Urgent Notice to All Conference Participants

It has been brought to our attention that EHS Housing has recently been cold calling our speakers offering accommodation for a named Fusion conference. Please note that we have no association with EHS Housing and they are acting on our behalf without our permission. We strongly advise that any calls from EHS Housing are ignored or ended immediately. If you are contacted by EHS Housing, please notify us immediately.

All Fusion registration fees are inclusive of accommodation (for three fixed nights) and reservations are handled internally, entirely by Fusion Conferences. If you have any questions concerning your accommodation, please contact Fusion Conferences directly via admin@fusion-conferences.com.

Home > Past Conferences >

The Ubiquitin System: Function, Physiology and its Role in Disease Conference

The registration process for this conference has now closed.

Registration Deadlines

Talk Submission – expired

Poster Submission – expired

Early bird – expired

Last Chance – expired

The Ubiquitin System: Function, Physiology and its Role in Disease Conference

03 Jun 2018 - 06 Jun 2018

Nassau, Bahamas

Synopsis

We have reached a fascinating point in the field of ubiquitin research. The attachment of ubiquitin to a protein in the cytosol was first identified as a means to enable the degradation of this protein by the proteasome. Much later it became clear that the ubiquitin system fulfils another crucial cellular function: through the dynamics offered by ubiquitination and subsequent deubiquitination it gives signalling platforms in a plethora of signal transduction pathways the means to initiate but, importantly, also to end the triggering of particular signals originating from these platforms. Whilst some of the signalling-related functions of the ubiquitin system are mediated via its proteasome-targeting function, the majority of these are mediated by different types of ubiquitin chains acting as scaffolds for the recruitment of signalling modules to protein complexes which serve as platforms for the triggering of specific signalling complexes.

Rather than discussing mainly structural aspects of the ubiquitin system, this conference is dedicated to the study of functional roles of the ubiquitin system, how it works to ensure normal signal transduction, what are the pathological consequences when it is perturbed and how we may be able to address such perturbances therapeutically in various diseases including cancer, autoimmunity and neurodegeneration.

Importantly, this conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues in the ubiquitin field will be presented and discussed.

Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference.

See the full list of confirmed speakers below.

Target Audience

This conference will appeal to researchers who are particularly interested in the diverse functions of the ubiquitin system, rather than structural aspects of it, as well the way this system is involved in normal physiology in a whole range of pathologies that have been shown to be associated with abnormal ubiquitin signalling. Naturally this target profile will bring together researchers from both academia and the biotech/pharma industries who want to be on top of the most recent developments in this fascinating and fast developing field.

Learning Objectives

  1. To be on top of the field with the diversity of functional roles of the ubiquitin system
  2. To understand how the ubiquitin system affects health and disease
  3. To develop an understanding for where the treatment options are currently seen in the ubiquitin fields 
  4. To learn which ubiquitin-related drugs are presently in preclinical and clinical development
  5. To get a feel for the opportunities of the future provided by the ubiquitin system

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the earlybird rate of $1,823 and bring a student for only $850. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 03, 04, 05 June 2018 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 30th April 2018. Once registered, please contact Emily Bicknell (emily@fusion-conferences.com) to obtain a special registration link for your student.

Confirmed Invited Speakers

Henning Walczak (UCL Cancer Institute)

Vishva Dixit (Genentech Inc)

Michael Rape (UC Berkeley)

Ivan Dikic (Institute of Biochemistry II - Goethe University Frankfurt)

Kim Newton (Genentech Inc) 

Domagoj Vucic (Genentech Inc)

Eric Bennett (UC San Diego)

Florian Bassermann (Technical University of Munich)

Mads Gyrd-Hansen (Ludwig Institute for Cancer Research)

Helle Ulrich (Institute of Molecular Biology - IMB)

Eric Baehrecke (UMass Medical School)

Pascal Meier (ICR London)

Anne Bertolotti (LMB Cambridge)

Richard Youle (NIH)

Jonathon Pines (ICR London)

Geert van Loo (VIB-UGent Center for Inflammation Research)

John Silke (WEHI)

Zhijian 'James' Chen (UT Southwestern)

Philip Cohen (University of Dundee)

Felix Randow (LMB Cambridge)

Yifat Merbl (Weizmann Institute)

Nieves Peltzer (UCL)

Alessandro Annibaldi (ICR London)

Adrian Ting (Mount Sinai, NYC)

Daniel Krappmann (Helmholtz Munich)

Paul Elliott (MRC Laboratory of Molecular Biology - LMB)

Mathieu Bertrand (VIB Ghent)

Philipp Jost (TU Munich)

Marc Schmidt-Supprian (TU Munich)

Fumiyo Ikeda (Institute of Molecular Biology - IMBA)

Annika Meinander (Åbo Akademi University, Turku)

Sonja Lorenz (University of Würzburg)

Sponsors

Sponsors

Programme

SUNDAY 3RD JUNE 2018

14:00 – 14:40

Registration

13:30 – 14:30

Group Welcome Lunch

14:40 – 14:45

Opening Comments

SESSION 1

14:45 – 15:15

Kim Newton 
Genentech Inc.

UBIQUITIN LIGASES CIAP1 & CIAP2 LIMIT CELL DEATH AND INFLAMMATION

15:15 – 15:45

Mathieu Bertrand 
VIB Ghent

RIPK1 LIFE/DEATH DECISION DURING TNF SIGNALING

15:45 – 16:15

Alessandro Annibaldi 
ICR London

UBIQUITIN-MEDIATED REGULATION OF RIPK1 KINASE ACTIVITY, INDEPENDENT OF IKK AND MK2

16:15 – 16:45

John Silke 
WEHI, Australia

UBIQUITIN MODIFICATION OF THE NECROPTOTIC EFFECTOR MLKL

16:45 – 17:15

Refreshments

17:15 – 17:45

Sonja Lorenz 
Universität Würzburg

EMBO YIP LECTURE - MECHANISTIC IDIOSYNCRASIES IN HECT-TYPE UBIQUITIN LIGASES

17:45 – 18:15

Domagoj Vucic 
Genentech Inc.

UBIQUITINATION OF RIP KINASES REGULATES INFLAMMATORY SIGNALING

18:15 – 18:45

Nieves Peltzer 
UCL

LUBAC AND CELL DEATH: A SURPRISE IN THREE ACTS

18:45 – 19:15

Henning Walczak 
UCL

LUBAC IN THE SKIN: UNDERSTANDING CELL DEATH-DRIVEN LETHAL INFLAMMATION BEYOND TNF

19:15

Group Dinner

Post Dinner Meeting Point: Estavida (lobby bar)

MONDAY 4TH JUNE 2018

07:00 – 08:30

Breakfast

SESSION 2

08:30 – 09:00

Vishva Dixit 
Genentech Inc.

OTULIN LIMITS CELL DEATH AND INFLAMMATION BY DEUBIQUITINATING LUBAC

09:00 – 09:30

Geert van Loo 
VIB Ghent

A20 AND OTULIN IN TISSUE HOMEOSTASIS AND PATHOLOGY

09:30 – 10:00

Marc Schmidt-Supprian 
TU Munich

A20 GENE DOSE EFFECTS IN B CELL-MEDIATED AUTOIMMUNITY IN MICE

10:00 – 10:30

Group Photo & Refreshments

10:30 – 11:00

Adrian Ting 
Mount Sinai, NYC

FAILURE TO SUPPRESS CYLD-MEDIATED CELL DEATH CAUSES IMMUNE DYSREGULATION

11:00 – 11:30

Daniel Krappmann 
Helmholtz Centre Munich

DISCOVERING NEW CELLULAR FUNCTIONS OF OTULIN USING HIGHLY-SELECTIVE ACTIVITY-BASED PROBES

11:30 – 12:00

Paul Elliott 
MRC LMB Cambridge

MECHANISTIC INSIGHTS INTO DEUBIQUITINASE REGULATION

12:00 – 16:00

Lunch & Free Time

12:30 – 15:00

Snorkel Trip (Sign ups required in advance)

SESSION 3

16:00 – 16:30

Sir Philip Cohen 
University of Dundee

ROLE OF HYBRID UBIQUITIN CHAINS AND TRAF6 IN REGULATING IMMUNE SIGNALING

16:30 – 17:00

Mads Gyrd-Hansen 
Ludwig Institute

REGULATION OF UBIQUITINATION IN INNATE IMMUNE SIGNALLING

17:00 – 17:30

Felix Randow 
LMB Cambridge

UBIQUITIN, A SHARED WEAPON IN THE BATTLE BETWEEN BACTERIA AND THEIR HOST CELLS

17:30 – 18:00

Refreshments

18:00 – 18:30

Zhijian 'James' Chen 
UT Southwestern

MECHANISM AND FUNCTION OF DNA-INDUCED AUTOPHAGY

18:30 – 19:00

Fumiyo Ikeda 
IMBA, Vienna

THE IAP PROTEIN FAMILY MEMBERS IN AUTOPHAGY

19:00 – 19:30

Annika Meinander 
Åbo Akademi University

M1-LINKED UBIQUITINATION BY LUBEL DRIVES INFLAMMATORY RESPONSES IN DROSOPHILA

19:30 – 21:00

Poster Session

21:00

Group Dinner

Post Dinner Meeting Point: Estavida (lobby bar)

TUESDAY 5TH JUNE 2018

07:00 – 08:30

Breakfast

SESSION 4

08:30 – 09:00

Anne Bertolotti 
MRC LMB Cambridge

COST-BENEFIT ANALYSIS OF A STRESS-RESPONSE

09:00 – 09:30

Eric Baehrecke 
UMass Medical School

A NOVEL FUNCTION FOR UBIQUITIN THAT LINKS MITOCHONDRIAL DYNAMICS AND AUTOPHAGY

09:30 – 10:00

Yifat Merbl 
Weizmann Institute

FINE-TUNING REGULATION OF GOLGI HOMEOSTASIS IS MEDIATED BY GOLGI-LOCALIZED PROTEASOMAL DEGRADATION

10:00 – 10:30

Refreshments

10:30 – 11:00

Eric Fischer

DFCI / Harvard

INDUCED DEGRADATION OF DEVELOPMENTAL TRANSCRIPTION FACTORS UNDERLIES THALIDOMIDE TERATOGENICITY

11:00 – 11:30

Ivan Dikic 
Goethe University Frankfurt

UNCONVENTIONAL SERINE UBIQUITINATION

11:30 – 16:15

Lunch & Free Time

SESSION 5

16:15 – 16:45

Anna Sablina 
VIB/KU Leuven

THE ROLE OF THE UBIQUITIN SYSTEM IN RAS-DRIVEN DISEASE

16:45 – 17:15

Najoua Lalaoui 
WEHI, Australia

ROLE OF RIPK1 CASPASE-8 MEDIATED CLEAVAGE

17:15 – 17:45

Hamid Kashkar 
University of Cologne

CHIP MEDIATES K63-LINKED UBIQUITINATION AND LYSOSOMAL DEGRADATION OF NOXA

17:45 – 18:15

Refreshments

18:15 – 18:45

Helle Ulrich 
IMB, Mainz

TAILOR-MADE UBIQUITIN LIGASES FOR THE STUDY OF POLYUBIQUITIN CHAIN LINKAGE IN DNA DAMAGE BYPASS

18:45 – 19:15

Philipp Jost 
TU Munich

FUNCTIONAL IMPACT OF ABERRANT UBIQUITINATION OF RIPK1 IN HEALTHY AND MALIGNANT HEMATOPOESIS

19:15 – 19:45

Florian Bassermann 
TU Munich

ABERRANT UBIQUITIN-PROTEASOME DEPENDENT NETWORKS IN B-CELL MALIGNANCIES

20:15

*Gala Dinner & Poster Awards*

WEDNESDAY 6TH JUNE 2018

07:00 – 08:30

Breakfast

SESSION 6

08:30 – 09:00

Richard Youle 
NIH

SYNTHETIC PHENOTYPES IN MICE LACKING PINK1 AND PARKIN-MEDIATED MITOPHAGY

09:00 – 09:30

Michael Rape 
UC Berkeley

UBIQUITIN-DEPENDENT CONTROL OF NEURONAL DEVELOPMENT AND SURVIVAL

09:30 – 10:00

Eric Bennett 
UC San Diego

PROTEIN HOMEOSTASIS CONTROL THROUGH PERVASIVE REGULATORY RIBOSOMAL UBIQUITYLATION

10:00 – 10:30

Refreshments

10:30 – 11:00

Pascal Meier 
ICR London

SUMO-MEDIATED REGULATION OF THE NLRP3 INFLAMMASOME

11:00 – 11:30

Jonathon Pines 
ICR London

THE SPINDLE ASSEMBLY CHECKPOINT: WITH GREAT POWER COMES GREAT RESPONSIVENESS

11:30 – 11:45

Closing Comments

 

Speakers

Invited Speakers

  • Prof. Michael Rape
    Investigator, HHMI; Professor, UC Berkeley, HHMI/UC Berkeley
  • Prof. Dr. Geert van Loo
    PI, VIB/Gent University
  • Prof. Mads Gyrd-Hansen
    Associate Professor, University of Oxford
  • Dr. Adrian Ting
    Associate Professor, Icahn School of Medicine at Mount Sinai
  • Prof. Dr. Helle Ulrich
    Scientific Director, Institute of Molecular Biology (IMB)
  • Prof. Dr. Marc Schmidt-Supprian
    Professor, Klinikum rechts der Isar der Technischen Universität München
  • Prof. Dr. Mathieu Bertrand
    Associate Professor, VIB Center for Inflammation Research / Ghent university
  • Dr. Fumiyo Ikeda
    Group leader, Institute of Molecular Biotechnology (IMBA)
  • Prof. Philip Cohen
    Professor of Enzymology, University of Dundee
  • Dr. Annika Meinander
    Dr, Åbo Akademi University
  • Dr. Richard Youle
    Senior Investigator , NIH/NINDS
  • Prof. Dr. Daniel Krappmann
    Director Research Unit, Helmholtz Zentrum Muenchen
  • Dr. Sonja Lorenz
    Group Leader, Rudolf Virchow Center, University of Wuerzburg
  • Prof. Eric Baehrecke
    Professor, UMass Medical School
  • Dr. Kim Newton
    Senior Scientist, Genentech
  • Dr. Paul Elliott
    Investigator Scientist, MRC Laboratory of Molecular Biology
  • Dr. Domagoj Vucic
    Principal Scientist, Genentech
  • Prof. John Silke
    Joint Division Head, The Walter and Eliza Hall Institute
  • Prof. Dr. Florian Bassermann
    Chairman, Dept. of Internal Medicine III (Hematology/Oncology), Technical University of Munich
  • Prof. Pascal Meier
    Professor, Institute of Cancer Research
  • Prof. Eric Bennett
    Associate Professor, University of California San Diego
  • Prof. Jonathon Pines
    Head, Division of Cancer Biology, The Institute of Cancer Research
  • Dr. Alessandro Annibaldi
    Postdoc, Institute of Cancer Research
  • Dr. Nieves Peltzer
    Postdoctoral fellow, UCL Cancer Institute
  • Prof. Dr. Philipp Jost
    Consultant, Technical University of Munich
  • Prof. Dr. Ivan Dikic
    Director, Institute of Biochemistry II, Goethe University Frankfurt
  • Dr. Yifat Merbl
    Assistant Professor, Weizmann Institute of Science
  • Dr. Anne Bertolotti
    Group Leader, MRC Laboratory of Molecular Biology, Medical Research Council
  • Prof. Felix Randow
    X, MRC Laboratory of Molecular Biology
  • Prof. Zhijian 'James' Chen
    Professor, UT Southwestern Medical Center
  • Prof. Dr. Anna Sablina
    Group Leader, VIB/KU Leuven

Feedback

Sign In

Your feedback has been received.