Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference

Synopsis

Lung development is governed by epithelial-mesenchymal interactions. These pathways are recapitulated during injury and repair. This conference will focus on understanding key processes underlying lung development, injury and repair in the context of age, environment and species, with the hope of better understanding disease development and to discover novel therapeutic approaches.

We will highlight critical issues on lung epithelial biology such as stem cells and regenerative medicine, while expanding sessions to encompass themes such as single cell analytical approaches, cell-cell communication, dissect the biological distinctions mesenchymal proliferation as a repair mechanism and fibrosis; present the impact of new tools in single cell analysis on understanding lung development, repair, and disease; and characterize epithelial-mesenchymal interrelationships that maintain lung homeostasis and orchestrate repair and regeneration. The entire program has been designed to achieve a better understanding of the key clinical research issues and how they relate to basic mechanistic investigation.

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For those interested, this meeting follows the 3^rdFibroblast Growth Factors in Development and Repair Conference, taking place from 15 February - 18 February 2019 at the same venue. A joint FGF session will take place on Monday 18 February from 08:30 - 12:30.

Key Sessions

Fgf signaling in lung development and fibrosis
Aging and lung fibrosis
Lung stem/progenitor cells and their regulation in health and disease
Organoid cultures to model lung development and disease
Epithelial-mesenchymal interactions in lung development and fibrosis

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,922 and bring a student for only $850. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 17, 18 and 19 February 2019 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 03 December 2018. Once registered, please contact Meredith Willmott to obtain a special registration link for your student.

Confirmed Invited Speakers

Joseph Arron (Genentech)
GENETIC INSIGHTS AND MODEL DEVELOPMENT TO INVESTIGATE EPITHELIAL CELL SENESCENCE IN IDIOPATHIC PULMONARY FIBROSIS
Saverio Bellusci (University of Giessen)
CHARACTERISATION OF A NOVEL FIBROBLAST GROWTH FACTOR 10 (FGF10)-PRODUCING RESIDENT
Zea Borok (Keck School of Medicine of USC)
ALVEOLAR EPITHELIUM IN PULMONARY FIBROSIS: ROLE OF ER STRESS
Wellington Cardoso (Columbia University)
ONTOGENY AND CONTROL OF THE AIRWAY STEM CELL POOL IN DEVELOPMENT AND DISEASE
Gianni Carraro (Cedars-Sinai)
SINGLE-CELL RECONSTRUCTION OF HUMAN BASAL CELL DIVERSITY IN NORMAL AND DISEASED LUNG
Harold Chapman (University of California, San Francisco)
Elie El Agha (Justus-Liebig-University Giessen)
INTERCONVERSION BETWEEN FIBROBLASTIC PHENOTYPES GOVERNS FIBROSIS FORMATION AND RESOLUTION
John Engelhardt (University of Iowa Carver College of Medicine)
WNT PATHWAY CONTROL OF GLANDULAR MYOEPITHELIAL STEM CELLS IN THE AIRWAY
Finn Hawkins (Boston University)
ORGANOID CULTURES TO MODEL LUNG DEVELOPMENT AND DISEASE
Brigid Hogan (Duke University)
DECONTRUCTING THE ALVEOLAR STEM CELL NICHE
Carla Kim (Boston Children's Hospital)
REGULATION OF PROGENITOR CELLS IN THE ADULT LUNG
Melanie Koenigshoff (University of Colorado Denver)
Mark Krasnow (Stanford University)
Maya Kumar (Stanford School of Medicine)
Roland Kolbeck (MedImmune)
TARGETING P16-INDUCED SENESCENCE PREVENTS CIGARETTE SMOKE-INDUCED PULMONARY EMPHYSEMA BY PROMOTING IGF1/Akt1 SIGNALING
Susan Majka (National Jewish Health)
RESIDENT LUNG MESENCHYMAL PROGENITORS MODULATE THE MICROVASCULAR NICHE
Parviz Minoo (Keck School of Medicine of USC)
GENETIC ARCHITECTURE OF ALVEOLAR FORMATION; THE PATH TO DECONVOLUTING PATHOGENESIS OF BRONCHOPULMONARY DYSPLASIA
Edward Morrisey (University of Pennsylvania)
Paul Noble (Cedars-Sinai)
David Ornitz (Washington University)
FGF SIGNALING IN LUNG DEVELOPMENT, CANCER, AND RESPONSE TO INJURY
Anne-Karina Perl (Cincinnati Children's Hospital)
BENEFICIAL INTERSTITIAL MATRIX FIBROBLASTS ARE LOST WITH AGE, A NEW HOPE FOR IDIOPATHIC PULMONARY FIBROSIS
Jayaraj Rajagopal (Massachusetts General Hospital)
THE AIRWAY EPITHELIAL HIERARCHY REVISITED
Emma Rawlins (University of Cambridge)
CELL-CELL INTERACTIONS IN NORMAL HUMAN LUNG DEVELOPMENT
Jason Rock (Boston University)
MACROPHAGES AND FIBROBLASTS AS NICHES IN THE ADULT LUNG
Jason Spence (University of Michigan)
BASAL CELL DIFFERENTIATION IN THE DEVELOPING HUMAN LUNG
Xin Sun (University of California, San Diego)
SIGNALS IN LUNG DEVELOPMENT AND FUNCTION
Nan Tang (National Institute of Biological Sciences)
THE DRIVING FORCE OF ALVEOLAR DEVELOPMENT, REGENERATION AND DISEASES
Victor Thannickal (University of Alabama at Birmingham)
METABOLIC CONTROL OF CELLULAR PLASTICITY IN LUNG FIBROSIS
David Warburton (Children's Hospital Los Angeles)
EPIGENETIC DNA METHYLATION DEPENDENT CONTROL OF MOUSE LUNG DEVELOPMENT: TEMPORAL AND COMPARTMENTAL SPECIFIC FUNCTIONAL EFFECTS OF INDUCIBLE DNMT1 DELETION IN DEVELOPING MOUSE LUNG MESENCHYME VERSUS EPITHELIUM

Target Audience

Lung developmental biologists
Stem cell researchers
Fibrosis researchers
Pulmonary fibrosis researchers

Educational Need

It’s is knowns that lung developmental pathways are reactivated in pulmonary fibrosis yet few if any meetings bring lung developmental biologists and researchers studying lung fibrosis together. This meeting will provide a unique opportunity to bring these 2 fields together.

Programme

SUNDAY 17^TH FEBRUARY 2019
13:15 – 14:00	Student Networking Lunch
14:00 – 14:50	Registration & Welcome Reception
Keynote and Emerging Topics session Session Chair: Barry Stripp
14:50 – 15:00	Opening Comments
15:00 – 15:30	Brigid Hogan Duke University	DECONSTRUCTING THE ALVEOLAR STEM CELL NICHE
15:30 – 16:00	Paul Noble Cedars-Sinai Medical Center	TARGETING INVASIVE FIBROBLASTS IN IDIOPATHIC PULMONARY FIBROSIS
16:00 – 16:30	Jayaraj Rajagopal Massachusetts General Hospital	THE AIRWAY EPITHELIAL HIERARCHY REVISITED
16:30 – 17:00	Nan Tang National Institute of Biological Sciences	THE DRIVING FORCE OF ALVEOLAR DEVELOPMENT, REGENERATION AND DISEASES
17:00 – 17:15	Lindsey Eldridge MedImmune LLC	IPSC DERIVED ALVEOLAR EPITHELIAL TYPE II CELLS PROVIDE A NEW TOOL FOR STUDYING ALVEOLAR REGENERATION
17:15 – 17:45	Refreshments & Poster Viewing
Keynote and Emerging Topics session Session Chair: Stijn De Langhe
17:45 – 18:15	John Engelhardt University of Iowa	WNT PATHWAY CONTROL OF GLANDULAR MYOEPITHELIAL STEM CELLS IN THE AIRWAY
18:15 – 18:45	Jane Connor MedImmune LLC	TARGETING P16-INDUCED SENESCENCE PREVENTS CIGARETTE SMOKE-INDUCED PULMONARY EMPHYSEMA BY PROMOTING IGF1/Akt1 SIGNALING
18:45 – 19:00	Arnaud Mailleux INSERM U1152	IDENTIFICATION OF PRRX1 AS A KEY MESENCHYMAL TRANSCRIPTION FACTOR IN IDIOPATHIC PULMONARY FIBROSIS
19:00 – 19:15	Jianwen Que Columbia University	WNT/FGF CROSSTALK IS REQUIRED FOR THE SPECIFICATION OF TRACHEAL BASAL PROGENITOR CELLS
19:15 – 20:00	Meet the Poster Presenters I Moderators: Zea Borok & Deneen Wellik
19:30 – 20:00	Accompanying Guests Pre-Dinner Welcome Cocktails
20:00	Dinner

MONDAY 18^TH FEBRUARY 2019
07:00 – 08:30	Buffet Breakfast at The Market Place
FGF Signaling in Lung Development and Fibrosis Session (joint session with 3rd Fibroblast Growth Factors in Development and Repair Conference) Session Chairs: Mohammad Hajihosseini (part 1) and Mark Lewandoski (part 2)
08:30 – 09:00	Mark Krasnow Stanford University	FGF SELECTION AND LIFELONG MAINTENANCE OF ALVEOLAR CELLS
09:00 – 09:30	Saverio Bellusci Justus-Liebig-Universitaet Giessen	CHARACTERISATION OF A NOVEL FIBROBLAST GROWTH FACTOR 10 (FGF10)-PRODUCING RESIDENT MESENCHYMAL CELL INVOLVED IN THE REPAIR PROCESS OF THE BRONCHIAL EPITHELIUM AFTER NAPHTHALENE INJURY
09:30 – 10:00	Stijn De Langhe University of Alabama at Birmingham	ROLE OF FGF10 SIGNALING IN THE RESOLUTION OF PULMONARY FIBROSIS
10:00 – 10:30	Xin Sun University of California, San Diego	SIGNALS IN LUNG DEVELOPMENT AND FUNCTION
10:30 – 11:00	Refreshments & Poster Viewing
11:00 – 11:30	David Ornitz Washington University	THE ALVEOLAR MYOFIBROBLAST AND THE ROLE OF FGF18 IN ALVEOLOGENESIS
11:30 – 11:45	Denise Al Alam Children's Hospital Los Angeles	FGF LIGANDS AND THE HUMAN LUNG
11:45 – 12:00	Stefan Hadzic Justus-Liebig-Universitaet Giessen	IMPAIRED FGF10 SIGNALLING IN THE ADULT LUNG LEADS TO DEVELOPMENT OF EMPHYSEMA AND PULMONARY HYPERTENSION
12:00 – 12:15	Robert Guzy The University of Chicago	ALVEOLAR EPITHELIAL FGFR SIGNALING IS REQUIRED FOR RECOVERY FROM BLEOMYCIN-INDUCED INJURY
12:15 – 12:30	Aurélien Justet Unité INSERM1152	IMPLICATION OF FGFR4 AND FGF19 IN IDIOPATHIC PULMONARY FIBROSIS
12:30 – 16:30	Lunch at Leisure & Free Time
12:45 – 16:00	Group Activity: Snorkel Trip (sign-ups required in advance)
Organoid Cultures to Model Lung Development and Disease Session Session Chair: Xin Sun
16:30 – 17:00	Jason Spence University of Michigan	BASAL CELL DIFFERENTIATION IN THE DEVELOPING HUMAN LUNG
17:00 – 17:30	Gianni Carraro Cedars-Sinai Medical Center	SINGLE-CELL RECONSTRUCTION OF HUMAN BASAL CELL DIVERSITY IN NORMAL AND DISEASED LUNG
17:30 – 18:00	Emma Rawlins University of Cambridge	CELL-CELL INTERACTIONS IN NORMAL HUMAN LUNG DEVELOPMENT
18:00 – 18:30	Finn Hawkins Boston University Center for Regenerative Medicine	ORGANOID CULTURES TO MODEL LUNG DEVELOPMENT AND DISEASE
18:30 – 18:45	Preethi Vijayaraj University of California, Los Angeles	MODELING PROGRESSIVE FIBROSIS WITH PLURIPOTENT STEM CELLS IDENTIFIES AN ANTI-FIBROTIC SMALL MOLECULE
18:45 – 19:15	Carla Kim Boston Children's Hospital	REGULATION OF PROGENITOR CELLS IN THE ADULT LUNG
19:15 – 20:30	Poster Session & Refreshments
20:30	Dinner

TUESDAY 19^TH FEBRUARY 2019
07:00 – 08:30	Buffet Breakfast at The Market Place
Lung Stem/Progenitor Cells and Their Regulation in Health and Disease Session Session Chair: Victor Thannickal
08:30 - 09:00	David Warburton Children's Hospital Los Angeles	EPIGENETIC DNA METHYLATION DEPENDENT CONTROL OF MOUSE LUNG DEVELOPMENT: TEMPORAL AND COMPARTMENTAL SPECIFIC FUNCTIONAL EFFECTS OF INDUCIBLE DNMT1 DELETION IN DEVELOPING MOUSE LUNG MESENCHYME VERSUS EPITHELIUM
09:00 – 09:30	Jason Rock Boston University School of Medicine	MACROPHAGES AND FIBROBLASTS AS NICHES IN THE ADULT LUNG
09:30 – 10:00	Wellington Cardoso Columbia University	ONTOGENY AND CONTROL OF THE AIRWAY STEM CELL POOL IN DEVELOPMENT AND DISEASE
10:00 – 10:15	Ana Pardo-Saganta University of Navarra	AIRWAY STEM CELLS DIRECTLY REGULATE IMMUNE CELLS
10:15 – 10:30	Alyssa Miller University of Michigan	BASAL STEM CELL INDUCTION IN THE DEVELOPING HUMAN LUNG
10:30 – 11:15	Group Photo, Refreshments & Poster Viewing
11:15 – 11:45	Susan Majka National Jewish Health	RESIDENT LUNG MESENCHYMAL PROGENITORS MODULATE THE MICROVASCULAR NICHE
11:45 – 12:15	Purushothama Rao Tata Duke University	MECHANISMS OF RESERVE STEM CELL MEDIATED AIRWAY REGENERATION
12:15 – 12:30	Jining Lu Columbia University	MIR-29 IN POSTNATAL GROWTH, LONGEVITY AND ADULT LUNG MAINTENANCE
12:30 – 12:45	Discussion on The Future of This Fusion Meeting
12:45 – 16:30	Lunch at Leisure & Free Time
12:45 – 16:00	Group Activity: Snorkel Trip (sign-ups required in advance)
Aging and Lung Fibrosis Session Session Chair: Wellington Cardoso
16:30 – 17:00	Victor Thannickal University of Alabama at Birmingham	METABOLIC CONTROL OF CELLULAR PLASTICITY IN LUNG FIBROSIS
17:00 – 17:30	Zea Borok University of Southern California	ALVEOLAR EPITHELIUM IN PULMONARY FIBROSIS: ROLE OF ER STRESS
17:30 – 18:00	Joseph Arron Genentech	GENETIC INSIGHTS AND MODEL DEVELOPMENT TO INVESTIGATE EPITHELIAL CELL SENESCENCE IN IDIOPATHIC PULMONARY FIBROSIS
18:00 – 18:45	Refreshments & Poster Viewing
18:45 – 19:15	Harold Chapman University of California, San Francisco	REVERSAL OF PRO-FIBROTIC SIGNALING IN IPF
19:15 – 19:45	Melanie Koenigshoff University of Colorado Denver	EXTRACELLULAR VESICLES AS NOVEL WNT MEDIATOR IN LUNG AGING AND FIBROSIS
19:45 – 20:00	Vera Krymskaya University of Pennsylvania School of Medicine	MTOR IN LUNG DISEASE, HOMEOSTASIS, AND AGING
20:00 – 20:15	Jacelyn Peabody University of Alabama at Birmingham	MUCUS MATTERS: FERRETS DEMONSTRATE SUSTAINED FIBROSIS, MUCOCILIARY DECREMENT, AND ABERRANT LUNG REPAIR FOLLOWING BLEOMYCIN-INDUCED PULMONARY FIBROSIS
20:15	Gala Dinner & Poster Awards

WEDNESDAY 20^TH FEBRUARY 2019
07:00 – 08:30	Buffet Breakfast at The Market Place
Epithelial-Mesenchymal Interactions in Lung Development and Fibrosis Session Session Chairs: Saverio Bellusci and Denise Al Alam
08:30 – 09:00	Maya Kumar Stanford School of Medicine	NEOINTIMA FORMATION FROM A PRE-EXISTING SUBPOPULATION OF VASCULAR SMOOTH MUSCLE CELLS
09:00 – 09:30	Anne-Karina Perl Cincinnati Children's Hospital	BENEFICIAL INTERSTITIAL MATRIX FIBROBLASTS ARE LOST WITH AGE, A NEW HOPE FOR IDIOPATHIC PULMONARY FIBROSIS
09:30 – 10:00	Parviz Minoo University of Southern California	GENETIC ARCHITECTURE OF ALVEOLAR FORMATION; THE PATH TO DECONVOLUTING PATHOGENESIS OF BRONCHOPULMONARY DYSPLASIA
10:00 – 10:30	Refreshments
10:30 – 11:00	Elie El Agha Justus-Liebig-University Giessen	INTERCONVERSION BETWEEN FIBROBLASTIC PHENOTYPES GOVERNS FIBROSIS FORMATION AND RESOLUTION
11:00 – 11:15	Mitsuru Morimoto RIKEN	SYNCHRONIZED MESENCHYMAL CELL POLARIZATION TOWARD EPITHELIUM SHAPES THE TRACHEA AND ESOPHAGUS
11:15 – 11:30	Randee Young University of California, San Diego	INVESTIGATING THE ROLE OF AIRWAY SMOOTH MUSCLE DURING BRANCHING MORPHOGENESIS OF THE MAMMALIAN LUNG
11:30 – 11:45	Deneen Wellik University of Wisconsin-Madison	HOX5 GENES PLAY A CONTINUING ROLE IN DISTAL LUNG EXTRACELLULAR MATRIX
11:45 – 12:00	Closing Comments

Speakers

Invited Speakers

Prof. David Ornitz
Professor, Washington University
Prof. Susan Majka
Associate Professor of Medicine, National Jewish Health
Dr. Wellington Cardoso
DIRECTOR, Columbia University Medical Center
Prof. Mark Krasnow
Professor of Biochemistry, Stanford University School of Medicine
Dr. Carla Kim
Principal Investigator, Boston Children's Hospital
PhD Anne-Karina Perl
Associate Professor, Cincinnati Children's Hospital
Prof. Dr. Saverio Bellusci
Chair for Lung Matrix Remodeling, Justus-Liebig-Universitaet Giessen, ECCPS
Prof. Hal Chapman
Professor, University of California San Francisco
Dr. Xin Sun
Professor, UCSD
Prof. Parviz Minoo
professor of Pediatrics, University of Southern California and Childrens Hospital
Dr. John Engelhardt
Professor and Head, University of Iowa
Prof. Dr. David Warburton
Jodi S. Ogden - VP, Research Administration , Children's Hospital Los Angeles
Dr. Elie El Agha
Researcher, Justus-Liebig University Giessen
Dr. Brigid Hogan
Chair - Cell Biology Department, Duke University
Dr. Jason Rock
Associate Professor, Boston University School of Medicine
Dr. Victor Thannickal
Professor and Director/Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham
Dr. Nan Tang
Assistant Investigator, National Institute of Biological Sciences, Beijing
Prof. Dr. Zea Borok
Professor and Division Chief, University of Southern California
Dr. Jay Rajagopal
Principal Investigator, Massachusetts General Hospital
Dr. Joseph Arron
Sr. Director, Immunology, Genentech
Dr. Jason Spence
Assoc. Prof, University of Michigan
Dr. Emma Rawlins
Group Leader, University of Cambridge
Dr. Maya Kumar
Instructor of Medicine, Stanford University School of Medicine
Dr. Paul Noble
Chairman, Cedars-Sinai Medical Center
Prof. Dr. Melanie Koenigshoff
Professor of Medicine, CU Denver
Dr. Gianni Carraro
Project Scientist, Cedars-Sinai Medical Center
Assist. Prof. Finn Hawkins
Assistant Professor, Boston University Center for Regenerative Medicine
Dr. Jane Connor
Associate Director, MedImmune

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