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Mitochondria: From Basic Biology to Mechanisms of Disease Conference

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Mitochondria: From Basic Biology to Mechanisms of Disease Conference

Mitochondria and Disease

27 Feb 2019 - 02 Mar 2019

Nassau, Bahamas

The conference registration date has past

Synopsis

Mitochondria act at the interface of numerous processes critical for cellular function and organismal health. Long recognized as the powerhouses of the cell, recent years have seen a growing appreciation for the diverse roles that mitochondria play not only in energy production and metabolism, but also in maintenance of redox balance, regulation of gene expression, ion homeostasis, and control of cell fate. Mitochondrial maintenance is critical for proper function of cells and tissues, and mitochondrial dysfunction underlies numerous disease processes ranging from severe childhood mitochondrial disorders, to heart disease, neurodegenerative disorders, cancer, and aging itself. This conference will bring together scientists and clinicians with expertise in a breadth of mitochondrial biology to explore topics at the interface of basic and translational biology. Mitochondrial basic mechanisms of organelle regulation, mitochondrial mechanisms of disease, cutting edge technologies, and interventional strategies will be emphasized.

Join the conference LinkedIn group to keep up to date with annoucements and latest news concerning the conference.

For those interested, this meeting is followed by our 3rd Interventions in Aging Conference, taking place from 03-06 March 2019 at the same venue.

Student Offer

Take advantage of this fantastic opportunity for students! Register a fully paying academic and bring a student for only $850. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 27, 28 Feb and 01 Mar 2019 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Laura Trundle to obtain a special registration link for your student.

Confirmed Keynote Speaker

Douglas Wallace (Children's Hospital of Philadelphia)
A MITOCHONDRIAL ETIOLOGY OF THE COMMON “COMPLEX” DISEASES

Confirmed Invited Speakers

Johan Auwerx (Ecole Polytechnique Federale de Lausanne)
NAD AND MITOCHONDRIA
Nika Danial (Dana-Farber Cancer Institute / Harvard Medical School)
MITOCHONDRIAL PYRUVATE HANDLING AND CELLULAR RESPONSES TO INFLAMMATION
José Antonio Enriquez (CNIC)
CONSEQUENCES OF mtDNA HETEROPLASMY
Steven Gross (Weill Cornell Medical College)
MITOCHONDRIAL GENE MUTATIONS TRIGGER A COMMON PATTERN OF METABOLIC REWIRING AND SUGGEST A NOVEL THERAPEUTIC STRATEGY
Cole Haynes (University of Massachusetts Medical School)
EXPANDING AND SHRINKING THE MITOCHONDRIAL NETWORK
Isha Jain (University of California, San Francisco)
TURNING THE OXYGEN DIAL AS A THERAPY: HYPOXIA TREATMENT FOR MITOCHONDRIAL DYSFUNCTION
Leanne Jones (University of California, Los Angeles)
ROLE OF MITOCHONDRIAL DYNAMICS IN TISSUE STEM CELLS
Thomas Langer (University of Cologne)
PROTEOLYTIC CONTROL OF MITOCHONDRIAL MEMBRANE HOMEOSTASIS
William Mair (Harvard University)
NEURONAL TORC1 MODULATES LONGEVITY VIA AMPK AND CELL NONAUTONOMOUS REGULATION OF MITOCHONDRIAL DYNAMICS IN C. ELEGANS
Heidi McBride (McGill University)
EXPLORING THE MECHANISM OF IRON DELIVERY TO MITOCHONDRIA
Jodi Nunnari (University of California, Davis)
MITOCHONDRIAL BEHAVIOR
Philipp Scherer (The University of Texas Southwestern Medical Center)
MITOCHONDRIAL DYSFUNCTION IN THE ADIPOCYTE
Luca Scorrano (University of Padova)
KEEPING MITOCHONDRIA IN SHAPE: A MATTER OF LIFE AND DEATH
Gerald Shadel (The Salk Institute for Biological Studies)
ADAPTIVE RESPONSES TO MITOCHONDRIAL STRESS
Yousin Suh (Albert Einstein College of Medicine)
FUNCTIONAL GENETIC VARIATION IN NUCLEAR-ENCODED MITOCHONDRIAL GENES ASSOCIATED WITH HUMAN LONGEVITY
Anu Suomalainen-War­tiovaara (University of Helsinki)
MITOCHONDRIAL DISEASE PHYSIOLOGY REVEALS MECHANISMS OF METABOLIC SIGNALING
Eileen White (Rutgers Cancer Institute of New Jersey)
MITOCHONDRIA AND CANCER
Kelvin Yen (University of Southern California)
A NOVEL MITOCHONDRIAL DERIVED PEPTIDE AFFECTING DIABETES

Learning Objectives

  • Basic mechanisms and regulation of mitochondrial biology
  • Discuss crosstalk and integration of mitochondrial pathways with other cellular compartments and cell signalling.
  • Learn about how these pathways of mitochondrial dysfunction contribute to diseases
  • Discuss therapies targeting mitochondria in human diseases
  • Discuss future directions for mitochondrial research

Target Audience

  • Basic scientists studying mechanisms of mitochondrial and cell biology
  • Clinicians and translational biologists interested in mitochondrial disease
  • Neuroscientists studying mitochondrial function and role of mitochondria in neurodegenerative disease
  • Scientists studying processes where mitochondria are important (metabolism, aging, cancer, heart function, etc.)

Educational Need

Mitochondria sit at the intersection of many important areas of biology and biomedicine, but there are limited opportunities for people studying different areas of biology where mitochondria are important (aging, neurodegenerative disease, inherited disorders, mitochondria disease, heart disease, myopathies and muscular dystrophies, evolutionary biology, obesity, diabetes, kidney disease, etc.) to come together at one meeting.  The primary outcome we hope to stimulate is interaction and cross fertilization of ideas between these diverse scientists leading to new collaborations and synergistic advances.

Sponsors

Sponsors

Programme

WEDNESDAY 27TH FEBRUARY 2019

13:00 – 14:00

Student & Postdoc Networking Lunch

14:00 – 15:00

Registration & Welcome Reception

15:00 – 15:10

Opening Comments

15:10 – 15:50

Douglas Wallace 
Children's Hospital of Philadelphia

A MITOCHONDRIAL ETIOLOGY OF THE COMMON “COMPLEX” DISEASES

AGING AND STEM CELLS 
Session Chair: Thomas Langer

15:50 – 16:20

Matt Kaeberlein 
University of Washington

AGING AND MITOCHONDRIAL DISEASE: SHARED MECHANISMS AND THERAPIES

16:20 – 16:50

Yousin Suh 
Albert Einstein College of Medicine

FUNCTIONAL GENETIC VARIATION IN NUCLEAR-ENCODED MITOCHONDRIAL GENES ASSOCIATED WITH HUMAN LONGEVITY

16:50 – 17:20

Leanne Jones 
University of California, Los Angeles

ROLE OF MITOCHONDRIAL DYNAMICS IN TISSUE STEM CELLS

17:20 – 17:40

Mireille Khacho 
University of Ottawa

MITOCHONDRIAL DYNAMICS AND REDOX REGULATION OF STEM CELL FATE

17:40 – 18:10

Refreshments

18:10 – 18:40

Johan Auwerx 
Ecole Polytechnique Federale de Lausanne

NAD AND MITOCHONDRIA

18:40 – 19:10

William Mair 
Harvard University

NEURONAL TORC1 MODULATES LONGEVITY VIA AMPK AND CELL NONAUTONOMOUS REGULATION OF MITOCHONDRIAL DYNAMICS IN C. ELEGANS

19:10 – 19:30

Changhan Lee 
University of Southern California

INTERGENOMIC BASIS OF MITONUCLEAR COMMUNICATION

19:30 - 19:50

Amanda Souza
Thermo Fisher Scientific

METABOLIC PHENOTYPING USING AN UNTARGETED METABOLOMICS APPROACH AND LC-MS ANALYSIS

19:20 – 19:50

Accompanying Guests Pre-Dinner Welcome Drinks

19:50

Dinner

THURSDAY 28TH FEBRUARY 2019

07:00 – 09:00

Buffet Breakfast at The Market Place

MITOCHONDRIA, DISEASE AND INTERVENTIONS 
Session Chair: Yousin Suh

09:00 – 09:30

Anu Suomalainen
University of Helsinki

MITOCHONDRIAL DISEASE PHYSIOLOGY REVEALS MECHANISMS OF METABOLIC SIGNALING

09:30 – 10:00

Isha Jain 
University of California, San Francisco

TURNING THE OXYGEN DIAL AS A THERAPY: HYPOXIA TREATMENT FOR MITOCHONDRIAL DYSFUNCTION

10:00 – 10:20

Anthony Grillo 
University of Washington

PROTEIN KINASE C IS A KEY TARGET FOR ATTENUTATION OF INFLAMMATION BY RAPAMYCIN DURING SEVERE MITOCHONDRIAL DISEASE

10:20 – 10:40

Katharina Schlacher 
MD Anderson Cancer Center

THE FANCONI ANEMIA PATHWAY PROTEINS PROTECT MITOCHONDRIAL DNA REPLICATION FORK TO SUPPRESS INFLAMMATION

10:40 – 11:25

Group Photo, Refreshments & Poster Viewing

11:25 – 11:45

Volkmar Weissig 
Midwestern University Glendale

MITOCHONDRIA-TARGETED NANOCARRIERS

11:45 – 12:05

Ronald Davis 
Scripps Research Institute Florida

SMALL MOLECULE PROBES TARGETING NEURONAL MITOCHONDRIAL DYNAMICS INCREASE ATP PRODUCTION, RESCUE OXIDATIVE STRESS AND AMYLOID BETA MEDIATED NEUROTOXICITY

12:05 – 12:25

Anna Klucnika 
University of Cambridge

THE USES AND MECHANISMS OF MITOCHONDRIAL RECOMBINATION

12:25 – 13:00

Meet the Poster Presenters 
Moderators: Marcia Haigis & Matt Kaeberlein

13:00 – 16:50

Lunch at Leisure & Free Time

MITOCHONDRIA, DISEASE AND INTERVENTIONS II 
Session Chair: Gerald Shadel

16:50 – 17:20

Eileen White 
Rutgers Cancer Institute of New Jersey

MITOCHONDRIA AND CANCER

17:20 – 17:50

Kelvin Yen 
University of Southern California

A NOVEL MITOCHONDRIAL DERIVED PEPTIDE AFFECTING DIABETES

17:50 – 18:10

David Kashatus 
University of Virginia

DRP1 PROMOTES KRAS-DRIVEN METABOLIC CHANGES AND PANCREATIC TUMOR GROWTH

18:10 – 18:30

Marija Sajic 
UCL Institute of Neurology

MITOCHONDRIAL DYSFUNCTION IN PERIPHERAL AXONS IS AN EARLY EVENT IN THE DEVELOPMENT OF DIABETIC NEUROPATHY INDUCED BY HIGH FAT DIET — A STUDY BY CONFOCAL MICROSCOPY AND ELECTROPHYSIOLOGY IN VIVO

18:30 – 20:30

Poster Session & Refreshments

20:30

Dinner

FRIDAY 01ST MARCH 2019

07:00 – 09:00

Buffet Breakfast at The Market Place

MITOCHONDRIAL HOMEOSTASIS AND MODES OF METABOLISM 
Session Chair: Cole Haynes

09:00 – 09:30

Thomas Langer 
Max Planck Institute for Biology of Ageing

PROTEOLYTIC CONTROL OF MITOCHONDRIAL MEMBRANE HOMEOSTASIS

09:30 – 09:50

David Patten 
University of Ottawa

ALTERED MITOCHONDRIAL DYNAMICS IN METABOLICALLY FLEXIBLE CELLS DRIVES PROTECTIVE GLUTATHIONE SYNTHESIS

09:50 – 10:20

Gerald Shadel 
The Salk Institute for Biological Studies

ADAPTIVE RESPONSES TO MITOCHONDRIAL STRESS

10:20 – 10:40

Brett Kaufman 
University of Pittsburgh

G-QUADRUPLEX DYNAMICS CONTRIBUTE TO EPIGENETIC REGULATION OF MITOCHONDRIAL FUNCTION

10:40 – 11:25

Refreshments & Poster Viewing

11:25 – 11:55

Heidi McBride 
McGill University

EXPLORING THE MECHANISM OF IRON DELIVERY TO MITOCHONDRIA

11:55 – 12:25

Luca Scorrano 
University of Padova

KEEPING MITOCHONDRIA IN SHAPE: A MATTER OF LIFE AND DEATH

12:25 – 16:45

Lunch at Leisure & Free Time

13:00 – 16:15

Group Activity: Snorkeling (sign-ups required in advance)

MITOCHONDRIAL HOMEOSTASIS AND MODES OF METABOLISM II 
Session Chair: Isha Jain

17:15 - 17:45

Marcia Haigis 
Harvard Medical School

THE ROLE OF METABOLISM IN THE TUMOR MICROENVIRONMENT

17:45 – 18:05

Michael O. Hottiger 
University of Zurich

MITOCHONDRIAL ADP-RIBOSYLATION REGULATES PROPER MITOCHONDRIAL FUNCTION AND NAD+ SIGNALLING

18:05 – 18:50

Refreshments & Poster Viewing

18:50 – 19:20

Nika Danial 
Dana-Farber Cancer Institute / Harvard Medical School

MITOCHONDRIAL PYRUVATE HANDLING AND CELLULAR RESPONSES TO INFLAMMATION

19:20 – 19:50

Steven S. Gross 
Weill Cornell Medical College

MITOCHONDRIAL GENE MUTATIONS TRIGGER A COMMON PATTERN OF METABOLIC REWIRING AND SUGGEST A NOVEL THERAPEUTIC STRATEGY

19:50 – 20:10

Fahmida Jahan 
University of Ottawa

NAD+ DEPLETION AS A CAUSE OF PLACENTAL DYSFUNCTION IN PREECLAMPSIA

20:10

Gala Dinner & Poster Awards

SATURDAY 02ND MARCH 2019

07:00 – 09:00

Buffet Breakfast at The Market Place

CROSSTALK AND COMMUNICATION 
Session Chair: Nika Danial

09:00 – 09:30

Cole Haynes 
University of Massachusetts Medical School

EXPANDING AND SHRINKING THE MITOCHONDRIAL NETWORK

09:30 – 10:00

Jodi Nunnari 
University of California, Davis

MITOCHONDRIAL BEHAVIOR

10:00 – 10:30

Jose Antonio Enriquez 
CNIC

CONSEQUENCES OF mtDNA HETEROPLASMY

10:30 – 10:50

Jorida Coku 
University of Pennsylvania

DISCRUPTED CALCIUM SIGNALING AT ENDOPLASMIC RETICULUM-MITOCHONDRIA CONTRACT SITES PROMOTES NEUROBLASTOMA MULTIDRUG RESISTANCE

10:50 – 11:20

Refreshments

11:20 – 11:40

John Lemasters 
Medical University of South Carolin

A UNIFYING HYPOTHESIS LINKING MITOCHONDRIAL ADAPTATIONS FOR ALDEHYDE METABOLISM TO THE PROINFLAMMATORY AND PROFIBROTIC EVENTS OF ALCOHOLIC AND NON-ALCOHOLIC STEATOHEPATITIS

11:40 – 12:00

Zhi Zhong 
Medical Univ. of South Carolina

SUPPRESSED MITOCHONDRIAL BIOGENESIS (MB) PLAYS AN IMPORTANT ROLE IN ACUTE KIDNEY INJURY (AKI) INDUCED BY SEVERE LIVER INJURY AND FIBROSIS

12:00 – 12:20

Liming Pei 
Children's Hospital of Philadelphia

SINGLE-NUCLEUS TRANSCRIPTOMIC SURVEY OF CELL HETEROGENEITY AND FUNCTIONAL REMODELING IN MITOCHONDRIAL CARDIOMYOPATHY

12:20 – 12:30

Closing Comments

Speakers

Plenary Speakers

  • Dr. Douglas Wallace
    Director and Professor, Children's Hospital of Philadelphia, Center for Mitochondrial and Epigenomic Medicine

Invited Speakers

  • Prof. Dr. Luca Scorrano
    Scientific director and Chair of Biochemistry, University of Padua, Venetian Institute of Molecular Medicine
  • Prof. Cole Haynes
    Professor, University of Massachusetts Medical School
  • Dr. Nika Danial
    Associate Professor of Medicine , Dana-Farber Cancer Institute/Harvard Medical School
  • Dr. Isha Jain
    UCSF Faculty Fellow, University of California, San Francisco
  • Prof. Anu Suomalainen Wartiovaara
    Academy Professor, University of Helsinki
  • Prof. Johan Auwerx
    Professor, Ecole Polytechnique Federale de Lausanne-EPFL
  • Prof. Jose Antonio Enriquez
    Full Professor, Fundacion CNIC
  • Prof. Eileen White
    Deputy Director, Rutgers Cancer Institute of New Jersey
  • Prof. Steven Gross
    Professor, Weill Cornell Medicine
  • Assoc. Prof. William Mair
    Assistant Professor, Harvard University
  • Dr. Kelvin Yen
    Research Assistant Professor, University of Southern California
  • Prof. Leanne Jones
    Professor, University of California, Los Angeles
  • Prof. Gerald Shadel
    Professor, The Salk Institute for Biological Studies
  • Prof. Dr. Thomas Langer
    Director, Max Planck Institute for Biology of Ageing
  • Prof. Dr. Jodi Nunnari
    Distinguished Professor and Chair, UC Davis Dept of Molecular and Cellular Biology
  • Prof. Heidi McBride
    Professor, McGill University
  • Dr. Yousin Suh
    Faculty, Albert Einstein College of Medicine

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