Synopsis

Chromatin is the template of life, the carrier of genetic information and the core regulator of fundamental processes such as gene expression and stem cell fate determination. Chromatin dysfunction on the other hand can trigger various diseases, including cancer. Although chromatin structure and function and the mechanisms of disease and their diagnostic and therapeutic approaches are the subject of many meetings, conferences bringing them together are less frequent. The boundaries among these various disciplines are disappearing and meeting on "Epigenetics: from mechanisms to disease" will focus on the discussion of the role of chromatin architecture, epigenetics, stem and single cell biology in cancer and other diseases. The talks will cover a broad range of topics, including chromosome organisation, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms, transcription regulation, DNA methylation and hydroxymethylation, exploiting the power of genome engineering technologies, single-cell approaches, cutting edge epigenomics and imaging approaches and novel cell systems such as organoids.

Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Young scientists will take center stage, presenting their work through a large number of talks selected from submitted abstracts as well as through poster presentation. The program has also allocated ample time for exchanging ideas and discussing novel hypotheses at the end of each session, as well as time for informal interactions and networking.

Confirmed Invited Speakers

Karen Adelman (Harvard University)
CONTROLLING TRANSCRIPTION ELONGATION
Genevieve Almouzni (Institut Curie)
HISTONE VARIANTS AND THEIR PARTNERS SHAPING CHROMATIN AND CELL FATE
Salvador Aznar-Benitah (IRB Barcelona)
INTRAGENERATIONAL EPIGENETIC INFLUENCE OF FATTY ACIDS ON LIVER DISEASE AND CANCER
Shelley Berger (University of Pennsylvania)
Adrian Bracken (Trinity College Dublin)
POLYCOMB REPRESSIVE COMPLEXES IN DEVELOPMENT AND CANCER
Anne Brunet (Stanford University)
SPATIOTEMPORAL TRANSCRIPTOMIC PROFILING AT SINGLE-CELL RESOLUTION IDENTIFIES CELL PROXIMITY EFFECTS OF AGING AND REJUVENATION
Ian Chambers (University of Edinburgh)
Danette Daniels (Foghorn Therapeutics)
TARGETING CHROMATIN REGULATORY PROTEINS AND DISEASE WITH THERAPEUTIC DEGRADERS
Yael David (Sloan Kettering Institute)
THINKING OUTSIDE THE CHROMOSOME: INTERROGATING EPIGENETIC MECHANISMS IN NONCANONICAL CHROMATIN SPECIES
Francois Fuks (Université Libre de Bruxelles)
RNA MODIFICATIONS IN HEALTH AND DISEASE
Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics)
EXPLOITING LIVER ORGANOIDS TO UNDERSTAND REGENERATION AND CANCER MECHANISMS
Cigall Kadoch (Harvard University)
STRUCTURE AND FUNCTION OF mSWI/SNF CHROMATIN REMODELING COMPLEXES IN HUMAN DISEASE 
Tony Kouzarides (Gurdon Institute)
RNA MODIFICATIONS PATHWAYS IN CANCER
Rob Martienssen (Cold Spring Harbour Laboratory)
CHROMATIN REMODELING OF HISTONE H3 VARIANTS AND THE EPIGENETIC INHERITANCE OF DNA METHYLATION
Lluis Morey (Sylvester Comprehensive Cancer Center)
ROLE OF POLYCOMB PROTEINS IN CANCER AND DEVELOPMENT
Danny Reinberg (University of Miami)
Anne Schaefer (Max Planck Institute for Biology of Ageing)
EPIGENETIC MECHANISMS OF MICROGLIA PLASTICITY
Yang Shi (Ludwig Cancer Research)
CHROMATIN REGULATION AND HUMAN DISEASES
Ramin Shiekhattar (Sylvester Comprehensive Cancer Center)
Ali Shilatifard (Northwestern University)
EPIGENETIC REGULATION OF GENE EXPRESSION IN DEVELOPMENT AND DISEASE
Maria-Elena Torres-Padilla (Helmholtz Zentrum München)
EPIGENETIC MECHANISMS OF CELLULAR PLASTICIY AND REPROGRAMMING TO TOTIPOTENCY
Ashley Webb (Buck Institute)
EPIGENETIC MECHANISMS UNDERLYING SEX DIFFERENCES IN BRAIN AGING

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying ‘single’ or ‘shared’ registrants can bring a student for only €990. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 10, 11, 12 October 2024 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Rosie Johnson to obtain a special registration link for your student.

Educational Need

The strong educational asset of this workshops is to enhance communication between junior and senior investigators. In particular, we are paying a strong attention towards fostering the chance for young scientists to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. We allocated ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as for informal interactions and networking. A career and Diversity, Equity and Inclusion round table will also be organized during the meeting.

Target Audience

This conference will be an ideal setting for PhD students, post-doc and group leaders working in the field of chromatin architecture, epigenetics, stem cell biology, single-cell biology, organoids and cancer. Scientists active in R&D of small, medium and big pharma or biotech companies will find an exciting new set of inputs and an interactive forum for exchange with academia.

Supported By

Bronze

If you're interested in sponsoring this conference please contact us.