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Home > Past Conferences > Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference

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Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference

17 Feb 2019 - 20 Feb 2019

Nassau, Bahamas

Synopsis

Lung development is governed by epithelial-mesenchymal interactions. These pathways are recapitulated during injury and repair. This conference will focus on understanding key processes underlying lung development, injury and repair in the context of age, environment and species, with the hope of better understanding disease development and to discover novel therapeutic approaches.

We will highlight critical issues on lung epithelial biology such as stem cells and regenerative medicine, while expanding sessions to encompass themes such as single cell analytical approaches, cell-cell communication, dissect the biological distinctions mesenchymal proliferation as a repair mechanism and fibrosis; present the impact of new tools in single cell analysis on understanding lung development, repair, and disease; and characterize epithelial-mesenchymal interrelationships that maintain lung homeostasis and orchestrate repair and regeneration. The entire program has been designed to achieve a better understanding of the key clinical research issues and how they relate to basic mechanistic investigation.

Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference.

For those interested, this meeting follows the 3rd Fibroblast Growth Factors in Development and Repair Conference, taking place from 15 February - 18 February 2019 at the same venue. A joint FGF session will take place on Monday 18 February from 08:30 - 12:30. 

Key Sessions

  • Fgf signaling in lung development and fibrosis
  • Aging and lung fibrosis
  • Lung stem/progenitor cells and their regulation in health and disease
  • Organoid cultures to model lung development and disease
  • Epithelial-mesenchymal interactions in lung development and fibrosis 

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,922 and bring a student for only $850. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 17, 18 and 19 February 2019 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 03 December 2018. Once registered, please contact Meredith Willmott to obtain a special registration link for your student. 

Confirmed Invited Speakers

Joseph Arron (Genentech)
GENETIC INSIGHTS AND MODEL DEVELOPMENT TO INVESTIGATE EPITHELIAL CELL SENESCENCE IN IDIOPATHIC PULMONARY FIBROSIS
Saverio Bellusci (University of Giessen)
CHARACTERISATION OF A NOVEL FIBROBLAST GROWTH FACTOR 10 (FGF10)-PRODUCING RESIDENT 
Zea Borok (Keck School of Medicine of USC)
ALVEOLAR EPITHELIUM IN PULMONARY FIBROSIS: ROLE OF ER STRESS
Wellington Cardoso (Columbia University)
ONTOGENY AND CONTROL OF THE AIRWAY  STEM CELL POOL IN DEVELOPMENT AND DISEASE
Gianni Carraro (Cedars-Sinai)
SINGLE-CELL RECONSTRUCTION OF HUMAN BASAL CELL DIVERSITY IN NORMAL AND DISEASED LUNG
Harold Chapman (University of California, San Francisco)
Elie El Agha (Justus-Liebig-University Giessen)
INTERCONVERSION BETWEEN FIBROBLASTIC PHENOTYPES GOVERNS FIBROSIS FORMATION AND RESOLUTION
John Engelhardt (University of Iowa Carver College of Medicine)
WNT PATHWAY CONTROL OF GLANDULAR MYOEPITHELIAL STEM CELLS IN THE AIRWAY
Finn Hawkins (Boston University)
ORGANOID CULTURES TO MODEL LUNG DEVELOPMENT AND DISEASE
Brigid Hogan (Duke University)
DECONTRUCTING THE ALVEOLAR STEM CELL NICHE
Carla Kim (Boston Children's Hospital)
REGULATION OF PROGENITOR CELLS IN THE ADULT LUNG
Melanie Koenigshoff (University of Colorado Denver)
Mark Krasnow (Stanford University)
Maya Kumar (Stanford School of Medicine)
Roland Kolbeck (MedImmune)
TARGETING P16-INDUCED SENESCENCE PREVENTS CIGARETTE SMOKE-INDUCED PULMONARY EMPHYSEMA BY PROMOTING IGF1/Akt1 SIGNALING
Susan Majka (National Jewish Health)
RESIDENT LUNG MESENCHYMAL PROGENITORS MODULATE THE MICROVASCULAR NICHE
Parviz Minoo (Keck School of Medicine of USC)
GENETIC ARCHITECTURE OF ALVEOLAR FORMATION; THE PATH TO DECONVOLUTING PATHOGENESIS OF BRONCHOPULMONARY DYSPLASIA 
Edward Morrisey (University of Pennsylvania)
Paul Noble (Cedars-Sinai)
David Ornitz (Washington University)
FGF SIGNALING IN LUNG DEVELOPMENT, CANCER, AND RESPONSE TO INJURY
Anne-Karina Perl (Cincinnati Children's Hospital)
BENEFICIAL INTERSTITIAL MATRIX FIBROBLASTS ARE LOST WITH AGE, A NEW HOPE FOR IDIOPATHIC PULMONARY FIBROSIS
Jayaraj Rajagopal (Massachusetts General Hospital)
THE AIRWAY EPITHELIAL HIERARCHY REVISITED
Emma Rawlins (University of Cambridge)
CELL-CELL INTERACTIONS IN NORMAL HUMAN LUNG DEVELOPMENT
Jason Rock (Boston University)
MACROPHAGES AND FIBROBLASTS AS NICHES IN THE ADULT LUNG 
Jason Spence (University of Michigan)
BASAL CELL DIFFERENTIATION IN THE DEVELOPING HUMAN LUNG
Xin Sun (University of California, San Diego)
SIGNALS IN LUNG DEVELOPMENT AND FUNCTION
Nan Tang (National Institute of Biological Sciences)
THE DRIVING FORCE OF ALVEOLAR DEVELOPMENT, REGENERATION AND DISEASES
Victor Thannickal (University of Alabama at Birmingham)
METABOLIC CONTROL OF CELLULAR PLASTICITY IN LUNG FIBROSIS
David Warburton (Children's Hospital Los Angeles)
EPIGENETIC DNA METHYLATION DEPENDENT CONTROL OF MOUSE LUNG DEVELOPMENT: TEMPORAL AND COMPARTMENTAL SPECIFIC FUNCTIONAL EFFECTS OF INDUCIBLE DNMT1 DELETION IN DEVELOPING MOUSE LUNG MESENCHYME VERSUS EPITHELIUM

Target Audience 

  • Lung developmental biologists
  • Stem cell researchers
  • Fibrosis researchers
  • Pulmonary fibrosis researchers

Educational Need

It’s is knowns that lung developmental pathways are reactivated in pulmonary fibrosis yet few if any meetings bring lung developmental biologists and researchers studying lung fibrosis together. This meeting will provide a unique opportunity to bring these 2 fields together.

Sponsors

Sponsors

Programme

SUNDAY 17TH FEBRUARY 2019

13:15 – 14:00

Student Networking Lunch

14:00 – 14:50

Registration & Welcome Reception

Keynote and Emerging Topics session 
Session Chair: Barry Stripp

14:50 – 15:00

Opening Comments

15:00 – 15:30

Brigid Hogan 
Duke University

DECONSTRUCTING THE ALVEOLAR STEM CELL NICHE

15:30 – 16:00

Paul Noble 
Cedars-Sinai Medical Center

TARGETING INVASIVE FIBROBLASTS IN IDIOPATHIC PULMONARY FIBROSIS

16:00 – 16:30

Jayaraj Rajagopal 
Massachusetts General Hospital

THE AIRWAY EPITHELIAL HIERARCHY REVISITED

16:30 – 17:00

Nan Tang 
National Institute of Biological Sciences

THE DRIVING FORCE OF ALVEOLAR DEVELOPMENT, REGENERATION AND DISEASES

17:00 – 17:15

Lindsey Eldridge 
MedImmune LLC

IPSC DERIVED ALVEOLAR EPITHELIAL TYPE II CELLS PROVIDE A NEW TOOL FOR STUDYING ALVEOLAR REGENERATION

17:15 – 17:45

Refreshments & Poster Viewing

Keynote and Emerging Topics session 
Session Chair: Stijn De Langhe

17:45 – 18:15

John Engelhardt 
University of Iowa

WNT PATHWAY CONTROL OF GLANDULAR MYOEPITHELIAL STEM CELLS IN THE AIRWAY

18:15 – 18:45

Jane Connor
MedImmune LLC

TARGETING P16-INDUCED SENESCENCE PREVENTS CIGARETTE SMOKE-INDUCED PULMONARY EMPHYSEMA BY PROMOTING IGF1/Akt1 SIGNALING

18:45 – 19:00

Arnaud Mailleux 
INSERM U1152

IDENTIFICATION OF PRRX1 AS A KEY MESENCHYMAL TRANSCRIPTION FACTOR IN IDIOPATHIC PULMONARY FIBROSIS

19:00 – 19:15

Jianwen Que 
Columbia University

WNT/FGF CROSSTALK IS REQUIRED FOR THE SPECIFICATION OF TRACHEAL BASAL PROGENITOR CELLS

19:15 – 20:00

Meet the Poster Presenters I 
Moderators: Zea Borok & Deneen Wellik

19:30 – 20:00

Accompanying Guests Pre-Dinner Welcome Cocktails

20:00

Dinner

MONDAY 18TH FEBRUARY 2019

07:00 – 08:30

Buffet Breakfast at The Market Place

FGF Signaling in Lung Development and Fibrosis Session (joint session with 3rd Fibroblast Growth Factors in Development and Repair Conference)

Session Chairs: Mohammad Hajihosseini (part 1) and Mark Lewandoski (part 2)

08:30 – 09:00

Mark Krasnow 
Stanford University

FGF SELECTION AND LIFELONG MAINTENANCE OF ALVEOLAR CELLS

09:00 – 09:30

Saverio Bellusci 
Justus-Liebig-Universitaet Giessen

CHARACTERISATION OF A NOVEL FIBROBLAST GROWTH FACTOR 10 (FGF10)-PRODUCING RESIDENT MESENCHYMAL CELL INVOLVED IN THE REPAIR PROCESS OF THE BRONCHIAL EPITHELIUM AFTER NAPHTHALENE INJURY

09:30 – 10:00

Stijn De Langhe 
University of Alabama at Birmingham

ROLE OF FGF10 SIGNALING IN THE RESOLUTION OF PULMONARY FIBROSIS

10:00 – 10:30

Xin Sun 
University of California, San Diego

SIGNALS IN LUNG DEVELOPMENT AND FUNCTION

10:30 – 11:00

Refreshments & Poster Viewing

11:00 – 11:30

David Ornitz 
Washington University

THE ALVEOLAR MYOFIBROBLAST AND THE ROLE OF FGF18 IN ALVEOLOGENESIS

11:30 – 11:45

Denise Al Alam 
Children's Hospital Los Angeles

FGF LIGANDS AND THE HUMAN LUNG

11:45 – 12:00

Stefan Hadzic 
Justus-Liebig-Universitaet Giessen

IMPAIRED FGF10 SIGNALLING IN THE ADULT LUNG LEADS TO DEVELOPMENT OF EMPHYSEMA AND PULMONARY HYPERTENSION

12:00 – 12:15

Robert Guzy 
The University of Chicago

ALVEOLAR EPITHELIAL FGFR SIGNALING IS REQUIRED FOR RECOVERY FROM BLEOMYCIN-INDUCED INJURY

12:15 – 12:30

Aurélien Justet 
Unité INSERM1152

IMPLICATION OF FGFR4 AND FGF19 IN IDIOPATHIC PULMONARY FIBROSIS

12:30 – 16:30

Lunch at Leisure & Free Time

12:45 – 16:00

Group Activity: Snorkel Trip (sign-ups required in advance)

Organoid Cultures to Model Lung Development and Disease Session

Session Chair: Xin Sun

16:30 – 17:00

Jason Spence 
University of Michigan

BASAL CELL DIFFERENTIATION IN THE DEVELOPING HUMAN LUNG

17:00 – 17:30

Gianni Carraro 
Cedars-Sinai Medical Center

SINGLE-CELL RECONSTRUCTION OF HUMAN BASAL CELL DIVERSITY IN NORMAL AND DISEASED LUNG

17:30 – 18:00

Emma Rawlins 
University of Cambridge

CELL-CELL INTERACTIONS IN NORMAL HUMAN LUNG DEVELOPMENT

18:00 – 18:30

Finn Hawkins 
Boston University Center for Regenerative Medicine

ORGANOID CULTURES TO MODEL LUNG DEVELOPMENT AND DISEASE

18:30 – 18:45

Preethi Vijayaraj 
University of California, Los Angeles

MODELING PROGRESSIVE FIBROSIS WITH PLURIPOTENT STEM CELLS IDENTIFIES AN ANTI-FIBROTIC SMALL MOLECULE

18:45 – 19:15

Carla Kim 
Boston Children's Hospital

REGULATION OF PROGENITOR CELLS IN THE ADULT LUNG

19:15 – 20:30

Poster Session & Refreshments

20:30

Dinner

TUESDAY 19TH FEBRUARY 2019

07:00 – 08:30

Buffet Breakfast at The Market Place

Lung Stem/Progenitor Cells and Their Regulation in Health and Disease Session

Session Chair: Victor Thannickal

08:30 - 09:00

David Warburton
Children's Hospital Los Angeles

EPIGENETIC DNA METHYLATION DEPENDENT CONTROL OF MOUSE LUNG DEVELOPMENT: TEMPORAL AND COMPARTMENTAL SPECIFIC FUNCTIONAL EFFECTS OF INDUCIBLE DNMT1 DELETION IN DEVELOPING MOUSE LUNG MESENCHYME VERSUS EPITHELIUM

09:00 – 09:30

Jason Rock 
Boston University School of Medicine

MACROPHAGES AND FIBROBLASTS AS NICHES IN THE ADULT LUNG

09:30 – 10:00

Wellington Cardoso 
Columbia University

ONTOGENY AND CONTROL OF THE AIRWAY STEM CELL POOL IN DEVELOPMENT AND DISEASE

10:00 – 10:15

Ana Pardo-Saganta 
University of Navarra

AIRWAY STEM CELLS DIRECTLY REGULATE IMMUNE CELLS

10:15 – 10:30

Alyssa Miller 
University of Michigan

BASAL STEM CELL INDUCTION IN THE DEVELOPING HUMAN LUNG

10:30 – 11:15

Group Photo, Refreshments & Poster Viewing

11:15 – 11:45

Susan Majka 
National Jewish Health

RESIDENT LUNG MESENCHYMAL PROGENITORS MODULATE THE MICROVASCULAR NICHE

11:45 – 12:15

Purushothama Rao Tata Duke University

MECHANISMS OF RESERVE STEM CELL MEDIATED AIRWAY REGENERATION

12:15 – 12:30

Jining Lu 
Columbia University

MIR-29 IN POSTNATAL GROWTH, LONGEVITY AND ADULT LUNG MAINTENANCE

12:30 – 12:45

Discussion on The Future of This Fusion Meeting

12:45 – 16:30

Lunch at Leisure & Free Time

12:45 – 16:00

Group Activity: Snorkel Trip (sign-ups required in advance)

Aging and Lung Fibrosis Session

Session Chair: Wellington Cardoso

16:30 – 17:00

Victor Thannickal 
University of Alabama at Birmingham

METABOLIC CONTROL OF CELLULAR PLASTICITY IN LUNG FIBROSIS

17:00 – 17:30

Zea Borok 
University of Southern California

ALVEOLAR EPITHELIUM IN PULMONARY FIBROSIS: ROLE OF ER STRESS

17:30 – 18:00

Joseph Arron 
Genentech

GENETIC INSIGHTS AND MODEL DEVELOPMENT TO INVESTIGATE EPITHELIAL CELL SENESCENCE IN IDIOPATHIC PULMONARY FIBROSIS

18:00 – 18:45

Refreshments & Poster Viewing

18:45 – 19:15

Harold Chapman 
University of California, San Francisco

REVERSAL OF PRO-FIBROTIC SIGNALING IN IPF

19:15 – 19:45

Melanie Koenigshoff 
University of Colorado Denver

EXTRACELLULAR VESICLES AS NOVEL WNT MEDIATOR IN LUNG AGING AND FIBROSIS

19:45 – 20:00

Vera Krymskaya 
University of Pennsylvania School of Medicine

MTOR IN LUNG DISEASE, HOMEOSTASIS, AND AGING

20:00 – 20:15

Jacelyn Peabody 
University of Alabama at Birmingham

MUCUS MATTERS: FERRETS DEMONSTRATE SUSTAINED FIBROSIS, MUCOCILIARY DECREMENT, AND ABERRANT LUNG REPAIR FOLLOWING BLEOMYCIN-INDUCED PULMONARY FIBROSIS

20:15

Gala Dinner & Poster Awards

WEDNESDAY 20TH FEBRUARY 2019

07:00 – 08:30

Buffet Breakfast at The Market Place

Epithelial-Mesenchymal Interactions in Lung Development and Fibrosis Session

Session Chairs: Saverio Bellusci and Denise Al Alam

08:30 – 09:00

Maya Kumar 
Stanford School of Medicine

NEOINTIMA FORMATION FROM A PRE-EXISTING SUBPOPULATION OF VASCULAR SMOOTH MUSCLE CELLS

09:00 – 09:30

Anne-Karina Perl 
Cincinnati Children's Hospital

BENEFICIAL INTERSTITIAL MATRIX FIBROBLASTS ARE LOST WITH AGE, A NEW HOPE FOR IDIOPATHIC PULMONARY FIBROSIS

09:30 – 10:00

Parviz Minoo 
University of Southern California

GENETIC ARCHITECTURE OF ALVEOLAR FORMATION; THE PATH TO DECONVOLUTING PATHOGENESIS OF BRONCHOPULMONARY DYSPLASIA

10:00 – 10:30

Refreshments

10:30 – 11:00

Elie El Agha 
Justus-Liebig-University Giessen

INTERCONVERSION BETWEEN FIBROBLASTIC PHENOTYPES GOVERNS FIBROSIS FORMATION AND RESOLUTION

11:00 – 11:15

Mitsuru Morimoto 
RIKEN

SYNCHRONIZED MESENCHYMAL CELL POLARIZATION TOWARD EPITHELIUM SHAPES THE TRACHEA AND ESOPHAGUS

11:15 – 11:30

Randee Young 
University of California, San Diego

INVESTIGATING THE ROLE OF AIRWAY SMOOTH MUSCLE DURING BRANCHING MORPHOGENESIS OF THE MAMMALIAN LUNG

11:30 – 11:45

Deneen Wellik 
University of Wisconsin-Madison

HOX5 GENES PLAY A CONTINUING ROLE IN DISTAL LUNG EXTRACELLULAR MATRIX

11:45 – 12:00

Closing Comments

Speakers

Invited Speakers

  • Prof. David Ornitz
    Professor, Washington University
  • Prof. Susan Majka
    Associate Professor of Medicine, National Jewish Health
  • Dr. Wellington Cardoso
    DIRECTOR, Columbia University Medical Center
  • Prof. Mark Krasnow
    Professor of Biochemistry, Stanford University School of Medicine
  • Dr. Carla Kim
    Principal Investigator, Boston Children's Hospital
  • PhD Anne-Karina Perl
    Associate Professor, Cincinnati Children's Hospital
  • Prof. Dr. Saverio Bellusci
    Chair for Lung Matrix Remodeling, Justus-Liebig-Universitaet Giessen, ECCPS
  • Prof. Hal Chapman
    Professor, University of California San Francisco
  • Dr. Xin Sun
    Professor, UCSD
  • Prof. Parviz Minoo
    professor of Pediatrics, University of Southern California and Childrens Hospital
  • Dr. John Engelhardt
    Professor and Head, University of Iowa
  • Prof. Dr. David Warburton
    Jodi S. Ogden - VP, Research Administration , Children's Hospital Los Angeles
  • Dr. Elie El Agha
    Researcher, Justus-Liebig University Giessen
  • Dr. Brigid Hogan
    Chair - Cell Biology Department, Duke University
  • Dr. Jason Rock
    Associate Professor, Boston University School of Medicine
  • Dr. Victor Thannickal
    Professor and Director/Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham
  • Dr. Nan Tang
    Assistant Investigator, National Institute of Biological Sciences, Beijing
  • Prof. Dr. Zea Borok
    Professor and Division Chief, University of Southern California
  • Dr. Jay Rajagopal
    Principal Investigator, Massachusetts General Hospital
  • Dr. Joseph Arron
    Sr. Director, Immunology, Genentech
  • Dr. Jason Spence
    Assoc. Prof, University of Michigan
  • Dr. Emma Rawlins
    Group Leader, University of Cambridge
  • Dr. Maya Kumar
    Instructor of Medicine, Stanford University School of Medicine
  • Dr. Paul Noble
    Chairman, Cedars-Sinai Medical Center
  • Prof. Dr. Melanie Koenigshoff
    Professor of Medicine, CU Denver
  • Dr. Gianni Carraro
    Project Scientist, Cedars-Sinai Medical Center
  • Assist. Prof. Finn Hawkins
    Assistant Professor, Boston University Center for Regenerative Medicine
  • Dr. Jane Connor
    Associate Director, MedImmune

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