Synopsis
Lung development is governed by epithelial-mesenchymal interactions. These pathways are recapitulated during injury and repair. This conference will focus on understanding key processes underlying lung development, injury and repair in the context of age, environment and species, with the hope of better understanding disease development and to discover novel therapeutic approaches.
We will highlight critical issues on lung epithelial biology such as stem cells and regenerative medicine, while expanding sessions to encompass themes such as single cell analytical approaches, cell-cell communication, dissect the biological distinctions mesenchymal proliferation as a repair mechanism and fibrosis; present the impact of new tools in single cell analysis on understanding lung development, repair, and disease; and characterize epithelial-mesenchymal interrelationships that maintain lung homeostasis and orchestrate repair and regeneration. The entire program has been designed to achieve a better understanding of the key clinical research issues and how they relate to basic mechanistic investigation.
Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference.
For those interested, this meeting follows the 3rd Fibroblast Growth Factors in Development and Repair Conference, taking place from 15 February - 18 February 2019 at the same venue. A joint FGF session will take place on Monday 18 February from 08:30 - 12:30.
Key Sessions
- Fgf signaling in lung development and fibrosis
- Aging and lung fibrosis
- Lung stem/progenitor cells and their regulation in health and disease
- Organoid cultures to model lung development and disease
- Epithelial-mesenchymal interactions in lung development and fibrosis
Student Offer
Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,922 and bring a student for only $850. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 17, 18 and 19 February 2019 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 03 December 2018. Once registered, please contact Meredith Willmott to obtain a special registration link for your student.
Confirmed Invited Speakers
Joseph Arron (Genentech)
GENETIC INSIGHTS AND MODEL DEVELOPMENT TO INVESTIGATE EPITHELIAL CELL SENESCENCE IN IDIOPATHIC PULMONARY FIBROSIS
Saverio Bellusci (University of Giessen)
CHARACTERISATION OF A NOVEL FIBROBLAST GROWTH FACTOR 10 (FGF10)-PRODUCING RESIDENT
Zea Borok (Keck School of Medicine of USC)
ALVEOLAR EPITHELIUM IN PULMONARY FIBROSIS: ROLE OF ER STRESS
Wellington Cardoso (Columbia University)
ONTOGENY AND CONTROL OF THE AIRWAY STEM CELL POOL IN DEVELOPMENT AND DISEASE
Gianni Carraro (Cedars-Sinai)
SINGLE-CELL RECONSTRUCTION OF HUMAN BASAL CELL DIVERSITY IN NORMAL AND DISEASED LUNG
Harold Chapman (University of California, San Francisco)
Elie El Agha (Justus-Liebig-University Giessen)
INTERCONVERSION BETWEEN FIBROBLASTIC PHENOTYPES GOVERNS FIBROSIS FORMATION AND RESOLUTION
John Engelhardt (University of Iowa Carver College of Medicine)
WNT PATHWAY CONTROL OF GLANDULAR MYOEPITHELIAL STEM CELLS IN THE AIRWAY
Finn Hawkins (Boston University)
ORGANOID CULTURES TO MODEL LUNG DEVELOPMENT AND DISEASE
Brigid Hogan (Duke University)
DECONTRUCTING THE ALVEOLAR STEM CELL NICHE
Carla Kim (Boston Children's Hospital)
REGULATION OF PROGENITOR CELLS IN THE ADULT LUNG
Melanie Koenigshoff (University of Colorado Denver)
Mark Krasnow (Stanford University)
Maya Kumar (Stanford School of Medicine)
Roland Kolbeck (MedImmune)
TARGETING P16-INDUCED SENESCENCE PREVENTS CIGARETTE SMOKE-INDUCED PULMONARY EMPHYSEMA BY PROMOTING IGF1/Akt1 SIGNALING
Susan Majka (National Jewish Health)
RESIDENT LUNG MESENCHYMAL PROGENITORS MODULATE THE MICROVASCULAR NICHE
Parviz Minoo (Keck School of Medicine of USC)
GENETIC ARCHITECTURE OF ALVEOLAR FORMATION; THE PATH TO DECONVOLUTING PATHOGENESIS OF BRONCHOPULMONARY DYSPLASIA
Edward Morrisey (University of Pennsylvania)
Paul Noble (Cedars-Sinai)
David Ornitz (Washington University)
FGF SIGNALING IN LUNG DEVELOPMENT, CANCER, AND RESPONSE TO INJURY
Anne-Karina Perl (Cincinnati Children's Hospital)
BENEFICIAL INTERSTITIAL MATRIX FIBROBLASTS ARE LOST WITH AGE, A NEW HOPE FOR IDIOPATHIC PULMONARY FIBROSIS
Jayaraj Rajagopal (Massachusetts General Hospital)
THE AIRWAY EPITHELIAL HIERARCHY REVISITED
Emma Rawlins (University of Cambridge)
CELL-CELL INTERACTIONS IN NORMAL HUMAN LUNG DEVELOPMENT
Jason Rock (Boston University)
MACROPHAGES AND FIBROBLASTS AS NICHES IN THE ADULT LUNG
Jason Spence (University of Michigan)
BASAL CELL DIFFERENTIATION IN THE DEVELOPING HUMAN LUNG
Xin Sun (University of California, San Diego)
SIGNALS IN LUNG DEVELOPMENT AND FUNCTION
Nan Tang (National Institute of Biological Sciences)
THE DRIVING FORCE OF ALVEOLAR DEVELOPMENT, REGENERATION AND DISEASES
Victor Thannickal (University of Alabama at Birmingham)
METABOLIC CONTROL OF CELLULAR PLASTICITY IN LUNG FIBROSIS
David Warburton (Children's Hospital Los Angeles)
EPIGENETIC DNA METHYLATION DEPENDENT CONTROL OF MOUSE LUNG DEVELOPMENT: TEMPORAL AND COMPARTMENTAL SPECIFIC FUNCTIONAL EFFECTS OF INDUCIBLE DNMT1 DELETION IN DEVELOPING MOUSE LUNG MESENCHYME VERSUS EPITHELIUM
Target Audience
- Lung developmental biologists
- Stem cell researchers
- Fibrosis researchers
- Pulmonary fibrosis researchers
Educational Need
It’s is knowns that lung developmental pathways are reactivated in pulmonary fibrosis yet few if any meetings bring lung developmental biologists and researchers studying lung fibrosis together. This meeting will provide a unique opportunity to bring these 2 fields together.
Sponsors
Programme
SUNDAY 17TH FEBRUARY 2019 |
||
13:15 – 14:00 |
Student Networking Lunch |
|
14:00 – 14:50 |
Registration & Welcome Reception |
|
Keynote and Emerging Topics session |
||
14:50 – 15:00 |
Opening Comments |
|
15:00 – 15:30 |
Brigid Hogan |
DECONSTRUCTING THE ALVEOLAR STEM CELL NICHE |
15:30 – 16:00 |
Paul Noble |
TARGETING INVASIVE FIBROBLASTS IN IDIOPATHIC PULMONARY FIBROSIS |
16:00 – 16:30 |
Jayaraj Rajagopal |
THE AIRWAY EPITHELIAL HIERARCHY REVISITED |
16:30 – 17:00 |
Nan Tang |
THE DRIVING FORCE OF ALVEOLAR DEVELOPMENT, REGENERATION AND DISEASES |
17:00 – 17:15 |
Lindsey Eldridge |
IPSC DERIVED ALVEOLAR EPITHELIAL TYPE II CELLS PROVIDE A NEW TOOL FOR STUDYING ALVEOLAR REGENERATION |
17:15 – 17:45 |
Refreshments & Poster Viewing |
|
Keynote and Emerging Topics session |
||
17:45 – 18:15 |
John Engelhardt |
WNT PATHWAY CONTROL OF GLANDULAR MYOEPITHELIAL STEM CELLS IN THE AIRWAY |
18:15 – 18:45 |
Jane Connor |
TARGETING P16-INDUCED SENESCENCE PREVENTS CIGARETTE SMOKE-INDUCED PULMONARY EMPHYSEMA BY PROMOTING IGF1/Akt1 SIGNALING |
18:45 – 19:00 |
Arnaud Mailleux |
IDENTIFICATION OF PRRX1 AS A KEY MESENCHYMAL TRANSCRIPTION FACTOR IN IDIOPATHIC PULMONARY FIBROSIS |
19:00 – 19:15 |
Jianwen Que |
WNT/FGF CROSSTALK IS REQUIRED FOR THE SPECIFICATION OF TRACHEAL BASAL PROGENITOR CELLS |
19:15 – 20:00 |
Meet the Poster Presenters I |
|
19:30 – 20:00 |
Accompanying Guests Pre-Dinner Welcome Cocktails |
|
20:00 |
Dinner |
TUESDAY 19TH FEBRUARY 2019 |
||
07:00 – 08:30 |
Buffet Breakfast at The Market Place |
|
Lung Stem/Progenitor Cells and Their Regulation in Health and Disease Session |
||
08:30 - 09:00 |
David Warburton |
EPIGENETIC DNA METHYLATION DEPENDENT CONTROL OF MOUSE LUNG DEVELOPMENT: TEMPORAL AND COMPARTMENTAL SPECIFIC FUNCTIONAL EFFECTS OF INDUCIBLE DNMT1 DELETION IN DEVELOPING MOUSE LUNG MESENCHYME VERSUS EPITHELIUM |
09:00 – 09:30 |
Jason Rock |
MACROPHAGES AND FIBROBLASTS AS NICHES IN THE ADULT LUNG |
09:30 – 10:00 |
Wellington Cardoso |
ONTOGENY AND CONTROL OF THE AIRWAY STEM CELL POOL IN DEVELOPMENT AND DISEASE |
10:00 – 10:15 |
Ana Pardo-Saganta |
AIRWAY STEM CELLS DIRECTLY REGULATE IMMUNE CELLS |
10:15 – 10:30 |
Alyssa Miller |
BASAL STEM CELL INDUCTION IN THE DEVELOPING HUMAN LUNG |
10:30 – 11:15 |
Group Photo, Refreshments & Poster Viewing |
|
11:15 – 11:45 |
Susan Majka |
RESIDENT LUNG MESENCHYMAL PROGENITORS MODULATE THE MICROVASCULAR NICHE |
11:45 – 12:15 |
Purushothama Rao Tata Duke University |
MECHANISMS OF RESERVE STEM CELL MEDIATED AIRWAY REGENERATION |
12:15 – 12:30 |
Jining Lu |
MIR-29 IN POSTNATAL GROWTH, LONGEVITY AND ADULT LUNG MAINTENANCE |
12:30 – 12:45 |
Discussion on The Future of This Fusion Meeting |
|
12:45 – 16:30 |
Lunch at Leisure & Free Time |
|
12:45 – 16:00 |
Group Activity: Snorkel Trip (sign-ups required in advance) |
|
Aging and Lung Fibrosis Session |
||
16:30 – 17:00 |
Victor Thannickal |
METABOLIC CONTROL OF CELLULAR PLASTICITY IN LUNG FIBROSIS |
17:00 – 17:30 |
Zea Borok |
ALVEOLAR EPITHELIUM IN PULMONARY FIBROSIS: ROLE OF ER STRESS |
17:30 – 18:00 |
Joseph Arron |
GENETIC INSIGHTS AND MODEL DEVELOPMENT TO INVESTIGATE EPITHELIAL CELL SENESCENCE IN IDIOPATHIC PULMONARY FIBROSIS |
18:00 – 18:45 |
Refreshments & Poster Viewing |
|
18:45 – 19:15 |
Harold Chapman |
REVERSAL OF PRO-FIBROTIC SIGNALING IN IPF |
19:15 – 19:45 |
Melanie Koenigshoff |
EXTRACELLULAR VESICLES AS NOVEL WNT MEDIATOR IN LUNG AGING AND FIBROSIS |
19:45 – 20:00 |
Vera Krymskaya |
MTOR IN LUNG DISEASE, HOMEOSTASIS, AND AGING |
20:00 – 20:15 |
Jacelyn Peabody |
MUCUS MATTERS: FERRETS DEMONSTRATE SUSTAINED FIBROSIS, MUCOCILIARY DECREMENT, AND ABERRANT LUNG REPAIR FOLLOWING BLEOMYCIN-INDUCED PULMONARY FIBROSIS |
20:15 |
Gala Dinner & Poster Awards |
Speakers
Invited Speakers
- Prof. David Ornitz
Professor, Washington University - Prof. Susan Majka
Associate Professor of Medicine, National Jewish Health - Dr. Wellington Cardoso
DIRECTOR, Columbia University Medical Center - Prof. Mark Krasnow
Professor of Biochemistry, Stanford University School of Medicine - Dr. Carla Kim
Principal Investigator, Boston Children's Hospital - PhD Anne-Karina Perl
Associate Professor, Cincinnati Children's Hospital - Prof. Dr. Saverio Bellusci
Chair for Lung Matrix Remodeling, Justus-Liebig-Universitaet Giessen, ECCPS - Prof. Hal Chapman
Professor, University of California San Francisco - Dr. Xin Sun
Professor, UCSD - Prof. Parviz Minoo
professor of Pediatrics, University of Southern California and Childrens Hospital - Dr. John Engelhardt
Professor and Head, University of Iowa - Prof. Dr. David Warburton
Jodi S. Ogden - VP, Research Administration , Children's Hospital Los Angeles - Dr. Elie El Agha
Researcher, Justus-Liebig University Giessen - Dr. Brigid Hogan
Chair - Cell Biology Department, Duke University - Dr. Jason Rock
Associate Professor, Boston University School of Medicine - Dr. Victor Thannickal
Professor and Director/Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham - Dr. Nan Tang
Assistant Investigator, National Institute of Biological Sciences, Beijing - Prof. Dr. Zea Borok
Professor and Division Chief, University of Southern California - Dr. Jay Rajagopal
Principal Investigator, Massachusetts General Hospital - Dr. Joseph Arron
Sr. Director, Immunology, Genentech - Dr. Jason Spence
Assoc. Prof, University of Michigan - Dr. Emma Rawlins
Group Leader, University of Cambridge - Dr. Maya Kumar
Instructor of Medicine, Stanford University School of Medicine - Dr. Paul Noble
Chairman, Cedars-Sinai Medical Center - Prof. Dr. Melanie Koenigshoff
Professor of Medicine, CU Denver - Dr. Gianni Carraro
Project Scientist, Cedars-Sinai Medical Center - Assist. Prof. Finn Hawkins
Assistant Professor, Boston University Center for Regenerative Medicine - Dr. Jane Connor
Associate Director, MedImmune
Feedback
Sign In
Your feedback has been received.