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Home > Past Conferences > RNA Nanotechnology Conference

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RNA Nanotechnology Conference

01 Aug 2016 - 04 Aug 2016

Berkshire, United Kingdom

 

Chair

 

Co-Chairs

Synopsis

In the past, two major milestones have occurred in pharmaceutical sciences: (1) chemical drugs; (2) protein-based drugs, either composed of proteins or specifically targeting proteins. It is believed the third milestone in pharmaceutics will be RNA drugs and chemical drugs that target RNA. The field of RNA nanotechnology was first realized and demonstrated in 1998 by Chair Peixuan Guo, thus giving birth to this third milestone in pharmaceutical sciences. Since, RNA nanotechnology has grown into a mature field composed of several subfields covered by many disciplines such as chemistry, biochemistry, molecular biology, microbiology, biophysics, engineering, and many more. There is need for an all-encompassing conference of RNA nanotechnology that brings together all scientists in the field.

The Fusion RNA Nanotechnology conference has been designed into the following session themes on two merits: (1) key scientific breakthroughs that have the potential to revolutionize the field; and (2) cross-disciplinary approach to solve challenging problems in RNA nanotechnology. 

Key Sessions

1. Biophysical Approaches in RNA Nanotechnology
2. RNA Nanoparticle Structure and Folding
3. RNA Modeling for RNA Nanotechnology
4. RNA Nanoparticles for Therapeutics
5. Image Guided Delivery of RNA Nanoparticles
6. Extracellular RNA for RNA Nanotechnology
7. Nanoimmunology and RNA Nanotechnology

Learning Objectives

The field of RNA nanotechnology is a multidisciplinary field that has scientist from varying background participating. Therefore there is often a gap between the disciplines in shared knowledge. This Fusion Conference RNA Nanotechnology conference will bring together scientist from chemistry, biochemistry, structural biology, microbiology, cancer biology, cell biology, biophysics, pharmacy, material sciences, nanotechnology, and engineering.  The goal of this conference is to share the most up to date findings of each discipline of RNA nanotechnology between subfields and session themes of the conference. This conference will provide a discussion platform for advancement of researchers and this field to (1) share existing knowledge, technology and platform development in order to set future research objectives; and (2) develop collaborations between scientists within or between disciplines of RNA nanotechnology.

Target Audience

This conference will appeal to scientist throughout the world that focus on the use of RNA in the field of nanotechnology, mainly for therapeutics using RNAi technologies. Previously, Peixuan Guo has chaired three RNA nanotechnology conferences (2015 Gordon Research Conference: RNA nanotechnology, 2013 and 2010 International Conference of RNA Nanotechnology and Therapeutics) that were each well attended with over 200 registered participants. Therefore, with the small number of participants for Fusion Conference, scientist should be well versed in the RNA field and have a strong interest in applying RNA toward nanotechnologies and the treatment of diseases. Within RNA nanotechnology field, there are individuals studying the delivery of the nanoparticles to cancers and other diseases, the structure and function of RNA motifs to be used for nanoparticles, computational modelling and predictions of RNA motifs, and the study of natural exosomal RNAs in the human body.

Educational Need

RNA nanotechnology is a rapidly emerging new field of science. According to PubMed, over 90% of publications with key words “RNA nanostructure” were published since 2006. Many high impact, well-respected journals have included articles focusing on RNA nanotechnology; including, Science, Nature Nanotechnology, Nature Methods, Nano Today, PNAS, Nano Letters, ACS Nano, and Nature Protocols. This rapid growth has led for a large amount of new finding and breakthroughs in the field in a rather short period of time. A conference, such as through Fusion, provides a platform for scientist to share their major recent findings, thus providing the field with an in depth view of state of the art technologies. There are currently conferences that focus on nanotechnologies, and nucleic acids; however, these conferences do not focus on RNA nanotechnologies and this conference will allow for a focused intimated discussion of the field. It is a hope that the RNA Nanotechnology conference will not only provide an educational platform, but also promote collaborations between scientist in different subcategories of RNA nanotechnology to further grow and expand the field.

Confirmed Speakers

Dr. Peixuan Guo (Ohio State University)
'ASSEMBLY MECHANISM OF THERMOSTABLE pRNA 3WJ AS POLYMER TO BUILD NANOSTRUCTURES FOR BIOMEDICAL AND MATERIAL SCIENCES'

Prof. Eric Westhof (IBMC-CNRS)
'NON-WATSON-CRICK BASE PAIRS AND RNA ARCHITECTURAL MODULES : BUILDING BLOCKS FOR RNA NANOTECHNOLOGY'

Prof. Xing-Jie Liang (National Center for Nanoscience and Technology of China)
'NANOTECHNOLOGY EMPLOYED TO IMPROVE RNAI RESEARCH'

Dr. Bruce A. Shapiro (NIH/National Cancer Institute)
'RNA TOEHOLD INTERACTIONS: THEIR USE IN CONDITIONAL ACTIVATION OF RNA NANOCONSTRUCTS'

Prof. David Lilley (University of Dundee)
‘THE K-TURN : A KEY ARCHITECTURAL ELEMENT IN RNA'

Dr. Thomas Hermann (University of Cal, San Diego)
‘CRYSTAL STRUCTURE-GUIDED DESIGN OF RNA NANOARCHITECTURES’

Prof. Jong Bum Lee (University of Seoul)
‘FABRICATION OF RNA-BASED MATERIALS FOR BIOMEDICAL APPLICATIONS’

Dr. Hao Yan (Arizona State University)
‘SINGLE STRANDED DNA AND RNA ORIGAMI’

Dr. Kirill Afonin (University of North Carolina at Charlotte)
‘SELF-RECOGNIZING NUCLEIC ACID-BASED SHAPE SWITCHING NANOPARTICLES: A NEW CONCEPT OF DYNAMIC RNA NANOTECHNOLOGY’

Prof. Dr. Yitzhak Tor (University of California, San Diego)
‘ISOMORPHIC FLUORESCENT NUCLEOSIDES AS BIOPHYSICAL TOOLS’

Dr. Rob DeLong (Kansas State University)
‘COMPARATIVE CHARACTERIZATION OF THE RNA NANOBIO INTERFACE WITH ZINC OXIDE AND OTHER BIO-ELEMENT BASED NANOPARTICLES’

Dr. Carlo Montemagno (University of Alberta)
'TEMPLATE LESS ENZYMATIC SYNTHESIS OF OLIGONUCLEOTIDES WITH SINGLE NUCLEOTIDE PRECISION'

Prof. Shi-jie Chen (University of Missouri)
‘MODELING ION EFFECTS AND COTRANSCRIPTIONAL KINETICS FOR RNA FOLDING’

Prof. Hirohide Saito (Kyoto University)
'SYNTHETIC microRNA SWITCHES & PROTEIN-DRIVEN RNA NANOSTRUCTURED DEVICES TO PROGRAM HUMAN CELL FATE'

Dr. Stuart F.J. Le Grice (National Cancer Institute)
‘SMALL MOLECULE TARGETING OF STRUCTURALLY AND FUNCTIONALLY DIVERSE RNAS’

Dr. Subba Reddy Palli (University of Kentucky)
'RNA INTERFERENCE IN AGRICULTURE: APPLICATIONS AND CHALLENGES'

Prof. Jeong-Woo Choi (Sogang University)
‘DETECTION OF MIRNA USING NANOMATERIALS BASED ON SPECTROELECTROCHEMICAL TECHNIQUE’

Dr. Francesca Storici (Georgia Institute of Technology)
‘EFFICIENT REPAIR OF A DNA DOUBLE-STRAND BREAK BY HOMOLOGOUS TEMPLATE RNA IN CIS’

Prof. Xiaoting Zhang (University of Cincinnati)
‘OVERCOMING TAMOXIFEN RESISTANCE OF HUMAN BREAST CANCER BY TARGETED GENE SILENCING USING MULTIFUNCTIONAL pRNA NANOPARTICLES’

Dr. Jiehua Zhou  (City of Hope)
‘CELL-SPECIFIC APTAMER-SIRNA NANOCONJUGATES FOR TARGETED HIV-1 THERAPY’

Dr. Subha R. Das (Carnegie Mellon University)
‘DNA- AND RNA-POLYMER HYBRIDS AS NANOTAGS AND NANODELIVERY AGENTS’

Dr. Haibo Hu (Liaoning Pharma-Union Pharmaceutical co. LTD)
'INTRODUCTION OF RNA NANOBIO LTD. AND LIAONING PHARMA-UNION PHARMACEUTICAL COMPANY'

Dr. Yizhou Dong (Ohio State University)
‘DEVELOPMENT OF NANOMATERIALS FOR RNA DELIVERY’

Dr. Dan Shu (Ohio State University)
‘SYSTEMIC DELIVERY OF ANTI-miRNA FOR SUPPRESSION OF TRIPLE NEGATIVE BREAST CANCER UTILIZING RNA NANOTECHNOLOGY’

Dr. Farzin Haque (Ohio State University)
'CONTROLLABLE SELF-ASSEMBLY OF RNA DENDRIMERS'

Dr. Richard A. Lease (Ohio State University)
‘RNA NANOTECHNOLOGY IN VIVO: HIGH-THROUGHPUT GENETIC SCREEN FOR TARGETED RNA-RNA INTERACTIONS VIA RATIONALLY DESIGNED STEM-LOOPS’

Dr. Hui Zhang (Ohio State University)  
'SINGLE MOLECULE APPROACH TO STUDY RNA NANOPARTICLES'                     

Asssit. Prof. Michael Ryckelynck (Architecture et réactivité de l'ARN-CNRS)
‘IN VITRO EVOLUTION OF RNA BY HIGH THROUGHPUT FUNCTIONAL SCREENING USING DROPLET-BASED MICROFLUIDICS’

Dr. Shuo Gu (NIH)
'OPTIMAL DESIGN OF shRNA TO REDUCE OFF-TARGET EFFECTS'

Dr. Katja Petzold (Karolinska Institutet)
'CHARACTERIZING TRANSIENT STRUCTURES OF RNA USING NMR'

Dr. Peng Yin (Harvard University)
‘MOLECULAR PROGRAMMING WITH DNA AND RNA’

Dr. Hua Zhu (Ohio State University)
‘A POTENTIAL ROLE OF MICRORNA IN MUSCULAR DYSTROPHY’

Dr. Jianhua Yu (Ohio State University)
'EXTRINSIC AND INTRINSIC ROLES FOR MICRORNAS IN REGULATING INNATE IMMUNITY AND TUMOR DEVELOPMENT'

Dr. Xiyun Yan (Chinese Academy of Sciences)
'NANOZYMES AND THEIR APPLICATION IN MEDICINE'

Sponsors

Sponsors

Report

You can find the De Gruyter conference report here

Programme

Monday 01st August 2016

12:30 – 14:00

Registration & Group Welcome Lunch

14:15 – 14:35

Opening Remarks by Peixuan Guo

14:35 – 15:10

Eric Westhof (Invited Speaker)
IBMC-CNRS

Keynote Talk: Non-Watson-Crick Base Pairs And RNA Architectural Modules: Building Blocks For RNA Nanotechnology

Structure and Folding of RNA Nanoparticles: Session I
Session Chair: Yitzhak Tor

15:10 – 15:45

Craig Zirbel (Invited Speaker)
Bowling Green State University

Tools To Understand The Sequence-Structure Relationship For RNA 3D Motifs

15:45 – 16:05

Michael Ryckelynck (Invited Speaker)
University of Strasbourg

In Vitro Evolution Of RNA By High Throughput Functional Screening Using Droplet-Based Microfluidics

16:05 – 16:35

Refreshments

Structure and Folding of RNA Nanoparticles: Session II
Session Chairs: Jong Bum Lee and Xing-Jie Liang

16:35 – 17:10

Peixuan Guo (Invited Speaker)
Ohio State University

Assembly Mechanism of Thermostable pRNA 3WJ as Polymer to Build Nanostructures for Biomedical and Material Sciences

17:10 – 17:30

Steffen Sparvath
Aarhus University

A 6-Helix Bundle Folded By Co-Transcriptional RNA Origami

17:30 – 17:50

Katja Petzold (Invited Speaker)
Karolinska Institute

Characterizing Transient Structures Of RNA Using NMR

17:50 – 18:00

PM Panel Discussion

18:00

Group Dinner

Tuesday 02nd August 2016

07:00 – 08:30

Group Breakfast

RNA Computation and Modeling: Session I
Session Chairs: Peng Yin and Hirohide Saito

08:30 – 09:05

Bruce Shapiro (Invited Speaker)
NIH/National Cancer Institute

RNA Toehold Interactions: Their Use In Conditional Activation Of RNA Nanoconstructs

09:05 – 09:25

Shi-Jie Chen (Invited Speaker)
University of Missouri

Modeling Ion Effects and Co-transcriptional Kinetics For RNA Folding

09:25 – 09:45

Stuart Le Grice (Invited Speaker)
National Cancer Institute

Small Molecule Targeting Of Structurally and Functionally Diverse RNAs

09:45 – 10:05

Magdalena Gebala
Stanford University

Dissecting The Ion Atmosphere: Understanding The Electrostatics Of Nucleic Acids

10:05 – 10:35

Refreshments

RNA Computation and Modeling: Session II
Session Chair: Eric Westhof

10:35 – 10:55

Hirohide Saito (Invited Speaker)
Kyoto University

Synthetic microRNA Switches & Protein-Driven RNA Nanostructured Devices To Program Human Cell Fate

10:55 – 11:15

Richard Lease (Invited Speaker)
Ohio State University

RNA Nanotechnology In Vivo: High-Throughput Genetic Screen For Targeted RNA-RNA Interactions via Rationally Designed Stem-Loops

11:15 – 11:25

AM Panel Discussion

11:25 – 13:30

Group Lunch & Free Time

Importing From DNA Nanotechnology
Session Chairs: Kirill Afonin and Jeong-Woo Choi

13:30 – 14:05

Hao Yan (Invited Speaker)
Arizona State University

Single Stranded DNA and RNA Origami

14:05 – 14:25

Peng Yin (Invited Speaker)  
Harvard University

Molecular Programming With DNA and RNA

RNA Immunology and Therapeutics: Session I
Session Chair:  Jianhua Yu

14:25 – 15:00

Xiyun Yan (Invited Speaker)
Chinese Academy of Sciences

Nanozymes And Their Application In Medicine

15:00 – 15:20

Hua Zhu (Invited Speaker)
Ohio State University

A Potential Role Of MicroRNA In Muscular Dystrophy

15:20 – 15:40

Shuo Gu (Invited Speaker)
National Cancer Institute

Optimal Design Of shRNA To Reduce Off-target Effects

15:40 – 16:10

Refreshments

RNA Immunology and Therapeutics: Session II
Session Chair: Xiyun Yan

16:10 – 16:30

Rob Delong (Invited Speaker)
Kansas State University

Comparative Characterization Of The RNA Nanobio Interface With Zinc Oxide And Other Bio-Element Based Nanoparticles

16:30 – 16:50

Haibo Hu
Liaoning Pharma-Union Pharmaceutical co.,LTD

Introduction of RNA Nanobio Ltd. and Liaoning Pharma-Union Pharmaceutical Company

 

16:50 – 17:10

Subba Palli (Invited Speaker)
University of Kentucky

RNA Interference in Agriculture: Applications and Challenges

17:10 – 17:30

Jianhua Yu (Invited Speaker)
The Ohio State University

Extrinsic And Intrinsic Roles For microRNAs In Regulating Innate Immunity And Tumor Development

17:30 – 17:40

PM Panel Discussion

17:40 – 18:40

Poster Session & Refreshments

18:40

Group Dinner

Wednesday 03rd August 2016

07:00 – 08:30

Group Breakfast

Nanotechnologies Relevant to RNA Research: Session I
Session Chairs: Bruce Shapiro and Carlo Montemagno

08:30 – 09:05

David Lilley (Invited Speaker)
University of Dundee

The k-turn : A Key Architectural Element In RNA

09:05 – 09:40

Xing-Jie Liang (Invited Speaker)
National Center for Nanoscience and Technology of China

Nanotechnology Employed To Improve RNAi Research

09:40 – 10:10

Refreshments

Nanotechnologies Relevant to RNA Research: Session II
Session Chair: David Lilley

10:10 – 10:30

Jeong-Woo Choi (Invited Speaker)
Sogang University

Detection of miRNA Using Nanomaterials Based On Spectroelectrochemical Technique

10:30 – 10:50

Joerg Vogel
University of Wuerzburg

Dual RNA-Seq Unveils Noncoding RNA Functions In Host-Pathogen Interactions

10:50 – 11:00

AM Panel Discussion

11:00 – 13:30

Group Photo, Group Lunch & Free Time

RNA Nanoparticles in Therapeutics: Session I
Session Chair: Farzin Haque

13:30 – 14:05

Thomas Hermann (Invited Speaker)
University of California, San Diego

Crystal Structure-Guided Design Of RNA Nanoarchitectures

14:05 – 14:25

Jiehua Zhou (Invited Speaker)
City of Hope

Cell-Specific Aptamer-siRNA Nanoconjugates For Targeted HIV-1 Therapy

14:25 – 14:45

Daniel Jasinski
Ohio State University

Significance Of RNA Nanoparticle Size And Shape In Relevance To Therapy And Delivery

14:45 – 15:20

Jong Bum Lee (Invited Speaker)
University of Seoul 

Fabrication Of RNA-Based Materials For Biomedical Applications

15:20 – 15:50

Refreshments

RNA Nanoparticles in Therapeutics: Session II
Session Chair: Craig Zirbel

15:50 – 16:10

Farzin Haque (Invited Speaker)
Ohio State University

Controllable Self-Assembly Of RNA Dendrimers

16:10 – 16:30

Carlo Montemagno (Invited Speaker)
University of Alberta

Template Less Enzymatic Synthesis Of Oligonucleotides With Single Nucleotide Precision

16:30 – 16:50

Yizhou Dong (Invited Speaker)
Ohio State University

Development Of Nanomaterials For RNA Delivery

16:50 – 17:10

Dan Shu (Invited Speaker)
Ohio State University

Systemic Delivery Of Anti-miRNA For Suppression Of Triple Negative Breast Cancer Utilizing RNA Nanotechnology

17:10 – 17:30

Xiaoting Zhang (Invited Speaker)
University of Cincinnati

Overcoming Tamoxifen Resistance Of Human Breast Cancer By Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles

17:30 – 17:40

PM Panel Discussion

17:40 – 18:40

Poster Session & Refreshments

19:00 – 22:00

Gala Dinner, Group Photo & Poster Awards

Thursday 04th August 2016

07:00 – 08:30

Group Breakfast

08:30 – 09:05

Kirill Afonin (Invited Speaker)
University of North Carolina at Charlotte

Liaoning Pharma-Union Pharmaceutical Lecture:
Self-Recognizing Nucleic Acid-Based Shape Switching Nanoparticles: A New Concept Of Dynamic RNA Nanotechnology

Physical and Chemical Approaches in RNA Nanotechnology: Session I
Session Chair: Francesca Storici

09:05 – 09:40

Yitzhak Tor (Invited Speaker)
University of California, San Diego

Isomorphic Fluorescent Nucleosides As Biophysical Tools

09:40 – 10:00

Hui Zhang
Ohio State University

Single Molecule Approach To Study RNA Nanoparticles

10:00 – 10:30

Refreshments

Physical and Chemical Approaches in RNA Nanotechnology: Session II
Session Chairs: Thomas Hermann and Shi-Jie Chen

10:30 – 10:50

Francesca Storici (Invited Speaker)
Georgia Institute of Technology

Efficient Repair Of A DNA Double-Strand Break By Homologous Template RNA In Cis

10:50 – 11:10

Subha Das (Invited Speaker)
Carnegie Mellon University

DNA- And RNA-Polymer Hybrids As Nanotags And Nanodelivery Agents

11:10 – 11:30

Shaoying Wang
University of Kentucky

Channel Size Conversion of Phi29 DNA-Packaging Nanomotor For Sensing Of Single--Stranded RNA and DNA

11:30 – 11:40

AM Panel Discussion

11:40 – 12:00

Closing Comments by Peixuan Guo

Speakers

Invited Speakers

  • Dr. Kirill Afonin
    Assistant Professor, UNC Charlotte
  • Prof. Jong Bum Lee
    Professor, University of Seoul
  • Prof. Thomas Hermann
    Professor, University of California, San Diego
  • Prof. Dr. Yitzhak Tor
    Professor of Chemistry, University of California, San Diego
  • Prof. Shi-Jie Chen
    Professor, University of Missouri-Columbia
  • Dr. Stuart Le Grice
    Senior Scientist, National Cancer Institute
  • Dr. Carlo Montemagno
    Professor, University of Alberta
  • Prof. Dr. Rob DeLong
    Associate Professor, Kansas State University
  • Prof. Dr. Hao Yan
    Professor, Arizona State University
  • Prof. David Lilley
    Professor, University of Dundee
  • Prof. Hirohide Saito
    Professor, Kyoto University
  • Dr. Subba Palli
    Professor and Chair , University of Kentucky
  • Prof. Jeong-Woo Choi
    Professor, Sogang University
  • Dr. Francesca Storici
    Assocaite professor, Georgia Institute of Technology
  • Dr. Haibo Hu
    V.P., Liaoning Pharma-Union Pharmaceutical co.,LTD
  • Dr. Xiaoting Zhang
    Associate Professor, University of Cincinnati
  • Dr. Jiehua Zhou
    Assistant Research Professor, Beckman Research Institute of City of Hope
  • Prof. Subha Das
    Associate Professor, Carnegie Mellon University
  • Assist. Prof. Yizhou Dong
    Assistant Professor, The Ohio State University
  • Dr. Dan Shu
    Associate Professor, The Ohio State University
  • Dr. Farzin Haque
    Research Specialist, The Ohio State University
  • Dr. Richard Lease
    Research Scientist, The Ohio State University
  • Dr. Hui Zhang
    Research Assistant Professor, The Ohio State University
  • Assist. Prof. Michael Ryckelynck
    Assistant professor, Architecture et réactivité de l'ARN-CNRS
  • Dr. Shuo Gu
    Investigator, National Instutes of Health, National Cancer Institute
  • Assist. Prof. Katja Petzold
    Assistant Professor, PhD, PI, Karolinska Institute
  • Prof. Dr. Peng Yin
    Professor, Department of Systems Biology, Harvard Medical School, Wyss Institute at Harvard University
  • Assist. Prof. Hua Zhu
    Assistant professor, The Ohio State University
  • Dr. Jianhua Yu
    Associate Professor, The Ohio State University
  • Prof. Xiyun Yan
    Director, Professor, Institute of Biophysics, Chinese Academy of Sciences
  • Dr. Craig Zirbel
    Professor, Bowling Green State University

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