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Home > Past Conferences > Immuno-Metabolic Mechanisms of Atherosclerosis Conference

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Immuno-Metabolic Mechanisms of Atherosclerosis Conference

Novel critical mediators and therapeutic targets

11 Mar 2017 - 14 Mar 2017

Cancun, Mexico

Synopsis

Atherosclerosis and its complications remain the major cause of death in the industrialized world and emerging economies worldwide. The disease is initiated after retention of cholesterol-rich lipoproteins within the arterial wall at sites characterized by low shear stress. Modification of retained lipoproteins and activation of endothelial and vascular smooth muscle cells trigger an inflammatory response and provoke a series of cellular events involving complex interactions between vascular cells,  innate immune cells (e.g., neutrophils, monocytes/macrophages, dendritic cells, mast cells, B1 B lymphocytes, innate lymphoid cells) and cells involved in adaptive immunity to atherosclerosis-related antigens (e.g., Th1, Tregs, B2 lymphocytes). Depending on the balance between pro-inflammatory responses and resolution promoting pathways, lesion development is either delayed or accelerated towards the formation of advanced and complex plaques characterized by chronic unresolved inflammation, extensive matrix remodelling and formation of large thrombogenic necrotic cores. Defective repair and weakening of the protective fibrous cap ultimately leads to plaque disruption, which triggers acute thrombosis and vascular occlusion.  The whole process of atherogenesis is also to put in the context of significant systemic disturbances, particularly metabolic dysfunction, in which adipose tissue inflammation plays a determinant role.

The goal of this meeting is to provide attendees with a comprehensive overview of current research on atherosclerosis with a focus on the latest and most exciting developments in the immuno-metabolic mechanisms that govern disease initiation and progression. There is little doubt that the next most exciting therapy to combat cardiovascular disease will be based on targeting a biological pathway that will have been discussed during this conference.

Seven sessions are planned and will highlight the following major research areas: vascular cell activation, monocyte/macrophage identity and activation by lipoproteins, microRNAs and immuno-metabolism, innate immune mechanisms involving inflammasome activation, NETosis, necroptosis and their interplay with the cell metabolic environment, pro- and anti-atherogenic mechanisms operated by selective subsets of T and B lymphocytes, adipose tissue inflammation, microbiome and immunometabolism. We will also review the pathways that govern inflammation resolution, their regulation by bioactive lipids, and how they can be harnessed to develop new therapeutic strategies to combat the disease. Finally, we will discuss existing and validated targets that are now in late-phase clinical trials.

This conference will bring together a restricted but high-level group of scientists from different disciplines and participants from all career levels enabling thorough discussions of the latest research between established and young investigators and trainees, and cross-fertilization among scientists from a variety of backgrounds.

Ziad Mallat (Chair) and Christoph Binder (Co-Chair) look forward to welcoming you to the Fiesta Americana Condesa, Cancun, Mexico from March 11-14, 2017.

Key Sessions

  1. Vascular Cell Activation and Dysfunction
  2. Arterial monocytes/macrophages in health and disease
  3. Innate immunity, NETosis, necroptosis, inflammasome
  4. T Cell Immune Responses
  5. B Cell Immune Responses
  6. Adipose Tissue Inflammation, Insulin Resistance, Atherosclerosis
  7. Resolution of Inflammation, Immunotherapies

Target Audience

We encourage young scientists/clinicians to attend and expect broad representation from various disciplines. The conference will especially appeal to scientists, scientists/clinicians in academia, biotech and pharmaceutical companies with interest in Cardiovascular Medicine/Biology, Immunology, Metabolic Diseases, Immuno-Metabolism, Molecular/Cellular Biology and Epigenetics. 

Learning Objectives

At the conclusion of the meeting, the participants should be able to:

  1. Describe and discuss the most recent research advances in our understanding of the origin and fate of innate and adaptive immune cells (macrophages, lymphocytes and innate lymphoid cells), and their critical functions in atherosclerosis
  2. Describe and discuss the basic molecular mechanisms that integrate cellular metabolism and the immune response in the context of obesity, metabolic syndrome and atherosclerosis
  3. Describe and discuss novel research on the various forms of cell death, and their pathophysiologic and therapeutic implications
  4. Discuss novel evidence-based opportunities to prevent and treat the immuno-metabolic disturbances of atherosclerosis

Plenary Speakers

Joseph Witztum (UCSD, San Diego)

Peter Libby (Harvard Medical School)
INFLAMMATION IN ATHEROSCLEROSIS: A TRANSLATIONAL TALE

Goran Hansson (Karolinska Institute, Stockholm)

Invited Speakers

Ajay Chawla (UCSF, San Francisco)
INNATE IMMUNE LICENSING OF THERMOGENESIS

Chris Glass (UCSD, San Diego)
REGULATION OF GENE EXPRESSION AND LIPID METABOLISM BY THE LXR/SREBP AXIS IN MACROPHAGES

Eicke Latz (University of Bonn)

Venizelos Papayannopoulos (Francis Crick Institute, London)
NEUTROPHIL EXTRACELLULAR TRAP SIGNALING IN ATHEROSCLEROSIS

Manolis Pasparakis (University of Cologne)
NF-KB AND CELL DEATH SIGNALLING IN ATHEROSCLEROSIS

Caetano Reis e Sousa (Francis Crick Institute, London)
ACTIN EXPOSURE IN STERILE INFLAMMATION

Christian Weber (Ludwig-Maximilians-University, Munich)

Ira Tabas (Columbia University, New York)
DEFECTIVE INFLAMMATION RESOLUTION IN ATHEROSCLEROSIS: MECHANISMS AND THERAPEUTIC OPPORTUNITIES

Laurent Yvan-Charvet (Inserm, Nice)
ALTERED HAEMATOMETABOLISM, INFLAMMATION AND ATHEROSCLEROSIS

Edward A. Fisher (NYU School of Medicine)
THE MANY GUISES OF MACROPHAGES IN ATHEROSCLEROSIS PROGRESSION AND REGRESSION

Clint S. Robbins (University of Toronto)

Guo-Ping Shi (Harvard University)
THE MANY GUISES OF MACROPHAGES IN ATHEROSCLEROSIS PROGRESSION AND REGRESSION

Hanjoong Jo (Emory University)
Flow sensitive genes in endothelial inflammation and atherosclerosis – OMICs approaches

Mark Febbraio (Garvan Institute for Medical Research, Sydney)
THE CHAMELEON ROLE OF TLR4 IN LIPID INDUCED MACROPHAGE INFLAMMATION

Filip Swirski (Harvard Medical School)
IMMUNE CELL CROSSTALK IN ATHEROSCLEROSIS

Andreas Habenicht (Ludwig-Maximilians-University (LMU) Munich)
ARTERY TERTIARY LYMPHOID ORGANS: POWERHOUSES OF ATHEROSCLEROSIS IMMUNITY

Gwen Randolph (Washington University in St. Louis)
HDL TRANSIT THROUGH THE INTERSTITIUM AND ITS LINK TO IMMUNOLOGICAL MECHANISMS IN ATHEROSCLEROSIS

Cecile Benezech (University of Edinburgh)
ROLE OF FAT-ASSOCIATED LYMPHOID CLUSTERS IN INFLAMMATION

Gary Owens (University of Virginia)
IL1b PROMOTES ATHEROPROTECTIVE CHANGES IN LATE STAGE ATHEROSCLEROTIC LESIONS

Kathryn J Moore (New York University Medical Center)
REGULATION OF MACROPHAGE IMMUNOMETABOLISM IN ATHEROSCLEROSIS

Claudia Kemper (King’s College, London)
COMPLEMENT-MEDIATED METABOLIC REPROGRAMMING REGULATES HUMAN TH1 RESPONSES

Matthew Spite (Brigham and Women’s Hospital, Harvard Medical School)
INFLAMMATION-RESOLVING LIPID MEDIATORS IN CARDIOVASCULAR DISEASE

Michael Sieweke (Centre d’Immunologie de Marseille Luminy)
SELF RENEWAL MECHANISMS OF DIFFERENTIATED MACROPHAGES

 

 

 

 

Sponsors

Sponsors

Report

The meeting was chaired by Ziad Mallat (Professor of Cardiovascular Medicine, University of Cambridge, UK) and Christoph Binder (Professor of Atherosclerosis Research, Medical University of Vienna, Austria).

Faculty included 3 plenary speakers: Joseph Witztum (UCSD, San Diego), Peter Libby (Harvard Medical School), Goran Hansson (Karolinska Institute, Stockholm), and 22 speakers (including the Chair and Co-Chair): Ajay Chawla (UCSF, San Francisco), Andreas Habenicht (Ludwig-Maximilians-University, Munich), Caetano Reis e Sousa (Francis Crick Institute, London), Cecile Benezech (University of Edinburgh), Christopher Glass (UCSD, San Diego), Claudia Kemper (King’s College, London), Edward A. Fisher (NYU School of Medicine), Eicke Latz (University of Bonn), Filip Swirski (Harvard Medical School), Gary Owens (University of Virginia), Guo-Ping Shi (Harvard University), Hanjoong Jo (Emory University), Ira Tabas (Columbia University, New York), Kathryn J Moore (New York University Medical Centre), Laurent Yvan-Charvet (Inserm, Nice), Manolis Pasparakis (University of Cologne), Mark Febbraio (Garvan Institute for Medical Research, Sydney), Matthew Spite (Brigham and Women’s Hospital, Harvard Medical School), Michael Sieweke (Centre d’Immunologie de Marseille Luminy), and Venizelos Papayannopoulos (Francis Crick Institute, London)

The meeting was unique in assembling world-leading experts from diverse disciplines, within and outside the field of atherosclerosis. The meeting highlighted several exciting areas at the interface of immunity and metabolism in the context of atherosclerosis: 1) Vascular Cell Activation and Dysfunction, 2) Monocytes/macrophages and lipid handling in health and disease, 3) Innate immunity, NETosis, necroptosis, inflammasome, 4) T and B Cell Immune Responses in atherosclerosis, 5) Adipose Tissue Inflammation, Microbiome and Atherosclerosis, 6) Immunometabolism, and 7) Resolution of Inflammation and Immuno-metabolic therapies.

Attendees listened to and interacted with the finest minds in those fields of research, which led to fruitful discussions and interrogation of new ideas and concepts between established and young investigators and trainees, and cross-fertilization among scientists from a variety of backgrounds.

All speakers and attendees were very pleased with the high quality of the science and the professional organisation led by Fusion Conferences, and we received a lot of positive feedback:

“Dear Ziad and Christoph,

I wanted to express my deep appreciation for the invitation to present our work in the Fusion Conference in Cancun.  It was one of the best meetings that I attended and I learned a lot, especially immunology and metabolism in atherosclerosis. I got a few really interesting ideas that I am going to test in my lab very soon.  The venue was fantastic and highly conducive to making new connections to the leaders in the field”.

“Dear Ziad and Christoph,

Just a note to thank you for the truly outstanding meeting.  You really did a marvellous job in bringing together many experts in our field, but also experts in novel areas that were most revealing. I know how difficult it is to put together such meetings and I know how hard you worked on this…”

We hope that this meeting will become a significant series of symposia within the atherosclerosis community.

Programme

SATURDAY 11TH MARCH 2017

14:00 – 14:45

Registration & Reception

14:00 – 14:45

Group Welcome Lunch

*Kalmia Buffet Restaurant*

14:45 – 15:00

Opening Comments

15:00 – 15:45

Joseph Witzum
UCSD, San Diego

 

VASCULAR CELL ACTIVATION AND DYSFUNCTION
Session Chair: Peter Libby

15:45 – 16:15

Hanjoong Jo
Emory University/GA Tech

FLOW SENSITIVE GENES IN ENDOTHELIAL INFLAMMATION AND ATHEROSCLEROSIS – OMICS APPROACHES

16:15 – 16:45

Gary Owens
University of Virginia

IL1b PROMOTES ATHEROPROTECTIVE CHANGES IN LATE STAGE ATHEROSCLEROTIC LESIONS

16:45 – 17:00

Johannes Schmid
Medical Univ. of Vienna

ENDOTHELIAL I-kappa B KINASE 2 IN ATHEROSCLEROS

17:00 – 17:30

Refreshments

ARTERIAL MONOCYTES/MACROPHAGES IN HEALTH AND DISEASE
Session Chair: Joseph Witztum

17:30 – 18:00

Christopher Glass
UCSD

REGULATION OF GENE EXPRESSION AND LIPID METABOLISM BY THE LXR/SREBP AXIS IN MACROPHAGES

18:00 – 18:30

Kathryn Moore
New York University

REGULATION OF MACROPHAGE IMMUNOMETABOLISM IN ATHEROSCLEROSIS

18:30 – 19:00

Michael Sieweke
Centre d'Immunologie de Marseille-Luminy

SELF RENEWAL MECHANISMS OF DIFFERENTIATED MACROPHAGES

19:00 – 19:15

Jesse Williams
Washington University in St. Louis

AORTIC INTIMA-RESIDENT MACROPHAGES CONTRIBUTE TO ATHEROSCLEROTIC LESION INITIATION AND PLAQUE PROGRESSION

19:15 – 19:30

PM Panel Discussion

19:30

Dinner at Leisure

SUNDAY 12TH MARCH 2017

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

INNATE IMMUNITY, INFLAMMASOME, NETOSIS, NECROPTOSIS
Session Chairs: Ajay Chawla and Chris Glass

08:30 – 09:00

Eicke Latz
University of Bonn

INNATE IMMUNE MEMORY RESPONSES TOWARDS WESTERN DIET.

09:00 – 09:30

Caetano Reis e Sousa
The Francis Crick Institute

ACTIN EXPOSURE IN STERILE INFLAMMATION.

09:30 – 10:00

Ira Tabas
Columbia University Medical Center

DEFECTIVE INFLAMMATION RESOLUTION IN ATHEROSCLEROSIS: MECHANISMS AND THERAPEUTIC OPPORTUNITIES

10:00 – 10:15

Edward Thorp
Northwestern University

MITOCHONDRIAL-DIRECTED MACROPHAGE REPROGRAMMING DURING EFFEROCYTOSIS AND POST MYOCARDIAL INFARCTION

10:15 – 10:30

Martina Rami
Ludwig-Maximilians-Universität München

CHRONIC TREATMENT WITH ANTIDEPRESSANT FLUOXETINE PROMOTES ATHEROGENESIS IN APOLIPOPROTEIN E-DEFICIENT MICE

10:30 – 11:00

Refreshments & Group Photo

11:00 – 11:30

Venizelos Papayannopoulos
The Francis Crick Institute

NEUTROPHIL EXTRACELLULAR TRAP SIGNALING IN ATHEROSCLEROSIS

11:30 – 12:00

Manolis Pasparakis
University of Cologne

NF-KB AND CELL DEATH SIGNALLING IN ATHEROSCLEROSIS.

12:00 – 12:15

AM Panel Discussion

12:15 – 16:15

Lunch at Leisure & Free Time 

12:40 – 16:00

Group Snorkeling Trip (optional)

T AND B CELL IMMUNE RESPONSES
Session Chairs: Göran Hansson and Ziad Mallat

16:15 – 17:00

Goran Hansson
Karolinska Institute, Stockhom

CELLULAR IMMUNITY IN ATHEROSCLEROSIS: MECHANISMS OF ACTION AND IMPLICATIONS FOR THERAPY

 

17:00 – 17:30

Andreas Habenicht
Ludwig-Maximilians-University Munich

ARTERY TERTIARY LYMPHOID ORGANS: POWERHOUSES OF ATHEROSCLEROSIS IMMUNITY

17:30 – 17:45

Carlos Neideck
Institute for Cardiovascular Prevention (IPEK) University of Munich

 

CCL17-DEPENDENT RELEASE OF CCL3 RESTRAINS REGULATORY T CELLS THEREBY AGGRAVATING ATHEROSCLEROSIS.

17:45 – 18:00

Máté Kiss
CeMM

HEMATOPOIETIC COMPLEMENT FACTOR H DEFICIENCY REDUCES ATHEROSCLEROTIC LESION FORMATION IN LDLR DEFICIENT MICE

18:00 – 18:30

Refreshments

18:30 – 19:00

Christoph Binder
Medical University of Vienna

B CELLS AND REGULATORY B CELL NETWORKS IN ATHEROSCLEROSIS

19:00 – 19:30

Filip Swirski
Massachusetts General Hospital and Harvard Medical School, Boston

IMMUNE CELL CROSSTALK IN ATHEROSCLEROSIS

19:30 – 19:45

Andrew Sage
University of Cambridge

MARGINAL ZONE B CELLS CONTROL THE FOLLICULAR T HELPER CELL RESPONSE TO HIGH CHOLESTEROL DIET

19:45 – 20:00

Katka Szilagyi
Sanquin Research and Landsteiner Laboratory

SIRPα IS A NOVEL IMMUNE CHECKPOINT ON B1 CELLS REGULATING NATURAL ANTIBODY PRODUCTION AND ATHEROSCLEROSIS DEVELOPMENT

20:00 – 20:15

PM Panel Discussion

20:15

Dinner at Leisure

MONDAY 13TH MARCH 2017

07:00 – 09:00

Breakfast

*Kalmia Buffet Restaurant*

ADIPOSE TISSUE INFLAMMATION, MICROBIOME, ATHEROSCLEROSIS
Session Chairs: Eicke Latz and Kathryn Moore

09:00 – 09:30

Ajay Chawla
UCSF, San Francisco

INNATE IMMUNE LICENSING OF THERMOGENESIS

09:30 – 10:00

Cecile Benezech
University of Edinburgh

ROLE OF FAT-ASSOCIATED LYMPHOID CLUSTERS IN INFLAMMATION

10:00 – 10:15

Robert Raffai
University of California / VA Medical Center

INFLUENCE OF HYPERGLYCEMIA ON MACROPHAGE-DERIVED EXOSOMES IN DIABETIC ATHEROSCLEROSIS REGRESSION

10:15 – 10:30

Dina Schneider   
University of California, San Diego

APOLIPOPROTEIN A-I BINDING PROTEIN REGULATES INFLAMMATION AND LIPOPROTEIN METABOLISM IN ATHEROSCLEROSIS

10:30 – 11:00

Refreshments

11:00 – 11:30

Guo-Ping Shi
Harvard University

NA+-H+ EXCHANGER 1 DETERMINES ATHEROSCLEROTIC LESION ACIDIFICATION AND PROMOTES ATHEROGENESIS

11:30 – 12:00

Mark Febbraio
Garvan Institute of Medical Research, Sydney

THE CHAMELEON ROLE OF TLR4 IN LIPID INDUCED MACROPHAGE INFLAMMATION

12:00 – 12:15

Laurienne Gardner
University of Oxford

HYPERGLYCAEMIA-INDUCED METABOLIC CHANGES IN MACROPHAGES ALTER GENE EXPRESSION AND FUNCTION

12:15 – 12:30

AM Panel Discussion

12:30 – 16:15

Lunch at Leisure & Free Time

IMMUNOMETABOLISM
Session Chair: Mark Febbraio

16:15 – 16:45

Claudia Kemper
National Institutes of Health, NHLBI

COMPLEMENT-MEDIATED METABOLIC REPROGRAMMING REGULATES HUMAN TH1 RESPONSES

16:45 – 17:15

Laurent Yvan-Charvet
Inserm U1065 -C3M, Nice

ALTERED HAEMATOMETABOLISM, INFLAMMATION AND ATHEROSCLEROSIS

17:15 – 17:45

Li-Hao "Paul" Huang
Washington University School of Medicine

HDL TRANSIT THROUGH THE INTERSTITIUM AND ITS LINK TO IMMUNOLOGICAL MECHANISMS IN ATHEROSCLEROSIS

17:45 – 18:00

PM Panel Discussion

18:00 – 20:00

Poster Session & Refreshments

20:00

*Gala Dinner & Poster Awards*

TUESDAY 14TH MARCH 2017

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

RESOLUTION OF INFLAMMATION, IMMUNOTHERAPIES
Session Chairs: Ira Tabas and Christoph Binder

08:30 – 08:45

Robin Choudhury
University of Oxford

ARTERIAL EFFECTS OF CANAKINUMAB IN PATIENTS WITH ATHEROSCLEROSIS AND TYPE 2 DIABETES OR GLUCOSE INTOLERANCE

08:45 – 09:15

Edward Fisher
New York University School of Medicine

THE MANY GUISES OF MACROPHAGES IN ATHEROSCLEROSIS PROGRESSION AND REGRESSION

09:15 – 09:45

Ziad Mallat
University of Cambridge

TARGETING THE IMMUNE RESPONSE IN ATHEROSCLEROSIS AND MYOCARDIAL INFRACTION.

09:45 – 10:00

Yosdel Soto
Centre for Molecular Immunology

NOVEL ANTI-PROTEOGLYCAN ANTIBODY INHIBITS ARTERIAL RETENTION OF PROATHEROGENIC LIPOPROTEINS IN A RAT MODEL OF INSULIN RESISTANCE

10:00 – 10:45

Matthew Spite
Harvard Medical School and Brigham and Women's Hospital, Boston

INFLAMMATION-RESOLVING LIPID MEDIATORS IN CARDIOVASCULAR DISEASE

10:45 – 11:15

Refreshments

11:15 – 12:00

Peter Libby
Brigham and Women’s Hospital, Boston

INFLAMMATION IN ATHEROSCLEROSIS: A TRANSLATIONAL TALE

12:00 – 12:15

AM Panel Discussion

12:15 – 12:30

Closing Comments



Speakers

Plenary Speakers

  • Prof. Peter Libby
    Cardiovascular Specialist, Brigham and Women’s Hospital
  • Prof. Goran Hansson
    Professor, Karolinska Institute
  • Prof. Joseph Witztum
    Prof of Medicine, UCSD

Invited Speakers

  • Prof. Mark Febbraio
    Head of Division of Diabetes & Metabolism, Garvan Institute of Medical Research
  • Dr. Caetano Reis e Sousa
    Laboratory Head, The Francis Crick
  • Prof. Dr. Edward Fisher
    Leon Charney Professor of Cardioascular Medicine, NYU School of Medicine
  • Dr. Hanjoong Jo
    Associate Chair, Emory University/GA Tech
  • Dr. Gary Owens
    Professor, University of Virginia
  • Prof. Kathryn Moore
    Professor, New York University
  • Dr. Matthew Spite
    Assistant Professor, Harvard Medical School and Brigham and Women's Hospital
  • Dr. Ajay Chawla
    Professor, University of California San Francisco
  • Prof. Guo-Ping Shi
    Associate Professor, Harvard Medical School
  • Dr. Michael Sieweke
    Head of Laboratory, Centre d'Immunologie de Marseille-Luminy
  • Prof. Dr. Manolis Pasparakis
    Professor, University of Cologne
  • Dr. Chris Glass
    Professor, UC San Diego
  • Dr. Cecile Benezech
    Chancellor Fellow, University of Edinburgh
  • Dr. Ira Tabas
    Professor, Columbia University Medical Center
  • Dr. Filip Swirski
    Associate Professor, Massachusetts General Hospital and Harvard Medical School
  • Dr. Laurent YVAN-CHARVET
    PhD, Ass. Prof, Group Leader, Inserm U1065 -C3M
  • Prof. Claudia Kemper
    Tenured Investigator, Section Chief, National Institutes of Health, NHLBI
  • Prof. Eicke Latz
    Director, University of Bonn
  • Dr. Venizelos Papayannopoulos
    Group leader, The Francis Crick Institute
  • Prof. Dr. Andreas Habenicht
    Professor of Medicine, Ludwig-Maximilians-University Munich

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