cancer Center)
INTEGRATIVE ANALYSIS REVEALS UNIQUE STRUCTURAL AND FUNCTIONAL FEATURES OF THE Smc5/6 COMPLEX

Target Audience

Academic and industrial researchers (including established and junior principal investigators, postdoctoral fellows and PhD students) interested in DNA damage responses and cancer including their intersection with replication, transcription, epigenetics, non-coding RNA, posttranslational modifications, cancer biology, and cancer drug discovery. The focus will be the molecular mechanisms of and interfaces controlling damage responses and cancer biology.

Educational Need

This conference will bring together scientists working at the forefront of DNA repair, replication, transcription, epigenetics, non-coding RNA, post-translational modification including PARylation, and cancer biology. Presentations will consider diverse cutting-edge methodologies and integrated approaches to investigate the structures and mechanisms of dynamic protein, chromatin, DNA and RNA complexes. The conference will showcase breakthrough advances and new developments in these areas. It will furthermore provide opportunities for industry and academia to consider and exchange their latest results in this exciting, rapidly advancing arena. The inter-disciplinary nature of the presented work will create strong synergies among participants and outstanding opportunities for exchanging information and developing new collaborations. The cross-disciplinary interactions will be invaluable training for young scientists to work in these and other emerging areas of science.

4th DRRSC Photos

Supported By

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Speakers

Plenary Speakers

Steve Kowalczykowski

Professor, University of California, Davis

Titia Sixma

Group leader, Netherlands Cancer Institute

Invited Speakers

Walter Chazin

Founding Director- Center for Structural Biology, Vanderbilt University

Joann Sweasy

Professor, University of Arizona

Patrick Cramer

Director, Max Planck Institute for Biophysical Chemistry

Aura Carreira

Group leader, CBMSO

Susan Lees-Miller

Professor, University of Calgary

Steve West

Senior Group Leader, Francis Crick Institute

Ben Van Houten

Richard M. Cyert Professor of Molecular Oncology, UPMC Hillman Cancer Center

Angela Eggleston

Team Manager and Senior Editor, Nature

Wei Yang

Section Chief, National Institutes of Health

Karl-Peter Hopfner

Professor, Gene Center

Xiaolan Zhao

Professor, Memorial Sloan-Kettering Cancer Center

Carolyn Larabell

Professor, University of California, San Francisco

Caroline Kisker

Professor, University of Wuerzburg

Mark O'Connor

Chief Scientist, AstraZeneca

Katharina Schlacher

Assistant Professor, MD Anderson Cancer Center

Scott Williams

Principal Investigator, NIH/NIEHS

Timothy Yap

Associate Professor, MD Anderson Cancer Center

Yuan He

Associate Professor, Northwestern Unviersity

Sylvie Doublié

Professor, University of Vermont

Magda Kordon-Kiszala

CEO, intoDNA S.A.

Helen Robinson

VP of Biology, Artios Pharma

Dale Wigley

Professor, Imperial College London

Eli Rothenberg

Associate Professor, New York University School of Medicine

John Pascal

Professor, Université de Montréal

Ivan Ahel

Professor of Chemical Pathology, University of Oxford

Dorothy Erie

Professor, University of North Carolina

Shan Zha

Professor, Columbia University

Junjie Chen

Professor and Chair, The University of Texas MD Anderson Cancer Center

Supported By

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Programme

Please note the programme is subject to change.
Discussion is valued: 5 minutes is saved for discussion following each talk.
*Selected from abstracts.

WEDNESDAY 27^TH APRIL 2022
15:00 – 16:00	Student & Postdoc Networking Reception
15:00 – 16:00	Registration & Refreshments
16:00 – 16:15	Opening Comments by John Tainer & Xiaodong Zhang
WEDNESDAY PM	DSB repair – NHEJ machines and Cancer Biology Session Chair: Jean-Baptiste Charbonnier
16:15 – 16:20	Session Introduction by Jean-Baptiste Charbonnier
16:20 – 16:40	Susan Lees-Miller University of Calgary	STRUCTURAL INSIGHTS INTO NON-HOMOLOGOUS END-JOINING
16:45 – 16:55	Shikang Liang * University of Cambridge	Cryo-EM OF NHEJ SUPERCOMPLEXES & INHIBITOR BINDING
17:00 – 17:10	Katheryn Meek * Michigan State University	EVIDENCE FOR SEPARATE FUNCTIONS FOR TWO DISTINCT NON-HOMOLOGOUS END-JOINING LONG-RANGE SYNAPTIC COMPLEXES
17:15 - 17:25	Ben Stinson * Harvard Medical School	HOW NON-HOMOLOGOUS END JOINING MINIMIZES ERRORS
17:30 – 17:50	Meet the Poster Presenters I
17:50 – 18:30	Refreshments
18:30 – 18:50	Meet the Poster Presenters II
18:50 – 19:10	Shan Zha Columbia University Medical Center	THE FUNCTIONAL IMPACTS OF KU C-terminal DOMAINS IN NON-HOMOLOGOUS END-JOINING AND BEYOND
19:15 – 19:45	Rising Star Plenary: Yuan He Northwestern University	STRUCTURAL BASIS OF DNA DOUBLE-STRAND BREAK REPAIR BY NHEJ
19:50	Group Dinner

THURSDAY 28^TH APRIL 2022
07:00 – 08:30	Breakfast at Leisure
THURSDAY AM	Replication and Repair Mechanisms Session Chair: Steve West
08:30 – 08:35	Session Introduction by Steve West
08:35 – 08:55	Steve West & Luke Greenhough Francis Crick Institute	STRUCTURE-FUNCTION STUDIES OF THE TUMOUR SUPPRESSOR COMPLEX RAD51B-RAD51C-RAD51D-XRCC2
09:00 – 09:10	Elwood Mullins * Vanderbilt University	THE STRUCTURAL BASIS OF NUCLEOTIDE COUNTING BY POLYMERASE α
09:15 – 09:25	Patrick Herr * University of Sheffield	NUDT22 COUNTERACTS REPLICATION STRESS THROUGH A NOVEL PYRIMIDINE SALVAGE PATHWAY
09:30 – 09:40	Margherita Botto * Leiden University Medical Center	A FOUR-POINT MOLECULAR HANDOVER DURING OKAZAKI MATURATION
09:45 – 10:05	Katharina Schlacher MD Anderson Cancer Center	NUCLEAR AND MITOCHONDRIAL GENOME INSTABILITY IN DISEASE AND INFLAMMATION
10:10 - 10:20	David Sherratt * University of Oxford	LIFE AT A BACTERIAL REPLICATION FORK
10:25 – 10:55	Refreshments & Poster Viewing
THURSDAY AM II	Replication/Repair Interface Session Chair: Caroline Kisker
10:55 – 11:00	Session Introduction by Caroline Kisker
11:00 – 11:20	Wei Yang NIH	THE INS AND OUTS OF V(D)J RECOMBINATION
11:25 – 11:45	Walter Chazin Vanderbilt University	EXPLORING NER MISSENSE MUTATIONS AND SENSITIVITY TO PT AGENTS
11:50 – 12:00	Pablo Alcón * MRC-LMB	STRUCTURAL INSIGHTS INTO THE REGULATION OF THE FANCONI ANEMIA PATHWAY
12:05 – 12:25	Eli Rothenberg NYU Langone Health	MECHANISMS OF REPLICATION FORK REMODELING AND REPAIR VIA SINGLE-MOLECULE IMAGING
12:30 – 12:40	Emanuel N Lissek * LUMICKS	A DYNAMIC SINGLE-MOLECULE APPROACH TO DIRECTLY VISUALIZE THE MOLECULAR MECHANISMS OF DNA-BINDING PROTEINS
12:45 – 16:30	Lunch at Leisure & Free Time

THURSDAY PM	Mismatch and Excision Repairs: From Molecules to Cells and Disease Session Chair: Susan Tsutakawa
16:30 – 16:35	Session Introduction by Susan Tsutakawa
16:35 – 16:55	Ben Van Houten UPMC Hillman Cancer Center	THE ROLE OF UV-DDB IN BASE EXCISION REPAIR: FROM SINGLE MOLECULES TO CELLS
17:00 – 17:20	Joann Sweasy University of Arizona	BASE EXCISION REPAIR AND HUMAN DISEASE
17:25 – 17:45	Sylvie Doublie University of Vermont	PROBING THE STRUCTURE AND FUNCTION OF POLYMERASE THETA HELICASE-LIKE DOMAIN
17:50 – 18:00	Alessandro Borsellini * Leiden University Medical Center	MutL BINDS TO 3' RESECTED DNA ENDS AND BLOCKS DNA POLYMERASE ACCESS
18:05 – 18:35	Plenary: Titia Sixma Netherlands Cancer Institute	INITIATION OF DNA MISMATCH REPAIR
18:40 – 20:00	Poster Session & Refreshments (even poster numbers only)
20:00	Dinner at Leisure

FRIDAY 29^TH APRIL 2022
07:00 – 08:30	Breakfast at Leisure
FRIDAY AM	Damage Sensing, Signaling and Therapeutic Implications Session Chair: Jessica Tyler
08:30 – 08:35	Session Introduction by Jessica Tyler
08:35 - 08:55	John Pascal University of Montreal	POLY(ADP-ribose) POLYMERASE ENZYMES AS SENSORS OF DNA DAMAGE AND TARGETS FOR CANCER THERAPY
09:00 - 09:20	Ivan Ahel University of Oxford	ADP-RIBOSYLATION SIGNALLING IN REGULATION OF DNA DAMAGE RESPONSE
09:25 – 09:35	Petr Cejka * Institute for Research in Biomedicine	MECHANISM OF DNA END SENSING BY THE MRE11 COMPLEX: IMPLICATIONS FOR CRISPR-BASED GENOME EDITING
09:40 – 09:50	Dorothee Kern * Brandeis University	PROTEIN DYNAMICS AT THE HEART OF NEW CANCER DRUG DESIGN APPROACHES
09:55 – 10:15	Carolyn Larabell University of California, San Francisco	LABEL-FREE IMAGING OF NUCLEAR ORGANIZATION WITH SOFT X-RAY TOMOGRAPHY
10:20 – 11:20	Group Photo, Refreshments & Poster Viewing
FRIDAY AM II	RNA, Transcription and Repair Session Chair: Xiaolan Zhao
11:20 – 11:25	Session Introduction by Xiaolan Zhao
11:25 – 11:45	Patrick Cramer Max Planck Institute for Biophysical Chemistry	STRUCTURAL STUDIES OF EUKARYOTIC TRANSCRIPTION-COUPLED DNA REPAIR
11:50 – 12:10	Caroline Kisker University of Würzburg	HOW TO LIMIT THE SPEED OF A MOTOR - THE INTRICATE REGULATION OF THE XPB ATPase AND TRANSLOCASE IN TFIIH
12:15 – 12:25	Ivaylo Ivanov * Georgia State University	MOLECULAR MECHANISM OF RAD26-ASSISTED RESCUE OF STALLED RNA POLYMERASE II IN TRANSCRIPTION-COUPLED REPAIR
12:30 – 12:40	Michal Roman Szymanski * University of Gdansk and Medical University of Gdansk	RNA PRIMER REMOVAL IN HUMAN MITOCHONDRIA
12:45 – 12:55	Raluca Gordan * Duke University	DNA-BOUND TRANSCRIPTION FACTORS COMPETE WITH MISMATCH REPAIR AND LEAD TO INCREASED MUTAGENESIS AT REGULATORY SITES
13:00 – 17:00	Lunch at Leisure & Free Time

FRIDAY PM	DSB Repair – HR and Cancer Session Chair: David Sherratt
17:00 – 17:05	Session Introduction by David Sherratt
17:05 – 17:25	Karl-Peter Hopfner Ludwig-Maximilians-University Munich	MECHANISM OF DNA DOUBLE-STRAND BREAK SENSING AND PROCESSING BY THE Mre11-Rad50 COMPLEX
17:30 – 17:40	Zamal Ahmed * MD Anderson Cancer Center	GRB2 ENFORCES HOMOLOGY-DIRECTED REPAIR INITIATION BY MRE11
17:45 – 17:55	Gloria Borgstahl * Eppley Institute for Research in Cancer	SELECTIVE KILLING OF HOMOLOGOUS RECOMBINATION-DEFICIENT CANCER CELL LINES BY INHIBITORS OF THE RPA:RAD52 PROTEIN-PROTEIN INTERACTION
18:00 – 18:30	Plenary: Steve Kowalczykowski University of California, Davis	CONTROL AND MECHANISM OF DNA RESECTION
18:35 – 20:05	Poster Session & Refreshments (odd poster numbers only)
20:05	Dinner at Leisure

SATURDAY 30^TH APRIL 2022
07:00 – 08:25	Breakfast at Leisure
SATURDAY AM	Targeting DNA Damage Responses for Cancer Therapy Session Chair: Mark O'Connor
08:25 – 08:30	Session Introduction by Mark O'Connor
08:30 – 09:00	Mark O'Connor AstraZeneca	DEVELOPING A NEXT-GENERATION PARP1-SELECTIVE INHIBITOR TO TREAT CANCER
09:05 – 09:25	Helen Robinson Artios	DNA POLYMERASE THETA INHIBITION FOR CANCER THERAPY
09:30 – 09:50	Magda Kordon-Kiszala intoDNA	DETECTION OF DNA DAMAGE USING STRIDE TECHNOLOGY AS NEW PD BIOMARKER IN LIQUID BIOPSIES AND FFPE TISSUE SECTIONS
09:55 – 10:25	Timothy Yap MD Anderson Cancer Center	DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES TO TARGET THE DNA DAMAGE RESPONSE IN THE CLINIC
10:30 – 11:00	Refreshments & Poster Viewing
SATURDAY AM II	Repair Machines and Mechanisms Session Chair: Dorothee Kern
11:00 – 11:05	Session Introduction by Dorothee Kern
11:05 – 11:25	Scott Williams NIH	MOLECULAR MECHANISMS OF DNA REPAIR FACTORS IMPACTED IN HERITABLE ATAXIA SYNDROMES
11:30 – 11:50	Dorothy Erie University of North Carolina at Chapel Hill	SINGLE-MOLECULE STUDIES OF DNA REPAIR ENZYMES
11:55 – 12:05	Jiri Wald * UKE Hamburg/DESY/CSSB	ARCHITECTURE AND OPERATING PRINCIPLES OF THE RuvAB HOLLIDAY JUNCTION BRANCH MIGRATION COMPLEX
12:10 – 12:20	Michael Latham * Texas Tech University	STRUCTURAL ENSEMBLE OF THE Mre11-Rad50 DNA DAMAGE REPAIR COMPLEX BOUND TO SUBSTRATE DNA
12:25 – 12:45	Angela Eggleston Nature	THE IMPACT OF cryoEM ON OUR UNDERSTANDING OF DNA REPAIR
12:50 – 16:30	Lunch at Leisure & Free Time
SATURDAY PM	Damage Processing and Repair Mechanisms Session Chair: Katharina Schlacher
16:30 – 16:35	Session Introduction by Katharina Schlacher
16:35 – 16:55	Dale Wigley Imperial College London	STRUCTURE AND MECHANISM OF THE SWR1 HISTONE EXCHANGE COMPLEX
17:00 – 17:20	Xiaolan Zhao Memorial Sloan Kettering Cancer Center	INTEGRATIVE ANALYSIS REVEALS UNIQUE STRUCTURAL AND FUNCTIONAL FEATURES OF THE Smc5/6 COMPLEX
17:25 – 17:35	Jessica Tyler * Weill Cornell Medicine	DNA-PK PROMOTES DNA END RESECTION AT DNA DOUBLE STRAND BREAKS IN G0 CELLS
17:40 – 17:50	Jean-Baptiste Charbonnier * CEA-CNRS-Univ Paris Saclay	INOSITOL HEXAKISPHOSPHATE (IP6) REGULATES Ku70/80 ACTIVITY AND THE NHEJ VERSUS HR BALANCE
17:55 – 18:05	Susan Tsutakawa * Lawrence Berkeley National Labs	MULTI-SUBUNIT PROTEIN MACHINES, AI, AND CANCER MUTATIONS; INSIGHTS FROM NUCLEOTIDE EXCISION REPAIR
18:10 – 19:35	Refreshments & Poster Viewing
20:00 – 23:00	Gala Dinner & Poster Awards
SUNDAY 01^ST MAY 2022
07:00 – 08:35	Breakfast at Leisure
SUNDAY AM	Damage Response and Decoding Cancer Variants Session Chair: Brandt Eichman
08:35 – 08:40	Session Introduction by Brandt Eichman
08:40 – 09:00	Xiaodong Zhang Imperial College London	MOLECULAR STRUCTURES AND REGULATIONS OF ATR/Mec1 IN DNA DAMAGE SIGNALING
09:05 – 09:25	Junjie Chen MD Anderson Cancer Center	TARGETING DNA DAMAGE RESPONSIVE PATHWAYS FOR CANCER THERAPY
09:30 - 09:50	Aura Carreira CBMSO	INSIGHTS ON BRCA2 FUNCTIONAL DOMAINS FROM BREAST CANCER VARIANTS
09:55 – 10:15	John Tainer MD Anderson Cancer Center	STRUCTURE AND EVOLUTION DECODES CANCER VARIANTS OF UNKNOWN SIGNIFICANCE
10:20 – 10:30	Closing Comments by John Tainer & Xiaodong Zhang

Supported By

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Prices

	Early Bird	Full Price	Additional Adult	Additional Child	Extra Night Adult	Extra Night Child
Academic	$1660	$1770	$677	$247	$268	$62
Industry	$1660	$1770	$677677	$247	$268	$62
Student	$1236	$1400	$677	$247	$268	$62

All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.

What's Included in our Registration Fees?

Our registration fees are inclusive of the following during the conference period only:

- Conference registration
- 4 nights’ fixed accommodation (27, 28, 29, 30 April 2022) on a single basis for academics and industry, on a shared basis for students
- Breakfast, lunch and dinner available at all restaurants according to their operational hours
- Unlimited alcoholic beverages, cocktails and soft drinks available by the glass at all restaurants and bars according to their operational hours
- Gala Dinner (includes an open bar)
- 24 hour room service
- Guest room mini bar (replenished daily)
- Complimentary WIFI in both conference rooms and your guest room

What's Included in our Accompanying Adult Fees?

Our accompanying adult fees are inclusive of the following during the conference period only:

- 4 nights’ fixed accommodation (27, 28, 29, 30 April 2022) on a shared basis with a conference participant
- Breakfast, lunch and dinner available at all restaurants according to their operational hours
- Unlimited alcoholic beverages, cocktails and soft drinks available by the glass at all restaurants and bars according to their operational hours
- Gala Dinner (includes an open bar)
- 24 hour room service
- Guest room mini bar (replenished daily)
- Complimentary WIFI in your guest room

Important Note: Accompanying guests are not permitted access to the conference.

What's Included in our Accompanying Child Fees?

Our accompanying child fees are inclusive of the following during the conference period only:

- 4 nights’ fixed accommodation (27, 28, 29, 30 April 2022) on a shared basis with the parent/s
- Breakfast, lunch and dinner available at all restaurants according to their operational hours
- Unlimited soft drinks available by the glass at all restaurants and bars according to their operational hours
- Gala Dinner
- 24 hour room service
- Complimentary WIFI in your guest room

Important Note: Accompanying child fees are applicable for children aged 5-12 years. Children younger than 5 years stay free of charge with a parent. Children aged 13 years and older are classified as an adult at this venue (Fiesta Americana Condesa Cancun). Please kindly ensure your child / children are supervised at all times during conference and related events. Childcare services are available at the hotel, please contact Laura for further information.

What's Included in our Extra Night Fees?

- 1 night’s accommodation for 1 person
- Breakfast, lunch and dinner available at all restaurants according to their operational hours
- Unlimited alcoholic beverages, cocktails and soft drinks available by the glass at all restaurants and bars according to their operational hours
- 24 hour room service
- Guest room mini bar (replenished daily)
- Complimentary WIFI in your guest room

Important Note: Extra night child fees are applicable for children aged 5-12 years. Children younger than 5 years stay free of charge with a parent. Children aged 13 years and older are classified as an adult at this venue (Fiesta Americana Condesa Cancun).

Supported By

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Supported By

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

LinkedIn forum

Bringing together the global community of researchers and scientists interested in the study of DNA. Relevant specialties are wide-ranging, reflecting the importance of DNA Research in many aspects of health and disease, including; DNA Repair, DNA Replication, DNA Damage, Cancer, Chromosomal Instability, RNA and Nucleic Acids.

The group is open to all and is intended as a networking forum for past, present and future participants of Fusion Conferences as well as those interested in the related topics.

Join our group

Supported By

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Venue

Fiesta Americana Condesa Cancun All Inclusive

Venue Rating

Currency

US Dollar (USD)

Address

Fiesta Americana Condesa Cancún All Inclusive Blvd. Kukulcan km 16.5 Zona Hotelera 77500 Cancun Q.R. Mexico

Nearest Airport

Cancun International Airport

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas

Location

Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.

Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.

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5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

https://events.maritur.com/fusion-conference/

Transportation

Cancun International Airport is just a short 20-minute journey from the Fiesta Americana Condesa Cancun and is easily accessible from almost every country in the world, with many major international airlines providing direct or interconnecting flights on a daily basis.

In the interest of safety, we would recommend booking a private transfer service from the airport to the Fiesta Americana Condesa Cancun, however, Taxi services are also available if preferred.

Private Transfers

Maritur are a reputable and reliable DMC based in Cancun. The Maritur team will be on hand to provide a seamless transfer service to and from Cancun International Airport. Maritur will manage and confirm all transportation bookings.

Private transfer service vehicles can accommodate a maximum of 7 persons, plus luggage. Upon arrival at the airport, please exit the terminal building and look for a member of the Maritur team holding a ‘Fusion Conferences’ welcome sign. Please note any transportation services need to be pre-booked with Maritur.

*Please note all bookings need to be made at least 5 days prior to your arrival date. Unfortunalty, there is no remaining availablilty for transfers on 5th May, due to demand. You will receive your booking confirmation up to 48 hours after booking your transfer*

Private Transfer Rates

One Way: $50.00 (USD)

Round Trip: $100.00 (USD)

In the event of any delays or cancellations, please ensure you contact Maritur at least 36 hours in advance; if Maritur are not informed within 36 hours full cancellation charges will apply (Not notified of flight cancellation: 100% penalty charge, No-Shows: 100% penalty charge).

To arrange transportation or make an enquiry, please contact Maritur directly, using their online booking facility (see link below). Please note: You can either pay via card or wire transfer

Taxi

Unlike other Airports, Cancun Airport Taxi Services must be pre-arranged. To obtain safe, licensed and bilingual transportation services please ensure you book your ground transportation online with an authorised transportation company prior to your arrival.

Approximate Taxi Fare

One way (Cancun Hotel Zone): $24.85+ (USD)
*subject to change, please check the Cancun International Airport website for a more accurate estimation for your trip.

Further information on Taxi services can be found on the Cancun International Airport website (see below link) along with some top tips for travellers from local experts and official authorities.

https://www.cancunairport.com/taxi.html

** Please note that Fusion Conferences is not responsible for any bookings made with Maritur or any other transfer/taxi service as transportation is not included within the registration package **

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5^th DNA Repair/Replication Structures and Cancer Conference

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27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Local Activities

Unfortunately, due to COVID-19, we will not be offering group activities on this occasion. However, if you wish to explore Mexico or organise an individual trip, we recommend the following activities. We ask that any off-site trips are organised during free time or pre/post conference, to ensure you are fully present for the meeting.

- AquaWorld. Lots of water based activities available including snorkelling, paragliding, glass bottom boat trips and more. Approx. 10 minute walk from the hotel. More information- https://aquaworld.com.mx/en/tours/

- Xcaret Park. Xcaret is a water, theme, amusement, eco-archaeological park and more, in one place. Due to its privileged location in the Mayan jungle among underground rivers, cenotes and facing the Caribbean Sea, there are lots of activities on offer. Approx. 1 hour drive from the hotel. More information - https://www.xcaret.com/en/about-xcaret/

- Tulum Mayan Ruins (Day Trip). The Mayan ruins in Tulum, Mexico, are a must-see attraction for anyone visiting the gorgeous Riviera Maya. Built as a seaport fortress with steep cliffs and limestone walls, the ancient city is one of the best-preserved coastal Maya sites in Mexico, much of which still stands after more than 800 years. Approx. 1 hour 50 minutes drive from the hotel. More information - https://www.islandlifemexico.com/tulum-ruins-visitors-guide/

- Isla Mujeres (Day Trip). A beautiful, peaceful paradise just across the Bahia de Mujeres (Bay of Women) from Cancun, Mexico. Known for beautiful white sand beaches, calm crystal clear turquoise waters and the friendliest locals in the Mexican Caribbean. With the beauty of the Caribbean, the heritage of the Mayans, and the easygoing charm of the people, Isla Mujeres has become a haven for people from all over the world. Approx. 1 hour 5 minutes from the hotel via ferry. The Gran Puerto Cancun (Ultramar) ferry dock is located in Puerto Juarez, a few minutes from downtown Cancun. The boats leave every half hour from 5:00 am until 9:30 pm and every hour after that. The crossing takes about 15 minutes. More information - https://www.isla-mujeres.net/

- Chichen Itza (Day Trip). Chichen Itza was one of the most important city-states in pre-Hispanic America. It’s one of the 7 Wonders of the World and is one of the most visited archaeological sites in Mexico. Chichen Itza is divided into Old Chichen and Chichen Itza where you can find 6 Mayan Ruins in Old Chichen and around 20 Mayan Ruins in Chichen Itza, making it a total of 26 Mayan Ruins to see on the Mayan Site. Approx. 2 hour 46 minutes drive from the hotel. More information - https://www.chichenitza.com/

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5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Group Activities

We are evaluating suitable group activities with an eye to both safety and interest. Health and safety is highly controlled within the hotel and for any activity providers we will be looking for strong health and safety assurances. Further details will be released approximately four weeks prior to the conference, dependent on guidance at the time.

If you wish to explore Cancun, Tulum or surrounding areas and sights, please visit the 'Local Activites' tab for suggestions of places to visit.

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5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Childcare

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If you're interested in sponsoring this conference please contact us.

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Oral Presenters

We have several oral opportunities available at this meeting. To be considered for a talk, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

If you are accepted for a talk, we recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference website.

Your Presentation

On the day of your presentation please make yourself known to our AV technician who will be present in the conference room. We advise running through your presentation at least 30minutes prior to your session commencing to ensure your slides and any videos or animations appear as expected. We prefer our speakers to run their presentation from the master PC or Mac, however, if you prefer to use your own laptop then please notify us prior to the session. A HDMI or VGA cable is usually available on the podium.

Our AV technician will apply your microphone and provide a combined slide advancer and laser pointer.

We ask all speakers to adhere to their time slots and respect their fellow presenters. A visual traffic light aide will be available to warn presenters as their time decreases.

Please make sure your presentation adheres to the following guidelines.

Aspect Ratio: On Screen Show (16:9)
File Type: Please save your presentation in PPT, PPTS or Keynote format.

Download Abstract Template

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If you're interested in sponsoring this conference please contact us.

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Posters

We have several poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

Please bring your poster to registration and hand this to a member of the Fusion team. They will advise of your poster number and display your poster for you.

Your poster will remain on display for the duration of the conference, allowing presenters to take advantage of the refreshment breaks and free time for valuable networking opportunities, in addition to the official poster session.

Please check the programme and note the date and time of the poster session(s). Your poster will be judged during the poster session and prizes will be awarded at the Gala Dinner.

Posters will be taken down by the Fusion team and will be ready for collection at the Fusion desk on the final day of the conference.

Download Abstract Template

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If you're interested in sponsoring this conference please contact us.

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

27 Apr 2022 - 01 May 2022

Cancun, Mexico

Chairs

Conference History

12 Feb 2014, 15 Feb 2014

Dynamic Structures in DNA Damage Responses and Cancer

Fiesta Americana Condesa, Cancun, Mexico

Key sessions will include: DNA and RNA complexes Chromatin Remodeling Post-translational modifications - Ub, SUMO kinases The repair interface with Replication Transcription, and Recomb...

22 Feb 2016, 25 Feb 2016

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

Fiesta Americana Condesa, Cancun, Mexico

This conference will focus on insights into dynamic DNA and RNA complexes involved in the damage response and cancer. It will emphasize informal as well as formal discussions together with informative talks and...

11 Feb 2018, 15 Feb 2018

3^rd DNA Replication/Repair Structures and Cancer Conference

Fiesta Americana Condesa, Cancun, Mexico

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a...

16 Feb 2020, 20 Feb 2020

4^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20

Melia Nassau Beach All Inclusive, Nassau, Bahamas

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate DNA repair in the context of oncogene-induced replication stress and elevated transcription. Intertwined roles of repair with replica...

27 Apr 2022, 01 May 2022

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico

Future master keys to cancer biology and advanced therapies are being forged from mechanistic understanding of the intertwined roles of DNA repair with DNA replication stress, transcription and immune responses. The remarkable stability of the hum...