Programme
Although the below programme is the most up to date version, please note minor changes may still occur.
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
Defects in DNA damage repair and checkpoint control are underlying mechanisms driving tumorigenesis, since they allow for the accumulation of genetic alternations. Indeed, defects associated with these pathways are the underlying cause of several human cancer-prone syndromes. On the other hand, defects in DNA repair and checkpoint control create vulnerabilities in cancer cells that can be targeted by DNA damaging agents and inhibitors that disrupt checkpoint pathways. More recently, defective DNA repair and checkpoint regulation have been shown to influence R-loop formation, replication fork stability, and innate immunity. These new findings not only reveal additional mechanisms contributing to tumorigenesis, but also provide new targets for cancer therapy. This conference will focus on exploring these vulnerabilities, taking advantage of the synthetic lethality concept, and targeting specific DNA repair and checkpoint pathways for cancer therapy, either alone or in combination with chemotherapy, radiation therapy, targeted therapy, and immunotherapy. This conference will bring together basic, translational and clinical investigators to discuss current and future directions, opportunities and obstacles to the development of these anti-cancer modalities and how to best translate these concepts to clinical practice.
Britt Adamson (Princeton University)
MAPPING THE CELLULAR DETERMINANTS OF GENOME EDITING SYSTEMS
Jiri Bartek (Danish Cancer Society Research Center)
UNDERSTANDING AND OVERCOMING CANCER CELL RESISTANCE TO THERAPY: MECHANISTIC LINKS WITH CELL CYCLE (DE)REGULATION AND GENOME INTEGRITY MAINTENANCE
Eric Brown (University of Pennsylvania)
EFFECTS OF DNA REPEAT SILENCING ON ATRi-DRIVEN GENOMIC BREAKS
Sharon Cantor (University of Massachusetts)
TARGETING CANCER BASED ON A GAP VULNERABILITY
Karlene Cimprich (Stanford University)
THE CAUSES AND CONSEQUENCES OF REPLICATION STRESS
Elizabeth Christie (Peter MacCallum Cancer Centre)
HETEROGENEITY OF ACQUIRED RESISTANCE IN HOMOLOGOUS RECOMBINATION REPAIR DEFICIENT OVARIAN CANCER
Alan D'Andrea (Dana-Farber Cancer Institute)
CHAMP1 COMPLEX DIRECTS HETEROCHROMATIN ASSEMBLY AND PROMOTES HOMOLOGY-DIRECTED DNA REPAIR
Jean Gautier (Columbia University)
REPAIR AND MIS-REPAIR IN 3D
Thanos Halazonetis (University of Geneva)
DNA REPLICATION STRESS IN CANCER - MECHANISTIC INSIGHTS
Maria Jasin (Memorial Sloan Kettering Cancer Center)
BRCA2 AND HR, FORK PROTECTION, AND GAP SUPPRESSION WHICH IS IMPORTANT?
Chris Lord (Institute of Cancer Research)
UNDERSTAND CLINICAL RESISTANCE TO HRD-TARGETING THERAPY IN ADVANCED BREAST CANCER
Zhenkun Lou (Mayo Clinic)
NSD3 CONFERS PARP INHIBITOR RESISTANCE IN PROSTATE CANCER
Nima Mosammaparast (Washington University in St. Louis)
RNA DAMAGE AS A THREAT TO GENOME INTEGRITY
Andre Nussenzweig (National Institutes of Health)
REPLICATION FORK COLLAPSE AND STABILITY
Mark O'Connor (AstraZeneca)
TARGETING THE DNA DAMAGE RESPONSE TO GENERATE NEW CANCER MEDICINES
Yves Pommier (National Cancer Institute)
NEW INSIGHTS IN THE REPAIR OF TOPOISOMERASE DNA-PROTEIN CROSSLINKS (DPCs) AND Schlafen 11 (SLFN11)
Helen Robinson (Artios)
TARGETED COVALENT INHIBITION OF PolQ
Katharina Schlacher (MD Anderson Cancer Center)
BRCA IN MITOCHONDRIAL AND NUCLEAR GENOME STABILITY FOR NOVEL THERAPEUTIC TARGETS
Clare L. Scott (Walter and Eliza Hall Institute of Medical Research)
NAVIGATING PARP INHIBITOR RESISTANCE IN CLINICAL PRACTICE: INTERVENTIONS AND INNOVATIONS
John Tainer (MD Anderson Cancer Center)
TARGETING ALLOSTERY AT THE REPLICATION-REPAIR INTERFACE
Madalena Tarsounas (University of Oxford)
MECHANISM OF PARP INHIBITOR RESISTANCE IN BRCA-DEFICIENT CELLS
Xiaohua Wu (Scripps Research Institute)
INVESTIGATING BREAK-INDUCED REPLICATION IN MAMMALIAN CELLS
Tim Yap (MD Anderson Cancer Center)
PROGRESS, PITFALLS AND THE PROMISE IN TARGETING THE DNA DAMAGE RESPONSE IN THE CLINIC
Shan Zha (Columbia University)
INHIBITION IS NOT DELETION IN DNA DAMAGE RESPONSE
Lee Zou (Duke University)
THE ROLE OF ATR IN THE RESPONSE TO TRANSCRIPTION-ASSOCIATED GENOMIC STRESS
Take advantage of this fantastic opportunity for students! Fully paying 'single' or 'shared' registrants can bring a student for only €990. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 07, 08, 09 October 2024 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Chloe to obtain a special registration code for your student.
This conference explores topics that should appeal to basic, translational, clinical investigators as well as clinicians ranging from academics to industry.
DNA damage repair and checkpoint control is an exciting field that has undergone tremendous growth in the past few years. While insightful new research on the molecular mechanisms that govern a variety of DNA repair and cell cycle checkpoint pathways has led to an expansion of our understanding of DNA damage response pathways in humans, it also offers new approaches for cancer prevention and treatment. The purpose of this conference is to accelerate the translation of basic research findings into clinical practice. The audience will benefit from the interactions with experts in the fields of DNA damage response, drug development and clinical trials.
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
Britt Adamson
Princeton University
Jiri Bartek
Danish Cancer Society Research Center
Eric Brown
University of Pennsylvania
Sharon Cantor
University of Massachusetts
Karlene Cimprich
Stanford University
Elizabeth Christie
Peter MacCallum Cancer Centre
Alan D'Andrea
Dana-Farber Cancer Institute
Jean Gautier
Columbia University
Thanos Halazonetis
University of Geneva
Maria Jasin
Memorial Sloan Kettering Cancer Center
Chris Lord
Institute of Cancer Research
Zhenkun Lou
Mayo Clinic
Nima Mosammaparast
Washington University in St. Louis
Andre Nussenzweig
National Institutes of Health
Mark O'Connor
AstraZeneca
Yves Pommier
National Cancer Institute
Helen Robinson
Artios
Katharina Schlacher
MD Anderson Cancer Center
Clare L. Scott
Walter and Eliza Hall Institute of Medical Research
John Tainer
MD Anderson Cancer Center
Madalena Tarsounas
University of Oxford
Xiaohua Wu
Scripps Research Institute
Timothy Yap
MD Anderson Cancer Center
Shan Zha
Columbia University
Lee Zou
Duke University
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
Although the below programme is the most up to date version, please note minor changes may still occur.
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
Ticket Type | Early Bird | Full Price |
---|---|---|
Single
Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.
|
€1952 | €2048 |
Shared
Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.
|
€1679 | €1775 |
Student
Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.
|
€1583 | €1679 |
Adult
€478
Child
€10
Adult
€244
Child
€0
All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.
Our registration fees are inclusive of the following during the conference period only:
- Conference registration
- 3 nights’ fixed accommodation (07, 08, 09 October 2024) on a single or shared basis.
- Buffet breakfast in Oceana restaurant
- Buffet lunch in the in Oceana restaurant with two soft drinks or juices, coffee/tea and water
- Buffet dinner in the in Oceana restaurant with a glass of wine, or two beers, or two soft drinks and water
- BBQ Gala Dinner with 3 drink tickets for a glass of house wine, beer or soft drink
- Complimentary WIFI in both conference rooms and your guest room
Our accompanying adult fees are inclusive of the following during the conference period only:
- 3 nights’ fixed accommodation (07, 08, 09 October 2024) on a shared basis with a conference participant
- Buffet breakfast in Oceana restaurant
- Buffet lunch in the in Oceana restaurant with two soft drinks or juices, coffee/tea and water
- Buffet dinner in the in Oceana restaurant with a glass of wine, or two beers, or two soft drinks and water
- BBQ Gala Dinner with 3 drink tickets for a glass of house wine, beer or soft drink
- Complimentary WIFI in guest room
Important Note: Accompanying persons are not permitted access to the conference. Meals are only available during the times listed in the conference programme and accompanying guests must dine with the group.
Our accompanying child fees are inclusive of the following during the conference period only:
- 3 nights’ fixed accommodation (07, 08, 09 October 2024) on a shared basis with the parent/s
- Buffet breakfast in Oceana restaurant
- Buffet lunch in the in Oceana restaurant with two soft drinks or juices and water
- Buffet dinner in the in Oceana restaurant with two soft drinks and water
- BBQ Gala Dinner with 3 drink tickets for soft drinks
- Complimentary WIFI in guest room
Important Note: Meals are only available during the times listed in the conference programme and accompanying children must dine with the group.
Accompanying child fees are applicable for children aged 0-10 years. Children aged 11+ years are classified as an adult.
Please notify a member of the Fusion team when adding accompanying children to your booking so we can assist with your reservation and check the correct room type is available for your stay.
- 1 night’s accommodation for 1 person
- Buffet breakfast in Oceana restaurant
- Complimentary WIFI in your guest room
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
Please see below opportunities for financial support for students, postdocs and early career researchers. If you have any questions, please reach out to the Conference Manager, Chloe Trundle.
Take advantage of this fantastic opportunity for students! Fully paying 'single' or 'shared' registrants can bring a student for only €990. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 07, 08, 09 October 2024 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Chloe to obtain a special registration code for your student.
We have been able to create several ECR awards. Two different award values are available, €500 or €1,000 and these have been set aside for early career researchers. If you are a student, postdoc or junior faculty (within 3 years of your position), you are eligible. To apply please email the conference manager, Chloe Trundle.
Your application should include your name, organisation, career level, an abstract for talk or poster consideration, and a short summary answering the below questions (no more than 50-100 words per question).
• What cutting edge aspects of your work will you share at the meeting?
• What knowledge gaps are you addressing in the field?
• Why do you require financial support to attend?
• How will attending #DNARepair24 benefit your science and career?
• Are there any other reasons as to why your application should strongly be considered?
Applications will be considered as they are submitted so although there is no application deadline, we recommend applying early to avoid disappointment as we only have a limited number of ECR awards available. If you are interested in presenting a poster, please ensure your abstract and ECR award application are submitted no later than midnight BST on Thursday 08 August 2024.
*Unfortunately, all current ECR grants have been awarded. However, we hope to release additional grants later following fundraising efforts. If you are interested in future opportuinities, please still send in an application - these will be considered in the first instance should additional grants be released.
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
Bringing together the global community of researchers and scientists interested in the study of DNA. Relevant specialties are wide-ranging, reflecting the importance of DNA Research in many aspects of health and disease, including; DNA Repair, DNA Replication, DNA Damage, Cancer, Chromosomal Instability, RNA and Nucleic Acids.
The group is open to all and is intended as a networking forum for past, present and future participants of Fusion Conferences as well as those interested in the related topics.
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
We are excited to be visiting this beautiful Mediterranean destination in autumn 2024 – the Hilton Malta in St Julian’s, Malta. The oceanfront resort overlooks the stunning Portomaso Marina in St. Julian’s.
This beautiful hotel is located only 15 minutes from the ancient capital city of Valletta, a UNESCO World Heritage Site. Megaliths, medieval dungeons and Calypso’s Cave – The Maltese Islands are positively mythic. As the countryside is dotted with medieval towers, wayside chapels and the oldest known human structures in the world, the Islands have rightly been described as an open-air museum.
This is not an all-inclusive property, but we have arranged a full food and beverage package for delegates during the conference period which is included within the registration fee. Breakfast will be at leisure each morning, but participants will dine together for conference lunches and dinners. For anyone staying any extra nights, the rate will be bed and breakfast only so delegates can choose whether to dine at the hotel or explore and eat elsewhere.
Hotel facilities include;
• Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
• 4 Seasonal Outdoor Pools
• Spa with Indoor Swimming Pool
• Fitness Center and Tennis Court
• 3 Restaurants
• 2 Bars
Venue Rating
Currency
Euro (EUR)
Address
Vjal Portomaso St Julian's PTM, 01, Malta
Nearest Airport
Malta International Airport
The Hilton Malta overlooks the stunning Portomaso Marina in St. Julian’s. This beautiful hotel is located only 15 minutes from the ancient capital city of Valletta, a UNESCO World Heritage Site.
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
The hotel is approximately 20 minutes from Malta International Airport, the official airport of the Maltese Islands.
Taxis are available outside the airport, however we would strongly recommend you use one of the transport app providers below.
There are 3 options for booking transport with an app- Uber, Bolt and eCabs. They all operate in and around Malta, and the fares are generally cheaper than a taxi. The cost of transfers between Malta International Airport and the city of St Julians generally ranges from €15 to €20.
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
Local activity details will be announced here soon.
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
During afternoon free time on Day 2 (Tuesday 08 October), you have the opportunity to visit the capital of Malta, Valletta. The guided tour will include Barracca Barrakka Gardens, the fortified Three Cities and breathtaking views of the Grand Harbour.
Price:
The total price of this trip is €53.
Payment will be made online via a portal. Payment methods accepted are: VISA, Mastercard, AMEX + ApplePay & GooglePay.
Tour Includes:
- Round-trip transportation
- Tour of Valletta including Barracca Barrakka Gardens, St John’s Co-Cathedral & the Church Museum
- Bottle of water
- Guided Tour
To sign up, please email Chloe noting your interest. If you have any accompanying guests who wish to join, please include their names in your email as well.
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
We have several oral opportunities available at this meeting. To be considered for a talk, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.
If you are unable to register for the conference for any reason, but still wish to submit an abstract for consideration, please email the Conference Manager directly.
Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.
If you are accepted for a talk, we recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference website.
On the day of your presentation please make yourself known to our AV technician who will be present in the conference room. We advise running through your presentation at least 30minutes prior to your session commencing to ensure your slides and any videos or animations appear as expected. We prefer our speakers to run their presentation from the master PC or Mac, however, if you prefer to use your own laptop then please notify us prior to the session. A HDMI or VGA cable is usually available on the podium.
Our AV technician will apply your microphone and provide a combined slide advancer and laser pointer.
We ask all speakers to adhere to their time slots and respect their fellow presenters. A visual traffic light aide will be available to warn presenters as their time decreases.
Please make sure your presentation adheres to the following guidelines.
Aspect Ratio: On Screen Show (16:9)
File Type: Please save your presentation in PPT, PPTS or Keynote format.
07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
We have several poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.
Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.
Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.
Please bring your poster to registration and hand this to a member of the Fusion team. They will advise of your poster number and display your poster for you.
Your poster will remain on display for the duration of the conference, allowing presenters to take advantage of the refreshment breaks and free time for valuable networking opportunities, in addition to the official poster session.
Please check the programme and note the date and time of the poster session(s). Your poster will be judged during the poster session and prizes will be awarded at the Gala Dinner.
Posters will be taken down by the Fusion team and will be ready for collection at the Fusion desk on the final day of the conference.
Download Abstract Template07 Oct 2024 - 10 Oct 2024
St. Julians, Malta
Chairs
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More InformationIf you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
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