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Home > Past Conferences > 3rd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference

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Past Conference

3rd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference

23 Feb 2019 - 26 Feb 2019

Nassau, Bahamas

Synopsis

Defect in DNA damage repair and checkpoint control is the underlying mechanism for tumorigenesis, since it allows the accumulation of multiple genetic alternations, which are essential for the initiation of tumorigenesis. This has been clearly illustrated to be the cause of several human cancer-prone syndromes and also revealed by recent human genome studies. On the other hand, defective DNA repair and checkpoint activation also make cancer cells more vulnerable for particular DNA damaging agents or inhibitors that specifically disrupt some of these checkpoint pathways. With the increasing understanding of defects in DNA repair and checkpoint control in tumorigenesis, there are extensive interests in exploring these deficiencies, especially taking advantage of the synthetic lethality concept and targeting particular DNA repair and checkpoint pathways for cancer therapy. The purpose of this conference is to bring together basic, translational and clinical investigators and discuss the current and future directions, opportunities and obstacles in the development of these anti-cancer modalities and how to best apply these concepts in clinical practice.

Key Sessions

  • Highlight recent advances in the field of DNA damage repair
  • Identify novel targets in DNA repair and checkpoint pathways
  • Explore the concept of synthetic lethality for cancer treatment
  • Assess the therapeutic potential of new anti-cancer modalities
  • Learn mechanisms of therapeutic resistance and ways to improve cancer therapy

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,716 and bring a student for only $850. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 23, 24 and 25 February 2019 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 12 December 2018. Once registered, please contact Jack Peters to obtain a special registration link for your student.

Confirmed Invited Speakers

Jan van Deursen (Mayo Clinic)
Susan Domchek (University of Pennsylvania)
Stephan Gasser (Roche)
Peter Glazer (Yale University)
Traver Hart (MD Anderson Cancer Center)
Stephen Kowalczykowski (UC Davis)
Lei Li (MD Anderson Cancer Center)
Jennifer Litton (MD Anderson Cancer Center)
Zhenkun Lou (Mayo Clinic)
Andre Nussenzweig (NCI)
Mark O'Connor (AstraZeneca)
Ketan J. Patel (MRC Laboratory of Molecular Biology)
David Pellman (Harvard University)
Abena Redwood (MD Anderson Cancer Center)
Rodney Rothstein (Columbia University Medical Center)
Agnel Sfeir (New York University)
Joann Sweasy (Yale University)
Johannes Walter (Harvard University)
Bin Wang (MD Anderson Cancer Center)
Xiaohua Wu (Scripps Research Institute)
Tim Yap (MD Anderson Cancer Center)
Zhongsheng You (Washington University)
Xiaochun Yu (City of Hope)
Lee Zou (Massachusetts General Hospital)

 

Sponsors

Sponsors

Programme

SATURDAY 23RD FEBRUARY 2019

13:00 – 14:00

Student Networking Lunch

 

14:00 – 15:00

Registration & Welcome Reception

 

Identifying and Targeting Cell Vulnerabilities, From Bench to Bedside
Agnel Sfeir

15:00 – 15:10

Opening Comments

 

15:10 – 15:35

Lee Zou
Massachusetts General Hospital

TARGETING THE ATR CHECKPOINT PATHWAY IN CANCER THERAPY

 

15:35 – 16:00

Helen Piwnica-Worms MD Anderson Cancer Center

IDENTIFYING AND TARGETING VULNERABILITIES IN TREATEMENT-NAÏVE TRIPLE NEGATIVE BREAST CANCER

 

16:00 – 16:25

Mark O'Connor
AstraZeneca

TARGETING THE DNA DAMAGE RESPONSE TO GENERATE NEW TREATMENTS FOR CANCER

 

16:25 – 16:50

Tim Yap
MD Anderson Cancer Center

TARGETING THE DNA DAMAGE RESPONSE IN THE CLINIC: LESSONS LEARNT AND THE PATH FORWARD

 

16:50 – 17:35

Refreshments

 

Identifying Novel Therapeutic Targets Via Genetic Screens
Johannes Walter

 

17:35 – 18:00

Traver Hart
MD Anderson Cancer Center

INTEGRATIVE ANALYSIS OF HUNDREDS OF CRISPR SCREENS YIELDS A GLOBAL VIEW OF INTERACTIONS BETWEEN CELLULAR PROCESSES

 

18:00 – 18:15

John Heath
Lady Davis Institute for Medical Research

EXPLORING THE NOVEL ROLES OF ZINC FINGER PROTEINS IN REGULATING GENOME STABILITY AND CELL CYCLE PROGRESSION

 

18:15 – 18:30

Abena Redwood
MD Anderson Cancer Center

CIA DISRUPTION PRESENTS AN EXPLOITABLE VULNERABILITY TO THERAPEUTIC AGENTS THAT PERTURB DNA FIDELITY

 

18:30 – 18:55

Junjie Chen
MD Anderson Cancer Center

CONTROL OF DNA DAMAGE RESPONSE AND TUMORIGENESIS

 

18:55 – 19:30

Meet the Poster Presenters I
Moderator:
Junjie Chen

 

19:00 – 19:30

Accompanying Guests Pre-Dinner Welcome Drinks

 

19:30

Dinner

 

SUNDAY 24TH FEBRUARY 2019

07:00 – 08:30

Buffet breakfast at The Market Place

Insights into Cellular Pathways that Maintain Genome Stability
Joann Sweasy

08:30 – 08:55

Zhongsheng You
Washington University

REPLICATION FORKS UNDER STRESS: SIGNALING THROUGH CA2+

08:55 – 09:20

Xiaochun Yu
City of Hope

THE ROLE OF POLY(ADP-RIBOSYL)ATION IN DNA DAMAGE REPAIR AND TUMOR SUPPRESSION

09:20 – 09:45

Bin Wang
MD Anderson Cancer Center

UBIQUITIN SIGNALING AT DNA DOUBLE STRAND BREAKS

09:45 – 10:30

Group Photo, Refreshments & Poster Viewing

10:30 – 10:55

Andre Nussenzweig
NCI

MAINTAINING GENOME STABILITY

10:55 – 11:20

Xiaohua Wu
Scripps Research Institute

PROTECTION OF DNA SECONDARY STRUCTURES AND ITS IMPLICATION IN CANCER THERAPY

11:20 – 11:55

Meet the Poster Presenters II
Moderator:
Junjie Chen

11:55 – 16:15

Lunch at Leisure & Free Time

Understanding and Exploiting BRCAness
Susan Domchek

16:15 – 16:40

Susan Domchek
University of Pennsylvania

CLINICAL TRIALS OF PARP INHIBITORS IN BRCA1/2 MUTATION CARRIERS

16:40 – 17:05

Ranjit Bindra
Yale School of Medicine

EXPLOITING ONCOMETABOLITE-INDUCED BRCAness – ON THE PATH FROM THE BENCH TO THE BEDSIDE

17:05 – 17:30

Stephen Kowalczykowski
UC Davis

SEEING AND UNDERSTANDING BRCA1, BRCA2 AND RAD51 FUNCTIONS IN CHROMOSOME MAINTENANCE BY HOMOLOGOUS RECOMBINATION

17:30 – 17:55

Jennifer Litton
MD Anderson Cancer Center

UPDATE ON PARP INHIBITORS IN CLINICAL PRACTICE FOR BREAST CANCER

17:55 – 20:00

Poster Session & Refreshments

20:00

Dinner

MONDAY 25TH FEBRUARY 2019

07:00 – 08:30

Buffet breakfast at The Market Place

Mechanisms of Old and New DNA Repair Pathways
Stephen Kowalczykowski

08:30 – 08:55

Johannes Walter
Harvard University

TRAIP IS A MASTER REGULATOR OF DNA INTERSTRAND CROSS-LINK REPAIR

08:55 – 09:10

John Fielden
University of Oxford

A NOVEL REPAIR COMPLEX FOR THE RESOLUTION OF TOP1-DNA ADDUCTS

09:10 – 09:35

Joann Sweasy
Yale University

BASE EXCISION REPAIR VARIANTS AND CANCER

09:35 – 10:00

Agnel Sfeir
New York University

INVESTIGATING THE IMPACT OF ALT-NHEJ DURING TUMOR PROGRESSION

10:00 – 10:25

Lei Li
MD Anderson Cancer Center

FANCONI ANEMIA AND COMPLEX DNA LESIONS

10:25 – 11:25

Poster Session & Refreshments

11:25 – 17:00

Lunch at Leisure & Free Time

12:30 – 16:00

Snorkel Trip (Signups required in advance)

Existing and Novel Regulation and Function of DNA Repair Processes
Katharina Schlacher

17:00 – 17:25

Peter Glazer
Yale University

ONCOMETABOLITES SUPPRESS HOMOLOGOUS RECOMBINATION DNA REPAIR BY INHIBITION OF CHROMATIN REMOLDING AT THE DNA DOUBLE STRAND BREAK

17:25 – 17:40

Razq Hakem
University Health Network

INTERPLAY OF DNA DOUBLE STRAND BREAK REPAIR AND NOTCH SIGNALING IN CANCER

17:40 – 17:55

Andrea Byrum
Washington University in St. Louis

MITOTIC REGULATORS TPX2 and AURORA A PROTECT DNA FORKS DURING REPLICATION STRESS BY COUNTERACTING 53BP1 FUNCITON

17:55 – 18:40

Refreshments

18:40 – 19:05

Rodney Rothstein
Columbia University Medical Center

GENOME INSTABILITY: THE GENETIC REPERCUSSIONS OF RAD5 OVEREXPRESSION

19:05 – 19:20

Kent Mouw
Dana-Farber Cancer Institute

NUCLEOTIDE EXCISION REPAIR (NER) PATHWAY ALTERATIONS AS CHEMO-IMMUNOTHERAPY BIOMARKERS

19:20 – 19:35

Jian Yuan
Mayo Clinic

THE ROLE OF THE BRD9-RAD51 AXIS IN CHEMORESISTANCE IN OVARIAN CANCER

20:00

Gala Dinner & Poster Awards


TUESDAY 26TH FEBRUARY 2019

07:00 – 08:30

Buffet breakfast at The Market Place

Emerging Concepts in Genome Stability and DNA Repair
Andre Nussenzweig

08:30 – 08:55

Stephan Gasser
Roche

THE ROLE OF ENDONUCLEASES IN THE GENERATION OF CYTOSOLIC DNA

08:55 – 09:20

Zhenkun Lou
Mayo Clinic

PD-L1 REGULATES THE DNA DAMAGE RESPONSE PATHWAY AND AFFECTS RADIOCHEMOSENSITIVITY

09:20 – 09:35

Katharina Schlacher
MD Anderson Cancer Center

RAD51C TUMOR SUPPRESSOR INHIBITS INFLAMMATION BY PROTECTING MITOCHONDRIAL REPLICATION DNA FORKS

09:35 – 10:00

David Pellman
Harvard University

MECHANISMS DRIVING RAPID GENOME EVOLUTION

10:00 – 10:30

Refreshments

10:30 – 10:55

Jan van Deursen
Mayo Clinic

CONTROL OF SENESCENT CELL IDENTITY

10:55 – 11:20

Ketan J. Patel
MRC Laboratory of Molecular Biology

 

11:20 – 11:35

Emanuela Dylgjeri
Thomas Jefferson University

NOVEL ROLES OF DNA-PK IN METABOLIC REGULATION

11:35 – 11:45

Closing Comments

Speakers

Invited Speakers

  • Dr. Traver Hart
    Assistant Professor, The University of Texas MD Anderson Cancer Center
  • Dr. Susan Domchek
    Executive Director, Basser Ctr for BRCA; Director, MacDonald Cancer Risk Evaluation Ctr; Basser Professor in Oncology, Penn Medicine/Abramson Cancer Center
  • Prof. Jan van Deursen
    Professor and Chair, Mayo Clinic
  • Prof. David Pellman
    Professor, Dana-Farber Cancer Institute
  • Dr. Jennifer Litton
    Associate Professor, The University of Texas MD Anderson Cancer Center
  • Prof. Joann Sweasy
    Professor, Yale University School of Medicine
  • Dr. Stephan Gasser
    Prinicipal Scientist, Roche Glycart
  • Dr. Lei Li
    Professor, The University of Texas MD Anderson Cancer Center
  • Dr. Timothy Yap
    Associate Professor , MD Anderson Cancer Center
  • Dr. Bin Wang
    Associate Professor, MD Anderson Cancer Center
  • Prof. Stephen Kowalczykowski
    Professor, University of California, Davis
  • Prof. Dr. Xiaochun Yu
    Professor , City Of Hope
  • Dr. Zhongsheng You
    Associate Professor, Washington University School of Medicine
  • Dr. Peter Glazer
    Professor and Chair, Yale University
  • Prof. Rodney Rothstein
    Professor of Genetics & Development, Columbia University Medical Center
  • Dr. Ranjit Bindra
    Associate Professor, Yale Medical School
  • Prof. Zhenkun Lou
    Professor, Mayo Clinic
  • Prof. Lee Zou
    Professor, Massachusetts General Hospital
  • Dr. Mark O'Connor
    Chief Scientist, AstraZeneca
  • Branch Chief Dr. Andre Nussenzweig
    Branch Chief, Laboratory of Genome Integrity, National Insitutes of Health
  • Prof. Johannes Walter
    Professor, Harvard Medical School
  • Assist. Prof. Agnel Sfeir
    assistant professor, NYU school of medicine
  • Prof. Xiaohua Wu
    Professor, The Scripps Research Institute
  • Dr. Ketan Patel
    PI, MRC LMB

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