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DNA and Interacting Proteins as Single Molecules - In Vitro and In Vivo Conference

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DNA and Interacting Proteins as Single Molecules - In Vitro and In Vivo Conference

21 Feb 2018 - 24 Feb 2018

Cancun, Mexico

The conference registration date has past

Synopsis

This conference has now passed however, the following meetings may be of interest;

Nucleic Acids | 13-16 Feb 2019 | Nassau, Bahamas
3rd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference | 23-26 Feb 2019 | Nassau, The Bahamas

The advent of single-molecule approaches has revolutionized our understanding of Molecular Biology. Combined advances in light microscopy, microfluidics, atomic force microscopy, and DNA sequencing have opened ways to bypass population averages and study individual molecular events for a variety of cellular processes. This meeting aims to present the most recent advances in the mechanistic understanding of biological processes involving DNA at the single-molecule level, using both in vivo and in vitro approaches.

Key Sessions will cover various aspects of:

  • DNA replication
  • DNA recombination
  • DNA repair
  • Transcription
  • Chromosome dynamics
  • Genomics

Each session will be divided into in vitro and in vivo sections to highlight differences and complementary information obtained.

Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference.

Target Audience

This conference will appeal to researchers interested in the study of DNA metabolic events at the single molecule level: both in vitro and in vivo. There will be significant focus on DNA replication, DNA recombination, DNA repair and transcription. In addition, we would encourage participation from groups involved in single cell sequencing/genomics.

Learning Objectives

To further understanding of:

  1. DNA metabolic processes
  2. Single molecule approaches in vitro and data analyses
  3. Live cell single molecule approaches
  4. Single cell genomics

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the normal rate and bring a student for only $745. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 21, 22, 23 Feb 2018 (on a shared basis for students, note guest rooms are open plan) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Emily Bicknell (emily@fusion-conferences.com) to obtain a special registration link for your student.

Keynote Speaker

Steve Kowalczykowski (UC Davis)

Plenary Speakers

Yuri L. Lyubchenko (University of Nebraska Medical Center)

Achillefs Kapanidis (University of Oxford)

Fuchou Tang (Peking University)

Dave Sherratt (University of Oxford)

Peter Fraser (Babraham Institute)

Invited Speakers

Eli Rothenberg (New York University School of Medicine)

Michael O'Donnell (Rockefeller University)

Joseph Loparo (Harvard University)

Eric Galburt (Washington University in St. Louis)

Will Greenleaf (Stanford University)

Johan Elf (Uppsala University)

Mark Leake (University of York)

Jie Yan (National University of Singapore)

Jie Xiao (John Hopkins University)

Terence Strick (University of Paris)

Richard Ebright (Rutgers)

Nick Dixon (University of Wollongong)

Myron Goodman (University of Southern California)

Samir Hamdan (King Abdullah University of Science and Technology)

Kiyoshi Mizuuchi (NIDDK)

Stephan Uphoff (University of Oxford)

Long Cai (Caltech)

Sponsors

Sponsors

Programme

WEDNESDAY 21ST FEBRUARY

14:00 – 15:00

Registration & Reception

14:00 – 15:00

Welcome Lunch
*Kalmia Buffet Restaurant*

15:00 – 15:15

Opening Comments

DNA Recombination
Dave Sherratt

15:15 – 16:00

Steve Kowalczykowski
UC Davis                                                             

SINGLE-MOLECULE VISUALIZATION OF PROTEIN-DNA COMPLEXES: UNDERSTANDING BIOLOGY, ONE MOLECULE AT A TIME

16:00 – 16:30

Eli Rothenberg
New York University School of Medicine   

SINGLE-MOLECULE STUDIES OF HUMAN DNA DOUBLE STRAND BREAK REPAIR PATHWAYS IN VITRO AND IN CELLS

16:30 – 17:00

Jie Yan
National University of Singapore

LABEL-FREE QUANTIFICATION OF SEQUENCE AND STRUCTURE SPECIFIC DNA-PROTEIN INTERACTIONS

17:00 – 17:30

Refreshments

17:30 – 18:00

Jie Xiao
John Hopkins University

MULTISTABLE CELL FATE DECISION - A SINGLE-MOLECULE STUDY OF GENE REGULATION

18:00 – 18:30

Joseph Loparo
Harvard University

VISUALIZING DNA BREAK REPAIR: HOW THE NHEJ MACHINERY MINIMIZES MISTAKES

18:30 – 18:45

Sharonda LeBlanc
University of North Carolina, Chapel Hill

THE DYNAMICS OF MISMATCH REPAIR INITIATION

18:45 – 19:00

Kata Sarlós

University of Copenhagen

SINGLE-MOLECULE AND BIOCHEMICAL RECONSTITUTION OF ANAPHASE DNA BRIDGE DISJUNCTION

 

19:00 – 19:30

Piero Bianco
University at Buffalo

INSIGHT INTO STALLED DNA REPLICATION FORK RESCUE IN E.COLI

19:30

Dinner at Leisure

THURSDAY 22ND FEBRUARY

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

Chromosome Dynamics

Tim Lohman

08:30 – 09:15

Dave Sherratt
University of Oxford

THE ACTION OF SINGLE MukBEF SMC COMPLEXES IN LIVE E. COLI CELLS

09:15 – 09:30

Hong Wang
North Carolina State University

COHESIN SA1 AND SA2 RECOGNIZE SPECIFIC DNA SEQUENCES AND STRUCTURES: A TALE OF TWO PROTEINS

 

09:30 – 10:00

Sunney Xie
Harvard University

3D GENOME STRUCTURES OF SINGLE DIPLOID HUMAN CELLS

10:00 – 10:30

Refreshments

10:30 – 11:00

Terence Strick
Ecole normale supérieure/CNRS

CORRELATIVE SINGLE-MOLECULE ANALYSIS OF DNA REPAIR SYSTEMS

11:00 – 11:30

Long Cai    
Caltech

SPATIAL GENOMICS AND SINGLE CELL LINEAGE DYNAMICS BY SEQFISH AND MEMOIR

11:30 – 12:00

Johan Elf 
Uppsala University

CHARACTERIZING A LIBRARY OF CELLS AT SINGLE MOLECULE SENSITIVITY

12:00 – 16:30

Lunch at Leisure & Free Time

12:30 – 16:00

Snorkel Trip (Sign-ups required in advance)

DNA Replication
Yuri Lyubchenko

16:30 – 17:00

Nick Dixon
University of Wollongong

THE BACTERIAL REPLISOME – DESIGN PRINCIPLES FOR A DYNAMIC MOLECULAR MACHINE

17:00 – 17:30

Mike O’Donnell
Rockefeller University

OPTICAL TRAPS, FLUORESCENT PROTEINS AND MICROFLUIDICS REVEAL UNEXPECTED DYNAMICS OF EUKARYOTIC CMG HELICASE

17:30 – 18:00

Kiyoshi Mizuuchi
NIH 

INTRACELLULAR LONG-RANGE COMMUNICATION IN BACTERIAL PLASMID SEGREGATION AND SEPTUM POSITIONING

18:00 – 18:30

Refreshments

18:30 – 19:00

Rodrigo Reyes Lamothe
McGill University

REPLISOME DYNAMICS IN LIVE BACTERIA AND BUDDING YEAST

19:00 – 19:30

Samir Hamdan
King Abdullah University of Science and Technology

SINGLE MOLECULE VIEW OF THE STRUCTURE SPECIFIC 5’ NUCLEASES

19:30 – 19:45

Enrico Monachino
University of Wollongong

SINGLE-MOLECULE AND BULK BIOPHYSICAL STUDIES OF ESCHERICHIA COLI DNA REPLICATION REVEAL A CONFORMATIONAL SWITCH CONTROLLING REPLISOME STABILITY

19:45 – 20:00

Lisanne Spenkelink
University of Wollongong

SINGLE-MOLECULE VISUALIZATION OF YEAST LEADING-STRAND SYNTHESIS REVEALS DYNAMIC INTERACTION BETWEEN MTC AND THE REPLISOME

20:00

Dinner at Leisure

FRIDAY 23RD FEBRUARY

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

DNA Repair
Fuchou Tan

08:30 – 09:15

Yuri Lyubchenko
University of Nebraska

DYNAMICS OF PROTEIN-DNA COMPLEXES AT NANOSCALE

09:15 – 09:30

Andrew Robinson
University of Wollongong

SINGLE-MOLECULE IMAGING OF TRANSLESION DNA POLYMERASES IN E. COLI

09:30 – 10:00

Mark Leake
University of York

PROBING GENE CONTROL IN LIVE CELLS USING HIGH-SPEED SINGLE-MOLECULE FLUORESCENCE MICROSCOPY

10:00 – 10:30

Refreshments

10:30 – 11:00

Stephan Uphoff
University of Oxford

ILLUMINATING THE REGULATION OF BACTERIAL DNA REPAIR AND MUTAGENESIS USING SINGLE-MOLECULE AND SINGLE-CELL MICROSCOPY

11:00 – 11:30

Myron Goodman
University of Southern California

A SINGLE MOLECULE WINDOW INTO ATP REGULATION OF THE DNA POLYMERASE V MUTASOME

11:30 – 12:00

Tim Lohman
Washington University in St. Louis

LARGE DOMAIN MOVEMENTS REGULATE UvrD HELICASE ACTIVITY

12:00 – 16:00

Lunch at Leisure & Free Time

Genomics   
Will Greenleaf

16:00 – 16:45

Fuchou Tang
Peking University

SINGLE-CELL MULTI-OMICS SEQUENCING OF MOUSE EARLY EMBRYOS AND EMBRYONIC STEM CELLS

16:45 – 17:00

Manal Zaher
King Abdullah University of Science and Technology

MISSED CLEAVAGE OPPORTUNITIES BY FEN1 LEAD TO OKAZAKI FRAGMENT MATURATION VIA THE LONG-FLAP PATHWAY

17:00 – 17:30

Will Greenleaf
Stanford University

SINGLE-CELL EPIGENOMICS MAPS THE CONTINUOUS REGULATORY LANDSCAPE OF HUMAN HEMATOPOIETIC DIFFERENTIATION

17:30 – 18:00

Refreshments

18:00 – 18:15

Wei Ting Chelsea Lee
New York University

SPATIOTEMPORAL ASSOCIATIONS OF DNA G4 AND REPLICATION IN HUMAN CELLS

18:15 – 19:00

Peter Fraser
Brabham Institute

3D CHROMOSOME AND GENOME DYNAMICS

19:00 – 19:30

Linda Kenney
Mechanobiology Institute

CHARGED RESIDUES IN THE H-NS LINKER DRIVE DNA BINDING AND GENE SILENCING IN SINGLE CELLS

20:00

*Gala Dinner*

SATURDAY 24TH FEBRUARY

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

Transcription
Terence Strick

08:30 – 09:15

Steve Block
Stanford University

RIBOSWITCH FOLDING, STRUCTURE AND FUNCTION

09:15 – 09:45

Richard Ebright
Rutgers

REPURPOSING NANOPORE DNA SEQUENCING TO ANALYZE RNA POLYMERASE TRANSLOCATION WITH SUB-NUCLEOTIDE, SUB-MILLISECOND RESOLUTION

09:45 – 10:15

Eric Galburt
Washington University in St. Louis

DNA UNWINDING AT A DISTANCE DURING EUKARYOTIC TRANSCRIPTION INITIATION

10:15 – 10:45

Refreshments

10:45 – 11:30

Achillefs Kapanidis
University of Oxford

UNCOVERING TRANSCRIPTION MECHANISMS VIA SINGLE-MOLECULE FLUORESCENCE IMAGING

11:30 – 12:00

Sabrina Leslie
McGill University

HOW BIOMOLECULES BEHAVE IN A SQUEEZE

12:00 – 12:15

Avin Ramaiya
Lumicks BV

QUICKER THAN QUICK? CORRELATIVE FLUORESCENCE-FORCE MICROSCOPY AS A VERSATILE TOOL FOR DNA-MECHANICS

12:15 – 12:35

Panel Discussion

12:35 – 12:45

Closing Comments

Speakers

Plenary Speakers

Invited Speakers

  • Prof. Michael O'Donnell
    Investigator, Rockefeller University
  • Dr. Jie Xiao
    Associate Professor, The Johns Hopkins University School of Medicine
  • Dr. Eric Galburt
    Assistant Professor, Washington University School of Medicine
  • Prof. Joseph Loparo
    Associate Professor, Harvard Medical School
  • Dr. Eli Rothenberg
    Associate Professor , New York University School of Medicine
  • Prof. Johan Elf
    Professor, Uppsala University
  • Prof. Nicholas Dixon
    Professor of Biological Chemistry, University of Wollongong
  • Dr. Richard H. Ebright
    Professor, Rutgers
  • Dr. Stephan Uphoff
    Sir Henry Dale Fellow, University of Oxford, Department of Biochemistry
  • Prof. Myron Goodman
    Porfessor, Biologiogical Sciences and Chemistry, University of Southern California
  • Prof Samir Hamdan
    Assistant Professor of Bioscience, King Abdullah University of Science and Technology
  • Prof. Timothy Lohman
    Professor, Washington University in St. Louis
  • Dr. Kiyoshi Mizuuchi
    Section Chief, National Institutes of Health
  • Prof. Mark Leake
    Professor, University of York
  • Prof. Linda Kenney
    Prof, Mechanobiology Institute
  • Dr. William Greenleaf
    Associate Professor, Stanford University
  • Prof. Jie Yan
    Principal Investigator, Mechanobiology Institute, NUS
  • Terence Strick
    Research Director, Ecole normale supérieure/CNRS
  • Dr. Long Cai
    Research Professor, Caltech
  • Prof. Sabrina Leslie
    Associate Professor, McGill University

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