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Home > Conferences > 2nd DNA Replication as a Source of DNA Damage Conference

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Registration Deadlines

Last Chance – 26 May 2017

Poster Submission – 26 May 2017

Talk Submission – expired

Early bird – expired

Past Conference

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health

03 Jul 2017 - 06 Jul 2017

Rome, Italy

Synopsis

The maintenance of genome integrity is critical for the suppression of cancer and premature ageing. Only recently has it become appreciated that DNA replication stress is a crucial driver of genomic instability. The timely progression of replisomes can be disrupted by lesions and secondary structures in the template, by bound proteins and by conflicts with the transcription machinery. A prolonged pause of the replisome then exposes single stranded DNA, which, due to its recombinogenic nature, can lead to genome rearrangements, fragile site expression and cell death. Importantly, some cancers present excessive endogenous levels of replication stress, which can be exploited for their clearance. In this conference, we aim to bring together scientists studying DNA replication and repair, with those interested in how DNA damage can influence cancer and ageing.

Key Sessions

  • Pathways for repair of damaged replication forks
  • Systems for site-specific perturbation of replication
  • Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins
  • Replication perturbation as a driver of tumorigenesis and ageing
  • Exploitation of replication defects in cancer treatment

Confirmed Speakers

Andre Nussenzweig (NIH/NCI)
'MECHANISMS OF GENOME INSTABILITY'

Johannes Walter (Harvard Medical School)
'NEW MECHANISMS OF REPLICATION-COUPLED DNA CROSS-LINK REPAIR'

Jiri Lukas (University of Copenhagen)
'CONFINEMENT AND HERITABILITY OF CELLULAR RESPONSES TO DNA REPLICATION STRESS'

Stephen West  (The Francis Crick Institute)
'UNRESOLVED RECOMBINATION INTERMEDIATES AS A SOURCE OF DNA BREAKS AND CHROMOSOME ABERRATIONS'

David Cortez (Vanderbilt University School of Medicine)
'REGULATION OF REPLICATION FORK STABILITY BY SINGLE-STRANDED DNA BINDING PROTEINS'

John Diffley (The Francis Crick Institute)

Thanos Halazonetis (University of Geneva)
'MECHANISMS OF ONCOGENE-INDUCED DNA REPLICATION STRESS'

Andrew Jackson (University of Edinburgh)
'DONSON ENCODES A NOVEL  REPLICATION FORK PROTECTION FACTOR MUTATED IN MICROCEPHALIC DWARFISM'

Thomas Helleday (Karolinska Institutet)
'IMPORTANCE OF ACCURATE AND TIMELY SUPPLY OF dNTPs FOR REPLICATION'

Juan Mendez (CNIO)

Jos Jonkers (Netherlands Cancer Institute)
'GENETIC DETERMINANTS OF TUMOR DEVELOPMENT, THERAPY RESPONSE AND RESISTANCE IN MOUSE MODELS OF BRCA-DEFICIENT BREAST CANCER'

Evi Soutoglou (IGBMC)
'DNA REPAIR PATHWAYS IN DIFFERENT HETEROCHROMATIN STRUCTURES'

Madalena Tarsounas (University of Oxford)

Niels Mailand (University of Copenhagen)

KJ Patel (University of Cambridge)

Andres Lopez-Contreras (University of Copenhagen)

Luis Ignacio Toledo Lazaro (University of Copenhagen)
'EXPLORING THE UNCOUPLING OF ENZYMATIC ACTIVITIES AT REPLICATION FORKS'

Arne Lindqvist (Karolinska Institutet)
'DNA REPLICATION IS AN INTEGRAL COMPONENT OF THE CELL-CYCLE ENGINE'

Wojciech Niedzwiedz (University of Oxford)

Philip Zegerman (The Gurdon Institute)
'CHECKPOINT KINASE TARGETTING OF DNA REPLICATION COMPLEXES'

Angelos Constantinou (CNRS)
'DIHYDROPYRIMIDINASE PROTECTS AGAINST DNA REPLICATION STRESS INDUCED BY PYRIMIDINE METABOLITES'

Eva Hoffmann (University of Sussex)

Michael Lisby (University of Copenhagen)
'Mte1/ZGRF1 MAINTAINS GENOME STABILITY DURING REPLICATION STRESS'

Manuel Mendoza (Centre de Regulació Genòmica)
'CELLULAR DETECTION OF CHROMATIN BRIDGES BY THE NoCut ABSCISSION CHECKPOINT'

Target Audience 

The conference aims to target a wide spectrum of scientists interested on how chromosomal rearrangements are generated, and their impact on cancer and ageing: The talks will include studies at various levels ranging from basic molecular biology to clinical studies on human patients. The conference will also appeal to oncologists and pharmaceutical companies with an interest in targeting replication stress as an Achilles’ heel in cancer.

Prices

All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.

Early Bird Full
Price
Additional
Adult
Additional
Child
Extra Night
Adult
Extra Night
Child
Academic €1,173.00 €1,263.00 €633.00 Free €152.00 Free
Industry €1,173.00 €1,236.00 €633.00 Free €152.00 Free
Student €1,008.00 €1,098.00 €633.00 Free €152.00 Free

Additional night prices are per person, per night. Accompanying persons are not permitted access to the conference.

We are pleased to confirm that for this particular meeting, the Student registration fee is also applicable to Postdocs.

What's Included in our Registration Fees?

Our registration fees are inclusive of the following during the conference period only:

- Conference registration
- 3 Nights’ fixed accommodation (03, 04, 05 July 2017) on a single basis for academics and industry, on a shared basis for students/Postdocs
- Buffet Breakfast with a selection of hot beverages and fresh juices
- 2 Course Buffet Lunch with a selection of free flow soft drinks
- 3 Course Buffet Dinner with a selection of free flow soft drinks and wine
- Gala Night entry (includes complimentary drink tickets)
- Complimentary WIFI in both conference rooms and your guest room

What's Included in our Accompanying Adult Fees?

Our accompanying adult fees are inclusive of the following during the conference period only:

- 3 Nights’ fixed accommodation (03, 04, 05 July 2017) on a shared basis with a conference participant
- Buffet Breakfast with a selection of hot beverages and fresh juices
- 2 Course Buffet Lunch with a selection of free flow soft drinks
- 3 Course Buffet Dinner with a selection of free flow soft drinks and wine
- Gala Night entry (includes complimentary drink tickets)
- Complimentary WIFI in both conference rooms and your guest room.

Important Note: Accompanying persons are not permitted access to the conference.

What's Included in our Accompanying Child Fees?

Our accompanying child fees are inclusive of the following during the conference period only:

- 3 Nights’ fixed accommodation (03, 04, 05 July 2017) on a shared basis with the parent/s (roll out bed supplied)
- Buffet Breakfast with a selection of hot beverages and fresh juices

Important Note: Accompanying child fees are applicable for children aged 10 years and younger. Children aged 11 years and older will be charged a €30 supplement per night. Children will be charged on consumption for all food and beverage (a supplement of €20 per child, per meal will be charged if you wish them to join conference lunches and dinner).

What's Included in our Extra Night Fees?

Additional nights are inclusive of one night’s accommodation and buffet breakfast only (applicable for adults and children aged 10 years or younger).

Speakers

Invited Speakers

  • Stephen West
    Stephen West
    Francis Crick Institute
  • John Diffley
    John Diffley
    The Francis Crick Institute
  • Johannes Walter
    Johannes Walter
    Harvard Medical School
  • Thomas Helleday
    Thomas Helleday
    Karolinska Institutet
  • Jiri Lukas
    Jiri Lukas
    Novo Nordisk Foundation Center for Protein Research
  • Dr. Andre Nussenzweig
    Dr. Andre Nussenzweig
    National Insitutes of Health
  • Angelos Constantinou
    Angelos Constantinou
    IGH-Institute of Human Genetics, CNRS UPR 1142
  • Manuel Mendoza
    Manuel Mendoza
    Centre for Genomic Regulation
  • Andrew Jackson
    Andrew Jackson
    MRC Human Genetics Unit
  • David Cortez
    David Cortez
    Vanderbilt University
  • Andres Lopez-Contreras
    Andres Lopez-Contreras
    CNIO
  • Jos Jonkers
    Jos Jonkers
    Netherlands Cancer Institute
  • Michael Lisby
    Michael Lisby
    University of Copenhagen
  • Luis Toledo
    Luis Toledo
    Center for Chromosome Stability - 18.1
  • Philip Zegerman
    Philip Zegerman
    Gurdon Institute
  • Wojciech Niedzwiedz
    Wojciech Niedzwiedz
    Oxford University
  • Eva Hoffmann
    Eva Hoffmann
    Department of Molecular Genetics, University of Lodz
  • Evi Soutoglou
    Evi Soutoglou
    IGBMC
  • Arne Lindqvist
    Arne Lindqvist
    Karolinska Institutet
  • Thanos Halazonetis
    Thanos Halazonetis
    University of Geneva
  • Juan Méndez
    Juan Méndez
    Spanish National Cancer Research Centre (CNIO)
  • Madalena Tarsounas
    Madalena Tarsounas
    The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford

Programme

Although the programme has not yet been released, we are able to confirm that the conference should begin no earlier than 14:45 with opening comments on 03rd July 2017. Registration and a welcome lunch should be available from 14:00. The conference will conclude no later than 12:30 on 06th July 2017.

Sponsors

No Sponsors info available

Sponsor this conference

Venue

Sheraton Roma

Rome, Italy

Sheraton Roma Sheraton Roma Sheraton Roma Sheraton Roma

Venue Rating
4 Stars
Currency
Euro (EUR)
Address
Viale del Pattinaggio, 100
00144
Rome
Italy
Nearest Airport
Fiumicino Airport

Hotel Details

The Sheraton Roma is ideally situated in the EUR Monumental neighbourhood, between the ancient city centre and Fiumicino Airport, providing an ideal location for all conference attendees to enjoy the magnificent historical and cultural sites this ancient and beautiful city has to offer.
 
Throughout the conference period you will enjoy a delicious buffet breakfast, followed by lunch served by the pool (weather permitting) and will round off the day with a delectable buffet dinner. The themed Gala Night takes place on the third evening of the conference with a mouth-watering feast exclusively designed by the head chef and entertainment provided by a live band.  We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
 

Hotel Facilities:

  • AQVI Pool Restaurant & Bar
  • Gymnasium
  • Putting green
  • Garden pathway - Walk, race, jog, sprint, dash or run in the circular garden pathway that surrounds the hotel
  • Outdoor tennis court
  • Squash courts
  • Outdoor pool (seasonal)
  • Golf courses nearby
  • Laundry/valet service
  • 24-hour room service
  • Cash machine (ATM)
  • Air conditioned facilities
  • Free Wi-Fi
  • Bus service to downtown (limited)
  • Car rental desk
  • Shopping arcade in Hotel
  • Business Center
  • Parking Available

Location

Sheraton Roma

Rome, Italy

Venue Rating
4 Stars
Currency
Euro (EUR)
Nearest Airport
Fiumicino Airport

Location Details

The Sheraton Roma is ideally situated in the green EUR Monumental neighbourhood, between the ancient city centre and Fiumicino Airport, providing an ideal location for all conference attendees to enjoy the magnificent historical and cultural sites this ancient and beautiful city has to offer.

Just a short taxi or bus ride, no more than 6 miles,  will take you to the majestic Colosseum, Sistine Chapel, Vatican City, Trevi Fountain, Pantheon, Spanish Steps and the numerous wondrous museums and gardens. 

Fiumicino Airport is just 13 miles (21km) from the Sheraton Roma and Ciampino Airport 11.8 miles (19km) with the drive time approximately 20 minutes.

Transport

To be announced.

Activities

To be announced.

Group Activities

To be announced shortly

Oral Presenters

Talk Deadline: 06 Feb 2017

We have a number of oral opportunities available at this meeting. To be considered for a talk, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the oral submission deadline: 06 February 2017.

Please check the conference programme carefully to note your presentation time (inclusive of Q&A) should you be accepted for an oral presentation. We recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference page.

Your Presentation on the Day

If you have prepared some slides to accompanying your talk please ensure you bring these with you on a USB or portable file saving device.

For those presenting on the first day, please email your slides to us so we can have everything prepared and ready for the first session. Please email your slides to: admin@fusion-conferences.com

On the day of your presentation please make yourself known to the AV team who will be available in the conference room. If you have any animations or videos we do advise to run through the presentation with the AV tech to make sure everything is compatible. We also advise that all speakers make themselves known to the AV tech in the conference room immediately before your session beings. The AV tech will apply your microphone and provide a laser pointer should you have an accompanying presentation. We prefer speakers to use our master laptop to run presentations from, however, if you prefer to use your own laptop, please notify us in advance.

It is important that all speakers adhere to their presentation time and respect their fellow presenters. A visual traffic light aide will be available to warn presenters and the audience as your time decreases.

If you have any questions, please don’t hesitate to approach our AV tech or a member of the Fusion team.

Helpful Tips for Presentation Slides

Aspect Ratio: On Screen Show (16:9) and in Landscape Orientation; in any other format (i.e 4:3) your presentation will not fill our screens.
Font Size: Minimum font size used should be 24pt. 
File Type: Please safe your presentation in PPT or PPTS format. 
Video Clips: Please save these separately and do not build them into the PowerPoint. Videos will be played via the AV control desk using the master laptop.

Download Template

Posters

Poster Deadline: 26 May 2017

We have a number of poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the poster submission deadline: 26 May 2017.

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

During conference registration if you are presenting a poster please request a poster number from the registration desk. Please do not put up your poster without notifying a member of the Fusion team. Certain adhesive agents are not permitted at some venues therefore; Fusion will be the sole provider of all poster fixings.

You can display your poster from registration. Your poster can remain on display for the entire duration of the conference and we ask that posters are taken down on the final day of the meeting. The poster session is usually scheduled on Day 3, but please check the official programme for exact timings. Refreshments will be provided and the poster prizes will be awarded during the conference Gala Night that evening. 

2017 DNA Poster Prize

The conference chairs will be awarding 3 poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 26 May 2017. The winners will be selected shortly after the Poster Session and the following prizes will be awarded: 1st Place €300, 2nd Place €200, 3rd Place €100.

Download Template