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Home > Past Conferences > Synthetic Biology for Natural Products Conference

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Synthetic Biology for Natural Products Conference

The Interface of (Meta)Genomics, Machine Learning, and Natural Product Discovery

05 Mar 2017 - 08 Mar 2017

Cancun, Mexico

Synopsis

Genome sequencing has revealed an enormous biosynthetic capacity for microbial natural products, only a small fraction of which are represented in fermentation-based screens. Synthetic biology tools are being developed to translate the encoded diversity of microbial biosynthetic pathways into novel compounds and natural products. The Synthetic Biology for Natural Products conference will blend these disciplines with the goal of generating new platforms, tools and technologies to capture, manipulate and engineer natural product genes and pathways. Converting this vast untapped (meta)genomic diversity into novel chemical leads for biomedical and agricultural applications will require breakthroughs in design, scale and biologics that currently limit the field.

Key Sessions Include:

- (Meta)Genomics-Enabled Natural Product Discovery
- New Tools for Capturing, Manipulating and Activating SM Pathways
- Advances in Heterologous Expression & Screening Technologies
- Designing Genes and Circuits for Novel Products and Yield Improvement

Target Audience

Synthetic biology scientists and companies looking to learn the latest engineering and synthetic biology technologies for converting small molecule, natural product pathways into novel compounds. Topics discussed during the conference will span the experimental spectrum from molecular biology, microbiology, drug discovery, chemistry and pharmacology, to antibiosis activities against cancer, viral and microbial pathogens.

Educational Need

A new generation of tools and technologies is needed to convert the vast biodiversity found in natural product pathways into bioactive compounds and treatments. The Synthetic Biology for Natural Products conference will bring together a broad spectrum of research scientists and corporate managers interested in learning about the latest developments in this new field.

Confirmed Speakers

Laurent Daviet (Firmenich SA)
"DEVELOPING BIOSYNTHETIC ROUTES FOR THE MICROBIAL PRODUCTION OF FLAVOR AND FRAGRANCE TERPENES"

Mark Liles (Auburn University)
"RECOVERY AND EXPRESSION OF INTACT SECONDARY METABOLITE BIOSYNTHETIC PATHWAYS FROM A LARGE-INSERT SOIL METAGENOMIC LIBRARY"

William Metcalf (University of Illinois)
"LARGE-SCALE GENOME MINING FOR NATURAL PRODUCT DISCOVERY"

Laura Motta-Mena (Optologix, LLC)
"LITE SWITCH: A LIGHT-INDUCIBLE SYSTEM TO RAPIDLY CONTROL GENE EXPRESSION SPATIALLY AND TEMPORALLY" 

Anne Osbourn (John Innes Centre)
“HARNESSING PLANT METABOLIC DIVERSITY: FROM GENOMES TO GRAM-SCALE QUANTITIES OF NATURAL PRODUCTS AND ANALOGS”

Michael Smanski (University of Minnesota)
"HIGH-THROUGHPUT CONSTRUCTION OF NATURAL PRODUCT BIOSYNTHETIC PATHWAYS"

Christopher Voigt (Massachusetts Institute of Technology)
“GENETIC DESIGN FOR DISCOVERY”

Larry Wackett (University of Minnesota)
"DISCOVERY OF β-LACTONE SYNTHETASE ENZYME REVEALS UNEXPECTED OVERLAP IN MICROBIAL HYDROCARBON AND ANTIBIOTIC BIOSYNTHESIS"

Gavin Williams (NC State University)
"SYNTHETIC BIOLOGY APPROACH FOR PRODUCTION AND DIVERSIFICATION OF COMPLEX POLYKETIDES"

Chengcang Charles Wu (Intact Genomics, Inc.)
"ACCESS 1,000,000 FULL-LENGTH SECONDARY METABOLITE BIOSYNTHETIC GENE CLUSTERS AND THEIR NATURAL PRODUCT COMPOUNDS FROM MICROBES AND METAGENOMES"

Huimin Zhao (University of Illinois at Urbana-Champaign)
"DISCOVERY AND ENGINEERING OF NOVEL NATURAL PRODUCTS VIA SYNTHETIC BIOLOGY"

David Cane (Brown University)
"NATURE AS STEREOCHEMIST"

Douglas Mitchell (University of Illinois at Urbana-Champaign)
"ROUNDING UP BIOSYNTHETIC GENE CLUSTERS WITH RODEO"

Patrick Westfall (Zymergen)
“SYSTEMATIC AND COMPREHENSIVE GENOME ENGINEERING FOR IMPROVED MICROBIAL PERFORMANCE”

Jay Keasling (UC Berkeley)
“ENGINEERED POLYKETIDE SYNTHASES FOR PRODUCTION OF COMMODITY AND SPECIALTY CHEMICALS”

Alexander Wentzel (Sintef)
"NEW BIOACTIVE COMPOUNDS FROM ENVIRONMENTAL MICROBIAL RESOURCES BY AN INTEGRATED FUNCTIONAL (META)GENOMICS APPROACH"

Kristy Hawkins (Antheia)
"A MICROBIAL PLATFORM FOR THE PRODUCTION OF BENZYLISOQUINOLINE ALKALOIDS"

Cornelia Scheitz (Autodesk)
"NEW FROM AUTODESK:  A HIGH POWERED, CLOUD BASED, OPEN SOURCE CAD TOOL TO DRIVE BIOLOGICAL DESIGN."

Mark Burk (Genomatica, Inc.)
“CELL-FREE BIOSYNTHESIS OF NATURAL PRODUCTS AND ANALOGS”

Colin Harvey (Stanford University)
“SACCHAROMYCES CEREVISIAE AS A PLATFORM FOR THE LARGE-SCALE EXPRESSION OF ORPHAN FUNGAL BIOSYNTHETIC GENE CLUSTERS"

Daisuke Umeno (Chiba University)
“LABORATORY EVOLUTION OF CAROTENOID AND TRITERPENOID PATHWAYS”

Elizabeth Sattely (Stanford University)
“DISCOVERY AND ENGINEERING PLANT CHEMISTRY”

Zhen Kang (Jiangnan University)
“DEVELOPMENT OF SYNTHETIC BIOLOGY TOOLS FOR IMPROVING NATURAL PRODUCTS BIOSYNTHESIS”

Brian Pfleger (University of Wisconsin Madison)
"ENGINEERING TRANS-ACTING REGULATORS TO DYNAMICALLY CONTROL GENE EXPRESSION IN BACTERIA"

Joerg Bohlmann (University of British Columbia)
"TERPENE FRAGRANCE BIOSYNTHESIS IN TROPICAL SANDALWOOD"

Charles Moore (Novartis Pharma AG)
“TOWARDS A SYNTHETIC BIOLOGY PLATFORM FOR NATURAL PRODUCT DISCOVERY”

Claudia Schmidt-Dannert (University of Minnesota)
"MAPPING THE TERPENOID NATURAL PRODUCTS DIVERSITY OF BASIDIOMYCOTA"

Wolfgang Wohlleben (University of Tübingen)
"ENGINEERING PRECUSOR SUPPLY IN SECONDRY METABOLITE BIOSYNTHESIS"

David L Pompliano (Lodo Therapeutics)
"MICROBIAL METAGENOME-BASED ANTIBACTERIAL DISCOVERY"

Christopher Boddy (University of Ottawa)
“FRONTIERS IN HETEROLOGOUS EXPRESSION OF BACTERIAL NATURAL PRODUCTS”

Jean-Etienne Bassard (University of Copenhagen)
“P450-MEDIATED METABOLISM ORGANIZED AS DYNAMIC METABOLONS - EXAMPLE OF THE DHURRIN METABOLON”

Andriy Luzhetskyy (Saarland University)
“BRIDGING IN SILICO AND IN VIVO FOR THE DISCOVERY OF NEW NATURAL PRODUCTS”

Derek Abbott (Amyris Inc)
"DATA-DRIVEN SYNTHETIC BIOLOGY FOR RAPID ADVANCES IN NATURAL PRODUCTS BIOSYNTHESIS"

Marc Chevrette (University of Wisconsin-Madison)
"COMPUTATIONAL INSIGHTS INTO THE DIVERSE NONRIBOSOMAL PEPTIDE CHEMISTRY OF ACTINOBACTERIA"

Rebecca Goss (University of St Andrews)
"BLENDING SYNTHETIC CHEMISTRY AND SYNTHETIC BIOLOGY FOR NATURAL PRODUCT DIVERSIFICATION"

José L. Avalos (Princeton University)
"OPTOGENETIC CONTROL OF ENGINEERED METABOLISMS"

Ina Häuslein (Technical University of Munich)
"USING ISOTOPOLOGUE PROFILING TO DECIPHER BIOSYNTHETIC PATHWAYS AND FLUXES IN PLANTS AND BACTERIA"

Blaine Pfeifer (University at Buffalo)
"HETEROLOGOUS CELLULAR DESIGN FOR COMPLEX NATURAL PRODUCT SUPPORT AND DISCOVERY"

Jason Sello (Brown University)
“EXPLOITING GENETIC REDUNDANCIES IN THE DISCOVERY AND MANIPULATION OF NATURAL PRODUCT BIOSYNTHESIS PATHWAYS”

Michael Burkart (University of California)
“TALES FROM THE INTERFACE: PROTEIN INTERACTIONS IN FAS, PKS, AND NRPS PATHWAYS”

2017 Synthetic Biology of Natural Products Poster Prize

The conference chairs will be awarding 3 poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 13 January 2017. The winners will receive the following prizes at the Gala dinner: 1st Place $350, 2nd Place $250, 3rd Place $150. 

Sponsors

Sponsors

Programme

SUNDAY 5TH MARCH 2017

14:00 – 14:45

Registration & Reception

14:00 – 14:45

Group Welcome Lunch
*Kalmia Buffet Restaurant*

(META) GENOMICS-ENABLED NATURAL PRODUCT DISCOVERY
Session Chair: Michael Thomas

14:45 – 15:00

Opening Comments

15:00 – 15:45

Anne Osbourn
John Innes Centre

HARNESSING PLANT METABOLIC DIVERSITY: FROM GENOMES TO GRAM-SCALE QUANTITIES OF NATURAL PRODUCTS AND ANALOGS

15:45 – 16:15

Elizabeth Sattely
Stanford University

DISCOVERY AND ENGINEERING PLANT CHEMISTRY

16:15 – 16:45

David Pompliano
Lodo Therapeutics

MICROBIAL METAGENOME-BASED ANTIBACTERIAL DISCOVERY

16:45 – 17:15

Michael Smanski
University of Minnesota

HIGH-THROUGHPUT CONSTRUCTION OF NATURAL PRODUCT BIOSYNTHETIC PATHWAYS

17:15 – 17:45

Refreshments

17:45 – 18:15

Claudia Schmidt-Dannert
University of Minnesota

MAPPING THE TERPENOID NATURAL PRODUCTS DIVERSITY OF BASIDIOMYCOTA

18:15 – 18:30

Mark Burk
Genomatica, Inc.

CELL-FREE BIOSYNTHESIS OF NATURAL PRODUCTS AND ANALOGS

18:30 – 18:45

Alexander Wentzel
SINTEF Materials and Chemistry

NEW BIOACTIVE COMPOUNDS FROM ENVIRONMENTAL MICROBIAL RESOURCES BY AN INTEGRATED FUNCTIONAL (META)GENOMICS APPROACH

18:45 – 19:00

Ina Häuslein
Technical University of Munich

USING ISOTOPOLOGUE PROFILING TO DECIPHER BIOSYNTHETIC PATHWAYS AND FLUXES IN PLANTS AND BACTERIA

19:00 – 19:30

Mark Liles
Auburn University

RECOVERY AND EXPRESSION OF INTACT SECONDARY METABOLITE BIOSYNTHETIC PATHWAYS FROM A LARGE-INSERT SOIL METAGENOMIC LIBRARY

19:30 – 20:00

Gavin Williams
NC State University

SYNTHETIC BIOLOGY APPROACH FOR PRODUCTION AND DIVERSIFICATION OF COMPLEX POLYKETIDES

20:00

Dinner at Leisure

MONDAY 6TH MARCH 2017

07:00 – 08:30

Breakfast
*Kalmia Buffet Restaurant*

DESIGNING GENES AND CIRCUITS FOR NOVEL PRODUCTS AND YIELD IMPROVEMENT
Session Chair: Claes Gustafsson

08:30 – 09:15

Patrick Westfall
Zymergen, Inc.

SYSTEMATIC AND COMPREHENSIVE GENOME ENGINEERING FOR IMPROVED MICROBIAL PERFORMANCE

09:15 – 09:45

Laurent Daviet
Firmenich SA

DEVELOPING BIOSYNTHETIC ROUTES FOR THE MICROBIAL PRODUCTION OF FLAVOR AND FRAGRANCE TERPENES

09:45 – 10:15

Brian Pfleger
University of Wisconsin-Madison

ENGINEERING TRANS-ACTING REGULATORS TO DYNAMICALLY CONTROL GENE EXPRESSION IN BACTERIA

10:15 – 10:45

Joerg Bohlmann
University of British Columbia

TERPENE FRAGRANCE BIOSYNTHESIS IN TROPICAL SANDALWOOD

10:45 – 11:15

Refreshments & Group Photo

11:15 – 11:45

Lawrence Wackett
University of Minnesota

DISCOVERY OF β-LACTONE SYNTHETASE ENZYME REVEALS UNEXPECTED OVERLAP IN MICROBIAL HYDROCARBON AND ANTIBIOTIC BIOSYNTHESIS

11:45 – 12:15

Kristy Hawkins
Antheia, Inc.

A MICROBIAL PLATFORM FOR THE PRODUCTION OF BENZYLISOQUINOLINE ALKALOIDS

12:15 – 12:45

Daisuke Umeno
Chiba University

LABORATORY EVOLUTION OF CAROTENOID AND TRITERPENOID PATHWAYS

12:45 – 16:15

Lunch at Leisure & Free Time

 13:30 – 15:35

Group Snorkel Trip (to be confirmed)

16:15 – 16:45

Blaine Pfeifer
University at Buffalo

HETEROLOGOUS CELLULAR DESIGN FOR COMPLEX NATURAL PRODUCT SUPPORT AND DISCOVERY

16:45 – 17:15

Christopher Boddy
University of Ottawa

FRONTIERS IN HETEROLOGOUS EXPRESSION OF BACTERIAL NATURAL PRODUCTS

17:15 – 17:45

Jean-Etienne Bassard
University of Copenhagen

P450-MEDIATED METABOLISM ORGANIZED AS DYNAMIC METABOLONS - EXAMPLE OF THE DHURRIN METABOLON

17:45 – 18:15

Andriy Luzhetskyy
Saarland University

BRIDGING IN SILICO AND IN VIVO FOR THE DISCOVERY OF NEW NATURAL PRODUCTS

18:15 – 18:45

Michael Thomas
University of Wisconsin

 

18:45 – 19:15

Refreshments

19:15 – 20:00

Michael Burkart
University of California

TALES FROM THE INTERFACE: PROTEIN INTERACTIONS IN FAS, PKS, AND NRPS PATHWAYS

20:00 – 20:30

Rebecca Goss
University of St Andrews

BLENDING SYNTHETIC CHEMISTRY AND SYNTHETIC BIOLOGY FOR NATURAL PRODUCT DIVERSIFICATION

20:30

Dinner at Leisure

TUESDAY 7TH MARCH 2017

07:00 – 08:30

Breakfast
*Kalmia Buffet Restaurant*

ADVANCES IN NATURAL PRODUCT ENGINEERING
Session Chair: David Mead

08:30 – 09:15

Christopher Voigt
Massachusetts Institute of Technology

GENETIC DESIGN FOR DISCOVERY

09:15 – 09:45

Derek Abbott
Amyris Inc

DATA-DRIVEN SYNTHETIC BIOLOGY FOR RAPID ADVANCES IN NATURAL PRODUCTS BIOSYNTHESIS

09:45 – 10:15

Jay Keasling
LBNL / UC Berkeley

ENGINEERED POLYKETIDE SYNTHASES FOR PRODUCTION OF COMMODITY AND SPECIALTY CHEMICALS

10:15 – 10:45

David Cane
Brown University

NATURE AS STEREOCHEMIST

10:45 – 11:15

Refreshments

11:15 – 11:45

Zhen Kang
Jiangnan University

DEVELOPMENT OF SYNTHETIC BIOLOGY TOOLS FOR IMPROVING NATURAL PRODUCTS BIOSYNTHESIS

11:45 – 12:15

Colin Harvey
Stanford University

SACCHAROMYCES CEREVISIAE AS A PLATFORM FOR THE LARGE-SCALE EXPRESSION OF ORPHAN FUNGAL BIOSYNTHETIC GENE CLUSTERS

12:15 – 12:45

Douglas Mitchell
University of Illinois at Urbana-Champaign

ROUNDING UP BIOSYNTHETIC GENE CLUSTERS WITH RODEO

12:45 – 16:15

Lunch at Leisure & Free Time

16:15 – 16:45

Wolfgang Wohlleben
University of Tübingen

ENGINEERING PRECUSOR SUPPLY IN SECONDRY METABOLITE BIOSYNTHESIS

16:45 – 17:15

Charles Moore
Novartis Pharma AG

TOWARDS A SYNTHETIC BIOLOGY PLATFORM FOR NATURAL PRODUCT DISCOVERY

17:15 – 17:45

William Metcalf
University of Illinois

LARGE-SCALE GENOME MINING FOR NATURAL PRODUCT DISCOVERY

17:45 – 18:15

Jason Sello
Brown University

EXPLOITING GENETIC REDUNDANCIES IN THE DISCOVERY AND MANIPULATION OF NATURAL PRODUCT BIOSYNTHESIS PATHWAYS

18:15 – 19:30

Poster Session & Refreshments

19:30

*Gala Dinner & Poster Awards*

WEDNESDAY 8TH MARCH 2017

07:00 – 08:30

Breakfast
*Kalmia Buffet Restaurant*

NEW TOOLS AND PROCESSES FOR CAPTURING, MANIPULATING AND ACTIVATING NP PATHWAYS
Session Chair: Michael Thomas

08:30 – 09:15

Huimin Zhao
University of Illinois at Urbana-Champaign

DISCOVERY AND ENGINEERING OF NOVEL NATURAL PRODUCTS VIA SYNTHETIC BIOLOGY

09:15 – 09:45

Laura Motta-Mena
Optologix, Inc.

LITE SWITCH: A LIGHT-INDUCIBLE SYSTEM TO RAPIDLY CONTROL GENE EXPRESSION SPATIALLY AND TEMPORALLY

09:45 – 10:15

Chengcang Charles Wu
Intact Genomics, Inc.

ACCESS 1,000,000 FULL-LENGTH SECONDARY METABOLITE BIOSYNTHETIC GENE CLUSTERS AND THEIR NATURAL PRODUCT COMPOUNDS FROM MICROBES AND METAGENOMES

10:15 – 10:45

Refreshments

10:45 – 11:15

Cornelia Scheitz
Autodesk

NEW FROM AUTODESK:  A HIGH POWERED, CLOUD BASED, OPEN SOURCE CAD TOOL TO DRIVE BIOLOGICAL DESIGN

11:15 – 11:30

José L. Avalos
Princeton University

OPTOGENETIC CONTROL OF ENGINEERED METABOLISMS

11:30 – 12:00

Marc Chevrette
University of Wisconsin-Madison

COMPUTATIONAL INSIGHTS INTO THE DIVERSE NONRIBOSOMAL PEPTIDE CHEMISTRY OF ACTINOBACTERIA

12:00 – 12:20

AM Panel Discussion

12:20 – 12:30

Closing Comments

Speakers

Invited Speakers

  • Prof. Huimin Zhao
    Professor, University of Illinois at Urbana-Champaign
  • Prof. Mark Liles
    Professor, Auburn University
  • Prof. Lawrence Wackett
    McKnight Professor, University of Minnesota
  • Dr. Laurent Daviet
    Principal Scientist, Firmenich SA
  • Prof. Gavin Williams
    Associate Professor, NC State University Chemistry
  • Assist. Prof. Mike Smanski
    Assistant Professor, University of Minnesota
  • Prof. Anne Osbourn
    Director, Norwich Research Park Industrial Biotechnology Alliance, John Innes Centre
  • Prof. David Cane
    Professor, Brown University
  • Prof. Douglas Mitchell
    Assoc. Prof., University of Illinois at Urbana-Champaign
  • Dr. Laura Motta-Mena
    Co-founder and CEO, Optologix, Inc.
  • Dr. William Metcalf
    Professor, Department of Microbiology/University of Illinois
  • Prof. Christopher Voigt
    Professor of Biological Engineering, Massachusetts Institute of Technology
  • Dr. Patrick Westfall
    Director, Zymergen, Inc
  • Dr. Cornelia Scheitz
    Principal Scientist, Autodesk
  • Dr. Alexander Wentzel
    Senior Researcher, SINTEF Materials and Chemistry
  • Prof. Brian Pfleger
    Professor, University of Wisconsin-Madison
  • Dr. Colin Harvey
    Staff Scientist, Stanford University
  • Prof. Claudia Schmidt-Dannert
    Professor, University of Minnesota
  • Dr. Chengcang Charles Wu
    CEO, Intact Genomics, Inc.
  • Prof. Dr. Wolfgang Wohlleben
    Professor, University Tuebingen, Microbiology Institute
  • Assist. Prof. Jose Avalos
    Assistant Professor, Princeton University
  • Dr. David Pompliano
    Co-Founder and Chief Scientific Officer, Lodo Therapeutics
  • Dr. Mark Burk
    EVP / Chief Technology Officer, Genomatica, Inc.
  • Dr. Kristy Hawkins
    CTO, Antheia, Inc.
  • Prof. Daisuke Umeno
    Associate Professor, Chiba University
  • Assist. Prof. Jean-Etienne Bassard
    Assistant Professor, University of Copenhagen
  • Dr. Rebecca Goss
    Reader, School of Chemistry
  • Mr. Marc Chevrette
    Graduate Student, Univ. of Wisconsin-Madison
  • Prof. Christopher Boddy
    Professor, University of Ottawa
  • Dr. Jay Keasling
    Associate Laboratory Director / Professor, LBNL / UC, Berkeley
  • Miss. Ina Häuslein
    scientific employee/ PhD student, Technical University of Munich, Chair of Biochemistry, apl. Prof. Dr. Wolfgang Eisenreich
  • Prof. Dr. Andriy Luzhetskyy
    Prof., University of Saarland
  • Dr. Charles Moore
    Research Investigator, Novartis Pharma AG
  • Dr. Derek Abbott
    Director, BioAnalytics, Amyris Inc
  • Prof. Blaine Pfeifer
    Assoc. Prof., University at Buffalo
  • Prof. Dr. Joerg Bohlmann
    Professor, University of British Columbia
  • Prof. Jason Sello
    Associate Professor, Brown University
  • Prof. Dr. Michael Burkart
    Professor, University of California, San Diego
  • Prof. Elizabeth Sattely
    Assistant Professor, Stanford University

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