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Home > Past Conferences > Cell Death, Cell Stress and Metabolism Conference

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Cell Death, Cell Stress and Metabolism Conference

From Basic Mechanisms to Novel Treatment Options

14 Mar 2017 - 17 Mar 2017

Cancun, Mexico

Synopsis

Urgent Notice: Registration without accommodation is now available! You can still register for the meeting however the conference venue has now reached full occupancy so we are therefore unable to offer a registration package inclusive of accommodation for participants that register post 16th January. In place of this, we are offering a day pass registration package ($955 for four days) which includes conference registration and an inclusive food and beverage package from 8am – 11pm per day for the conference period. Accommodation will have to be arranged independently, please contact us should you require any nearby hotel suggestions. Please direct enquiries to Emily Bicknell (emily@fusion-conferences.com) if you are interested in obtaining a day pass registration package.

The interplay between cell death, cell stress and metabolism plays a crucial role in shaping normal turnover of tissues, in sensing of danger posed by pathogens or other damage and the immunological response that is mounted to response to them.

At this conference we will discuss the basic biological principles that govern cell death, cell stress and metabolism. We will also cover how cellular stress and alterations in metabolism influence the cellular death programs such as apoptosis, necroptosis, ferroptosis and others.

Importantly, this conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues in the fields of cell death, cell stress and metabolism will be presented and discussed.   

Target Audience

We anticipate representation from researchers interested in cell death, cell stress and metabolism in both academia and the biotech/pharma industries who want to be on top of these interconnected fields and participate in an international meeting serving as platform for presentation and discussion of the most up-to-date preclinical and clinical work emerging from them.

Learning Objectives

  1. To be on top of the field with the diversity of new mechanisms of cell death induction, in addition to apoptosis, which recently entered this field of research
  2. To understand the interplay between cell death, cell stress and metabolism
  3. To develop an understanding for where the treatment options are currently seen in these fields 
  4. To learn what is presently being developed preclinically and what is already in clinical trials
  5. To develop a good sense for where the opportunities for the future lie, both with respect of mechanistic insight and treatment options for the various diseases affected by dysregulated cell death, cell stress and metabolism

Invited Speakers

Henning Walczak (UCL Cancer Institute)
"LINEAR UBIQUITIN IN CELL DEATH, INFLAMMATION AND IMMUNITY"

Poul Sorensen (BC Cancer Research Centre)
"STRESS-MEDIATED TRANSLATIONAL CONTROL OF TUMOR METASTASIS”

Vishva Dixit (Genentech)
"WHY SO MANY WAYS TO DIE? THE NON-CANONICAL INFLAMMASOME PATHWAY"   

Douglas Green (St. Jude Children's Research Hospital)
"CELL DEATH AND RESUSCITATION:  TO THE EDGE OF NECROPTOSIS AND BACK"

Karen Vousden (CRUK, Glasgow)
"A ROLE FOR p53 IN RESPONSE TO METABOLIC STRESS"

Manolis Pasparakis (University of Cologne)
"RIPK1 IN CELL DEATH AND INFLAMMATION"

Michael Karin (UCSD)
"METABOLISM, INFLAMMATION AND IMMUNITY IN LIVER CANCER"

Celeste Simon (University of Pennsylvania)
"STRIKING A BALANCE BETWEEN CELLULAR GROWTH AND HOMEOSTASIS"

Scott Lowe (MSKCC)
"TUMOR SUPPRESSOR AND TUMOR MAINTENANCE GENES"

Jiri Bartek (Danish Cancer Society)
"REPLICATION STRESS: MECHANISMS AND RELEVANCE FOR CANCER DEVELOPMENT AND TREATMENT"

Navdeep Chandel (Northwestern University)
"WHY MAMMALIAN CELLS RESPIRE?"

Ralph Deberardinis (UT Southwestern)
"METABOLIC PHENOTYPES AND VULNERABILITIES IN CANCER CELLS"

Gerry Melino (MRC Toxicology Unit Leicester, University of Rome – Tor Vergata Italy)
"THE p53 FAMILY IN CANCER BIOLOGY"

Andreas Linkermann (Universitätsklinikum Carl Gustav Carus)
"HUMAN pMLKL AND ESCRT-EXPRESSION IN ACUTE KIDNEY INJURY AND KIDNEY TRANSPLANTATION"

Brent Derry (University of Toronto)
"YOUR NEIGHBOURS MATTER! NON-AUTONOMOUS CONTROL OF CELL DEATH IN C. elegans”

Atan Gross (Weizmann Institute of Science)
"THE MANY FACES OF MITOCHONDRIA"

William Kaiser (University of Texas Health Science Center San Antonio)
"DAI’ING TO FIGHT HERPESVIRUSES"

Pascal Meier (the Institute of Cancer Research)
'UBIQUITIN-MEDIATED REGULATION OF CELL DEATH AND INFLAMMATION'

Ana J. García-Sáez (University of Tübingen)
"NECROPTOSIS EXECUTION IS MEDIATED BY PLASMA MEMBRANE NANOPORES INDEPENDENT OF CALCIUM"

Mads Daugaard (University of British Columbia)
"GLYCOSAMINOGLYCANS IN CANCER"

Claudio Mauro (William Harvey Research Institute)
“LOCAL AND SYSTEMIC METABOLIC CONTROL OF THE ADAPTIVE IMMUNE RESPONSE”

Will Wood (University of Bristol)
‘DETECTING DEATH AND DAMAGE; MACROPHAGE MIGRATION IN DROSOPHILA’

Ivan Topisirovic (McGill University)
EXPLOITING CROSS-TALK BETWEEN THE TRANSLATION APPARATUS AND THE METABOLOME IN CANCER

Mike Overholtzer (MSKCC)
"CELL POPULATION EFFECTS OF FERROPTOSIS AND ENTOSIS"

Scott Dixon (Stanford University)
"FERROPTOSIS: AN UNUSUAL FORM OF METABOLIC STRESS-INDUCED CELL DEATH"

Lars Jønson (Roche Innovation Center Copenhagen)
"RNA THERAPEUTICS - DEVELOPING A NEW CLASS OF DRUGS"

Michael Pollak (McGill University)
"A NEW METFORMIN – P53 LINK"

Sponsors

Sponsors

Programme

TUESDAY 14TH MARCH 2017

14:00 – 14:45

Registration & Reception

14:00 – 14:45

Group Welcome Lunch
*Kalmia Buffet Restaurant*

CELL DEATH, CELL STRESS & METABOLISM I
Session Chairs: Michelle Kelliher & Henning Walczak

14:45 – 15:00

Opening Comments by Henning Walczak & Poul Sorensen

15:00 – 15:30

Will Wood
University of Bristol

DETECTING DEATH AND DAMAGE: MACROPHAGE MIGRATION IN DROSOPHILA

15:30 – 16:00

Manolis Pasparakis
University of Cologne

RIPK1 IN CELL DEATH AND INFLAMMATION

16:00 – 16:30

Michelle Kelliher
UMass Medical School

ENDOTHELIAL RIPK1 IN TNF-INDUCED ENDOTOXIC SHOCK

16:30 – 17:00

Pascal Meier
Institute of Cancer Research

UBIQUITIN-MEDIATED REGULATION OF CELL DEATH AND INFLAMMATION

17:00 – 17:30

Refreshments

17:30 – 18:00

Henning Walczak
University College London

DEATH RECEPTORS AND UBIQUITIN IN INFLAMMATION, IMMUNITY AND CANCER

18:00 – 18:15

Maurice Darding
University College London

DEFICIENCY IN THE DIFFERENT LUBAC COMPONENTS: A SURPRISE IN THREE ACTS

18:15 – 18:30

Beiyun Liu
Tufts University

HOST-INTRINSIC IFN DRIVES TWO FORMS OF LPS-INDUCED NECROTIC CELL DEATH

18:30 – 19:00

Ralph Deberardinis
UT Southwestern

METABOLIC PHENOTYPES AND VULNERABILITIES IN CANCER

19:00 – 19:15

Erik Norberg
Karolinska Institute

PHGDH DEFINES A METABOLIC SUBTYPE IN LUNG CANCER ADENOCARCINOMAS WITH POOR PROGNOSIS DISPLAYING UNIQUE METABOLIC DEPENDENCIES

19:15 – 19:45

Atan Gross
Weizmann Institute of Science

THE MANY FACES OF MITOCHONDRIA

19:45 – 20:15

Michael Karin
UCSD

METABOLISM, INFLAMMATION AND IMMUNITY IN LIVER CANCER

20:15

Drinks at the Lobby Bar followed by Dinner at Leisure & Free Time

WEDNESDAY 15TH MARCH 2017

07:00 – 09:00

Breakfast
*Kalmia Buffet Restaurant*

CELL DEATH, CELL STRESS & METABOLISM II
Session Chairs: Celeste Simon & Poul Sorensen

09:00 – 09:30

Robin Aglietti
Genentech

WHY SO MANY WAYS TO DIE? THE NON-CANONICAL INFLAMMASOME PATHWAY

09:30 – 10:00

Poul Sorensen
BC Cancer Research Center

STRESS-MEDIATED TRANSLATIONAL CONTROL OF TUMOR METASTASIS

10:00 – 10:15

Bo Rafn
BC Cancer Research Center

ETV6-NTRK3 REGULATION OF OXIDATIVE STRESS IN BREAST CANCER

10:15 – 10:45

Refreshments & Group Photo

10:45 – 11:15

Ana Garcia Saez
University of Tuebingen

NECROPTOSIS EXECUTION IS MEDIATED BY PLASMA MEMBRANE NANOPORES INDEPENDENT OF CALCIUM

11:15 – 11:30

Sam Katz
Yale University

BOK CONTROLS CALCIUM TRANSFER THROUGH ER-MITOCHONDRIAL CONTACT SITES

11:30 – 11:45

Reuven Stein
Tel Aviv University

TARGETING CD38 IN THE TUMOR MICROENVIRONMENT INHIBITS GLIOMA AND MELANOMA PROGRESSION

11:45 – 12:15

Navdeep Chandel
Northwestern University

WHY MAMMALIAN CELL RESPIRE

12:15 – 16:30

Lunch at Leisure & Free Time

16:30 – 17:00

Michael Pollack
McGill University

A NEW METFORMIN-P53 LINK

17:00 – 17:15

Iñigo San-Millán
University of Colorado

REEXAMINING  CANCER METABOLISM: LACTATE PRODUCTION FOR CARCINOGENESIS AS THE PURPOSE AND EXPLANATION OF THE WARBURG EFFECT

17:15 – 17:45

Ivan Topisirovic
McGill University

EXPLOITING CROSSTALK BETWEEN THE TRANSLATION APPARATUS AND THE METABOLOME IN CANCER

17:45 – 18:00

Laura Hulea
McGill University

EIF4F LINKS TRANSLATION TO ENERGY STRESS RESPONSE IN CANCER

18:00 – 18:30

Claudio Mauro
Barts and The London SMD

LOCAL AND SYSTEMIC METABOLIC CONTROL OF THE ADAPTIVE IMMUNE RESPONSE

18:30 – 19:00

Refreshments

19:00 – 19:30

Brent Derry
University of Toronto

YOUR NEIGHBORS MATTER! NON-AUTONOMOUS CONTROL OF CELL DEATH IN C. ELEGANS

19:30 – 20:00

Jiri Bartek
Danish Cancer Society

REPLICATION STRESS: MECHANISMS AND RELEVANCE FOR CANCER DEVELOPMENT AND TREAT

20:00 – 20:15

Denise Montell
UCSB

ANASTASIS: RECOVERY FROM THE BRINK OF DEATH

20:15 – 20:45

Doug Green
St. Jude Children's Research Hospital

CELL DEATH AND RESUSCITATION: TO THE EDGE OF NECROPTOSIS AND BACK

20:45

Dinner at Leisure & Free Time

THURSDAY 16TH MARCH 2017

07:00 – 09:00

Breakfast
*Kalmia Buffet Restaurant*

CELL DEATH, CELL STRESS & METABOLISM III
Session Chairs: Ana Garcia Saez & Manolis Pasparakis

09.00 – 09:30

Karen Vousden
Francis-Crick Institute

A ROLE FOR P53 IN RESPONSE TO METABOLIC STRESS

09:30 – 10:00

Gerry Melino
MRC Toxicology Unit

THE P53 FAMILY IN CANCER BIOLOGY

10:00 – 10:30

Mads Daugaard
University of British Columbia

GLYCOSAMINOGLYCANS IN CANCER

10:30 – 10:45

Davide Tortora
University of British Columbia

AN ONCOFETAL GLYCOSAMINOGLYCAN MODIFICATION PROVIDES THERAPEUTIC ACCESS TO MESOTHELIOMA

10:45 – 11:15

Refreshments

11:15 – 11:45

Mike Overholtzer
MSKCC

CELL POPULATION EFFECTS OF FERROPTOSIS AND ENTOSIS

11:45 – 12:00

Shefali Krishna
MSKCC

METABOLIC CONSEQUENCES OF ENTOTIC AND APOPTOTIC CELL CLEARANCE

12:00 – 12:30

Scott Dixon
Stanford University

FERROPTOSIS: AN UNUSUAL FORM OF METABOLIC STRESS-INDUCED CELL DEATH

12:30 – 12:45

Amy Tarangelo
Stanford University

INVESTIGATING THE ROLE OF P53 IN NON-APOPTOTIC CELL DEATH

12:45 – 16:30

Lunch at Leisure & Free Time

16:30 – 17:00

Andreas Linkermann
University of Dresden

HUMAN PMLKL AND ECRT EXPRESSION IN ACUTE KIDNEY INJURY AND KIDNEY TRANSPLANTATION

17:00 – 17:15

Corey Rogers
Thomas Jefferson University

CLEAVAGE OF DFNA5 BY CASPASE-3 MEDIATES PROGRESSION FROM APOPTOSIS TO SECONDARY NECROSIS

17:15 – 17:30

Kirill Rosen
Dalhousie University

THE AUTOPHAGY MEDIATOR ATG12 AS A KILLER OF ONCOGENIC RAS-CARRYING CANCER CELLS

17:30 – 17:50

Lars Joenson
Roche

RNA THERAPEUTICS – DEVELOPING A NEW CLASS OF DRUGS

17:50 – 18:20

Scott Lowe
MSKCC

TUMOR SUPPRESSOR AND TUMOR MAINTENANCE GENES

18:20 – 18:50

Celeste Simon
University of Pennsylvania

STRIKING A BALANCE BETWEEN CELLULAR GROWTH AND METABOLISM

18:50 – 20:00

Poster Session & Refreshments

20:00

*Gala Dinner & Poster Awards*

Speakers

Invited Speakers

  • Prof. Dr. Manolis Pasparakis
    Professor, University of Cologne
  • Prof. Karen Vousden
    Group Leader, CRUK Beatson Institute
  • Prof. Celeste Simon
    Scientific Director and Professor, University of Pennsylvania Perelman School of Medicine
  • Prof. Navdeep Chandel
    Professor of Medicine, Feinberg School of Medicine, Northwestern University
  • Prof. Dr. Jiri Bartek
    Department Head, Danish Cancer Society
  • Prof. Michael Karin
    Distinguished Professor of Pharmacology, UC San Diego
  • Dr. Ralph DeBerardinis
    Associate Professor, UT Southwestern Medical Center
  • Dr. Douglas Green
    Member and Chair, St Jude Children's Research Hospital
  • Prof. Scott Lowe
    Chair, Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center
  • Prof. Atan Gross
    Associate Professor, Weizmann Institute
  • Prof. Brent Derry
    Senior Scientist, The Hospital for Sick Children
  • Dr. Mads Daugaard
    Senior Research Scientist , Vancouver Prostate Centre
  • Prof. Will Wood
    Professor, University of Bristol
  • Dr. Scott Dixon
    Assistant Professor, Stanford University
  • Dr. Ivan Topisirovic
    Investigator/Assistant Professor, Lady Davis Institute/McGill University
  • Dr. Lars Joenson
    Principal Scientist, Roche Pharma Research & Early Development, Roche Innovation Center Copenhagen
  • Prof. Dr. Ana Jesus Garcia Saez
    Professor, University of Tuebingen
  • Dr. Andreas Linkermann
    Deputy Director - Department of Nephrology, UKD Dresden
  • Dr. Claudio Mauro
    Senior Lecturer, Molecular Immunology, Barts and the London School of Medicine and Dentristry
  • Prof. Pascal Meier
    Professor, Institute of Cancer Research
  • Dr. Michael Overholtzer
    Associate Professor, Memorial Sloan Kettering Cancer Center
  • Dr. Michael Pollak
    Oncologist, Jewish General Hospital
  • Prof. Gerry Melino
    Head of 'Apoptosis & Cancer' Section, MRC Toxicology Unit Leicester, University of Rome – Tor Vergata Italy

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