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Home > Past Conferences > 6th Nucleic Acids Conference

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6th Nucleic Acids Conference

13 Feb 2019 - 16 Feb 2019

Nassau, Bahamas

Synopsis

This meeting is a continuation of the Zing Conferences Nucleic Acids series.

The key role of nucleic acids is to encode and process genetic information at a molecular level. DNA is the genetic library of the cell, while RNA transports, translates and controls the expression of that information. DNA must be copied with unprecedented accuracy once every cell cycle. It is under constant endogenous and environmental onslaught, and a variety of repair pathways are necessary to maintain the integrity of the genetic blueprint. DNA is the only cellular molecule for which repair occurs to a significant extent. DNA undergoes recombination, a kind of molecular cut and re-join that creates diversity to facilitate evolution, as well as providing an important repair pathway. In eukaryotes something like 2m DNA is packaged into chromosomes so that it packs into the cell nucleus with a diameter of just 6 µm, while remaining accessible to the cellular machinery that reads out its genetic information. 

RNA is the dynamic worker bee of genetics to the DNA's queen, and an extremely versatile molecule. In the central dogma RNA is the messenger (mRNA) and translators (tRNA) that passes the information between the DNA genome and the protein synthesis machinery, yet it does much, much more. In translation of the genetic information it forms the architectural framework and catalytic center of the ribosome. In eukaryotic cells the pre-mRNA must be processed by the precise removal of intervening sequences (introns), carried out by a large and dynamic RNA-protein machine called the spliceosome. Increasingly we realize that RNA is also involved in critical and complex regulatory processes. RNA can act as a molecular switch responding to small molecules in order to control gene expression. Indeed while most of the genomic DNA does not encode proteins, almost all of it is transcribed into RNA. We are only just beginning the long journey of understanding what all this non-coding RNA is doing - it is very much the 'dark matter' of biology ! Lastly RNA can also accelerate chemical reactions by a million fold or more in the manner of an enzyme. This is very likely of key significance in the origin of life on the planet more than three billion years ago.

Understanding processes involving DNA and RNA at the molecular and chemical level is the central theme of this conference, with a marked structural and mechanistic perspective. The meeting will provide a platform for researchers to discover and discuss the latest advances in the field of nucleic acids, DNA and RNA, with exciting opportunities to share and receive feedback on unpublished data.

Discussion topics will include;

  • DNA replication
  • DNA repair
  • DNA recombination
  • RNA structure and function
  • Translation and the ribosome
  • Silencing
  • CRISPR/Cas and genome editing
  • Gene regulation and riboswitches
  • RNA catalysis

Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference.

Student Offer

Take advantage of this fantastic opportunity for students! Register a fully paying academic and bring a student for only $850. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 13, 14 and 15 February 2019 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Laura Trundle to obtain a special registration link for your student.

Confirmed Invited Speakers

Ronald Breaker (Yale University)
COMPREHENSIVE DISCOVERY OF BACTERIAL RIBOZYMES AND RIBOSWITCHES
John Diffley (The Francis Crick Institute)
CHROMOSOME REPLICATION: FROM MECHANISM TO MISREGULATION IN CANCER
Chuan He (University of Chicago / HHMI)
RNA METHYLATION IN GENE EXPRESSION REGULATION
Ailong Ke (Cornell University)
SPACER ACQUISITION MECHANISM IN TYPE II-A CRISPR SYSTEM
Stephen Kowalczykowski (University of California, Davis)
SINGLE-MOLECULE VISUALIZATION OF PROTEIN-DNA COMPLEXES: UNDERSTANDING BIOLOGY, ONE MOLECULE AT A TIME
Yamuna Krishnan (University of Chicago)
QUANTITATIVE CHEMICAL IMAGING IN IMMUNE CELLS
Joseph A. Piccirilli (University of Chicago)
ANTIBODY FRAGMENTS AS CHAPERONES FOR RNA CRYSTALLIZATION AND STRUCTURE DETERMINATION
Bik-Kwoon Tye (Hong Kong University of Science & Technology)
SELECTIVITY FOR REPLICATION ORIGINS BY THE ORIGIN RECOGNITION COMPLEX
Yanli Wang (Institute of Biophysics, CAS)
RNA-GUIDED RNA CLEAVAGE AND BEYOND IN CRISPR-Cas SYSTEMS
Steve West (The Francis Crick Institute)
MutSβ STIMULATES HOLLIDAY JUNCTION RESOLUTION BY THE SMX TRI-NUCLEASE

Highlighted Talks

Edwin Anthony (Marquette University)
RE-ESTABLISHING THE ROLES OF DNA BINDING DOMAINS OF REPLICATION PROTEIN A (RPA)
Richard Brennan (Duke University)
A NOVEL RNA POLYMERASE UNDERLIES THE PATHOGENICITY OF FRANCISELLA TULARENSIS
Marvin Caruthers (University of Colorado)
DNA ANALOGUES FOR CRISPER/CAS FIDELITY AND EXON SKIPPING
Zhen Huang (Georgia State University)
DNA POLYMERASE MOONLIGHTING ACTIVITY IN THE PRESENCE OF RNA
David Jeruzalmi (City College of New York)
MECHANISMS OF OPENING AND CLOSING OF THE BACTERIAL REPLICATIVE HELICASE
Marcin Nowotny (International Institute of molecular and Cell Biology)
MECHANISM OF HOLLIDAY JUNCTION RESOLVASES
Michael O'Donnell
(Rockefeller University)
REGULATION OF FORK REGRESSION BY Mcm10, LOCATED AT THE FORKED NEXUS ON THE N-tier OF CMG HELICASE
Alexander Serganov (New York University School of Medicine)
INSIGHTS INTO THE MODIFICATION OF 5' ENDS AND DEGRADATION OF RNA IN BACTERIA
Juliane Soukup (Creighton University)
EVOLUTIONARY CONSERVATION OF ORNITHINE DECARBOXYLASE ANTIZYME PSEUDOKNOT RNA BINDING TO SPERMINE
John Tainer (The University of Texas MD Anderson Cancer Center)
ATPases AT DNA REPLICATION FORKS AND BREAKS
Nils Walter (University of Michigan)
THE RNA NANOMACHINES OF GENE EXPRESSION DISSECTED AT THE SINGLE MOLECULE LEVEL
Dong Wang (University of California, San Diego)
STRUCTURAL BASIS OF EUKARYOTIC TRANSCRIPTION-COUPLED REPAIR INITIATION
Loren Williams (Georgia Tech)
FROZEN IN TIME: THE HISTORY OF THE RIBOSOME
Darrin York (Rutgers University)
CATALYTIC MECHANISMS OF NUCLEOLYTIC RIBOZYMES UNCOVERED BY COMPUTATIONAL RNA ENZMOLOGY

Standard Talks

Dev Arya (Clemson University)
BACTERIAL AND FUNGAL RIBOSOME SELECTIVE ANTIMICROBIALS
Paul Babitzke (Pennsylvania State University)
MECHANISM OF TYLOSIN RESISTANCE IN BACILLUS SUBTILIS: TRANSCRIPTION ATTENUATION, TRANSLATION REPRESSION, NUSG-DEPENDENT RNA POLYMERASE PAUSING, AND TYLOSIN-INDUCED RIBOSOME STALLING
Jamie DeNizio (University of Pennsylvania)
SELECTIVITY AND PROMISCUITY IN TET-MEDIATED OXIDATION OF 5-METHYLCYTOSINE IN DNA AND RNA
Solen Ekesan (Rutgers University)
WHEN IT COMES TO FAST RNA CLEAVAGE – DNA GETS THE LED OUT: CATALYTIC MECHANISM OF THE 8-17 DNAZYME
Jack Hardwick (University of Oxford)
THE EFFECT OF EPIGENETIC CYTOSINE DERIVATIVES ON DNA STRUCTURE
Ashish Lal (NCI/NIH)
A MESSAGE FROM A PUTATIVE LONG NONCODING RNA
Rakhi Rajan (University of Oklahoma)
BRIDGE HELIX OF CAS9 IMPACTS TARGET DNA CLEAVAGE
Sudha Sharma (Howard University)
RECQ1 HELICASE AT A CROSSROAD OF DNA REPAIR AND TRANSCRIPTIONAL REGULATION
Willem Vanderlinden (Ludwig-Maximilians-Universität München)
DNA SUPERCOILING DYNAMICS AT HIGH SPATIOTEMPORAL RESOLUTION

Sponsors

Sponsors

Programme

WEDNESDAY 13TH FEBRUARY 2019

13:30 – 15:00

Student Networking Lunch

 

15:00 – 16:00

Registration & Welcome Reception

 

Session 1 
Session Chair: David Lilley

16:00 – 16:10

Opening Comments

 

16:10 – 16:55

Ronald Breaker 
Yale University

COMPREHENSIVE DISCOVERY OF BACTERIAL RIBOZYMES AND RIBOSWITCHES

 

16:55 – 17:20

Michael O'Donnell 
Rockefeller University

REGULATION OF FORK REGRESSION BY Mcm10, LOCATED AT THE FORKED NEXUS ON THE N-tier OF CMG HELICASE

 

17:20 – 17:45

Marvin Caruthers 
University of Colorado

DNA ANALOGUES FOR CRISPER/CAS FIDELITY AND EXON SKIPPING

 

17:45 – 18:30

Refreshments

 

Session 2 
Session Chair: David Lilley

 

18:30 – 19:15

Steve West 
The Francis Crick Institute

MutSβ STIMULATES HOLLIDAY JUNCTION RESOLUTION BY THE SMX TRI-NUCLEASE

 

19:15 – 19:40

Loren Williams 
Georgia Tech

FROZEN IN TIME: THE HISTORY OF THE RIBOSOME

 

19:10 – 19:40

Accompanying Guests Pre-Dinner Welcome Cocktail

 

19:40

Dinner

 

THURSDAY 14TH FEBRUARY 2019

07:00 – 08:30

Buffet Breakfast at The Market Place

Session 3 
Session Chair: Yamuna Krishnan

08:30 – 09:15

David Lilley 
University of Dundee

MULTIPLE STRATEGIES RNA USES TO ACCELERATE PHOSPHORYL TRANSFER REACTIONS

09:15 – 09:40

Zhen Huang 
Georgia State University

DNA POLYMERASE MOONLIGHTING ACTIVITY IN THE PRESENCE OF RNA AND SELENIUM NUCLEIC ACIDS (SeNA) FOR STRUCTURE AND FUNCTION STUDIES

09:40 – 10:05

Edwin Anthony 
Marquette University

RE-ESTABLISHING THE ROLES OF DNA BINDING DOMAINS OF REPLICATION PROTEIN A (RPA)

10:05 – 10:35

Meet the Poster Presenters (Moderators: Juliane Soukup & Yanli Wang)

10:35 – 11:20

Group Photo, Refreshments & Poster Viewing

Session 4 
Session Chair: Yamuna Krishnan

11:20 – 11:35

Sudha Sharma 
Howard University

RECQ1 HELICASE AT A CROSSROAD OF DNA REPAIR AND TRANSCRIPTIONAL REGULATION

11:35 – 12:20

Yanli Wang 
Chinese Academy of Sciences

RNA-GUIDED RNA CLEAVAGE AND BEYOND IN CRISPR-Cas SYSTEMS

12:20 – 12:45

Marcin Nowotny 
International Institute of Molecular and Cell Biology

MECHANISM OF HOLLIDAY JUNCTION RESOLVASES

12:45 – 16:30

Lunch at Leisure & Free Time

Session 5 
Session Chair: Ailong Ke

16:30 – 16:45

Willem Vanderlinden 
Ludwig-Maximilians-Universität München

DNA SUPERCOILING DYNAMICS AT HIGH SPATIOTEMPORAL RESOLUTION

16:45 – 17:30

Stephen Kowalczykowski 
University of California, Davis

SINGLE-MOLECULE VISUALIZATION OF PROTEIN-DNA COMPLEXES: UNDERSTANDING BIOLOGY, ONE MOLECULE AT A TIME

17:30 – 17:55

Juliane Soukup 
Creighton University

EVOLUTIONARY CONSERVATION OF ORNITHINE DECARBOXYLASE ANTIZYME PSEUDOKNOT RNA BINDING TO SPERMINE

17:55 – 18:10

Jack Hardwick 
University of Oxford

THE EFFECT OF EPIGENETIC CYTOSINE DERIVATIVES ON DNA STRUCTURE

18:10 – 18:25

Paul Babitzke 
Pennsylvania State University

MECHANISM OF TYLOSIN RESISTANCE IN BACILLUS SUBTILIS: TRANSCRIPTION ATTENUATION, TRANSLATION REPRESSION, NUSG-DEPENDENT RNA POLYMERASE PAUSING, AND TYLOSIN-INDUCED RIBOSOME STALLING

18:25 – 19:10

John Diffley 
The Francis Crick Institute

CHROMOSOME REPLICATION: FROM MECHANISM TO MISREGULATION IN CANCER

19:10 – 20:40

Poster Session & Refreshments

20:40

Dinner

FRIDAY 15TH FEBRUARY 2019

07:00 – 09:00

Buffet Breakfast at The Market Place

Session 6 
Session Chair: Susan Lees-Miller

09:00 – 09:45

Wei Yang 
NIH

MECHANISMS OF MAKING AND BREAKING NUCLEIC ACIDS

09:45 – 10:10

Darrin York 
Rutgers University

CATALYTIC MECHANISMS OF NUCLEOLYTIC RIBOZYMES UNCOVERED BY COMPUTATIONAL RNA ENZMOLOGY

10:10 – 10:35

Alexander Serganov 
New York University School of Medicine

INSIGHTS INTO THE MODIFICATION OF 5¢ ENDS AND DEGRADATION OF RNA IN BACTERIA

10:35 – 11:20

Refreshments & Poster Viewing

Session 7 
Session Chair: Susan Lees-Miller

11:20 – 12:05

Joseph A. Piccirilli 
University of Chicago

ANTIBODY FRAGMENTS AS CHAPERONES FOR RNA CRYSTALLIZATION AND STRUCTURE DETERMINATION

12:05 – 12:30

David Jeruzalmi 
City College of New York

MECHANISMS OF OPENING AND CLOSING OF THE BACTERIAL REPLICATIVE HELICASE

12:30 – 16:45

Lunch at Leisure & Free Time

13:15 – 16:15

Group Activity: Snorkeling (signups required in advance)

Session 8 
Session Chair: Loren Williams

16:45 – 17:30

Chuan He 
University of Chicago / HHMI

RNA METHYLATION IN GENE EXPRESSION REGULATION

17:30 – 17:55

John Tainer 
LBL / MD Anderson Cancer Center

ATPases AT DNA REPLICATION FORKS AND BREAKS

17:55 – 18:10

Solen Ekesan 
Rutgers University

WHEN IT COMES TO FAST RNA CLEAVAGE – DNA GETS THE LED OUT: CATALYTIC MECHANISM OF THE 8-17 DNAZYME

18:10 – 18:25

Ashish Lal 
NCI / NIH

A MESSAGE FROM A PUTATIVE LONG NONCODING RNA

18:25 – 19:10

Refreshments & Poster Viewing

Session 9 
Session Chair: Loren Williams

19:10 – 19:25

Jamie DeNizio 
University ofPennsylvania

SELECTIVITY AND PROMISCUITY IN TET-MEDIATED OXIDATION OF 5-METHYLCYTOSINE IN DNA AND RNA

19:25 – 20:10

Yamuna Krishnan 
University of Chicago

QUANTITATIVE CHEMICAL IMAGING IN IMMUNE CELLS

20:10

Gala Dinner & Poster Awards

SATURDAY 16TH FEBRUARY 2019

07:00 – 08:30

Buffet Breakfast at The Market Place

Session 10 
Session Chair: Wei Yang

08:30 – 09:15

Bik-Kwoon Tye 
Hong Kong University of Science & Technology

SELECTIVITY FOR REPLICATION ORIGINS BY THE ORIGIN RECOGNITION COMPLEX

09:15 – 09:40

Richard Brennan 
Duke University

A NOVEL RNA POLYMERASE UNDERLIES THE PATHOGENICITY OF FRANCISELLA TULARENSIS

09:40 – 10:05

Nils Walter 
University of Michigan

THE RNA NANOMACHINES OF GENE EXPRESSION DISSECTED AT THE SINGLE MOLECULE LEVEL

10:05 – 10:35

Refreshments

Session 11 
Session Chair: Wei Yang

10:35 – 10:50

Rakhi Rajan 
University of Oklahoma

BRIDGE HELIX OF CAS9 IMPACTS TARGET DNA CLEAVAGE

10:50 – 11:35

Ailong Ke 
Cornell University

SPACER ACQUISITION MECHANISM IN TYPE II-A CRISPR SYSTEM

11:35 – 12:00

Dong Wang 
University of California, San Diego

STRUCTURAL BASIS OF EUKARYOTIC TRANSCRIPTION-COUPLED REPAIR INITIATION

12:00 – 12:10

Closing Comments

Speakers

Invited Speakers

  • Prof. Dr. Chuan He
    Professor, The University of Chicago/HHMI
  • Dr. Stephen West
    Senior Group Leader, Francis Crick Institute
  • Prof. Ailong Ke
    Professor, Cornell University
  • Prof. Yanli Wang
    Principal Investigator, Institute of Biophysics, Chinese Academy of Sciences
  • Dr. John Diffley
    Associate Research Director, The Francis Crick Institute
  • Prof. Stephen Kowalczykowski
    Professor, University of California, Davis
  • Prof. Yamuna Krishnan
    Professor of Chemistry, The University of Chicago
  • Prof. Bik-Kwoon Tye
    Professor, The Hong Kong University of Science & Technology
  • Prof. Joseph Piccirilli
    Professor, University of Chicago
  • Prof. Dr. Ronald Breaker
    Sterling Professor of Molecular, Cellular & Developmental Biology and Professor of Molecular Biophysics & Biochemistry; Investigator, Howard Hughes Medical Institute, Yale University

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