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Home > Past Conferences > 2nd Fibroblast Growth Factors in Development and Repair Conference

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Past Conference

2nd Fibroblast Growth Factors in Development and Repair Conference

08 Mar 2017 - 11 Mar 2017

Cancun, Mexico

Synopsis

The major goal of this Fusion Conference is to bring together in a single forum the diverse group of researchers who study fibroblast growth factor (FGF) signaling. This will provide a unique opportunity to discuss new results and to target future research areas.

Key Sessions

  1. The mechanisms by which FGF signaling governs organogenesis and tissue patterning during embryonic development.
  2. The role of FGF signaling in adult tissue homeostasis, repair, regeneration, and angiogenesis.
  3. Aberrant FGF signaling in developmental/hereditary diseases including skeletal, cardiovascular, neurological, respiratory, digestive, genitourinary, and endocrine disorders.

Speakers

Zamal Ahmed (The University of Texas MD Anderson Cancer Center)
Stijn de Langhe (National Jewish Health)
Masatoshi Fujiwara (Ribomic)
Mitchell Goldfarb (Hunter College)
Richard Grose (Queen Mary University of London)
Robert Guzy (The University of Chicago)
Mohammad Hajihosseini (University of East Anglia)
Stacey House (Washington University)
Sung-Ho Huh (University of Nebraska Medical Center)
Marja Hurley (UConn Health)
Fernanda Laezza (UTMB Health)
Laurence Legeai-Mallet (Imagine Institute-Inserm U1163)
Mark Lewandoski (NCI)
Helen Makarenkova (The Scripps Research Institute)
Suzanne Mansour (The University of Utah)
Ivor Mason (King's College London)
Nora M. Navone (MD Anderson Cancer Center)
Victor Nurcombe (IMB)
Bradley Olwin (University of Colorado Boulder)
Dina Ron (Technion - Israel Institute of Technology)
Michael Seckl (Imperial College London)
Michael Simons (Yale University)
Philippe Soriano (Icahn School of Medicine at Mt. Sinai)
Jeffrey Stavenhagen (Therachon)
Xin Sun (University of Wisconsin–Madison)
Jerry Turnbull (University of Liverpool)
Hisashi Umemori (Harvard Medical School)
Fen Wang (Texas A&M)
David Warburton (University of Southern California)
Sabine Werner (ETH Zurich Institute of Molecular Health Sciences)
Zipora Yablonka-Reuveni (University of Washington)
Avner Yayon (ProCore Bio Med)
Jin-San Zhang (Mayo Clinic)
Xin Zhang (Columbia University)

Target Audience

Reflecting the pleiotropic functions of FGF signaling in human biology, FGF researchers encompass a wide range of scientific disciplines, including structural biologists, biochemists, cell biologists, endocrinologists, developmental biologists, geneticists, pharmacologists and clinicians. 

 

Sponsors

Sponsors

Report

This second Fusion conference on Fibroblasts Growth Factors in Development and Repair took place in Cancun Mexico, from March 8 through March 11, 2017. The meeting was chaired again by Prof. David Ornitz (Washington University, St Louis, USA) and Prof. Saverio Bellusci (Justus Liebig University, Giessen, Germany).

The invited Faculty, which presented state of the art data, included Dr. Richard Grose (Queen Mary University of London), Dr. Stijn de Langhe (University of Alabama Birmingham), Dr. Mohammad Hajihosseini (University of East Anglia), Dr. Laurence Legeai-Mallet (Imagine Institute-Inserm U1163), Dr. Bradley Olwin (University of Colorado Boulder), Dr. Dina Ron (Technion - Israel Institute of Technology), Dr. Michael Simons (Yale University), Dr. Philippe Soriano (The Mount Sinai Hospital), Dr. Sabine Werner (ETH, Zurich), Dr. Xin Sun (University of Calif, San Diego), Dr. Fen Wang (Texas A&M) and Dr. Jin-San Zhang (Mayo Clinic). 

We also recruited other speakers, both junior, mid-level, and senior scientists from the submitted abstracts. We had a good ratio of speakers both in terms of gender and seniority, with the priority given to junior to mid-level scientists.

Contrarily to the first meeting, which was organized on a relatively short notice, the chairs had plenty of time to organize this meeting as well as to do fund raising, with most of the money coming from biotech companies, scientific publishing companies and academic institutions. This allowed us to provide substantial funding for travel awards to most of the students, postdocs, and junior faculty attending to this meeting. The program set by the chairs attracted participants from many countries with various scientific interest. The participants at this meeting primarily worked in the field of FGFs in cancer, neurobiology, regeneration and disease, organogenesis, musculoskeletal and vascular development. This meeting allowed networking and cross fertilization of ideas between overlapping but related fields of research.

The conference venue, the fusion staff and the fantastic weather at this time of the year permitted us to conduct the meeting in a stress-free atmosphere which was very helpful to allow the field to advance. Most of the attendees participated to the discussion and plenty of time was available for networking and setting up collaborations. The poster presentations were also actively attended and provided an additional platform for discussion and collaboration.

In conclusion, this Fusion meeting was very successful and the attendants decided to organize another meeting in 2019 which will be chaired by Dr. Sabine Werner and Dr. Brad Olwin. 

 

Programme

WEDNESDAY 8TH MARCH 2017

14:00 – 14:45

Registration

14:00 – 14:45

Welcome Lunch

*Kalmia Buffet Restaurant*

14:45 – 15:00

Opening Comments

CANCER
Session Chair: Gary Schoenwolf, University of Utah

15:00 – 15:25

Richard Grose
Queen Mary, University of London

UNDERSTANDING DRUG RESISTANCE IN FGFR DRIVEN CANCER

15:25 – 15:50

Fen Wang
Texas A&M

FGF SIGNALING IN PROSTATE CANCER PROGRESSION

15:50 – 16:15

Nora Navone
MD Anderson Cancer Center

TARGETING THE BONE COMPARTMENT IN METASTATIC PROSTATE CANCER

16:15 – 16:35

Zamal Ahmed
MD Anderson Cancer Center

ROLE OF GRB2 IN FGFR2 SIGNALING AND BEYOND

16:35 – 17:00

Jin-San Zhang
Mayo Clinic

FGF 2 PROTECTS AGAINST RENAL ISCHEMIA/REPERFUSION INJURY BY ATTENUATING MITOCHONDRIAL DAMAGE AND PROINFLAMMATORY SIGNALING

17:00 – 17:30

Refreshments & Poster Viewing

BONE AND CARTILAGE
Session Chair: Jerry Turnbull, University of Liverpool

17:30 – 17:50

Marja Hurley
UCONN Health, School of Medicine

FGF2 ISOFORMS AND OSTEOARTHRITIS

17:50 – 18:10

David Ornitz
Washington University

FIBROBLAST GROWTH FACTORS: CRITICAL REGULATORS OF OSTEOGENIC AND CHONDROGENIC GROWTH PROGRAMS

18:10 – 18:30

Laurence Legeai-Mallet
Imagine Institute-Inserm U1163

FGFR3 REGULATES PRIMARY CILIA ELONGATION THROUGH AUTOPHAGY

18:30 – 18:50

Jeffrey Stravenhagen
Therachon AG

DEVELOPMENT OF A NOVEL BIOLOGIC FOR THE TREATMENT OF ACHONDROPLASIA

18:50 – 19:10

Avner Yayon
Procore Ltd

RECEPTOR SELECTIVE, HEPARAN SULFATE DEPENDENT, ENGINEERED VARIANTS OF FGF18 FOR THE TREATMENT OF DAMAGE INDUCED OSTEOARTHRITIS

19:10

Dinner at Leisure

THURSDAY 9TH MARCH 2017

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

MUSCLE, SKIN AND VASCULATURE
Session Chair: Mohammad Hajihosseini, University of East Anglia

08:30 – 08:50

Stacey House
Washington University in St. Louis

ROLE OF FGF9 AND FGF16 IN ACUTE CARDIAC INJURY AND REPAIR

08:50 – 09:15

Michael Simons
Yale School of Medicine

FGF-DEPENDENT CONTROL OF VASCULAR METABOLISM

09:15 – 09:40

Bradley Olwin
University of Colorado Boulder

REGULATING SKELETAL MUSCLE REGENERATION AND SIZE BY DISRUPTING SATELLITE CELL TERMINAL DIFFERENTIATION

09:40 – 10:20

Refreshments & Group Photo

10:20 – 10:45

Sabine Werner
ETH Zurich Institute of Molecular Health Sciences

ROLE AND MECHANISM OF ACTION OF FIBROBLAST GROWTH FACTORS IN INFLAMMATORY SKIN DISEASE

10:45 – 11:10

Zipora Yablonka-Reuveni
University of Washington School of Medicine

THE STATUS OF FGFRS AND THEIR KLOTHO CO-RECEPTORS IN SKELETAL MUSCLE MYOGENESIS AND FIBRO/ADIPOGENESIS

11:10 – 11:30

Elissavet Kardami
University of Manitoba

FGF-2 EXERTS DIRECT PROTECTIVE OR DESTRUCTIVE EFFECTS ON CARDIAC MITOCHONDRIA, IN AN ISOFORM-SPECIFIC MANNER, MEDIATED BY A MITOCHONDRIAL RECEPTOR

11:30 – 11:50

Peter Cattini
University of Manitoba

FGF-16 AND ACUTE DOXORUBICIN CARDIOTOXICITY: AN EARLY TARGET FOR EARLY PROTECTION

11:50 – 16:30

Lunch at Leisure & Free Time

SIGNALING
Session Chair: Richard Grose, Queen Mary, University of London

16:30 – 16:55

Philippe Soriano
Icahn School of Medicine at Mt. Sinai

FGF SIGNALING PATHWAYS IN MOUSE DEVELOPMENT

16:55 – 17:20

Jerry Turnbull
University of Liverpool

TUNING FGF SIGNALING WITH DEFINED HEPARAN SULFATE SACCHARIDES

17:20 – 17:45

Dina Ron
Technion, Israel Instititute of Technology

DISSECTING THE ROLE OF THE TUMOR SUPPRESSOR SEF: FROM IN-VITRO TO IN-VIVO

17:45 – 18:10

Michael Seckl
Imperial College London

FGF-2 PROSURVIVAL SIGNALLING AND THE USE OF AN FGFR INHIBITOR TO REVERSE RESISTANCE TO THERAPY IN CANCER: FROM BENCH TO BEDSIDE

POSTER TALKS

18:10 – 18:20

Malgorzata Zakrzewska
University of Wroclaw

TRANSLOCATED FGF1 AND FGF2 PROTECT THE CELL AGAINST APOPTOSIS

18:20 – 18:30

Stephanie Kainrath
Institute of Science and Technology, Austria

LIGHT INDUCED INHIBITION OF AN OPTOGENETIC FGFR1 MIMICKING CONSTITUTIVE ACTIVITY

18:30 – 18:40

David Dolivo
Worcester Polytechnic Institute

FIBROBLAST GROWTH FACTOR 2 INHIBITS FIBROBLAST ACTIVATION AND ATTENUATES MYOFIBROBLAST PHENOTYPES IN HUMAN DERMAL FIBROBLASTS

18:40 – 19:40

Poster Session I & Refreshments

19:40

Dinner at Leisure

FRIDAY 10TH MARCH 2017

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

LUNG
Session Chair: Saverio Bellusci, Justus-Liebig-Universitaet Giessen, ECCPS

08:30 – 08:40

Navid Koleini
University of Manitoba

FIBROBLAST GROWTH FACTOR-2 PROTECTION FROM CANCER DRUG CARDIOTOXCITY IS MEDIATED BY THE MTOR/NRF2/HEMOXYGENASE-1 PATHWAY

08:40 – 08:50

Stefan Hadzic     
ECCPS

THE ROLE OF FGF10 IN THE PATHOGENESIS OF CIGARETTE SMOKE-INDUCED EMPHYSEMA AND PULMONARY HYPERTENSION

08:50 – 09:15

Cho-Ming Chao
ECCPS, University Justus Liebig Giessen

ROLE OF FGF10 SIGNALLING IN ALVEOLAR EPITHELIAL LINEAGE FORMATION

09:15 – 09:40

Xin Sun
University of California, San Diego

FGF FUNCTION IN LUNG MATURATION

09:40 – 10:05

David Warburton
Children's Hospital Los Angeles

SOME NEW IDEAS REGARDING THE POTENTIAL FUNCTION OF FGF SIGNALING IN DEVELOPMENT OF THE GAS DIFFUSION SURFACES OF THE LUNG

10:05 – 10:30

Robert Guzy
Washington University School of Medicine

MESENCHYME-SPECIFIC FGF SIGNALING IN PULMONARY FIBROSIS

10:30 – 11:00

Refreshments & Poster Viewing

11:00 – 11:25

Stijn de Langhe
University of Alabama at Birmingham

EPITHELIAL YAP TUNES FGF10 EXPRESSION IN THE STROMAL NICHE

11:25 – 11:50

Xin Zhang
Columbia University

NEURAL CREST FGF SIGNALING CONTROLS LACRIMAL GLAND DEVELOPMENT

POSTER TALKS

11:50 – 12:00

Andrew Hagan
Washington University School of Medicine

FGF18 SIGNALING IN POSTNATAL ALVEOLOGENESIS

12:00 – 12:10

Amit Shrestha
Justus Liebig University of Giessen

MIR-142 REGULATES ALVEOLAR LINEAGE FORMATION DURING LUNG DEVELOPMENT

12:10 – 12:25

Discussion on the future of the FGF series

12:25 – 16:30

Lunch at Leisure & Free Time

DEVELOPMENT
Session Chair: Stijn de Langhe, University of Alabama at Birmingham

16:30 – 16:55

Helen Makarenkova
The Scripps Research Institute

FGF10 REGULATES ADULT LACRIMAL GLAND STEM CELL DYNAMIC AND HIERARCHY

16:55 – 17:20

Mohammad Hajihosseini
University of East Anglia

NEW INSIGHTS INTO THE EXPRESSION AND FUNCTIONS OF FGF10 DURING MOUSE LIMB DEVELOPMENT

17:20 – 17:45

Mark Lewandoski
NCI, NIH

THE ROLE OF FGF ACTIVITY DURING SOMITOGENESIS AND EXTENSION OF THE VERTEBRATE AXIS

PHARMACOLOGY
Session Chair: Avner Yayon, Procore Ltd.

17:45 – 18:10

Masatoshi Fujiwara
Ribomic

DIVERGENT ROLES OF FGF2 IN DISEASE PROGRESSION: MULTIACTIONS OF ANTI-FGF2 APTAMER

18:10 – 18:25

Jin-San Zhang
Shanghai Tenry Pharmaceutical Co. Ltd (on behalf of)

TENRYPHARM FROM CHINA, WITH ACIDIC FGF FOR WOUND HEALING USE

18:25 – 19:25

Poster Session II & Refreshments

20:00

*Gala Dinner & Poster Awards*

SATURDAY 11TH MARCH 2017

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

NEUROBIOLOGY AND INTRACELLULAR FGFS
Session Chair: Mark Lewandoski, NCI, NIH

08:30 – 08:55

Suzanne Mansour
University of Utah

FGFR2B LIGANDS IN HEARING

08:55 – 09:20

Ivor Mason
King's College London

FGF REGULATION OF CONNECTIVITY IN THE DEVELOPING VERTEBRATE BRAIN

09:20 – 09:45

Sung-Ho Huh
University of Nebraska Medical Center

ADMINISTRATION OF FGF9 IN VIVO RESCUES LOSS OF LATERAL COMPARTMENT OF ORGAN OF CORTI CUASED BY DELETION OF FGF20

09:45 – 10:10

Mitchell Goldfarb
Hunter College

FHF MODULATION OF SODIUM CHANNELS IN BRAIN AND HEART: 

NORMAL AND PATHOLOGICAL MECHANISMS

10:10 – 10:40

Refreshments

10:40 – 11:05

Fernanda Laezza
University of Texas Medical Branch

DEVELOPING FGF14-BASED PROBES TARGETING NEURONAL EXCITABILITY

11:05 – 11:30

Hisashi Umemori
Harvard Medical School

THE FGF22–IGF2 SIGNALING REGULATES SYNAPSE STABILIZATION AND AFFECTIVE BEHAVIOR

11:30 – 11:50

Daniel Sinden
Weill Cornell Medical College

FGF13 REGULATES OBESITY IN MICE

11:50 – 12:00

Closing Comments

Speakers

Invited Speakers

  • Dr. Richard Grose
    Senior Lecturer, Queen Mary, University of London
  • Prof. Marja Hurley
    Professor of Medicine, UCONN Health, School of Medicine
  • Dr. Suzanne Mansour
    Professor, University of Utah
  • Prof. Stijn De Langhe
    Associate Professor, University of Alabama at Birmingham
  • Dr. Xin Sun
    Professor, University of California, San Diego.
  • Dr. Helen Makarenkova
    Assistant Professor, The Scripps Research Institute
  • Dr. Zamal Ahmed
    Assistant Professor, MD Anderson Cancer Center
  • Prof. Mitchell Goldfarb
    Professor, Hunter College
  • Prof. Fen Wang
    Professor, Texas A&M
  • Prof. Dr. Sabine Werner
    Prof. Dr., ETH Zurich Institute of Molecular Health Sciences
  • Prof. Fernanda Laezza
    Associate Professor, UTMB
  • Dr. Xin Zhang
    Associate Professor, Columbia University
  • Prof. Michael Seckl
    Professor of Molecular Oncology, Imperial College London
  • Dr. Robert Guzy
    Assistant Professor, The University of Chicago
  • Dr. Mark Lewandoski
    Senior Investigator, NCI, NIH
  • Prof. Dr. David Warburton
    Jodi S. Ogden - VP, Research Administration , Children's Hospital Los Angeles
  • Dr. Mohammad K Hajihosseini
    Senior Lecturer in Neuroscience, University of East Anglia
  • Assist. Prof. Sung-Ho Huh
    Assistant Professor, University of Nebraska Medical Center
  • Dr. Stacey House
    Research Director in Emergency Medicine, Washington University in St. Louis
  • Dr. Masatoshi Fujiwara
    Board Director, Research & Development Division, RIBOMIC Inc.
  • Dr. Jeffrey Stavenhagen
    Vice president, Therachon
  • Prof. Avner Yayon
    CEO, Procore Ltd.
  • Prof. Dr. Dina Ron
    Faculty Member/Lab Chief, Technion, Israel Instititute of Technology
  • Prof. NORA NAVONE
    PROFESSOR, UT MD ANDERSON CANCER CENTER
  • Prof. Jerry Turnbull
    Johnston Professor of Biochemistry, University of Liverpool
  • Prof. Philippe Soriano
    Professor, Icahn School of Medicine at Mt. Sinai
  • Prof. Hisashi Umemori
    Associate Professor, Harvard Medical School
  • Dr. Laurence Legeai-Mallet
    Director of Research, Imagine Institute-Inserm U1163
  • Prof. Michael Simons
    Professor, Yale University
  • Dr. Bradley Olwin
    Professor, University of Colorado
  • Prof. Zipora Yablonka-Reuveni
    Professor, University of Washington School of Medicine
  • Prof. Jin-San Zhang
    Professor, WU-WMU Joint Biomedical Innovation Center

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