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Home > Past Conferences > 3rd Natural Products Conference

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Past Conference

3rd Natural Products Conference

Interface of Science and Technology as Applied to Natural Product Research

20 Mar 2017 - 23 Mar 2017

Cancun, Mexico

Synopsis

Working with a natural product compound has always been a challenge. From extraction, purification, isolation, structure characterization and chemical synthesis, natural product research has faced many pitfalls and hurdles that can be overcome by an intelligent use of analytical technology. This conference will focus on key areas of natural product research.

Key Sessions

  • Synthesis of complex natural products
  • Biosynthetic pathways
  • Contribution of women scientists in natural product research
  • Natural product consortiums
  • Marine natural products
  • Technology

Learning Objectives

Exposure to the vast array of analytical technology that is or can be used in natural product research.
 

Target Audience

Anyone that is involved in natural product research from graduate students to full professors. There will be a diverse represenation of delegates from USA, Europe and Asia.
 

Confirmed Speakers

Raymond Andersen (Univ. of British Columbia)
BIOLOGICALLY ACTIVE MARINE NATURAL PRODUCTS: DISCOVERY, SAR, AND INTERACTIONS WITH PROTEIN TARGETS

Dimitris Argyropoulos (Advanced Chemistry Development Labs)
UNIFIED TREATMENT OF ANALYTICAL DATA FOR NATURAL PRODUCT RESEARCH


Nadja Cech (UNC Greesnboro)
MASS SPECTROMETRY METABOLOMICS TO IDENTIFY BIOACTIVE COMPOUNDS FROM NATURAL PRODUCT MIXTURES

Phil Crews (UC Santa Cruz)

Rupika Delgoda (University of the West Indies)

Bill Fenical (Scripps Inst. of Oceanography)
MARINE MICROBES AND THE QUEST FOR NEW TREATMENTS FOR CANCER


William Gerwick (UC San Diego) 
SMALL MOLECULE ACCURATE RECOGNITION TECHNOLOGY (SMART), A NEW NMR-BASED TOOL TO ASSIST STRUCTURAL IDENTIFICATIONS
 
Sandra Groscurth (Bruker BioSpin) 
STRUCTURE ELUCIDATION BY COMBINED USE OF MS AND NMR

Patrick Harran (University of California, Los Angeles)

Giorgis Isaac (Waters Corporation)
SOLVING NATURAL PRODUCTS CHALLENGES USING NOVEL MS TECHNOLOGIES 

Paul Jensen (Scripps Inst. of Oceanography)
THE BIOSYNTHETIC GENE CLUSTER REVOLUTION: MAKING SENSE OF THE MASSES

Sandra Loesgen (Oregon State University)
MICROBIAL NATURAL PRODUCTS IN DRUG DISCOVERY- NEW SOURCES, SCREENS AND TARGETS.

José Angel Marañon (Tradichem)
PELVIGEN CLINICAL EFFICACY AND TOLERABILITY IN PERIMENOPAUSAL WESTERN EUROPE WOMEN WITH URINARY INCONTINENCE


James McChesney (Cloaked Therapeutics, LLC)
DESIGN AND DEVELOPMENT OF A NEXT GENERATION TAXANE

Brian Murphy (University of Illinois, Chicago)
MALDI-TOF MS-BASED TAXONOMIC AND METABOLOMIC PROFILING FOR INFORMED MICROBIAL LIBRARY GENERATION


Cassandra Quave (Emory University)
NATURAL PRODUCTS AND ANTI-INFECTIVE DRUG DISCOVERY

David Sherman (Univ. of Michigan)

Alejandra Prieto-Davo (Universidad Nacional Autónoma de México)
MICROBIAL ECOLOGY OF MANGROVE SEDIMENT BACTERIA AND THEIR POTENTIAL FOR NATURAL PRODUCT DISCOVERY

Paul Wender (Stanford University)

Dr. Ning-Sun Yang(Academia Sinica)
EVALUATION OF POTENT AND MULTI-FACETED IMMUNE-MODIFYING ACTIVITIES OF MEDICINAL PHYTOCHEMICALS USING OMICS APPROACHES.

 

Sponsors

Sponsors

Report

The third in the series of natural product conferences was convened in beautiful Cancun, Mexico.  Extending on the theme of the science of natural product research and the technology that drives the results from version #2, a wonderful group of scientists comprised of synthetic chemist, marine natural product chemists and young investigators in the field presented stirring science of all facets of natural product research.  The hardware and technology that drives natural product research was evident in all presentations.

The meeting was chaired by Mark O’Neil-Johnson, Sequoia Sciences, Inc.

The opening talk was given by Bill Gerwick (Univ. of California, San Diego) where he detailed an NMR tool, Small Molecule Accurate Recognition Technology (SMART), which helps identify and map structural classes based on molecular fragments of natural product molecules from marine sources.  This was followed by a macrolide synthesis lecture from Patrick Harran (Univ. of California, Los Angeles that concluded a short morning session.

Kicking off the afternoon session on biosynthetic pathways of natural products was a talk from David Sherman (University of Michigan) on a new class of indole alkaloid cyclases from cyanobacteria.  Paul Jensen (Univ. of California, San Diego) gave an excellent talk about understanding certain gene clusters and what their function may be in biosynthetic pathways of a marine natural product.  A diversion followed with a graduate student talk from Ross McLennan (Univ. of St. Andrews) on his approach to the synthesis of pyronnazol A.  The afternoon highlight was the final speaker of the day, Paul Wender (Stanford Univ.) sharing many marvelous synthetic projects, inspired by a natural product, on therapeutic agents to treat HIV, Alzheimer’s disease and cancer.

Day two began with the morning session on marine natural products.  Raymond Andersen (Univ. of British Columbia) gave a lecture on many of the marine natural product structures that he has uncovered and their protein targets.  Bill Fenical (Scripps Inst. of Oceanography) and Phil Crews (Univ. of California, Santa Cruz) followed, sharing their many years of marine natural product discoveries from ocean sediments and sponges that target cancer and gram-negative bacteria.  Moving into fresh water discoveries, Alejandra Prieto-Davo (Univ. Nacional Autonoma de Mexico) shared her research on potential natural product discoveries from mangrove sediment off the coast of the Yucatan, where fresh water and the sea intersect.  Last for the morning session was Cassandra Quave (Emory University) who gave a spirited ethanobotanical talk on plant based natural product discoveries toward the prevention of bacterial biofilm formation.

The afternoon session contained a series of technology lectures that started with Nadja Cech (Univ. of North Carolina, Greensboro) sharing her labs approach to generating metabolomic mapping data using accurate mass to identify bioactive components from natural product mixtures.  Brian Murphy (Univ. of Illinois, Chicago) gave a talk on his innovations to improve on sample collection of unique sources and the chemical library production of these sources for biological screening.  Ning-Sun Yang (Academia Sinica, Taiwan) gave a lecture evaluating omics approaches to evaluating Phytochemicals as potent medical treatments.  The next two pure technology talks were from Sandra Groscurth (Bruker Biospin) and Giorgis Isaac (Waters Corporation).  Sandra shared the latest Bruker NMR technology for improved sensitivity and Bruker’s approach to automated structure elucidation.  Giorgis spoke on Ion Mobility MS.

The final session of the day started with a talk from Sandra Loesgen (Oregon State Univ.) on her labs discovery platform from marine microbes and their screens and targets.  The final talk, from Dimitris Argyropoulos (ACD/Labs), revealed ACD/Labs' suite of Enterprise Software and how to track the multitude of data coming from all instrument vendors and instrument technologies.

The final day began with a talk from Mariza Abreu Miranda (Univ. of Sao Paulo) on nanoparticle encapsulation for the delivery of glycoalkaloids of solanum lycocarpum and its biological evaluation.  This was followed by a wonderful technology talk by Phil Koerner (Phenomenex) on the history of HPLC columns.  James McChesney (Cloaked Therapeutics) finished the morning session with a lecture on the next generation of taxanes.

The afternoon was a short session that began with an interesting lecture from Rupika Delgoda (Uiv. of the West Indies) on the education and use of botanicals os therapeutic agents in Jamaica.  The final lecture of the conference came from Alexander Komienko (Texas State Univ.) on the synthesis of a tublin targeting alkaloid discovered from a marine organism.

In conclusion, each and every talk presented had an underlying theme of technology and how it was used to uncover an answer from their respective research into natural product drug discovery.  It is clear to us all that technology is crucial for getting to the endpoint in every scientific endeavor.

Programme

MONDAY 20TH MARCH 2017

14:00 – 14:45

Registration & Reception

14:00 – 14:45

Group Welcome Lunch

14:45 – 15:00

Opening Comments

Session Chair: Mark O’Neil-Johnson

15:00 – 15:45

Bill Gerwick
Scripps Institution of Oceanography, UCSD

SMALL MOLECULE ACCURATE RECOGNITION TECHNOLOGY (SMART), A NEW NMR-BASED TOOL TO ASSIST STRUCTURAL IDENTIFICATIONS

15:45 – 16:30

Patrick Harran
University of California, Los Angeles

COMBATING THE LONGEST LINEAR SEQUENCE IN MACROLIDE SYNTHESIS

16:30 – 17:00

Refreshments & Poster Viewing

Sessions Chair: Phil Crews

17:00 – 17:45

David Sherman
University of Michigan

DECODING A NEW CLASS OF INDOLE ALKALOID CYCLASES IN THE STIGONEMATALES CYANOBACTERIA

17:45 – 18:30

Paul Jensen
University of California San DIego

THE BIOSYNTHETIC GENE CLUSTER REVOLUTION: MAKING SENSE OF THE MASSES

18:30 – 19:00

Ross McLennan
University of St Andrews

TOWARDS THE SYNTHESIS OF PYRONNAZOL A

19:00 – 20:00

Paul Wender
Stanford University

THERAPEUTIC FUNCTION THROUGH SYNTHESIS INFORMED DESIGN: FIRST-IN-KIND APPROACHES TO HIV/AIDS ERADICATION, TREATING ALZHEIMER’S DISEASE AND CANCER IMMUNOTHERAPY

20:00

Dinner at Leisure

TUESDAY 21ST MARCH 2017

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

Session Chair: Sandra Loesgen

08:30 – 09:15

Raymond Andersen
The University of British Columbia

BIOLOGICALLY ACTIVE MARINE NATURAL PRODUCTS: DISCOVERY, SAR, AND INTERACTIONS WITH PROTEIN TARGETS

09:15 – 10:00

William Fenical
Scripps Institution of Oceangraphy

MARINE MICROBES AND THE QUEST FOR NEW TREATMENTS FOR CANCER

10:00 – 10:45

Phil Crews
University of California Santa Cruz

MINING THE UCSC REPOSITORY FOR MARINE BIOSYNTHETIC PRODUCTS FROM SPONGES AND GRAM-NEGATIVE BACTERIA TO OBTAIN SIGNIFICANT OUTCOMES

10:45 – 11:15

Alejandra Prieto-Davo
Universidad Nacional Autónoma de México

MICROBIAL ECOLOGY OF MANGROVE SEDIMENT BACTERIA AND THEIR POTENTIAL FOR NATURAL PRODUCT DISCOVERY

11:15 – 11:45

Refreshments & Group Photo

11:45 – 12:15

Cassandra Quave
Emory University

NATURAL PRODUCTS AND ANTI-INFECTIVE DRUG DISCOVERY

12:15 – 15:00

Lunch at Leisure & Free Time

Session Chair: Paul Jensen

15:00 – 15:45

Nadja Cech
University of North Carolina Greensboro

MASS SPECTROMETRY METABOLOMICS TO IDENTIFY BIOACTIVE COMPOUNDS FROM NATURAL PRODUCT MIXTURES

15:45 – 16:30

Brian Murphy
University of Illinois Chicago

INNOVATING THE FRONT END OF THE MICROBIAL DRUG DISCOVERY PROCESS

16:30 – 17:00

Ning-Sun Yang
Academia Sinica, Taiwan

EVALUATION OF POTENT AND MULTI-FACETED IMMUNE-MODIFYING ACTIVITIES OF MEDICINAL PHYTOCHEMICALS USING OMICS APPROACHES

17:00 – 17:30

Sandra Groscurth
Bruker BioSpin

STRUCTURE ELUCIDATION BY COMBINED USE OF MS AND NMR

17:30 – 18:00

Giorgis Isaac
Waters Corporation

SOLVING NATURAL PRODUCTS CHALLENGES USING NOVEL MS TECHNOLOGIES

18:00 – 18:30

Refreshments & Poster Viewing

18:30 – 19:15

Sandra Loesgen
Oregon State University

MICROBIAL NATURAL PRODUCTS IN DRUG DISCOVERY – NEW SOURCES, SCREENS, AND TARGETS

19:15 – 19:45

Dimitris Argyropoulos
ACD/Labs

UNIFIED TREATMENT OF ANALYTICAL DATA FOR NATURAL PRODUCT RESEARCH

19:45

Dinner at Leisure

WEDNESDAY 22RD MARCH 2017

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

Session Chair: Nadja Cech

08:30 – 09:15

Mariza Abreu Miranda University of Sao Paulo

DEVELOPMENT OF NANOPARTICLES FOR THE DELIVERY OF GLYCOALKALOIDS OF SOLANUM LYCOCARPUM AND BIOLOGICAL EVALUATION

09:15 – 10:00

Phil Koerner
Phenomenex

RECENT ADVANCES IN HPLC AND UHPLC COLUMN TECHNOLOGY AND APPLICATION TO COMPLEX SAMPLES

10:00 – 10:30

James McChesney
Cloaked Therapeutics, LLC

DESIGN AND DEVELOPMENT OF A NEXT GENERATION TAXANE

10:30 – 11:00

Refreshments & Poster Viewing

11:00 – 11:30

Rupika Delgoda
University of the West Indies

EVALUATING NATURAL INHIBITORS OF DRUG METABOLISING ENZYMES: IMPLICATIONS FOR DRUG DEVELOPMENT AND SAFETY

11:30 – 12:00

Silvana Rodriguez
INQUISUR, Universidad Nacional del Sur, Argentina

BIOACTIVITIES AND METABOLITES OBTAINED FROM ATRIPLEX UNDULATA (MOQ) D. DIETR. (CHENOPODIACEAE)

12:00 – 12:30

Alexander Komienko
Texas State University

DISCOVERY OF A NOVEL TUBULIN-TARGETING SCAFFOLD DERIVED FROM THE RIGIDIN FAMILY OF MARINE ALKALOIDS

12:30 – 19:30

 Lunch at Leisure & Free Time

19:30

*Gala Dinner*

 

Speakers

Invited Speakers

  • Prof. Paul Jensen
    Professor, University of California San DIego
  • Dr. William Gerwick
    Professor, Scripps Institution of Oceanography, UCSD
  • Dr. Cassandra Quave
    Assistant Professor, Emory University
  • Dr. Sandra Groscurth
    Product Portfolio Manager, Bruker BioSpin AG
  • Dr. James D. McChesney
    CEO, Cloaked Therapeutics, LLC
  • Prof. Raymond Andersen
    Professor, University of British Columbia
  • Dr. Alejandra Prieto-Davó
    Professor, Universidad Nacional Autónoma de México
  • Prof. William Fenical
    Distinguished Professor, Scripps Institution of Oceangraphy
  • Dr. Dimitris Argyropoulos
    NMR Business Manager, ACD/Labs
  • Prof. Patrick Harran
    Professor, University of California, Los Angeles
  • Prof. Nadja cech
    Professor, University of North Carolina Greensboro
  • Prof. Dr. David Sherman
    Hans W. Vahlteich Professor of Medicinal Chemistry, University of Michigan
  • Prof. Paul Wender
    Professor, Stanford University
  • Prof. Phillip Crews
    Distinguished Research Professor, University of California Santa Cruz
  • Dr. Giorgis Isaac
    Principal Scientist, Waters Corporation
  • Dr. Ning-Sun Yang
    Distinguished Professor and Research Fellow , Academia Sinica
  • Prof. Brian Murphy
    Associate Professor, University of Illinois Chicago
  • Prof. Sandra Loesgen
    Assistant Professor, Oregon State University
  • Dr. Rupika Delgoda
    Director, University of the West Indies

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