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Home > Past Conferences > 3rd Fibroblast Growth Factors in Development and Repair Conference

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Past Conference

3rd Fibroblast Growth Factors in Development and Repair Conference

15 Feb 2019 - 18 Feb 2019

Nassau, Bahamas

The conference registration date has past

Synopsis

The Fibroblast Growth Factor (FGF) Fusion Conference aims to bring together researchers from different disciplines with an interest in FGF biology/biochemistry and clinical applications. This will be the third FGF Fusion conference, building on two very successful previous meetings. This meeting will provide a unique opportunity for researchers to meet each other, to discuss their project and to initiate new and in some cases highly interdisciplinary research projects and collaborations. 

For those interested, this meeting takes place just before the Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference, taking place from 17 - 20 February 2019 at the same venue. A joint session takes place on Monday 18 February from 08:30 - 12:30. 

Key Sessions

  • FGF signalling in normal and impaired development
  • Role of FGFs in stem cell biology
  • Interaction of FGF signalling with other signalling pathways
  • Role of endogenous and efficacy of exogenous FGFs in tissue repair and regeneration
  • Role of altered FGF signalling in human diseases, ranging from rare developmental disorders to major diseases such as metabolic syndrome and cancer
  • Role of FGFs and FGFRs as therapeutic targets
  • FGFs as endocrine hormones

Grant Opportunity

We have two $1,000 grants available on a first-come, first-serve basis. To apply send an abstract for poster consideration to Emily Bicknell by 25th January 2019. Please note that these grants are only available to those who have not yet registered.

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the rate of $1,922 and bring a student for only $850. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 15, 16, 17 February 2019 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 25th January 2019. Once registered, please contact Emily Bicknell to obtain a special registration link for your student.

Confirmed Invited Speakers

Denis Barritault (OTR3)
'40 YEARS AND HOW IDENTIFICATION OF FGF IN RETINA LED TO A NEW BRANCH IN REGENERATIVE MEDICINE'
Saverio Bellusci (Justus-Liebig-Universitaet Giessen, ECCPS)
'CHARACTERISATION OF A NOVEL FIBROBLAST GROWTH FACTOR 10 (FGF10)-PRODUCING RESIDENT MESENCHYMAL CELL INVOLVED IN THE REPAIR PROCESS OF THE BRONCHIAL EPITHELIUM AFTER NAPHTHALENE INJURY'
Ralph Bradshaw (University of California, Irvine)
'THE EARLY HISTORY OF THE FGF FAMILY: DISCOVERY, IDENTIFICATION AND CHARACTERIZATION' by Ralph A. Bradshaw and Kenneth A. Thomas
Richard Grose (Barts Cancer Institute)
'3D MODELLING APPROACHES TO DISSECT FGFR SIGNALLING IN CANCER'
Mohammad Hajihosseini (University of East Anglia)
'NEW FOCI OF NEUROGLIOGENESIS BY FGF10-EXPRESSING CELLS IN THE ADULT MOUSE BRAIN'
Marja Hurley (UCONN Health)
'FIBROBLAST GROWTH FACTOR 2 AND FRACTURE REPAIR'
Alexei Kharitonenkov (Novo Nordisk)
'MOLECULAR ELEMENTS IN FGF19 AND FGF21 DEFINING KLB/FGFR SPECIFICITY AND ACTIVITY'
Steven Kliewer (UT Southwestern)
'RECENT INSIGHTS INTO FGF21 PHYSIOLOGY AND PHARMACOLOGY'
Stijn de Langhe (University of Alabama at Birmingham)
'ROLE OF FGF10 SIGNALING IN THE RESOLUTION OF PULMONARY FIBROSIS'
Laurence Legeai-Mallet (INSERM)
'HYPOCHONDROPLASIA: LESSONS FROM MOUSE MODEL'
Mark Lewandoski (NIH)
'FGF4 SETS THE SOMITIC CLOCK'
Xiaokun Li (Wenzhou Medical University)
'MECHANISTIC DISCOVERY AND THERAPEUTIC APPLICATIONS OF FGFS IN CHINA'
Suzanne Mansour (University of Utah)
'FGF SIGNALING IN INNER EAR DEVELOPMENT AND FUNCTION'
Amy Merrill (University of Southern California)
'FGF SIGNALING AND INTEGRATED DEVELOPMENT OF THE MUSCULOSKELETAL SYSTEM'
Moosa Mohammadi (New York University School of Medicine)
'aKLOTHO IS A NON-ENZYMATIC MOLECULAR SCAFFOLD FOR FGF23 HORMONE SIGNALING'
Luke Noon (CIPF - Centro de Investigacion Principe Felipe)
'RESISTING REPAIR: INSULIN RESISTANCE DISRUPTS HEPATIC FGF7 SIGNALLING DURING INJURY'
David Ornitz (Washington University in St. Louis)
'THE ALVEOLAR MYOFIBROBLAST AND THE ROLE OF FGF18 IN ALVEOLOGENESIS'
Tatjana Piotrowski (Stowers Institute for Medical Research)
'FGF SIGNALING IN ZEBRAFISH SENSORY ORGAN DEVELOPMENT AND REGENERATION'
Dina Ron (Technion - Israel Institute of Technology)
'REGULATION AND ANTI-TUMOR ACTIVITY OF HUMAN-SEF (SIMILAR EXPRESSION TO FGFS)'
Michael Seckl (Imperial College London)
FGFR INHIBITORS: WHICH CANCER PATIENTS ARE MOST LIKELY TO BENEFIT?
Philippe Soriano (Mount Sinai)
'FGF SIGNALLING IN EARLY DEVELOPMENT'
Fen Wang (Texas A&M University)
'ABERRANT FGFR TYROSINE KINASE SIGNALING ENHANCES THE WARBURG EFFECT BY REPROGRAMMING LDH ISOFORM EXPRESSION AND ACTIVITY IN PROSTATE CANCER'
Jin-San Zhang (Wenzhou Medical University)
'FGF10-MEDIATED PROTECTION AGAINST RENAL ISCHEMIA-REPERFUSION INJURY THROUGH REGULATION OF BOTH AUTOPHAGY AND ER-STRESS'

Target Audience

FGFs are key regulators of development, repair, disease, and metabolic homeostasis for many organs and therefore, FGF researchers come from various disciplines. These include structural biologists, biochemists, cell biologists, clinical researchers, clinicians, geneticists, pharmacologists and bioengineers. FGF meetings usually attract people from academia, but also from various pharmaceutical companies due to the important roles of FGFs and FGF receptors as drug targets.

FGF research is well represented at different places in the world, with major hubs in Europe, in the US, in China and in Japan. However, researchers from other countries also join the FGF conferences.

Educational Need

The role of FGFs in stem cell biology, tissue response to injury, as potentially treatable genetic diseases, and as endocrine factors affecting health and aging are rapidly progressing. Each month there are dozens of papers that have either FGF signalling as a primary focus or that examine FGF interactions with other signalling pathways. Because of this rapid progress there remains a need to have relatively frequent conferences that serve to educate newcomers to the field and allow seasoned FGF researchers to catch up on FGF biology in different organ systems or diseases.

 

 

 

 

 

Sponsors

Sponsors

Programme

FRIDAY 15TH FEBRUARY

14:00 – 14:45

Registration & Welcome Reception

FGFs – A: From History to Application; B: FGFs in Development 
Session Chairs: David Ornitz (part 1) and Richard Grose (part 2)

14:45 – 15:00

Opening Comments

15:00 – 15:30

Ralph Bradshaw 
Trefoil Therapeutics

IDENTIFYING ACIDIC AND BASIC FGF: THE EARLY HISTORY OF THE FGF FAMILY

15:30 – 15:50

Denis Barritault 
University Paris Est-Créteil

40 YEARS AND HOW IDENTIFICATION OF FGF IN RETINA LED TO A NEW BRANCH IN REGENERATIVE MEDICINE

15:50 – 16:20

Xiaokun Li 
Wenzhou Medical University

MECHANISTIC DISCOVERY AND THERAPEUTIC APPLICATIONS OF FGFS IN CHINA

16:20 – 16:35

Michael Boylan 
NCI, NIH

KEEPING IT TOGETHER: THE ROLE OF FGF SIGNALING IN MURINE EMBRYONIC VENTRAL WALL CLOSURE

16:35 – 16:50

Cho-Ming Chao 
Justus-Liebig-Universitaet Giessen

FGF10/FGFR2B SIGNALING IN ALVEOLAR LINEAGE FORMATION AND HOMEOSTASIS

16:50 – 17:05

Sougata Roy 
University of Maryland

FGF GRADIENT SELF-GENERATES DYNAMIC RECIPIENT TISSUE-SPECIFIC SHAPES BY FEEDBACK REGULATING CYTONEME-MEDIATED DISPERSION

17:05 – 17:35

Refreshments & Poster Viewing

17:35 – 18:05

Mark Lewandoski 
NIH

FGF4 SETS THE SOMITIC CLOCK

 

18:05 – 18:35

Suzanne Mansour 
University of Utah

FGFR2B LIGANDS IN INNER EAR DEVELOPMENT AND FUNCTION

18:35 – 18:50

Stephanie Padula 
Miami University

FGFR SIGNALING DURING MOUSE LENS DEVELOPMENT IS REGULATED BY PTEN

18:50 – 19:20

Mohammad Hajihosseini 
University of East Anglia

NEW FOCI OF NEUROGLIOGENESIS BY FGF10-EXPRESSING CELLS IN THE ADULT MOUSE BRAIN

19:20 – 19:50

Jin-San Zhang 
Wenzhou Medical University

FGF10-MEDIATED PROTECTION AGAINST RENAL ISCHEMIA-REPERFUSION INJURY THROUGH REGULATION OF BOTH AUTOPHAGY AND ER-STRESS

19:20 – 19:50

Accompanying Guests Pre-Dinner Welcome Cocktail

19:50

Dinner

SATURDAY 16TH FEBRUARY

07:00 – 08:30

Buffet Breakfast at The Market Place

Endocrine-acting FGFs 
Session Chairs: Marja Hurley (part 1) and Jin-San Zhang (part 2)

08:30 – 09:00

Moosa Mohammadi 
New York University

aKLOTHO IS A NON-ENZYMATIC MOLECULAR SCAFFOLD FOR FGF23 HORMONE SIGNALING

09:00 – 09:15

Sangwon Lee 
Yale University

STRUCTURAL BASIS OF ENDOCRINE FGF RECOGNITION BY Β-KLOTHO

09:15 – 09:45

Alexei Kharitonenkov 
Novo Nordisk

MOLECULAR ELEMENTS IN FGF19 AND FGF21 DEFINING KLB/FGFR SPECIFICITY AND ACTIVITY

09:45 – 10.00

Zhifeng Huang 
Wenzhou Medical University

PARACRINE-ENDOCRINE CHIMERAS AS CLINICALLY EFFECTIVE FGF HORMONE ANALOGUE

10:00 – 10:30

Refreshments & Poster Viewing

10:30 – 10:45

Xiaojie Wang 
Wenzhou Medical University

OPTIMIZATION AND EVALUATION OF A POLOXAMER HYDROGEL LOADED KGF-2 COMBINED WITH FGF21 AND THEIR THERAPEUTIC EFFECT ON DIABETIC SCALD SKIN WOUND REPAIR

10:45 – 11:15

Steven Kliewer 
UT Southwestern

RECENT INSIGHTS INTO FGF21 PHYSIOLOGY AND PHARMACOLOGY

11:15 – 11:35

Kenneth White 
Indiana University School of Medicine

PHOSPHATE METABOLISM AND FGF23: ENDOCRINE CROSSTALK IN COMMON DISEASES

11:35 – 11:50

Christopher Yanucil
University of Alabama at Birmingham

SOLUBLE KLOTHO AND HEPARIN ACT AS CIRCULATING FGF23 CO-RECEPTORS THAT MODIFY FGF23`S RECEPTOR AFFINITY AND SUBSEQUENT DOWNSTREAM SIGNALING

11:50 – 16:30

Lunch at Leisure & Free Time

12:15 – 15:30

Snorkel Trip: Sign-up’s Required in Advance

FGFs in Tissue Repair and Regeneration 
Session Chairs: Tatjana Piotrowski (part 1) and Steven Kliewer (part 2)

16:30 – 16:45

Ivonne Sehring 
Universität Ulm

TISSUE-SPECIFIC ROLES OF FGF SIGNALING DURING ZEBRAFISH FIN REGENERATION

16:45 – 17:15

Tatjana Piotrowski 
Stowers Institute for Medical Research

SINGLE CELL RNASEQ REVEALS FGF SIGNALING DYNAMICS DURING SENSORY HAIR CELL REGENERATION

17:15 – 17:30

Jared Tangeman 
Miami University

RESETTING OF THE EPIGENOME DURING FGF-MEDIATED RETINA REGENERATION

17:30 – 18:00

Refreshments & Poster Viewing

18:00 – 18:30

Luke Noon 
Centro de Investigacion Principe Felipe

RESISTING REPAIR: INSULIN RESISTANCE DISRUPTS HEPATIC FGF7 SIGNALLING DURING INJURY

 

18:30 – 19:00

Sabine Werner 
ETH Zurich

FIBROBLAST GROWTH FACTOR SIGNALING IN EPITHELIAL REPAIR AND INFLAMMATORY DISEASE

19:00 – 19:15

Kel Vin Woo 
Washington University School of Medicine

ENDOTHELIAL FGF PREVENTS HYPOXIA-INDUCED PULMONARY HYPERTENSION: ROLE OF ENDOTHELIAL TO MESENCHYMAL TRANSITION

19:15 – 20:30

Poster Session & Refreshments

20:30

Dinner

SUNDAY 17TH FEBRUARY

07:00 – 08:30

Buffet Breakfast at The Market Place

FGFs in Developmental / Genetic Diseases 
Session Chairs: Ralph Bradshaw (part 1) and Michael Seckl (part 2)

08:30 – 09:00

Marja Hurley 
UCONN Health, School of Medicine

FIBROBLAST GROWTH FACTOR 2 AND FRACTURE REPAIR

09:00 – 09:30

Laurence Legeai-Mallet
Hopital Universitaire Neckar

HYPOCHONDROPLASIA: LESSONS FROM MOUSE MODEL

09:30 – 09:50

Jeffrey Stavenhagen 
Therachon

DEVELOPMENT OF A NOVEL BIOLOGIC FOR THE TREATMENT OF ACHONDROPLASIA

09:50 – 10:05

Malgorzata Zakrzewska 
University of Wroclaw

FGF1 PROTECTS CELLS AGAINST P53-DEPENDENT APOPTOSIS INDEPENDENTLY OF FGFR ACTIVATION

10:05 – 10:35

Group Photo, Refreshments & Poster Viewing

10:35 – 11:05

Philippe Soriano 
Icahn School of Medicine at Mount Sinai

FGF SIGNALING IN EARLY DEVELOPMENT

11:05 – 11:35

Amy Merrill 
University of Southern California

FGF SIGNALING AND INTEGRATED DEVELOPMENT OF THE MUSCULOSKELETAL SYSTEM

11:35 – 11:55

Aaron N. Johnson
Washington University School of Medicine

FGF SIGNALING IN MUSCLE MORPHOGENESIS

11:55 – 16:00

Lunch at Leisure & Free Time

FGFs in Cancer 
Session Chairs: Phil Soriano (part 1) and Amy Merrill (part 2)

16:00 – 16:30

Lewis (Rusty) T. Williams
Five Prime Therapeutics

DISCOVERY OF NEW GROWTH FACTOR AND CYTOKINE FUNCTIONS THROUGH COMPREHENSIVE SCREENING OF THE EXTRACELLULAR PROTEOME

16:30 – 17:00

Richard Grose 
Barts Cancer Institute

3D MODELLING APPROACHES TO DISSECT FGFR SIGNALLING IN CANCER

17:00 – 17:15

Pino Bordignon 
Université de Lausanne

DUALISM OF FGF AND TGFβ SIGNALING IN HETEROGENEOUS ACTIVATION OF CANCER-ASSOCIATED FIBROBLASTS CONVERGES ON CANCER DEVELOPMENT

17:15 – 17:45

Dina Ron 
Technion - Israel Institute of Technology

REGULATION AND ANTI-TUMOR ACTIVITY OF HUMAN-SEF (SIMILAR EXPRESSION TO FGFS)

17:45 – 18:15

Refreshments & Poster Viewing

18:15 – 18:35

Laetitia Comps-Agrar 
Genentech

CHALLENGES IN TARGETING FGFR1 USING MONOCLONAL ANTIBODIES

18:35 – 19:05

Fen Wang 
Texas A&M University

ABERRANT FGFR TYROSINE KINASE SIGNALING ENHANCES THE WARBURG EFFECT BY REPROGRAMMING LDH ISOFORM EXPRESSION AND ACTIVITY IN PROSTATE CANCER

19:05 – 19:35

Michael Seckl 
Imperial College London

FGFR INHIBITORS: WHICH CANCER PATIENTS ARE MOST LIKELY TO BENEFIT?

20:00

Gala Dinner & Poster Awards

MONDAY 18TH FEBRUARY

07:00 – 08:30

Buffet Breakfast at The Market Place

FGF Signaling in Lung Development and Fibrosis Session (Joint Session with the Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference) 
Session Chairs: Mohammad Hajihosseini (part 1) & Mark Lewandoski (part 2)

08:30 – 09:00

Mark Krasnow 
Stanford University

 
FGF SELECTION AND LIFELONG MAINTENANCE OF ALVEOLAR CELLS

09:00 – 09:30

Saverio Bellusci 
Justus-Liebig-Universitaet Giessen

CHARACTERIZATION OF A NOVEL FIBROBLAST GROWTH FACTOR 10 (FGF10)-PRODUCING RESIDENT MESENCHYMAL CELL INVOLVED IN THE REPAIR PROCESS OF THE BRONCHIAL EPITHELIUM AFTER NAPHTHALENE INJURY

09:30 – 10:00

Stijn de Langhe 
University of Alabama at Birmingham

ROLE OF FGF10 SIGNALING IN THE RESOLUTION OF PULMONARY FIBROSIS

10:00 – 10:30

Xin Sun 
University of California, San Diego

SIGNALS IN LUNG DEVELOPMENT AND FUNCTION

 

10:30 – 11:00

Refreshments

11:00 – 11:30

David Ornitz 
Washington University St. Louis

THE ALVEOLAR MYOFIBROBLAST AND THE ROLE OF FGF18 IN ALVEOLOGENESIS

11:30 – 11:45

Denise Al Alam 
Children`s Hospital Los Angeles

FGF LIGANDS AND THE HUMAN LUNG

11:45 – 12:00

Stefan Hadzic 
Justus-Liebig-Universitaet Giessen

IMPAIRED FGF10 SIGNALLING IN THE ADULT LUNG LEADS TO DEVELOPMENT OF EMPHYSEMA AND PULMONARY HYPERTENSION

12:00 – 12:15

Robert Guzy 
The University of Chicago

ALVEOLAR EPITHELIAL FGFR SIGNALING IS REQUIRED FOR RECOVERY FROM BLEOMYCIN-INDUCED INJURY

12:15 – 12:30

Aurélien Justet 
Unité INSERM1152

IMPLICATION OF FGFR4 AND FGF19 IN PULMONARY FIBROSIS

12:30 – 12:40

Closing Comments

 

Speakers

Invited Speakers

  • Prof. Stijn De Langhe
    Associate Professor, University of Alabama at Birmingham
  • Prof. Dr. Saverio Bellusci
    Chair for Lung Matrix Remodeling, Justus-Liebig-Universitaet Giessen, ECCPS
  • Prof. David Ornitz
    Professor, Washington University
  • Dr. Richard Grose
    Reader, Queen Mary, University of London
  • Prof. Marja Hurley
    Professor of Medicine, UCONN Health, School of Medicine
  • Dr. Tatjana Piotrowski
    Primary Investigator, Stowers Institute for Medical Research
  • Dr. Alexei Kharitonenkov
    Researcher, Novo Nordisk
  • Dr. Mohammad K Hajihosseini
    Senior Lecturer in Neuroscience, University of East Anglia
  • Dr. Amy Merrill
    Associate Professor, University of Southern California
  • Dr. Ralph Bradshaw
    consultant, Trefoil Therapeutics
  • Prof. Moosa Mohammadi
    Professor, New York University School of Medicine
  • Prof. Fen Wang
    Professor, Texas A&M University
  • Prof. Denis Barritault
    president, OTR3 & Paris University
  • Dr. Suzanne Mansour
    Professor, University of Utah
  • Dr. Mark Lewandoski
    Senior Investigator, NCI, NIH
  • Prof. Michael Seckl
    Professor of Molecular Oncology, Imperial College London
  • Dr. Laurence Legeai-Mallet
    Director of Research, Imagine Institute-Inserm U1163
  • Prof. Steven Kliewer
    Professor, UT Southwestern
  • Dr. Lewis (Rusty) T. Williams
    Founder & Executive Chairman, Five Prime Therapeutics
  • Prof. Philippe Soriano
    Professor, Icahn School of Medicine at Mt. Sinai
  • Prof. Jin-San Zhang
    Professor, WU-WMU Joint Biomedical Innovation Center
  • Prof. Xiaokun Li
    Vice president , Wenzhou Medical University
  • Dr. Luke Noon
    Ramon y Cajal Investigator (CIBERDEM), CIPF (Centro de Investigacion Principe Felipe)
  • Prof. Dr. Dina Ron
    Faculty Member/Lab Chief, Technion, Israel Instititute of Technology

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