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Home > Past Conferences > Epigenetics Conference

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Epigenetics Conference

From Mechanisms to Disease

15 Feb 2018 - 18 Feb 2018

Cancun, Mexico

Synopsis

The DNA of eukaryotic cells is organized into chromatin fibres, where the nucleosome is the basic repeating unit. Chromatin is thus at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. By and large, these topics have traditionally been covered by separated meetings. However, recent literature indicates that the boundaries among these various disciplines are becoming less clear. This meeting on "Epigenetics: from mechanisms to disease" will bring together scientists studying chromatin architecture, epigenetics, stem cell biology and cancer. The talks will cover a broad range of topics, including chromosome organisation, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms, transcription regulation, DNA methylation and hydroxymethylation.

Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Young scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. The program has also allocated ample time for exchanging ideas and discussing novel hypotheses at the end of each session, as well as time for informal interactions and networking.

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Target Audience

This conference will appeal to PhD students, post-doc and group leaders working in the field of chromatin architecture, epigenetics, stem cell biology and cancer.

Learning Objectives

This conference integrates the burgeoning field of epigenetics with the underlying processes of chromatin organization, transcription regulation and aspects of stem cell biology. This knowledge can be exploited for the generation and improvement of novel tools for the prediction, the diagnosis, and eventually the individualized treatment of human diseases.

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the normal rate and bring a student for only $745. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 15, 16, 17 Feb 2018 (on a shared basis for students, note guest rooms are open plan) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Emily Bicknell (emily@fusion-conferences.com) to obtain a special registration link for your student.

Confirmed Invited Speakers

Tony Kouzarides (Gurdon Institute)
RNA MODIFICATION PATHWAYS: THEIR FUNCTION AND ROLE IN CANCER

Ramin Shiekhattar (University of Miami Miller School of Medicine)
INTEGRATOR REGULATES FIDELITY OF TERMINATION

Job Dekker (University of Massachussets Medical School)
FOLDING, UNFOLDING AND REFOLDING OF GENOMES

Victor Corces (Emory University)
MECHANISMS OF TRANSGENERATIONAL INHERITANCE OF OBESITY EPIPHENOTYPES

Maria-Elena Torres-Padilla (Institute of Epigenetics and Stem Cells) 
EPIGENETIC MECHANISMS IN EARLY MAMMALIAN DEVELOPMENT: A TRANSPOSON SHOT

Ali Shilatifard (Northwestern University)
PRINCIPLES OF EPIGENETICS AND CHROMATIN IN DEVELOPMENT AND HUMAN DISEASE

Salvador Aznar Benitah (IRB Barcelona)
EPIGENETIC MECHANISMS IN ADULT STEM CELLS FUNCTION

Robert Schneider (University of Munich)
NOVEL PLAYERS IN CHROMATIN

Robert Sims (Constellation Pharmaceuticals)
UTILIZING CHEMICAL BIOLOGY TO IDENTIFY NOVEL STRATEGIES TARGETING HISTONE ACETYL SIGNALING IN CANCER

Anne Ferguson-Smith (University of Cambridge)
VARIABLE SILENCING OF THE REPEAT GENOME - IMPLICATIONS FOR NON-GENETIC INHERITANCE

Jerome Déjardin (Institute of Human Genetics of Montpellier)
TRANSCRIPTIONALLY ACTIVE HETEROCHROMATIN CONTROLS THE ACTIVATION OF ALTERNATIVE LENGTHENING OF TELOMERES

François Fuks (Université Libre de Bruxelles)
TRANSCRIPTOME-WIDE DISTRIBUTION AND FUNCTION OF RNA MODIFICATIONS

Alvaro Rada-Iglesias (University of Cologne)POLYCOMB PROTEINS AS TOPOLOGICAL FACILITATORS OF ENHANCER FUNCTION DURING NEURAL INDUCTION

Adrian Bracken (Smurfit Institute of Genetics)
A NEW FAMILY OF VERTEBRATE-SPECIFIC POLYCOMB PROTEINS BALANCE PRC2 ACTIVITIES.

Cigall Kadoch (Dana-Farber Cancer Institute)
STRUCTURE AND FUNCTION OF MAMMALIAN SWI/SNF (BAF) COMPLEXES IN HUMAN DISEASE

Leonie Ringrose (Humboldt-Universität zu Berlin)
EPIGENETICS MEETS MATHEMATICS: THEORETICAL ANALYSIS OF MEMORY AND SWITCHING IN POLYCOMB/ TRITHORAX REGULATION

Roberto Bonasio (University of Pennsylvania)
EPIGENETIC REGULATION OF SOCIAL BEHAVIOR IN ANTS

Michael Levine (Lewis-Sigler Institute)
TRANS-CHROMOSOMAL ENHANCER-PROMOTER INTERACTIONS IN LIVING DROSOPHILA EMBRYOS

Sandra Peiro (Vall d’Hebron Institute of Oncology - VHIO)
TRANS-CHROMOSOMAL ENHANCER-PROMOTER INTERACTIONS IN LIVING DROSOPHILA EMBRYOS

Iva Tchasovnikarova (Harvard University)
NEUROPATHIC MUTATIONS IN MORC2 HYPERACTIVATE EPIGENETIC SILENCING BY THE HUSH COMPLEX

Sponsors

Sponsors

Programme

THURSDAY 15TH FEBRUARY 2018

15:00 – 16:00

Registration & Reception

15:00 – 15:45

Welcome Lunch 
*Kalmia Buffet Restaurant*

3D Genome, epigenetic inheritance and development 
Giacomo Cavalli

16:00 – 16:10

Opening Comments

16:10 – 16:40

Giacomo Cavalli 
Institute of Human Genetics, Centre National de la Recherche Scientifique

3D GENOME ORGANIZATION AND POLYCOMB IN DEVELOPMENT AND EPIGENETIC INHERITANCE

16:40 – 17:10

Victor Corces 
Emory University

MECHANISMS OF TRANSGENERATIONAL INHERITANCE OF OBESITY PHENOTYPES

17:10 – 17:40

Job Dekker 
University of Massachusetts Medical School

FOLDING, UNFOLDING AND REFOLDING OF GENOMES

17:40 – 18:10

Leonie Ringrose 
Humboldt-Universität zu Berlin

EPIGENETICS MEETS MATHEMATICS: THEORETICAL ANALYSIS OF BISTABILITY AND BIVALENT CHROMATIN IN THE POLYCOMB/TRITHORAX SYSTEM.

18:10 – 18:40

Refreshments

18:40 – 19:10

Maria-Elena Torres-Padilla 
Institute of Epigenetics and Stem Cells

EPIGENETIC MECHANISMS IN EARLY MAMMALIAN DEVELOPMENT: SEARCHING FOR GLOBAL CHROMATIN TRENDS

19:10 – 19:40

Anne Ferguson-Smith 
University of Cambridge

VARIABLE SILENCING OF THE REPEAT GENOME - IMPLICATIONS FOR NON-GENETIC INHERITANCE

19:40 – 19:55

Anne-Marie Martinez 
Institute of Human Genetics, University of Montpellier

COORDINATE REDEPLOYMENT OF PRC1 PROTEINS SUPPRESSES TUMOR FORMATION DURING DROSOPHILA DEVELOPMENT

19:55 – 20:10

Marc Rehmsmeier - 
Humboldt University Berlin

GENOME-WIDE PREDICTION OF FLY POLYCOMB/TRITHORAX RESPONSE ELEMENTS USING HIGH-THROUGHPUT EXPERIMENTAL DATA

20:10

Dinner at Leisure

FRIDAY 16TH FEBRUARY 2018

07:00 – 08:45

Breakfast 
*Kalmia Buffet Restaurant*

Chromatin Complexes 
Luciano Di Croce

09:00 – 09:15

Ruslan Sadreyev 
Massachusetts General Hospital & Harvard Medical School

COOPERATION BETWEEN POLYCOMB AND TRITHORAX/COMPASS COMPLEXES AT BIVALENT PROMOTERS

09:15 – 09:30

Claudia Gentile 
Montreal Clinical Research Institute (IRCM)

UNCOVERING THE ROLE OF POLYCOMB GROUP PROTEINS IN CHROMATIN ARCHITECTURE AND HOXA GENE REGULATION DURING LIMB DEVELOPMENT

09:30 – 10:00

Alvaro Rada-Iglesias 
University of Cologne

POLYCOMB PROTEINS AS TOPOLOGICAL FACILITATORS OF ENHANCER FUNCTION DURING NEURAL INDUCTION

10:00 – 10:30

Adrian Bracken 
Trinity College Dublin

A NEW FAMILY OF VERTEBRATE-SPECIFIC POLYCOMB PROTEINS BALANCE PRC2 ACTIVITIES

10:30 – 11:00

Refreshments & Group Photo

11:00 – 11:30

Luciano Di Croce 
Centre for Genomic Regulation

ROLE OF POLYCOMB AND MLL COMPLEXES IN NUCLEAR ARCHITECTURE AND GENE REGULATION

11:30 – 12:00

Iva Tchasovnikarova

Massachusetts General Hospital

NEUROPATHIC MUTATIONS IN MORC2 HYPERACTIVATE EPIGENETIC SILENCING BY THE HUSH COMPLEX

12:00 – 16:30

Lunch at Leisure & Free Time

12:30 – 16:00

Snorkel Trip (TBC)

Chromatin, ncRNAs, Cell Fate and Disease 
Ali Shilatifard

16:30 – 17:00

Tony Kouzarides 
Gurdon Institute

MODIFICATIONS OF RNA: THEIR FUNCTION AND ROLE IN CANCER

17:00 – 17:15

Ranjan Perera 
Sanford Burnham Prebys Medical Discovery Institute

THE LONG NONCODING RNA SPRIGHTLY ACTS AS AN INTRA-NUCLEAR ORGANIZING HUB FOR PRE-mRNA MOLECULES

17:15 – 17:45

Ali Shilatifard 
Northwestern University

PRINCIPLES OF EPIGENETICS AND CHROMATIN IN DEVELOPMENT AND HUMAN DISEASE

17:45 – 18:00

Gabriella Ficz 
Barts Cancer Institute

NAÏVE HUMAN PLURIPOTENCY AS A MODEL FOR MECHANISMS OF ABERRANT DNA HYPERMETHYLATION IN CANCER

18:00 – 18:30

Salvador Aznar Benitah 
IRB

EPIGENETIC MECHANISMS IN ADULT STEM CELLS FUNCTION

18:30 – 20:00

Poster Session

20:00

Dinner at Leisure

SATURDAY 17TH FEBRUARY 2018

07:00 – 08:45

Breakfast 
*Kalmia Buffet Restaurant*

Heterochromatin and Chemical Biology Approaches 
Robert Sims

09:00 – 09:15

Paul Guilhamon 
Princess Margaret Cancer Centre

CHROMATIN-BASED GBM CANCER STEM CELL CLASSIFICATION REVEALS THREE SUBTYPES SENSITIVE TO UNIQUE DRUG TREATMENTS

09:15 – 09:45

Robert Schneider 
University of Munich

NOVEL PLAYERS IN CHROMATIN

09:45 – 10:15

François Fuks 
Université Libre de Bruxelles

TRANSCRIPTOME-WIDE DISTRIBUTION AND FUNCTION OF RNA MODIFICATIONS

10:15 – 10:45

Refreshments

10:45 – 11:15

Jerome Déjardin 
Institute of Human Genetics of Montpellier

TRANSCRIPTIONALLY ACTIVE HETEROCHROMATIN CONTROLS THE ACTIVATION OF ALTERNATIVE LENGTHENING OF TELOMERES

11:15 – 11:45

Robert Sims 
Constellation Pharmaceuticals

UTILIZING CHEMICAL BIOLOGY TO IDENTIFY NOVEL STRATEGIES TARGETING HISTONE ACETYL SIGNALING IN CANCER

11:45 – 12:00

Y. George Zheng 
University of Georgia

BIOORTHOGONAL PROBES TO INTERROGATE PROTEIN LYSINE ACETYLATION AND ACYLATION

12:00 – 12:15

Till Bartke 
Helmholtz Zentrum M ü nchen

DECODING CHROMATIN MODIFICATION STATES USING CHEMICAL BIOLOGY AND PROTEOMIC APPROACHES

12:15 – 16:00

Lunch at Leisure & Free Time

Transcription and Chromatin Reprogramming 
Cigall Kadoch

16:00 – 16:30

Ramin Shiekhattar 
University of Miami, Miller School of Medicine

INTEGRATOR REGULATES FIDELITY OF TERMINATION

16:30 – 16:45

Michael Tolstorukov 
Massachusetts General Hospital

UNRAVELING INTRICATE RELATIONSHIP BETWEEN NUCLEOSOME OCCUPANCY AND CHROMATIN ACCESSIBILITY

16:45 – 17:15

Cigall Kadoch 
Dana-Farber Cancer Institute

STRUCTURE AND FUNCTION OF MAMMALIAN SWI/SNF (BAF) COMPLEXES IN HUMAN DISEASE

17:15 – 17:30

Qin Yan 
Yale School of Medicine

KDM5 HISTONE DEMETHYLASES REGULATE ANTI-VIRAL AND ANTI-TUMOR IMMUNE RESPONSES THROUGH THE STING PATHWAY

17:30 – 17:45

David Katz 
Emory University

THE FUNCTION OF THE HISTONE DEMETHYLASE LSD1 IN CELL FATE AND TAU MEDIATED NEURODEGENERATION

17:45 – 19:30

Poster Session

20:00

*Gala Dinner & Poster Awards*

SUNDAY 18TH FEBRUARY 2018

07:00 – 08:30

Breakfast 
*Kalmia Buffet Restaurant*

X-inactivation and Epigenetic Phenomena 
Maria-Elena Torres-Padilla

09:00 – 09:15

Sundeep Kalantry 
University of Michigan Medical School

RANDOM X-CHROMOSOME INACTIVATION BY THE HISTONE DEMETHYLASE SMCX/KDM5C

09:15 – 09:30

Stefan Pinter 
University of Connecticut

 

09:30 – 10:00

Roberto Bonasio 
University of Pennsylvania

EPIGENETIC REGULATION OF SOCIAL BEHAVIOR IN ANTS

10:00 – 10:30

Refreshments

10:30 – 11:00

Michael Levine 
Lewis-Sigler Institute

TRANS-CHROMOSOMAL ENHANCER-PROMOTER INTERACTIONS IN LIVING DROSOPHILA EMBRYOS

11:00– 11:30

Sandra Peirò 
Vall D’Hebron Institute of Oncology

GENOME-WIDE MAPPING OF LAMIN B1 REVEALS THE EXISTENCE OF DYNAMIC AND FUNCTIONAL EUCHROMATIN LAMIN B1 DOMAINS (eLADs) DURING EPITHELIAL-TO-MESENCHYMAL TRANSITION (EMT)

11:30 – 11:45

Closing Comments

Speakers

Invited Speakers

  • Prof. Francois Fuks
    Professor, University of Brussels
  • Dr. Ramin Shiekhattar
    Professor , University of Miami
  • Dr. Ali Shilatifard
    Chairman Dept of Biochemistry and Molecular Genetices, Northwestern University Feinberg School of Medicine
  • Dr. Alvaro Rada-Iglesias
    Junior Research Group Leader, Center for Molecular Medicine Cologne (CMMC), University of Cologne
  • Prof. Leonie Ringrose
    Professor , Humboldt University Berlin
  • Dr. Roberto Bonasio
    Assistant Professor, University of Pennsylvania
  • Dr. Robert Schneider
    PI, Institute of Functional Epigenetics, HMGU
  • Prof. Maria-Elena Torres-Padilla
    Director, Institute of Epigenetics & Stem Cells
  • Prof. Tony Kouzarides
    Deputy Director , University of Cambridge
  • Prof. Dr. Salvador Aznar Benitah
    Group Leader - ICREA Research Professor, IRB Barcelona
  • Prof. Job Dekker
    Professor and Co-Director, Univ. of Massachusetts Medical School
  • Dr. Robert Sims
    Sr. VP Research, Constellation Pharmaceuticals
  • Dr. Jerome Dejardin
    Group Leader, IGH CNRS
  • Prof. Anne Ferguson-Smith
    Arthur Balfour Professor of Genetics and Head of Department, University of Cambridge
  • Prof. Victor Corces
    Professor, Emory University
  • Prof. Michael Levine
    Professor & Director, Princeton University
  • Prof. Dr. Cigall Kadoch
    Assistant Professor, Dana-Farber Cancer Institute and Harvard Medical School
  • Dr. Sandra Peirรณ
    Head of Chromatin Dynamics in Cancer Group, Vall D'Hebron Institute of Oncology
  • Prof. Adrian Bracken
    Associate Professor, Trinity College Dublin
  • Dr. Iva Tchasovnikarova
    Research Fellow, Massachusetts General Hospital

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