Nuclear Receptors are, physiologically and pharmacologically, a critical superfamily of transcription factors. They drive key processes at every stage from development and reproduction to ageing and cancer. They are critical determinants of everyday health via their roles in metabolism and circadian rhythms. Nuclear receptors allow external factors to influence cellular pathways and the fact that many bind and are activated by small molecules means they represent highly druggable targets; currently, 13% of FDA-approved drugs target nuclear receptors.
This meeting will address the new roles and novel crosstalk mechanisms that are emerging for many of the 48 human nuclear receptors, in health and disease. For example, it has long been known that the estrogen receptor drives progression of breast cancer, and patients with estrogen receptor-positive disease are treated using antiestrogens or aromatase inhibitors to inhibit estrogen signalling. Now however, it is apparent that the androgen receptor can in some cases drive breast cancer progression and is a therapeutic target, resulting in clinical trials for androgen receptor-targeting therapies in advanced breast cancer. The androgen receptor, itself long the main therapeutic target in prostate cancer, is emerging as a key player in metabolic disease, while conversely other nuclear receptor including the glucocorticoid receptor and several orphan nuclear receptors are implicated in prostate cancer progression. Meanwhile, given the impact of many nuclear receptors on the central nervous system, it is unsurprising that they are being explored in the context of neurological disorders and depression. Thus there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases.
Crosstalk between nuclear receptors and other fundamental processes is another exciting expanding area that will also be covered. DNA damage repair pathways are inextricably linked to steroid signalling via transcriptional processes, with implications for drug combinations in several diseases. Hitherto unsuspected roles of nuclear receptors in epigenetic control and the processing and function of non-coding RNAs opens up to capacity of this superfamily to further means of impacting on development and normal functioning, but also on disease development.
This unique meeting will bring together many of the leading figures in nuclear receptor research from across the globe, to discuss emerging roles and their implications for health and disease – and both human and drug development – in an intimate meeting that will generate meaningful idea exchange and interaction that will help to further shape this influential field.
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- Further emerging roles for nuclear receptors in cancer
- Structural insights into nuclear receptor function and crosstalk
- Nuclear receptors’ role in epigenetic regulation and non coding RNA
- Nuclear receptors and DNA damage
- Nuclear receptors and cell cycle
- Nuclear receptors in metabolism/metabolic disease
- Nuclear receptors in the CNS
Scientists and Clinician Scientists at a range of levels from postdoctoral and up: Principal Investigators, Junior Team Leaders, Research Fellows. Ambitious postgraduate students in the field will also be encouraged to attend.
Relevant specialties are wide-ranging, reflecting the importance of nuclear receptors in many aspects of health and disease. These include Endocrinology, Oncology, Paediatrics, Urology, Gynaecology, Obstetric Medicine, Neuroscience, Cardiology.
Take advantage of this fantastic opportunity for students! Register an academic at the earlybird rate of $1,748.00 and bring a student for only $745. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 27th February, 28th February and 1st March 2018 (on a shared basis for students, note guest rooms are open plan) and a 24hour all-inclusive food and beverage package for the conference period. Once you have registered and paid in full, please contact Meredith Willmott (Meredith@fusion-conferences.com) to obtain a special registration link for your student.
We are delighted to be working with Bioscientifica publishing house to publish abstracts from the Nuclear Receptors Conference, 27th February – 02nd March 2018 in Cancun, Mexico. Bioscientifica publishes many of the leading journals and online products in endocrinology on behalf of, and in collaboration with, key endocrine societies worldwide. They provide permanent, citable, free-to-read records of meeting abstracts, ensuring the content from an event remains discoverable and available in perpetuity, prolonging the life of the event.
If consent is given abstracts from speakers, oral presenters and poster presenters will be published. Please see the Bioscientifica website for more information about them.
If you would like your abstract to be published, please provide consent by confirming via email (firstname.lastname@example.org). Please note this opportunity is not mandatory we will only publish abstracts if consent has been given.
Confirmed Plenary Speakers
Geoffrey Greene (The University of Chicago)
UNDERSTANDING AND EXPLOITING STEROID RECEPTOR CROSS TALK IN HORMONE SENSITIVE CANCERS
Bert O'Malley (Baylor College of Medicine)
NUCLEAR RECEPTORS AND THEIR COACTIVATORS: AN ENTRE TO UNDERSTANDING HUMAN DISEASES
David Moore (Baylor College of Medicine)
Confirmed Invited Speakers
Myles Brown (Dana-Farber Cancer Institute/ Harvard Cancer Center )
Suzanne Conzen (The University of Chicago)
Scott Dehm (University of Minnesota)
Frank Claessens (University of Leuven)
DIRECT AND INDIRECT EFFECTS OF ANDROGENS ON THE MUSCULOSKELETAL SYSTEM
Theresa Hickey (The University of Adelaide)
Lee Kraus (The University of Texas Southwestern Medical Center)
Luca Magnani (Imperial College London)
MAPPING THE EPIGENOME OF BREAST CANCER PATIENTS TO EXPOSE NEW MECHANISMS OF ENDOCRINE THERAPY RESISTANCE
Susanne Mandrup (University of Southern Denmark)
TRANSCRIPTIONAL NETWORKS REGULATING MSC DIFFERENTIATION
Sebastiaan Meijsing (Max Planck Institute for Molecular Genetics)
TRANSCRIPTIONAL REGULATION BY THE GLUCOCORTICOID RECEPTOR: ROLE OF DNA SHAPE AND SEQUENCE IN MODULATING OUTPUT AND NOISE
Eric Ortlund (Emory University)
TARGETING LRH-1 WITH SMALL MOLECULE MODULATORS
Steffi Oesterreich (Women's Cancer Research Institute)
Eva Estébanez-Perpiñá (University of Barcelona)
David Ray (The University of Manchester)
Philippa Saunders (University of Edinburgh)
ANDROGENS AND ENDOMETRIAL FUNCTION: REPLICATION, REPAIR AND REGENERATION
Carol Sartorius (University of Colorado)
PROGESTERONE RECEPTOR REGULATION OF CANCER CELL TRANSLATION
Carlie de Vries (University of Amsterdam)
NUR77 GOES METABOLIC IN MACROPHAGES
Catherine Williamson (King's College London)
Wilbert Zwart (Netherlands Cancer Institute)
All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.
Additional night prices are per person, per night. Accompanying persons are not permitted access to the conference.
Accompanying child fees and extra night child fees are applicable for children aged 5-12 years of age. Children aged 13 years and older are classified as an adult at this venue (Fiesta Americana Condesa).
What's Included in our Registration Fees?
The Fiesta Americana Condesa, Cancun offers a 24hour all inclusive service. Our registration and additional adult/child fees are inclusive of the following;
- Accommodation for 3 Nights (27th February, 28th February and 1st March 2018).
- Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.
- International Bar available by the glass in restaurants and bars according to operational hours.
- Pool snacks and International Bar available by the glass at Pool Area.
- Minibar including: soft drinks, domestic beer, bottled water and coffee. Refreshed daily.
- 24 Hour Room Service.
- In Room amenity – Bottle of wine, per room, per stay.
- Gala Night Entry (includes an open bar).
- Complimentary WI-FI throughout the hotel.
Additional nights (per person) are inclusive of the following;
- Accommodation for 1 Night
- Lunch on day of arrival
- Dinner on day of arrival
- Breakfast on day of departure
- International bar available by the glass in restaurants and bars from lunch on day of arrival until breakfast on day of departure
University of chicago
Baylor College of Medicine
Baylor College of Medicine
Max Planck Institute for Molecular Genetics
Carlie de Vries
Academic Medical Center, Uni of Amsterdam
University of Adelaide
W. Lee Kraus
Ut Southwestern Medical Center
Imperial College London
The University of Edinburgh
University of Southern Denmark
University of Manchester
Women's Cancer Research Institute
Although the programme has not yet been released, we are able to confirm that the conference should begin no earlier than 14:45 with opening comments on 27th March 2018. Registration and a welcome lunch should be available from 14:00. The conference will conclude no later than 12:30 on 2nd March 2018.
Fiesta Americana Condesa
Blvd.Kukulkán km 16.5 Zona Hotelera,
This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
The Fiesta Americana Condesa, Cancun is the 2015 Winner of the Trip Advisor Certificate of Excellence and also received the Travellers Choice Award in 2014.
The remains of ancient Mayan cities are scattered throughout the Yucatan Peninsula and no trip to Cancun would be complete without a visit to these majestic temples and pyramids set amongst lush tropical vegetation. We will be working very closely with a reputable tour company who will be organising trips to Tulum, Chichen Itza, Coba and Xcaret to name a few, some of which may require a full day. Full day excursions will be arranged pre or post conference and may be on an individual or group booking so we would recommend booking extra nights to extend your stay as early as possible to avoid disappointment should these excursions be of interest to you and/or your party. For further information please contact us.
Fiesta Americana Condesa
Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.
Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.
Details will be available at a later date.
Details will be available at a later date.
Talk Deadline: 06 Nov 2017
We have a number of oral opportunities available at this meeting. To be considered for a talk, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.
Please take note of the oral submission deadline:
6th Nov 2017
Please check the conference programme carefully to note your presentation time (inclusive of Q&A) should you be accepted for an oral presentation. We recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference page.
Your Presentation on the Day
If you have prepared some slides to accompanying your talk please ensure you bring these with you on a USB or portable file saving device.
For those presenting on the first day, please email your slides to us so we can have everything prepared and ready for the first session. Please email your slides to: email@example.com
On the day of your presentation please make yourself known to the AV team who will be available in the conference room. If you have any animations or videos we do advise to run through the presentation with the AV tech to make sure everything is compatible. We also advise that all speakers make themselves known to the AV tech in the conference room immediately before your session beings. The AV tech will apply your microphone and provide a laser pointer should you have an accompanying presentation. We prefer speakers to use our master laptop to run presentations from, however, if you prefer to use your own laptop, please notify us in advance.
It is important that all speakers adhere to their presentation time and respect their fellow presenters. A visual traffic light aide will be available to warn presenters and the audience as your time decreases.
If you have any questions, please don’t hesitate to approach our AV tech or a member of the Fusion team.
Helpful Tips for Presentation Slides
Aspect Ratio: 4:3 in Presenter View, Landscape in Orientation
Font Size: Minimum font size used should be 24pt.
File Type: Please save your presentation in PPT or PPTS format.
Video Clips: Please save these separately and do not build them into the PowerPoint. Videos will be played via the AV control desk using the master laptop.
Poster Deadline: 15 Dec 2017
We have a number of poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.
Please take note of the poster submission deadline: 15th Dec 2017
Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.
Displaying & Presenting Your Poster
During conference registration if you are presenting a poster please request a poster number from the registration desk. Please do not put up your poster without notifying a member of the Fusion team. Certain adhesive agents are not permitted at some venues therefore; Fusion will be the sole provider of all poster fixings.
You can display your poster from registration. Your poster can remain on display for the entire duration of the conference and we ask that posters are taken down on the final day of the meeting. The poster session is usually scheduled on Day 3, but please check the official programme for exact timings. Refreshments will be provided and the poster prizes will be awarded during the conference Gala Night that evening.
2018 Nuclear Receptors Poster Prize
The conference chairs will be awarding 3 poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 15 December 2017. The winners will be selected shortly after the Poster Session and the following prizes will be awarded: 1st Place $350, 2nd Place $250, 3rd Place $150.