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Home > Past Conferences > 2nd Musculoskeletal Development and Regeneration Conference

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Past Conference

2nd Musculoskeletal Development and Regeneration Conference

24 Feb 2017 - 27 Feb 2017

Cancun, Mexico

Synopsis

The 2017 Fusion Conference on "Musculoskeletal Development and Regeneration", a premier scientific forum for the scientific investigation of the musculoskeletal system, will cover a wide range of topics to encompass basic to translational aspects of the biology and pathology of musculoskeletal tissues, including cartilage, bone, tendon, ligament, and muscle. These topics will include morphogenesis, development, evolutionary specification of tissue types, cellular organization, production and assembly of extracellular matrix, biological and biomechanical functions, functional modeling, genetic basis of musculoskeletal diseases, cellular and molecular mechanisms of degeneration, and therapeutic strategies to regenerate, repair and functionally restore damaged or diseased tissues and organs. Special emphasis will be on the application of contemporary approaches to address epigenetic, molecular, cellular, and tissue biology of musculoskeletal tissues, including a session featuring new directions and technologies, and challenges and opportunities in musculoskeletal research. The conference will be interdisciplinary and multidisciplinary, merging concepts and approaches from the sciences, engineering, medicine and more.

We expect the 2017 Musculoskeletal Development and Regeneration Fusion Conference to be an exciting and stimulating meeting for both established and new investigators in the field, and provide ample opportunities for interaction and networking.

Key Sessions

  • Injury and Healing
  • Repair and Reconstruction Strategies
  • Developmental and Degenerative Diseases
  • Experimental Models
  • Stem Cells: Biology and Engineering

Confirmed Plenary Speakers

Tamara Alliston (UCSF)
Hani Awad (University of Rochester)
John P. Fisher (University of Maryland)
Lisa A. Fortier (Cornell University)
Mark Grinstaff (Boston University)
Rita Kandel (University of Toronto)
Catherine K. Kuo (University of Rochester)
Helen H. Lu (Columbia University)
Susan Mackem (NIH)
Elise Morgan (Boston University)
Robert L. Sah (UC San Diego)
Rocky Tuan (University of Pittsburgh)
Thomas Webster (Northeastern University)

2017 MDR Poster Prize

The conference chairs will be awarding 3 poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 02 December 2016. The winners will receive the following prizes at the Gala dinner: 1st Place $350, 2nd Place $250, 3rd Place $150. 

Sponsors

Sponsors

Report

Overview

Professors Rocky S. Tuan and Catherine K. Kuo co-chaired the first Fusion Conference on Musculoskeletal Development and Regeneration (MDR) in Cancun, Mexico. The conference began the afternoon of February 6, and concluded mid-day on February 9, 2015. Special events for the conference included a group tour to Tulum one afternoon (not included in registration), and also a gala dinner (and live band) for all registered attendees. A particularly unique aspect of the conference was a merged session the morning of February 7, 2015, with the Fusion Conference on Fibroblast Growth Factor (chaired by Professors David Ornitz and Saverio Bellusci) in the same venue.

Conference Theme

The theme of the conference was Musculoskeletal Development and Regeneration (MDR), indicated by the conference title. Seven sessions included (by order of first to last): Injury and Healing; Repair and Reconstruction Strategies; Skeletal Development (joint session with FGF conference); Developmental and Degenerative Diseases; Experimental Models; Stem Cells: Biology and Engineering 1 and 2. One or two plenary speakers were invited for each session, followed by invited and submitted shorter abstract talks. (Please see attached for the conference program and abstracts.)

Plenary Speakers

Stuart Goodman, Stanford University
Robert Guldberg, Georgia Institute of Technology
Suzanne Maher, Hospital for Special Surgery
Maria Siemionow, University of Illinois
Vicki Rosen, Harvard School of Dental Medicine
Maurizio Pacifici, University of Pennsylvania
Veronique Lefebvre, Cleveland Clinic
Linda Sandell, Washington University
Jennifer Westendorf, May Clinic
Catherine K. Kuo, Tufts University
Johnny Huard, University of Pittsburgh
Farshid Guilak, Duke University
Rocky S. Tuan, University of Pittsburgh

Conference Format

The conference was held at the Fiesta Americana Condesa in Cancun, Mexico. Lodging and all meals were included with the registration fee at the all-inclusive resort. The format of the conference was morning and afternoon sessions, with lunch and leisure time between the two sessions. Out of 45 registered attendees, 36 talks including plenary (45 min) and invited (30 min) and submitted (15 min) abstract talks were delivered. Additionally, more than 30 posters were presented on abstracts accepted for podium or poster presentations. Poster sessions were ongoing during refreshment breaks and two different hour-long scheduled sessions. Poster awards with cash prizes funded by the Fusion Conference were given for the top three posters, judged by the conference co-chairs. Invited plenary speakers were asked to chair various sessions throughout the conference. The organizers and attendees found the Fusion Conference staff to be highly professional, organized and attentive. Jack Peters was excellent throughout the entire process.

Attendee Feedback

Feedback regarding the conference was outstanding, regarding the speakers, selected topics, quality of talks and venue. Attendees have explicitly stated that continued interactions in the form of collaborations and university exchanges have resulted from attending this conference. Numerous attendees and non-attendees that have heard by word-of-mouth have expressed interest in attending a future MDR conference. Notably, this conference was held a little more than a month before the Annual Conference of the Orthopaedic Research Society (ORS) and also the Cartilage Gordon Research Conference (GRC), each of which many of the MDR attendees also attended this year or previously. Multiple attendees stated that, even after attending all three (MDR, ORS and Cartilage GRC), they will definitely attend a future MDR conference.

Some notable feedback from attendees has been included here.

Professor Veronique Lefebvre, who chaired the Cartilage Gordon Conference shortly after attending the MDR conference: “…I came back home knowing that I would definitely attend the next conference and recommend it to many people…I most importantly appreciated the breadth of cutting-edge topics in the musculoskeletal field and the gathering of scientists working on basic processes and translational questions from development to late adulthood and on various tissues in the musculoskeletal system. This integration of scientific and translational topics, broad range of tissues and broad range of disease questions was made very successfully and was very instructive. I learned a lot! The shared session with the FGF conference was a brilliant idea too and it worked out extremely well, adding another dimension to the conference. As important as the scientific content of the conference, I truly enjoyed the very friendly and collegial atmosphere that was spearheaded by both of you and that was happily embraced and amplified by all participants. This helped generate lots of interesting discussions. I made new friends and started new scientific collaborations with them.”

Professor Farshid Guilak, ORS 1st Vice President and Editor-in-Chief of the Journal of Biomechanics: “Overall, one of the best meetings of its kind, and I would certainly come back to it again.”

Professor Vicki Rosen: “…After attending both the Cartilage GRC and the ORS, I think the greatest benefit of the Fusion Meeting was the combination of small size and diversity of topics within musculoskeletal biology… I would definitely attend a future meeting.”

In addition to extremely positive feedback from well established and senior investigators, it is important to highlight how valuable this conference was for junior investigators.

Postdoctoral fellow Dr. Thomas Lozito:“…It was definitely one of the most rewarding meetings I’ve ever been to, both personally and professionally. Not only did I get the chance to meet and interact with leaders in the field, but I was also invited to give several talks by faculty who found my research interesting, which is huge for someone at my stage in career development. All these opportunities were made possible by this Fusion Conference, and I would definitely like to attend similar conferences in the future.”

Assistant Professor Rhima Coleman: “This was an excellently organized conference... I learned so much in so little time. It was also community building, especially for junior investigators; a good mix of fun and science. The opportunity to interact with experts in the field at that level is very rare, but quite fulfilling. I would go every year to get critical feedback on my own research.”

Sponsors

The generous donation provided by the Arthritis Foundation enabled the registration of 12 attendees (students, postdoctoral fellows and PIs) that delivered either abstract talks or posters. Travel grants were disbursed in dollar amounts of $500, id="mce_marker"000, or full registration, based on need.

Programme

FRIDAY 24TH FEBRUARY

14:00 – 14:45

Registration & Reception

14:00 – 14:45

Welcome Lunch

*Kalmia Buffet Restaurant*

14:45 – 15:00

Opening Comments

MUSCULOSKELETAL DEVELOPMENT
Session Chair: Catherine K. Kuo

15:00 – 15:45

Susan Mackem
National Cancer Institute

COORDINATE FORMATION OF PHALANGES AND JOINTS FROM PROGENITORS IN THE DEVELOPING DIGIT DISTAL TIP

15:45 – 16:30

Tamara Alliston
UCSF

THE CELLULAR CONTROL OF BONE QUALITY THROUGH OSTEOCYTE-MEDIATED PERILACUNAR REMODELING

16:30 – 16:45

Ronald Kwon
University of Washington

RAPID-THROUGHPUT SKELETAL PHENOMICS IN ZEBRAFISH

16:45 – 17:10

Refreshments

STEM CELLS
Session Chairs: Rita Kandel & Thomas Webster

17:10 – 17:55

Lisa Fortier
Cornell University College of Veterinary Medicine

ALPHA-10/B1 MESENCHYMAL STEM CELLS MITIGATE THE DEVELOPMENT OF POST-TRAUMATIC OSTEOARTHRITIS

17:55 – 18:25

Johnny Huard
Steadman Philippon Research Institute

SUPER-HEALER MICE EXHIBIT SUPERIOR MUSCULOSKELETAL TISSUE REGENERATION AND HIGHER POTENCY OF MUSCLE STEM CELLS

18:25 – 18:40

Nidhi Bhutani
Stanford University

DUAL ADVANTAGE OF HUMAN INDUCED PLURIPOTENT STEM CELLS (hiPSC)-DERIVED CHONDROCYTES FOR CARTILAGE ENGINEERING-UNIQUE ECM AND RESISTANCE TO INFLAMMATION

18:40 – 18:55

Anna Maria Ranzoni
University College London

AMNIOTIC FLUID STEM CELLS: POTENTIAL FOR CELL THERAPY OF SKELETAL DISEASES AND BONE TISSUE ENGINEERING

18:55

Dinner at Leisure & Free Time

SATURDAY 25TH FEBRUARY

07:00 – 08:30

Breakfast
*Kalmia Buffet Restaurant*

BIOMECHANICS AND MECHANOBIOLOGY
Session Chair: Farshid Guilak

08:30 – 09:15

Catherine K. Kuo
University of Rochester

MECHANOREGULATION OF LYSYL OXIDASE DURING TENDON DEVELOPMENT

09:15 – 10:00

Elise Morgan
Boston University

COMBINING IN VIVO MODELS, EXPERIMENTAL MECHANICS, AND SIMULATION TO ELUCIDATE INPUTS AND OUTPUTS IN THE MECHANOBIOLOGY OF BONE HEALING

10:00 – 10:30

Mark Buckley
University of Rochester

PROTECTIVE ADAPTATION OF ARTICULAR CHONDROCYTES IN RESPONSE TO MECHANICAL LOADS

10:30 – 11:00

Refreshments & Group Photo

BIOMATERIALS AND BIOSCAFFOLDS
Session Chair: Robert Sah

11:00 – 11:45

John Fisher
University of Maryland

3D PRINTING FOR ENGINEERING COMPLEX TISSUES

11:45 – 12:15

Helen Lu
Columbia University

SCAFFOLD DESIGN STRATEGIES FOR ENGINEERING TISSUE INTEGRATION

12:15 – 13:00

Mark Grinstaff
Boston University

BIOMATERIALS FOR TISSUE SUPPLEMENTATION AND LUBRICATION

13:00 – 13:30

Elizabeth Cosgriff-Hernandez
Texas A&M University

EMULSION INKS FOR 3D PRINTING BONE GRAFTS

13:30 – 16:45

Lunch at Leisure & Free Time

TECHNOLOGIES
Session Chair: Rocky Tuan

16:45 – 17:30

Thomas Webster
Northeastern University

ADVANCES IN NANOTECHNOLOGY FOR ORTHOPEDICS: A SUMMARY OF 15 YEARS OF RESEARCH AND COMMERCIALIZATION

17:30 – 18:15

Farshid Guilak
Washington University

TARGETED GENOME ENGINEERING TO DEVELOP CELL-BASED VACCINES FOR ARTHRITIS

18:15 – 18:40

Refreshments

18:40 – 19:10

Henning Madry
Saarland University Medical Center

GENE THERAPY FOR OSTEOCHONDRAL REPAIR

19:10 – 19:25

Riccardo Gottardi
University of Pittsburgh

AN OSTEOCHONDRAL MICROPHYSIOLOGICAL SYSTEM TO STUDY CARTILAGE-BONE INTERACTION IN NATIVE TISSUES AND ENGINEERED MODEL CONSTRUCTS

19:25 – 19:40

Vishal Deshmukh
Samumed

DISCOVERY OF A SMALL MOLECULE WNT PATHWAY INHIBITOR (SM04690) AS A POTENTIAL DISEASE MODIFYING TREATMENT FOR KNEE OSTEOARTHRITIS

19:40

Dinner at Leisure & Free Time

SUNDAY 26TH FEBRUARY 2017

07:00 – 08:30

Breakfast
*Kalmia Buffet Restaurant*

TISSUE ENGINEERING
Session Chairs: Lisa Fortier & Johnny Huard

08:30 – 09:15

Rita Kandel
Mount Sinai Hospital

TISSUE ENGINEERED INTERVERTEBRAL DISC REPLACEMENT: TOWARDS A NEW TREATMENT OPTION

09:15 – 10:00

Rocky Tuan
University of Pittsburgh

APPLICATION OF DECELLULARIZED MATRIX FOR TISSUE-SPECIFIC ENGINEERING

10:00 – 10:15

Josef Jancar
Brno University of Technology

MORPHOGENESIS, PROPERTIES AND CLINICAL USE OF COLLAGEN/nHAP NANOCOMPOSITE IMPLANTS

10:15 – 10:45

Yunzhi Yang
Stanford University

BIOINSPIRED APPROACHES FOR ACCELERATED BONE REGENERATION

10:45 – 16:30

Lunch at Leisure & Free Time

DEGENERATION AND REGENERATION
Session Chair: Helen Lu

16:30 – 17:15

Hani Awad
University of Rochester

GENETIC AND THERAPEUTIC MANIPULATION OF FLEXOR TENDON HEALING AND ADHESIONS IN A MOUSE MODEL

17:15 – 18:00

Robert Sah
UC San Diego

ARTICULAR CARTILAGE GROWTH AND REGENERATION

18:00 – 18:25

Refreshments

18:25 – 18:40

Juraj Sutovsky
Comenius University & BioMed

CYTOKINE AND CHEMOKINE PROFILE CHANGES IN PATIENTS WITH LOWER SEGMENT LUMBAR DEGENERATIVE SPONDYLOLISTHESIS

18:40 – 18:55

Suroosh Madanipour
Royal Free London NHS Trust

A SYSTEMATIC REVIEW AND META-ANALYSIS OF PLATELET RICH PLASMA VERSUS CORTICOSTEROID INJECTIONS FOR PLANTAR FASCIOPATHY

18:55 – 19:10

Prashant Singh
Kingston Hospital NHS Trust

A SYSTEMATIC REVIEW AND META-ANALYSIS OF PLATELET RICH PLASMA VERSUS CORTICOSTEROID INJECTIONS FOR PLANTAR FASCIOPATHY

19:30

*Gala Dinner & Closing Comments*

 

Speakers

Plenary Speakers

  • Prof. Dr. John Fisher
    Professor and Chair, University of Maryland
  • Dr. Rita Kandel
    Chief, Pathology and Lab Medicine, Mount Sinai Hospital
  • Dr. Lisa Fortier
    Professor of Large Animal Surgery, Cornell University College of Veterinary Medicine
  • Prof. Dr. Robert Sah
    Professor, UC San Diego
  • Prof. Hani Awad
    Professor, University of Rochester
  • Prof. Thomas Webster
    Chair and Professor, Northeastern University
  • Dr. Susan Mackem
    Senior Investigator, National Cancer Institute
  • Dr. Tamara Alliston
    Associate Professor, UCSF
  • Prof. Helen Lu
    Professor, Columbia University
  • Prof. Elise Morgan
    Professor, Boston University
  • Prof. Mark Grinstaff
    Professor, Boston University

Invited Speakers

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