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3rd DNA Replication/Repair Structures and Cancer Conference

The registration process for this conference has now closed.

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Early bird – expired

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Past Conference

3rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Synopsis

This conference has now passed however, the following meetings may be of interest;

Nucleic Acids | 13-16 Feb 2019 | Nassau, The Bahamas
3rd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference | 23-26 Feb 2019 | Nassau, The Bahamas

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a surprisingly fragile and complex process requiring fork protection and restart, template-switching, R-loop resolution, gap-filling, and repair. Unresolved replication and repair intermediates signal apoptosis. The synthetic lethality and essentiality resulting from replication-repair stresses thus suggest repair inhibitors as tools to control pathway selection and damage outcomes and to design advanced therapeutics.

The 3rd DNA Replication/Repair Structures & Cancer conference in February 2018 will focus on structural and mechanistic insights into dynamic protein, chromatin, DNA and RNA complexes acting in DNA replication and repair events relevant to cancer. Conference talks and discussions will center on developing an actionable mechanistic knowledge of DNA replication and repair stress responses suitable to guide advanced intervention strategies for cancer. The conference will emphasize an environment suitable for initiating productive collaborations. It will include vibrant informal and formal discussions together with informative talks and poster sessions.

To include late-breaking advances and innovating new investigators, one or more talks for every session will be selected from submitted abstracts. Meeting attendance is limited. Applicants seeking to present talks or posters are strongly encouraged to submit applications and abstracts early. All presenters are asked to focus on unpublished work, cutting-edge approaches and novel mechanistic insights that aid prediction of biological outcomes and plans to best apply basic research advances for cancer research and treatment.

What makes this meeting unique? Professor Ben Van Houten from the University of Pittsburgh says:

‘I can honestly say your meeting, by combining hard core structure-function studies with beautiful biology, hits an important area that many meetings miss; being part of that science is just terrific.’

Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference. 

Key Sessions

Sessions will include emerging results and breakthrough methods concerning:

  • Repair and replication complexes, structures and mechanisms
  • Mutational signatures, kataegis, DNA repair, and cancer
  • Damage signaling, pathway selection & cross-talk
  • Targeting synthetic lethality and essentiality for damage responses
  • Chromatin and chromosome instability
  • Epigenetics, DNA damage and repair
  • PARP, PARG, and metabolic signaling
  • Mitochondrial replication/repair and damage signaling
  • RNA damage responses and actions in repair
  • DNA repair, apoptosis and cancer

Confirmed Keynote Speakers

Steve Jackson (University of Cambridge)
'CELLULAR RESPONSES TO DNA DOUBLE-STRAND BREAKS'

Bruce Stillman (CSHL)
'THE ORIGIN RECOGNITION COMPLEX AND CHROMOSOME DUPLICATION: STRUCTURE, FUNCTION AND HUMAN GENETICS'

Steve West (The Francis Crick Institute)
'UNRESOLVED DNA INTERMEDIATES AS A SOURCE OF DNA BREAKS AND CHROMOSOME ABERRATIONS'

Serena Nik-Zainal (University of Cambridge)
'ADVANCES IN THE FIELD OF MUTATIONAL SIGNATURES: MECHANISTIC INSIGHTS AND CLINICAL APPLICATIONS'

Confirmed Invited Speakers

Lorena Beese (Duke University Medical Center)

Simon Boulton (The Francis Crick Institute)
'PITCH MODULATION AND EXTENSION DEFINES RAD51 FILAMENT REMODELLING BY HUMAN RAD51C-XRCC3 COMPLEX'

Chris Brosey (MD Anderson Cancer Center)
'BRIDGING DNA REPAIR AND NAD(H) ENERGETICS: TRACKING ARCHITECTURAL REGULATION OF APOPTOSIS-INDUCING FACTOR DURING PARTHANATOS'

Cynthia Burrows (University of Utah)
'DNA DAMAGE REGULATES GENE EXPRESSION VIA BASE EXCISION REPAIR'

Jean-Baptiste Charbonnier (University Paris‐Saclay)
'ROLES OF Ku70/Ku80 IN NHEJ, FROM DSB RECOGNITION TO LIGATION'

Walter Chazin (Vanderbilt University)
'UNDERSTANDING HOW DNA PRIMASE WORKS REQUIRES KNOWLEDGE OF ITS ARCHITECTURAL DYNAMICS'

Karlene Cimprich (Stanford University School of Medicine)
'MECHANISMS FOR MAINTAINING GENOME STABILITY AT THE REPLICATION FORK'

David Cortez (Vanderbilt University)
'FUNCTIONS OF SINGLE-STRAND DNA BINDING PROTEINS IN MAINTAINING GENOME STABILITY'

Sheila David (University of California, Davis)
'BASE EXCISION REPAIR GLYCOSYLASES MUTYH AND NEIL1: THE GOOD, THE BAD AND THE DAMAGED'

Michelle Debatisse (Gustave Roussy Institute)
'COMMON FRAGILE SITE INSTABILITY: A RACE AGAINST TIME'

Sylvie Doublié (University of Vermont)
'STRUCTURAL ANALYSES OF DNA POLYMERASE THETA VARIANTS'

Structural analyses of DNA polymerase theta variants'

Brandt Eichman (Vanderbilt University)
'MECHANISMS OF REMODELING STALLED REPLICATION FORKS'

Dorothy Erie (University of North Carolina)

Ilya Finkelstein (University of Texas at Austin)
'ASSEMBLING THE HUMAN RESECTOSOME ONE MOLECULE AT A TIME'

Marco Foiani (University of Milan)
'AN INTEGRATED ATR, ATM AND mTOR-MECHANICAL NETWORK CONTROLLING NUCLEAR PLASTICITY AND CELL MIGRATIONB'

Mark Glover (University of Alberta)
'PNKP - A MEANS TO FIX THE ENDS'

Jane Grasby (Krebs Institute)
'COUPLING RECOGNITION AND REACTIVITY IN A STRUCTURE-SPECIFIC NUCLEASE'

Samir Hamdan (KAUST)
'SINGLE MOLECULE VIEW OF THE STRUCTURE SPECIFIC 5' NUCLEASES'

Reuben Harris (University of Minnesota)
'APOBEC MUTAGENESIS IN CANCER'

Karl-Peter Hopfner (Ludwig-Maximilians-University Munich)
'STRUCTURAL ANALYSIS OF PROTEIN DNA REMODELLER'

Ben Van Houten (University of Pittsburgh)
'DAMAGE SENSOR ROLE OF UV-DDB DURING BASE EXCISION REPAIR:STIMULATION OF APE1 AND OGG1'

Meindert Lamers (Leiden University Medical Center)
'STRUCTURAL FEATURES OF HIGH FIDELITY DNA REPLICATION'

Susan Lees-Miller (Arnie Charbonneau Cancer Institute)
'NON-REPAIR FUNCTIONS OF DNA-PKcs'

Karolin Luger (University of Colorado at Boulder)
'POLY (ADP-RIBOSE) POLYMERASE 1 IN DNA DAMAGE RECOGNITION'

Mauro Modesti (Cancer Research Center of Marseille)
'DYNAMICS AND MECHANICS OF DNA TETHERING BY CORE c-NHEJ FACTORS AND BY THE MRE11/RAD50/NBS1 COMPLEX'

Zachary Nagel (Harvard University)
'COMPREHENSIVE ANALYSIS OF DNA REPAIR CAPACITY IN NORMAL AND CANCEROUS CELLS'

Mark O'Connor (AstraZeneca)
'TARGETING THE REPLICATION STRESS RESPONSE IN CANCER'

John Pascal (Université de Montréal)
'STRUCTURAL BIOLOGY OF POLY(ADP-ribose) POLYMERASE ENZYMES'

Tanya Paull (University of Texas at Austin)
'THE Mre11-Rad50-Nbs1 COMPLEX AND REGULATION OF DNA REPAIR'

Phoebe Rice (University of Chicago)
'AN MCM-RELATED HELICASE AND OTHER REPLICATION-RELATED MACHINERY FOUND ON THE MOBILE ELEMENT BEHIND THE MRSA EPIDEMIC'

Andrej Sali (University of California, San Francisco)
'INTEGRATIVE STRUCTURE MODELING OF DNA-PKcs'

Orlando Scharer (Ulsan National Institute of Science and Technology)
'REPLICATIVE AND TRANSLESION SYNTHESIS DNA POLYMERASES IN ICL REPAIR'

Katharina Schlacher (MD Anderson Cancer Center)
'RAD51C IN DNA FORK PROTECTION AND STABILITY'

David Schriemer (University of Calgary)
'PROTEOMICS-GRADE STRATEGIES FOR INTEGRATIVE STRUCTURAL BIOLOGY'

Titia Sixma (NKI)
'STRUCTURAL BIOLOGY OF DNA MISMATCH REPAIR'

Maria Spies (University of Iowa)
'INHIBITORS OF THE RAD52-ssDNA INTERACTION'

Terence Strick (Institut Jacques Monod)
'SINGLE-MOLECULE ANALYSIS OF MULTICOMPONENT DNA REPAIR SYSTEMS'

Madalena Tarsounas (The CR-UK/MRC Oxford Institute for Radiation Oncology)
'WNT/b-CATENIN SIGNALING IN BRCA-DEFICIENT CELLS'

Susan Tsutakawa (Lawrence Berkeley National Laboratory)
'PHOSPHATE STEERING IS CRITICAL FOR CATALYSIS AND PREVENTION OF OFF-TARGET INCISIONS IN HUMAN FLAP ENDONUCLEASE'

Ashok Venkitaraman (University of Cambridge)
'INSIGHTS INTO CARCINOGENESIS FROM STRUCTURAL AND BIOLOGIC ANALYSES OF THE BRCA2 TUMOUR SUPPRESSOR'

Dale Wigley (Imperial College London)
'STRUCTURE AND REGULATION OF HUMAN INO80 COMPLEX'

Scott Williams (NIEHS)
'ENFORCEMENT OF DNA LIGATION FIDELITY'

Sponsors

Sponsors

Report

The 3rd DNA Replication/Repair Structures and Cancer Conference, which took place in Cancun, Mexico from 11-15 February 2018, centered on developing an actionable mechanistic knowledge of DNA replication and repair responses to stress for advanced cancer intervention strategies. Returning conference chairs, Sir Tom Blundell (FRS, FMedSci, Department of Biochemistry, University of Cambridge, UK) and Dr. John Tainer (Director SIBYLS Advanced Light Source, Professor and Director of Structural Biology, MD Anderson Cancer Center, Houston, Texas, USA) brought to Cancun many of the people driving advances in relevant structural biology and mechanisms, enabling uniquely productive and informative interactions for those working on DNA replication, damage responses and cancer. There was a total of 157 attendees who travelled worldwide to join us; Australia, USA, UK, The Netherlands, Japan, France, Saudi Arabia, China, South Korea, Germany, Italy, Poland, Canada, Sweden and Austria are just a few of the countries that were represented. Talks and poster sessions focused on cutting-edge structural and single-molecule approaches and novel mechanistic insights.

The remarkable stability of the human genome is lost in cancer cells due to the loss of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a surprisingly fragile and complex process requiring fork protection and restart, R-loop resolution, and repair. Unresolved replication and repair intermediates signal apoptosis. The synthetic lethality and essentiality resulting from replication-repair stresses thus suggest repair inhibitors as tools to control pathway selection and damage outcomes and to design advanced therapeutics.

The 2018 meeting focused on structural and mechanistic insights into dynamic protein, DNA and RNA complexes acting in DNA replication and repair events relevant to cancer. The large diverse audience including many internationally distinguished speakers and the lively debates emphasised the importance of the theme. Comments from participants of all career stages emphasised their wish to see the series continue in this format and location.

“You and Tom did a really wonderful job putting together the conference with Laura and her colleagues. The science, discussions and location were all spot-on! I very much enjoyed participating in your conference and hope that I will have the opportunity to doing so again should you organise further events of this type.” Prof. Stephen Jackson (Wellcome Trust/Cancer Research UK Gurdon Institute)

The first day begun with a lively discussion of DNA Replication Machinery chaired by John Tainer and focused on structural features of high fidelity DNA replication and its enforcement. This was presented by an impressive line-up of international speakers. On this first day we had two breaks in the lecture schedule for sessions, expertly chaired by Susan Tsutakawa and Chris Brosey, of Meet the Poster Presenters, where all gave concise introductions and invitations to their poster. The evening concluded with an exciting plenary overview by Bruce Stillman from Cold Spring Harbor Laboratory on the structure, function and human genetics of the origin recognition complex and chromosome duplication.

The second day theme was replication fork stability, including mechanisms for maintaining genome stability at forks and for remodeling stalled replication forks. The following session focused further on sensing & signaling cellular genome instability. Mechanistic aspects were informed by amazing structural insights arising from state of the art techniques, for example of the structures of poly(ADP-ribose) polymerase enzymes. This session culminated in a brilliant plenary talk encompassing advances on cellular responses to DNA double-strand breaks by Steve Jackson of the Wellcome Trust/Cancer Research UK Gurdon Institute. The evening of the second day included sessions on defining & targeting the damage response. The final session, late in the evening but still with full attendance, was introduced by Tom Blundell, describing an opportunity to contribute to a themed volume of Progress in Biophysics and Molecular Biology, to be published by Elsevier.

These exciting sessions included breaks for discussions with refreshments & poster viewing, further sessions to ‘Meet the Poster Presenters’, and a short break for leisure in the afternoon. Some sought relaxing conversations on the beautiful beach 50 meters from the restaurants and lecture room! Discussions often further took place over dinner that could be taken at several lovely restaurants in the hotel.

The third day began with sessions on mutational signatures & mechanisms, focusing on mutagenesis in cancer, the concerted roles of genes in the protection of common fragile sites, the characterization of genomic rearrangements and DNA damage recognition. This session culminated with a fascinating plenary talk from Serena Nik-Zainal of the Wellcome Trust Sanger Institute. She detailed mechanistic insights and clinical applications of advances emerging from mutational signatures.

After a snorkeling expedition for some of the more energetic participants and informal afternoon discussions by others, the talks focused on DNA double-strand-break repair through Non-Homologous End Joining. This session was anchored by many strong talks and especially by the breakthrough new structure of the giant DNA-PK molecule, the largest single chain kinase in the human genome, which furthermore forms a point for assembly of many other components. New methods of investigating DNA end joining using proteomics-grade strategies for integrative structural biology and modelling were discussed, as well as exciting single-molecule analyses by Terence Strick measuring the time frame and energetics from the core and added components for this multicomponent DNA repair system.

The fourth day, Wednesday, started with talks and discussions of resection, repair and break signaling in homologous recombination of DNA double-strand breaks. One of the highlights was the way rad51 filament defines remodeling by human Rad51c-XRCC3. The discussion continued with a focus on DNA intermediates in repair and replication, and a discussion of mutagenesis, culminating with a very stimulating integrative plenary talk by Stephen West of the Francis Crick Institute on unresolved DNA intermediates as a source of DNA breaks and chromosome aberrations. The evening session continued with talks and discussions on coupling repair to replication and mitosis, with many stand out talks including those by Titia Sixma of the Netherlands Cancer Institute on structural biology of DNA mismatch repair and by Susan Lees-Miller of University of Calgary on non-repair functions of DNA-PKcs. All of this discussion included a look behind the scenes on publishing with the Nature research journals by Beth Moorefield that was followed by a gala dinner and poster awards (see below).

Despite the intensive schedule in talks and interactions, the final day continued with the same intensity of brilliant and exciting presentations on damage interactions with expression & chromatin. Talks included DNA damage sensor roles during base excision repair, structural analysis of protein DNA remodeler and structure and regulation of human ino80 complex by Dale Wigley. John Tainer from the MD Anderson Cancer Center completed the meeting with an exciting thought piece on the “rise of the molecular machines with cancer implications”.

The closing comments from the organisers expressed their happiness with the range of superb talks – probably the most intense five day meeting many have had for a long time and a great learning period. The meeting was attended by an enthusiastic and diverse audience, both with respect to stage of career, gender and nationality. We were proud to see that 20% of our attendees were students and this was due to the special rate offered by Fusion enabling many students to attend at cost price when accompanied by an academic.

The topic of DNA damage response and repair and its interface with replication remains an exciting area of research, still with many unanswered questions.

“Thank you, and all the organisers, so much for this wonderful opportunity to meet other researchers and make valuable contacts. I won't hesitate to say that this is one of the best conferences I've been to so far. Organisation is perfect and I will definitely want to attend in next edition…” Dr. Jacek Kabzinski (Medical University of Lodz)

Congratulations to all of those who received an award, details of which can be found below.

Organisers Short Talk Award

Noa Lamm-Shale (Children's Medical Research Institute)
Ravindra Amunugama (Harvard Medical School)

Poster Prize Awards

Zhe Yang (The Rockefeller University)
Taiana Maia de Oliveira (AstraZeneca)
Marcel Tuppi (Goethe-Universität Frankfurt)
Harshad Ghodke (University of Wollongong)
Benjamin Foster (IFE, Helmholtz Zentrum München)
Elizabeth O'Brien (California Institute of Technology) 

FEBS Short Talk Award

Domi Baretic (MRC Laboratory of Molecular Biology)
Franz Klein (MFPL, University of Vienna) 

We thank AstraZeneca for generously supporting this meeting and emphasising the importance of knowledge exchange between academia and industry, which is critical in our area and in this case can assist in the early development of new therapeutics for cancer. We also thank all our other wonderful sponsors; TESARO, Oncotarget, Repare Therapeutics, DECTRIS, artios, FEBS, Worldwide Cancer Research and the University of Pittsburgh. Their support was greatly appreciated and enabled us to fund many participants who otherwise may not have been able to attend. Special thanks to Elsevier for supporting the meeting and publishing the themed volume on selected talks.

The meeting was expertly organized, smoothly run, and supported by Fusion Conferences, Ltd.  We thank Laura Trundle and her team for their helpful interactions with organisers and participants.

Programme

DISCUSSION IS VALUED: 5 MINUTES IS SAVED FOR DISCUSSION AFTER EACH TALK

SUNDAY 11TH FEBRUARY 2018

09:00 – 15:00

Group Trip: Tulum (signups required in advance)

15:00 – 16:00

Registration & Welcome Reception

16:00 – 16:10

Welcome and Opening Remarks by John Tainer & Tom Blundell

SUNDAY PM

DNA Replication Machinery 
Session Chair: John Tainer

16:10 – 16:30

Meindert Lamers 
Leiden University Medical Center

STRUCTURAL FEATURES OF HIGH FIDELITY DNA REPLICATION

16:35 – 16:45

Ravindra Amunugama * 
Harvard Medical School

REPLICATION FORK REVERSAL DURING DNA INTERSTRAND CROSSLINK REPAIR REQUIRES CMG HELICASE UNLOADING

16:50 – 17:00

Philipp Oberdoerffer * 
NCI

REPLICATION STRESS SHAPES A PROTECTIVE CHROMATIN ENVIRONMENT ACROSS FRAGILE GENOMIC REGIONS

17:05 – 17:25

Samir Hamdan 
KAUST

SINGLE MOLECULE VIEW OF THE STRUCTURE SPECIFIC 5' NUCLEASES

17:30 – 17:50

Scott Williams 
NIEHS

ENFORCEMENT OF DNA LIGATION FIDELITY

17:55 – 18:20

Meet the Poster Presenters I 
Moderators: Susan Tsutakawa and Chris Brosey

18:20 – 18:50

Refreshments

18:50 – 19:10

Meet the Poster Presenters II 
Moderators: Susan Tsutakawa and Chris Brosey

19:10 – 19:20

Tahir Tahirov * 
Nebraska Medical Center

ELABORATED ACTION OF THE HUMAN PRIMOSOME

19:25 – 19:45

Walter Chazin 
Vanderbilt University

UNDERSTANDING HOW DNA PRIMASE WORKS REQUIRES KNOWLEDGE OF ITS ARCHITECTURAL DYNAMICS

19:50 – 20:30

Plenary Speaker: 
Bruce Stillman 

Cold Spring Harbor Laboratory

THE ORIGIN RECOGNITION COMPLEX AND CHROMOSOME DUPLICATION: STRUCTURE, FUNCTION AND HUMAN GENETICS

20:35

Dinner at Leisure

MONDAY 12TH FEBRUARY 2018

07:00 – 08:15

Breakfast

MONDAY AM

Replication Fork Stability 
Session Chair: Marco Foiani

08:15 – 08:20

Session Introduction by Marco Foiani

08:20 – 08:40

Karlene Cimprich 
Stanford University

MECHANISMS FOR MAINTAINING GENOME STABILITY AT THE REPLICATION FORK

08:45 – 09:05

Brandt Eichman 
Vanderbilt University

MECHANISMS OF REMODELING STALLED REPLICATION FORKS

09:10 – 09:30

David Cortez 
Vanderbilt University

FUNCTIONS OF SINGLE-STRAND DNA BINDING PROTEINS IN MAINTAINING GENOME STABILITY

09:35 – 09:45

Martin Cohn * 
University of Oxford

IDENTIFICATION OF UHRF2 (RNF107) AS A NOVEL ICL SENSOR PROTEIN REQUIRED FOR THE FANCONI ANEMIA PATHWAY

09:50 – 10:10

Katharina Schlacher 
MD Anderson Cancer Center

RAD51C IN DNA FORK PROTECTION AND STABILITY

10:15 – 10:45

Refreshments & Poster Viewing

MONDAY AM

Sensing & Signaling Cellular Genome Instability 
Session Chair: Katharina Schlacher

10:45 – 10:50

Session Introduction by Katharina Schlacher

10:50 – 11:10

Marco Foiani 
IFOM - FIRC Institute of Molecular Oncology

AN INTEGRATED ATR, ATM AND mTOR-MECHANICAL NETWORK CONTROLLING NUCLEAR PLASTICITY AND CELL MIGRATION

11:15 – 11:25

Noa Lamm-Shalem * 
Children's Medical Research Institute

ATR AND mTOR REGULATE NUCLEUR ACTIN POLYMERIZATION IN RESPONSE TO REPLICATION STRESS TO ALTER NUCLEUR ARCHITECTURE AND MAINTAIN GENOME STABILITY

11:30 – 11:50

John Pascal 
Université de Montréal

STRUCTURAL BIOLOGY OF POLY(ADP-ribose) POLYMERASE ENZYMES

11:55 – 12:15

Chris Brosey 
University of Texas M.D. Anderson Cancer Center

BRIDGING DNA REPAIR AND NAD(H) ENERGETICS: TRACKING ARCHITECTURAL REGULATION OF APOPTOSIS-INDUCING FACTOR DURING PARTHANATOS

12:20 – 13:00

*Partially sponsored by Worldwide Cancer Research*

Plenary Speaker: 
Steve Jackson 
Wellcome Trust/Cancer Research UK Gurdon Institute

CELLULAR RESPONSES TO DNA DOUBLE-STRAND BREAKS 

13:05 – 16:25

Lunch at Leisure & Free Time

MONDAY PM

Defining & Targeting The Damage Response 
Session Chair: Susan Lees-Miller

16:25 – 16:30

Session Introduction by Susan Lees-Miller

16:30 – 16:50

Mark O'Connor 
AstraZeneca

TARGETING THE REPLICATION STRESS RESPONSE IN CANCER

16:55 – 17:15

Jane Grasby 
Krebs Institute

COUPLING RECOGNITION AND REACTIVITY IN A STRUCTURE-SPECIFIC NUCLEASE

17:20 – 17:30

Mohiuddin * 
The Hospital for Sick Children

CTIP-BRCA1 COMPLEX AND MRE11 NUCLEASE PLAY A CRITICAL ROLE IN MAINTAINING REPLICATION FORKS IN THE PRESENCE OF CHAIN TERMINATING NUCLEOTIDE ANALOGS

17:35 – 18:15

Meet the Poster Presenters III 
Moderators: Susan Tsutakawa and Chris Brosey

18:15 – 18:55

Poster Session & Refreshments (even poster numbers only)

18:55 – 19:15

Madalena Tarsounas 
University of Oxford

WNT/b-catenin signaling in BRCA-deficient cells

19:20 – 19:40

Maria Spies 
University of Iowa

INHIBITORS OF THE RAD52-ssDNA INTERACTION

19:45 – 19:55

Mona Al-Mugotir * 
UNMC Eppley Institute

TARGETING RAD52 PROTEIN-PROTEIN INTERACTIONS IN CANCER THERAPY

20:00 – 20:20

Zachary Nagel 
Harvard University

COMPREHENSIVE ANALYSIS OF DNA REPAIR CAPACITY IN NORMAL AND CANCEROUS CELLS

20:25 – 20:40

Publication Opportunity: Progress in Biophysics and Molecular Biology (Published by Elsevier)

Announcement by Tom Blundell

20:40

Dinner at Leisure

TUESDAY 13TH FEBRUARY 2018

07:00 – 08:15

Breakfast

TUESDAY AM

Mutational Signatures & Mechanisms 
Session Chair: Bennett Van Houten

08:15 – 08:20

Session Introduction by Bennett Van Houten

08:20 – 08:40

Reuben Harris 
University of Minnesota

APOBEC MUTAGENESIS IN CANCER

08:45 – 08:55

Agnel Sfeir * 
NYU School of Medicine

POLYMERASE THETA PROMOTES ERROR-PRONE REPAIR BY alt-NHEJ AT THE EXPENSE OF ERROR-FREE HR

09:00 – 09:10

Xiaohua Wu * 
The Scripps Research Institute

THE CONCERTED ROLES OF FANCM AND Rad52 IN THE PROTECTION OF COMMON FRAGILE SITES

09:15 – 09:35

Ashok Venkitaraman 
University of Cambridge

INSIGHTS INTO CARCINOGENESIS FROM STRUCTURAL AND BIOLOGIC ANALYSES OF THE BRCA2 TUMOUR SUPPRESSOR

09:40 – 10:10

Group Photo, Refreshments & Poster Viewing

10:10 – 10:20

Anne Bothmer * 
Editas Medicine

CHARACTERIZATION OF GENOMIC REARRANGEMENTS IN RESPONSE TO CRISPR/Cas9-INDUCED DOUBLE-STRAND BREAKS

10:25 – 10:45

Susan Tsutakawa 
Lawrence Berkeley National Laboratory

PHOSPHATE STEERING IS CRITICAL FOR CATALYSIS AND PREVENTION OF OFF-TARGET INCISIONS IN HUMAN FLAP ENDONUCLEASE

10:50 – 11:10

Karolin Luger 
University of Colorado Boulder

POLY (ADP-RIBOSE) POLYMERASE 1 IN DNA DAMAGE RECOGNITION

11:15 – 11:35

Michelle Debatisse 
UMR8200 CNRS

COMMON FRAGILE SITE INSTABILITY: A RACE AGAINST TIME

11:40 – 12:20

 

Plenary Speaker: 
Serena Nik-Zainal 
University of Cambridge

ADVANCES IN THE FIELD OF MUTATIONAL SIGNATURES: MECHANISTIC INSIGHTS AND CLINICAL APPLICATIONS

12:25 – 16:30

Lunch at Leisure & Free Time

12:40 – 16:00

Group Trip: Snorkeling (signups required in advance)

TUESDAY PM

Non-Homologus End Joining 
Session Chair: Simon Boulton

16:30 – 16:35

Session Introduction by Simon Boulton

16:35 – 16:55

Tom Blundell 
University of Cambridge

DNA-PKcs STRUCTURE FORMS A STAGE FOR THE ACTORS AND SUGGESTS AN ALLOSTERIC MECHANISM FOR MODULATING DNA DOUBLE-STRAND-BREAK REPAIR

17:00 – 17:20

David Schriemer 
University of Calgary

PROTEOMICS-GRADE STRATEGIES FOR INTEGRATIVE STRUCTURAL BIOLOGY

17:25 – 17:35

Benjamin Stinson * 
Harvard Medical School

NON-HOMOLOGOUS END JOINING OPERATES BY A “LIGASE-FIRST” MECHANISM

 

17:40 – 18:00

Terence Strick 
Institut Jacques Monod

SINGLE-MOLECULE ANALYSIS OF MULTICOMPONENT DNA REPAIR SYSTEMS

18:05 – 18:25

Andrej Sali 
UCSF

INTEGRATIVE STRUCTURE MODELING OF DNA-PKcs

18:30 – 19:10

Poster Session & Refreshments (odd poster numbers only)

19:10 – 19:30

Jean-Baptiste Charbonnier 
CEA-CNRS-Univ Paris Saclay

ROLES OF Ku70/Ku80 IN NHEJ, FROM DSB RECOGNITION TO LIGATION

19:35 – 19:55

Tanya Paull 
The University of Texas at Austin

INTERSECTIONS BETWEEN MRN AND THE NON-HOMOLOGOUS END JOINING MACHINERY

20:00 – 20:20

Mark Glover 
University of Alberta

PNKP - A MEANS TO FIX THE ENDS

20:25

Dinner at Leisure

WEDNESDAY 14TH FEBRUARY 2018

07:00 – 08:15

Breakfast

WEDNESDAY AM

Resection, Repair and Break Signaling in Homologous Recombination

Session Chair: Lorena Beese

08:15 – 08:20

Session Introduction by Lorena Beese

08:20 – 08:40

Mauro Modesti 
Cancer Research Center of Marseille

DYNAMICS AND MECHANICS OF DNA TETHERING BY CORE c-NHEJ FACTORS AND BY THE MRE11/RAD50/NBS1 COMPLEX

08:45 – 09:05

Ilya Finkelstein 
UT-Austin

ASSEMBLING THE HUMAN RESECTOSOME ONE MOLECULE AT A TIME

09:10 – 09:20

Michael Trakselis * 
Baylor University

FUNCTION AND REGULATION OF MCM8-9 IN DNA RECOMBINATION

09:25 – 09:35

Domi Baretic * 
MRC Laboratory of Molecular Biology

STRUCTURAL INSIGHTS INTO THE ACTIVATION OF ATM AND ATR KINASES

09:40 – 10:00

Simon Boulton 
The Francis Crick Institute

PITCH MODULATION AND EXTENSION DEFINES RAD51 FILAMENT REMODELLING BY HUMAN RAD51C-XRCC3 COMPLEX

10:05 – 10:50

Poster Session & Refreshments (all posters)

WEDNESDAY AM

DNA Intermediates in Repair, Replication, and Mutagensis

Session Chair: Richard Wood

10:50 – 10:55

Session Introduction by Richard Wood

10:55 – 11:05

Markus Löbrich * 
Darmstadt University of Technology

ATRX PROMOTES DNA REPAIR SYNTHESIS AND CROSS-OVER FORMATION DURING HOMOLOGOUS RECOMBINATION

11:10 – 11:20

Charles Bell * 
The Ohio State University

STRUCTURE AND MECHANISM OF THE RED RECOMBINATION SYSTEM FROM BACTERIOPHAGE LAMBDA

11:25 – 11:35

Franz Klein * 
University of Vienna

THE RELEASE OF MEIOTIC dsDNA FRAGMENTS PROMPTS A NOVEL VIEW ON DSB FORMATION

11:40 – 11:50

David Yu * 
Emory University School of Medicine

SAMHD1 PROMOTES DNA END RESECTION TO FACILITATE DNA REPAIR BY HOMOLOGOUS RECOMBINATION

11:55 – 12:15

Sylvie Doublié 
University of Vermont

STRUCTURAL ANALYSES OF DNA POLYMERASE THETA VARIANTS

12:20 – 12:30

Marc Delarue 
Institut Pasteur

STRUCTURAL BASIS FOR THE ESSENTIAL ROLE OF LOOP1 IN POLYMERASE μ WHILE PROCESSING DOUBLESTRAND BREAKS DNA SUBSTRATES DURING NHEJ

12:35 – 13:15

Plenary Speaker: Stephen West 
Francis Crick Institute

UNRESOLVED DNA INTERMEDIATES AS A SOURCE OF DNA BREAKS AND CHROMOSOME ABERRATIONS

13:20 – 16:25

Lunch at Leisure & Free Time

WEDNESDAY PM

Coupling Repair to Replication and Mitosis 
Session Chair: Jane Grasby

16:25 – 16:30

Session Introduction by Jane Grasby

16:30 – 16:50

Orlando D. Schärer 
Institute for Basic Science

REPLICATIVE AND TRANSLESION SYNTHESIS DNA POLYMERASES IN ICL REPAIR

16:55 – 17:15

Lorena Beese 
Duke University Medical Center

REPLICATION ASSOCIATED DNA REPAIR

17:20 – 17:40

Dorothy Erie 
University of North Carolina

COMBINING SINGLE-MOLECULE METHODS TO STUDY DNA MISMATCH REPAIR

17:45 – 17:55

Beth Moorefield * 
Nature SMB

PUBLISHING WITH THE NATURE RESEARCH JOURNALS: A LOOK BEHIND THE SCENES

17:55 – 18:25

Refreshments & Poster Viewing

18:25 – 18:45

Titia Sixma 
Netherlands Cancer Institute

USP48 RESTRAINS RESECTION BY SITE-SPECIFIC CLEAVAGE OF THE BRCA1 UBIQUITIN MARK FROM H2A

18:50 – 19:00

Alba Guarne * 
McGill University

DIFFERENTIAL INTERACTIONS BETWEEN THE SLIDING CLAMP AND MUTL

19:05 – 19:25

Susan Lees-Miller 
University of Calgary

NON-REPAIR FUNCTIONS OF DNA-PKcs

20:00

Gala Dinner & Poster Awards

THURSDAY 15TH FEBRUARY 2018

07:00 – 08:15

Breakfast

THURSDAY AM

Damage Interactions With E xpression & Chromatin 
Session Chair: Tom Blundell

08:15 – 08:20

Session Introduction by Tom Blundell

08:20 – 08:40

Bennett Van Houten 
University of Pittsburgh Cancer Institute

DAMAGE SENSOR ROLE OF UV-DDB DURING BASE EXCISION REPAIR:STIMULATION OF APE1 AND OGG1

08.45 – 09:05

Cynthia Burrows 
University of Utah

DNA DAMAGE REGULATES GENE EXPRESSION VIA BASE EXCISION REPAIR

09:10 – 09:30

Karl-Peter Hopfner 
Gene Center

STRUCTURAL ANALYSIS OF PROTEIN DNA REMODELLER

09:35 – 09:55

Dale Wigley 
Imperial College London

STRUCTURE AND REGULATION OF HUMAN INO80 COMPLEX

10:00 – 10:30

Refreshments

THURSDAY AM

DNA Sculpting & Human Disease 
Session Chair: Dorothy Erie

10:30 – 10:35

Session Introduction by Dorothy Erie

10:35 – 10:45

Dong Wang * 
UCSD

MOLECULAR MECHANISM OF TRANSCRIPTION TRANSCRIPTION-COUPLED REPAIR

10:50 – 11:10

Phoebe Rice 
The University of Chicago

AN MCM-RELATED HELICASE AND OTHER REPLICATION-RELATED MACHINERY FOUND ON THE MOBILE ELEMENT BEHIND THE MRSA EPIDEMIC

11:15 – 11:35

Sheila David 
University of California, Davis

BASE EXCISION REPAIR GLYCOSYLASES MUTYH AND NEIL1: THE GOOD, THE BAD AND THE DAMAGED

11:40 – 11:50

Ivaylo Ivanov * 
Georgia State University

LESION SEARCH AND BASE EXTRUSION STRATEGY OF THYMINE DNA GLYCOSYLASE

11:55 – 12:15

John Tainer 
MD Anderson Cancer Center

THE RISE OF THE MOLECULAR MACHINES WITH CANCER IMPLICATIONS

12:20 – 12:30

Closing Comments by John Tainer & Tom Blundell


FRIDAY 16TH FEBRUARY 2018

07:15 – 19:00

Group Trip: Chichen Itza (signups in advance required)

*Selected from abstracts.

 

MEET OUR POSTER PRESENTERS

Poster #

Name

Organisation

Country

1

Noritaka Adachi

Yokohama City University

Japan

2

Matthew Bochman

Indiana University

USA

3

Gloria Borgstahl

Eppley Institute for Research in Cancer

USA

4

Amer Bralic

King Abduallah University of Science and Technology

Saudi Arabia

5

Brian Caldwell

Ohio State Biochemistry Program

USA

6

Rodrigo Orlandini de Castro

Oklahoma Medical Research Foundation

USA

7

Petr Cejka

Institute for Research in Biomedicine

Switzerland

8

Heejin Chung

Sungkyunkwan University

South Korea

9

Anders Clausen

University of Gothenburg

Sweden

10

Debanu Das

Accelero Biostructures

USA

11

Anthony Davis

UT Southwestern Medical Center

USA

12

Ambra Dondi

European Institute of Oncology

Italy

13

Pauline Douglas

University of Calgary

Canada

14

Amira Fitieh

University of Alberta

Canada

15

Benjamin Foster

IFE, Helmholtz Zentrum München

Germany

16

Harshad Ghodke

University of Wollongong

Australia

17

Morgan Hepburn

University of Calgary

Canada

18

Han Ho

University of Wollongong

Australia

19

JinKyung Hong

Sungkyunkwan University School of Medicine

South Korea

20

Jerry Houl

University of Texas MD Anderson Cancer Center

USA

21

Christopher Jackson

Yale University

USA

22

Seong-Whan Jeong

The Catholic University of Korea

South Korea

23

David Jeruzalmi

City College of New York

USA

24

Nicholas Jette

University of Calgary

Canada

25

Stanislaw Jozwiakowski

University of Zurich

Switzerland

26

Jacek Kabzinski

Medical University of Lodz

Poland

27

Yoko Katsuki

Kyoto University

Japan

28

Yoori Kim

The University of Texas at Austin

USA

29

Ina Klusmann

Universitätsmedizin Göttingen

Germany

30

Rebecca Ley

University of Sheffield

UK

31

Ireneusz Majsterek

Medical University of Lodz

Poland

32

Lucia Francesca Massari

European Institute of Oncology

Italy

33

Riccardo Miggiano

University of Piemonte Orientale

Italy

34

Yeom Mina

Sungkyunkwan University School of Medicine

South Korea

35

Davide Moiani

UT MD Anderson Cancer Center

USA

36

Elizabeth O'Brien

California Institute of Technology

USA

37

Taiana Maia de Oliveira

AstraZeneca

UK

38

Richard Pomerantz

Temple University

USA

39

Fahad Rashid

KAUST

Saudi Arabia

40

Samuel Redstone

University of Utah

USA

41

Liton Kumar Saha

Kyoto University

Japan

42

Lauren Salay

Vanderbilt University

USA

43

Daniel Saltzberg

University of California San Francisco

USA

44

Altaf Sarker

Lawrence Berkeley National Lab

USA

45

Lisa Schubert

University of Copenhagen

Denmark

46

Runze Shen

The University of Texas M.D. Anderson Cancer Center

USA

47

Agnieszka Anna Smolińska

Ernst-Moritz-Arndt-University Greifswald

Germany

48

Lucas Struble

UNMC Eppley Institute

USA

49

Michal Roman Szymanski

University of Gdansk and Medical University of Gdansk

Poland

50

Roopa Thapar

MD Anderson Cancer Research Center

USA

51

Marcel Tuppi

Goethe-Universität Frankfurt

Germany

52

Felicity Watts

University of Sussex

UK

53

Richard Wood

The University of Texas MD Anderson Cancer Center

USA

54

Dongyi Xu

Peking University

China

55

Yixi Xu

Peking University

China

56

Zhe Yang

The Rockefeller University

USA

57

Manal Zaher

King Abdullah University of Science and Technology

Saudi Arabia

 

Speakers

Plenary Speakers

  • Dr. Stephen West
    Senior Group Leader, Francis Crick Institute
  • Dr. Bruce Stillman
    President and Professor, Cold Spring Harbor Laboratory
  • Professor Stephen Jackson
    Head of Cancer Research UK Laboratories, Wellcome Trust/Cancer Research UK Gurdon Institute
  • Dr. Serena Nik-Zainal
    ., University of Cambridge

Invited Speakers

  • Dr. Madalena Tarsounas
    CR-UK Senior Group Leader, The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford
  • Prof. Marco Foiani
    Scientific Director, IFOM- the FIRC Institute of Molecular Oncology
  • Assist. Prof. Katharina Schlacher
    Assistant Professor, MD Anderson Cancer Center
  • Prof. Simon Boulton
    Senior Group Leader, The Francis Crick Institute
  • Prof. Tanya Paull
    Professor, The University of Texas at Austin
  • Dr. David Cortez
    Professor, Vanderbilt University
  • Prof. Andrej Sali
    Professor, University of California, San Francisco
  • Prof. Dr. Titia Sixma
    head of division, Netherlands Cancer Institute
  • Prof. Karolin Luger
    Investigator, HHMI; Professor, CU Boulder, University of Colorado Boulder
  • Prof. Cynthia Burrows
    Distinguished Professor, University of Utah
  • Professor Walter Chazin
    Director- Center for Structural Biology, Vanderbilt University
  • Dr. Chris Brosey
    Research Scientist, The University of Texas M.D. Anderson Cancer Center
  • Assist. Prof. Ilya Finkelstein
    Assistant Professor, UT-Austin
  • Dr. Susan Tsutakawa
    Research Scientist, Lawrence Berkeley National Laboratory
  • Dr. Brandt Eichman
    Professor, Vanderbilt University
  • Dr. Mark O'Connor
    Chief Scientist, AstraZeneca
  • Prof. Mark Glover
    Professor, University of Alberta
  • Prof. Meindert Lamers
    Associate Professor, Leiden University Medical Center
  • Professor Sylvie Doublié
    Professor, University of Vermont
  • Dr. Mauro Modesti
    Principal Investigator, Cancer Research Center of Marseille
  • Prof. David Schriemer
    Professor, University of Calgary
  • Professor Dorothy Erie
    Professor, University of North Carolina
  • Prof. Maria Spies
    Associate Professor of Biochemistry, University of Iowa
  • Professor Michelle Debatisse
    Researcher, UMR8200 CNRS
  • Prof. Reuben Harris
    Professor, University of Minnesota
  • Prof. Sheila David
    Professor of Chemistry, University of California, Davis
  • Dr. Ben Van Houten
    Richard M. Cyert Professor of Molecular Oncology , University of Pittsburgh Cancer Institute
  • Professor Karlene Cimprich
    Professor, Stanford University
  • Prof Karl-Peter Hopfner
    Professor, Gene Center
  • Dr Jean-Baptiste Charbonnier
    Team Leader , CEA-CNRS-Univ Paris Saclay, France
  • Prof. Dr. Orlando D. Schärer
    Associate Director, Institute for Basic Science
  • Prof. Ashok Venkitaraman
    Director, MRC Cancer Unit, University of Cambridge
  • Prof Samir Hamdan
    Assistant Professor of Bioscience, King Abdullah University of Science and Technology
  • Prof. Dr. John Pascal
    Associate Professor, Université de Montréal
  • Dr Susan Lees-Miller
    Professor, University of Calgary
  • Professor Dale Wigley
    , Imperial College London
  • Assist. Prof. Zachary Nagel
    Assistant Professor of Radiation Biology, Harvard U
  • Professor Lorena Beese
    Professor, Duke University Medical Center
  • Prof. Phoebe Rice
    Professor, The University of Chicago
  • Principal Investigator Scott Williams
    Principal Investigator, NIH/NIEHS
  • Terence Strick
    Research Director, Ecole normale supérieure/CNRS
  • Prof. Jane Grasby
    Professor of Biological Chemistry, University of Sheffield

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