Urgent Notice to All Conference Participants

It has been brought to our attention that EHS Housing has recently been cold calling our speakers offering accommodation for a named Fusion conference. Please note that we have no association with EHS Housing and they are acting on our behalf without our permission. We strongly advise that any calls from EHS Housing are ignored or ended immediately. If you are contacted by EHS Housing, please notify us immediately.

All Fusion registration fees are inclusive of accommodation (for three fixed nights) and reservations are handled internally, entirely by Fusion Conferences. If you have any questions concerning your accommodation, please contact Fusion Conferences directly via admin@fusion-conferences.com.

Home > Past Conferences > 2nd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference

The registration process for this conference has now closed.

Registration Deadlines

Early bird – expired

Talk Submission – expired

Poster Submission – expired

Last Chance – expired

Past Conference

2nd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference

Target DNA repair for Cancer Therapy

27 Feb 2017 - 02 Mar 2017

Cancun, Mexico

Synopsis

Defect in DNA damage repair and checkpoint control is the underlying mechanism for tumorigenesis, since it allows the accumulation of multiple genetic alternations, which are essential for the initiation of tumorigenesis. This has been clearly illustrated to be the cause of several human cancer-prone syndromes and also revealed by recent human genome studies. On the other hand, defective DNA repair and checkpoint activation also make cancer cells more vulnerable for particular DNA damaging agents or inhibitors that specifically disrupt some of these checkpoint pathways. With the increasing understanding of defects in DNA repair and checkpoint control in tumorigenesis, there are extensive interests in exploring these deficiencies, especially taking advantage of the synthetic lethality concept and targeting particular DNA repair and checkpoint pathways for cancer therapy. The purpose of this conference is to bring together basic, translational and clinical investigators and discuss the current and future directions, opportunities and obstacles in the development of these anti-cancer modalities and how to best apply these concepts in clinical practice.

Key Sessions

  1. Highlight recent advances in the field of DNA damage repair
  2. Identify novel targets in DNA repair and checkpoint pathways
  3. Explore the concept of synthetic lethality for cancer treatment
  4. Assess the therapeutic potential of new anti-cancer modalities
  5. Learn mechanisms of therapeutic resistance and ways to improve cancer therapy

Target Audience

This conference explores topics that should appeal to basic, translational and clinical investigators as well as clinicians ranging from academics to industry. The audience will benefit greatly from the interactions with experts in the fields of DNA damage response, drug development and clinical trials.

2017 DNA Poster Prize

The conference chairs will be awarding 3 poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 08 December 2016. The winners will be selected shortly after the Poster Session and each winner will receive $250! 

Confirmed Invited Speakers

Christopher Bakkenist (University of Pittsburgh)
Michelle Barton (MD Anderson Cancer Center)
Lauren Averett Byers (MD Anderson Cancer Center)
Dipanjan Chowdhury (Dana-Farber Cancer Institute)
Karlene Cimprich 
(Stanford University) 
Giulio Draetta (MD Anderson Cancer Center)
Daniel Durocher
(The Lunenfeld-Tanenbaum Research Institute)
Yi Fan (University of Pennsylvania)
Shridar Ganesan (Rutgers Cancer Institute of New Jersey)
Jean Gautier (Columbia University)
Reuben Harris (University of Minnesota)
Robert Hromas (University Of Florida)
Jos Jonkers (Netherlands Cancer Institute)
Chuan-Yuan Li (Duke University Medical Center)
Zhenkun Lou (Mayo Clinic)
KyungJae Myung (Institute for Basic Science)
Jac A. Nickoloff (Colorado State University)
Mark J O'Connor (AstraZeneca)
Akihiro Ohashi (Takeda)
Yves Pommier (NCI)
Brendan Price (Dana-Farber Cancer Institute)
Elizabeth Swisher (University of Washington)
Lorraine Symington (Columbia University)
Yinsheng Wang (UC Riverside) 
Matthew Weitzman (The Children’s Hospital of Philadelphia)
Richard Wood (MD Anderson Cancer Center)
Fen Xia (UAMS)


Sponsors

Sponsors

Programme

MONDAY 27TH FEBRUARY 2017

14:00 – 14:45

Registration & Reception

14:00 – 14:45

Welcome Lunch
*Kalmia Buffet Restaurant*

14:45 – 15:00

Opening Comments

MECHANISMS OF GENOME MAINTENANCE
Session Chairs: Eli Rothenberg and Dipanjan Chowdhury

15:00 – 15:30

Karlene Cimprich
Stanford University

WHEN RNA MEETS DNA: DANGEROUS LIAISONS IN THE GENOME

15:30 – 16:00

Jean Gautier
Columbia University

MOVING DNA DOUBLE-STRAND BREAKS

16:00 – 16:30

Dipanjan Chowdhury
Dana Farber Cancer Institute

TIRR MASKS THE HISTONE METHYL-LYSINE BINDING FUNCTION OF 53BP1 TO REGULATE ITS ACTIVITY

16:30 – 17:00

Jingsong Yuan
Columbia University

RPA-BINDING PROTEIN ETAA1 PARTICIPATES IN THE ACTIVATION OF ATR SIGNALING PATHWAY IN RESPONSE TO DNA REPLICATION STRESS

17:00 – 17:30

Lorraine Symington
Columbia University

DNA END RESECTION AND REPAIR PATHWAY CHOICE

17:30 – 18:00

Refreshments

18:00 – 18:30

Zhenkun Lou
Mayo Clinic

UFMYLATION SIGNALLING IN THE DNA DAMAGE RESPONSE

18:30 – 18:45

Nima Mosammaparast

Washington University in St. Louis

A UBIQUITIN-DEPENDENT SIGNALING AXIS SPECIFIC FOR ALKYLATION DAMAGE REPAIR

18:45 – 19:00

Wei Zhang
University of Toronto

SELECTIVE MODULATION OF HUMAN E3 LIGASES AND DEUBIQUITINASES FOR CANCER THERAPY BY ENGINEERED UBIQUITIN VARIANTS

19:00 – 19:30

Robert A Hromas
University of Florida

THE ENDONUCLEASE EEPD1 IS A GATEKEEPER FOR 5’ END RESECTION FOR HOMOLOGOUS RECOMBINATION AND RESCUE OF STRESSED REPLICATION FORKS

19:30 – 19:45

Eli Rothenberg

New York University School of Medicine

SPATIOTEMPORAL DYNAMICS OF THE INTERNAL ORGANIZATION OF INDIVIDUAL DSB REPAIR FOCI

19:45 – 20:15

Yinsheng Wang

UC Riverside

POST-TRANSLATIONAL REGULATIONS OF REPAIR OF INTERSTRAND CROSS-LINK LESIONS AND DNA DOUBLE-STRAND BREAKS

20:15

Dinner at Leisure

TUESDAY 28TH FEBRUARY 2017

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

EMERGING CONCEPTS IN TARGETED THERAPIES
Session Chairs: Lauren Byers and Giulio Draetta

08:30 – 09:00

Mark J O'Connor
AstraZeneca

EXPLOITING CANCER REPLICATION STRESS USING PHARMACOLOGICAL INHIBITORS OF ATR AND WEE1

09:00– 09:30

Akihiro Ohashi

Takeda

A NOVEL CDC7-SELECTIVE INHIBITOR TAK-931 WITH POTENT ANTITUMOR ACTIVITY

09:30 – 10:00

Giulio Draetta
MD Anderson Cancer Center

CRITICAL VULNERABILITIES OF PANCREATIC CANCER CELL SUBPOPULATIONS

 

10:00 – 10:45

Refreshments & Group Photo

10:45 – 11:15

Lauren Averett Byers
MD Anderson Cancer Center

TARGETING DNA DAMAGE RESPONSE (DDR) FOR THE TREATMENT OF LUNG CANCER

 

11:15 – 11:30

Laura Butler
Atrin Pharmaceuticals 

POTENT AND SELECTIVE ATR INHIBITORS FOR THE TREATMENT OF HOMOLOGOUS-RECOMBINATION DEFICIENT AND PARPi-RESISTANT CANCERS

11:30 – 12:00

Philip Hinds
Tufts University School of Medicine

TARGETING SENESCENCE AS A TUMOR PROMOTER IN CELLS WITH DEFECTIVE DDR OR REPLICATION STRESS

12:00 – 12:15

Naoaki Fujii
St. Jude Children's Research Hospital

 

DISCOVERY OF SMALL MOLECULE INHIBITORS TARGETING THE TRANSLESION DNA SYNTHESIS MACHINERY

12:15 – 16:15

Lunch at Leisure & Free Time

CLINICAL EXPLORATION OF DEFECTS IN DNA DAMAGE CHECKPOINT AND DNA REPAIR
Session Chairs: Guang Peng and Shridar Ganesan

16:15 – 16:45

Elizabeth Swisher
University of Washington

DNA THERAPIES FOR OVARIAN CANCER AND PREDICTORS OF RESPONSE AND RESISTANCE

16:45 – 17:15

Yi Fan

University of Pennsylvania

DNA-PK-MEDIATED THERAPY RESISTANCE IN CANCER STEM CELLS

17:15 – 17:45

Shridar Ganesan
Rutgers Cancer Institute of New Jersey

PROTEIN (LYSINE) METHYLTRANSFERASES G9A AND GLP1 PROMOTE RESPONSES TO DNA DAMAGE

17:45 – 18:15

Guang Peng
MD Anderson Cancer Center

 

DYSFUNCTIONAL UBIQUITINATION PROCESS GENERATES A THERAPEUTIC VULNERABILITY IN ARID1A-DEFICIENT CANCERS FOR DNA DAMAGE CHECKPOINT INHIBITORS

18:15 – 18:45

Mien-Chie Hung
MD Anderson Cancer Center

MARKER-GUIDED COMBINATION THERAPY WITH PARP INHIBITORS

18:45 – 19:30

Poster Session & Refreshments

19:30

Dinner at Leisure

WEDNESDAY 1ST MARCH 2017

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

CHROMATIN BIOLOGY AND DNA DAMAGE RESPONSE
Session Chairs: David Yu and Brendan Price

08:30 – 09:00

Michelle Barton
MD Anderson Cancer Center

TRIM24: AN INTERSECTION BETWEEN P53 REGULATION AND EPIGENETIC FUNCTION

09:00 – 09:15

Sudhakar Jha
Cancer Science Institute of Singapore

ROLE OF RVBS IN MAINTAINING TIP60.COM’S OPTIMAL ACTIVITY FOR DNA DAMAGE RESPONSE

09:15 – 09:45

Brendan Price
Dana Farber Cancer Institute

CHROMATIN DYNAMICS, EPIGENETICS AND THE REPAIR OF DNA BREAKS

09:45 – 10:15

Refreshments

10:15 – 10:30

David Yu
Emory University School of Medicine

EXPLOITING A NOVEL ROLE FOR SAMHD1 IN DNA END RESECTION FOR DISCRIMINATING RADIATION VS CHEMOTHERAPY RESISTANCE FOR PERSONALIZING CANCER THERAPY

10:30 – 11:00

Jac A. Nickoloff
Colorado State University

NUCLEASES AND SIGNALING PATHWAYS IN REPLICATION STRESS RESPONSES

11:00 – 11:30

Jos Jonkers
Netherlands Cancer Institute

GENETIC DISSECTION OF TUMOR DEVELOPMENT, THERAPY RESPONSE AND RESISTANCE IN MOUSE MODELS OF BRCA-DEFICIENT BREAST CANCER

11:30 – 12:00

Kyungjae Myung
Institute of Basic Science

A NOVEL CHEMOTHERAPEUTIC AGENT TO TREAT TUMORS WITH DNA MISMATCH REPAIR DEFICIENCIES

12:00 – 16:15

Lunch at Leisure & Free Time

ARISING TOPICS IN GENOME MAINTENANCE
Session Chairs: Matthew Weitzman and Chuan-Yuan Li

16:15 – 16:45

Richard Wood
MD Anderson Cancer Center

DNA POLYMERASES WITH DISTINCT MECHANISMS FOR MAINTAINING CHROMOSOME STABILITY

 

16:45 – 17:00

Richard Pomerantz
Temple University

DNA POLYMERASE Θ SPECIALIZES IN INCORPORATING SYNTHETIC EXPANDED-SIZE (XDNA) NUCLEOTIDES

17:00 – 17:30

Daniel Durocher
Lunenfeld-Tanenbarum Research Institute

PROSPECTIVE IDENTIFICATION OF VULNERABILITIES TO DNA REPAIR INHIBITORS

17:30 – 18:00

Reuben Harris
University of Minnesota

MUTAGENESIS BY APOBEC3 ENZYMES IN CANCER

18:00 – 18:30

Matthew Weitzman
Children's Hospital of Philadelphia

APOBEC3A SENSITIZES CANCER CELLS TO CHECKPOINT INHIBITORS

18:30 – 18:45

Katharina Schlacher
MD Anderson Cancer Center

TP53 PROMOTES GENOMIC STABILITY AND REPLICATION PATHWAY HOMEOSTASIS BY EPIGENETICS-ENABLED MRE11 REPLICATION RESTART

18:45 – 19:00

Ranjit Bindra
Yale School of Medicine

ONCOMETABOLITES INDUCE A BRCANESS STATE THAT CAN BE EXPLOITED BY PARP INHIBITORS

19:00 – 20:00

Poster Session & Refreshments

20:15

*Gala Dinner & Poster Awards*

THURSDAY 2ND MARCH 2017

07:00 – 08:30

Breakfast

*Kalmia Buffet Restaurant*

DEVELOPING IDEAS IN CANCER TREATMENT
Session Chair: Yi Fan

08:30 – 09:00

Chuan-Yuan Li
Duke University Medical Center

DNA DOUBLE STRAND BREAKS INDUCED BY SUBLETHAL ACTIVATION OF APOPTOTIC CASPASES AND THEIR ROLES IN CARCINOGENESIS AND TUMOUR GROWTH

09:00 – 09:30

Chris Bakkenist

University of Pittsburg

DNA DAMAGE SIGNALING TO IMMUNE CHECKPOINTS

09:30 – 10:00

Yves Pommier
NIH/NCI

TOPOISOMERASE CLEAVAGE COMPLEXES AND GENOMIC STABILITY

10:00 – 10:30

Refreshments

10:30 – 11:00

Fen Xia
UAMS

IONIZING RADIATION-INDUCED SYNTHETIC LETHALITY OF PARP INHIBITION IN BRCA1-PROFICIENT CANCER CELLS DEPENDS ON P53

11:00 – 11:30

Eric A. Hendrickson
University of Minnesota

THE ROLES OF DNA LIGASES IN CHROMOSOMAL TRANSLOCATIONS AND TELOMERE FUSIONS

11:30 – 11:45

Olimpia Alessandra Buoninfante
NKI-AVL

A NOVEL SYNTHETIC LETHALITY IN THE DDT NETWORK: STRATEGIES FOR PRECISION CANCER THERAPY

11:45 – 12:00

Closing Comments

Speakers

Invited Speakers

  • Prof. Lorraine Symington
    Professor, Columbia University
  • Professor Karlene Cimprich
    Professor, Stanford University
  • Prof. Reuben Harris
    Professor, University of Minnesota
  • Prof. Dr. Robert Hromas
    Professor and Chair, University of Florida
  • Prof. Jac Nickoloff
    Professor and Head, Colorado State University
  • Dr. Lauren Byers
    Assistant Professor, The University of Texas MD Anderson Cancer Center
  • Dr. Yves Pommier
    Branch Chief, National Cancer Institute, NIH
  • Dr. Giulio Draetta
    Professor, UT MD Anderson Cancer Center
  • Prof. Dipanjan Chowdhury
    Associate Professor, Dana-Farber Cancer Institute (Harvard Medical School)
  • Dr. Daniel Durocher
    Senior Scientist, Lunenfeld-Tanenbarum Research Institute, Sinai Health System
  • Prof. Dr. Elizabeth Swisher
    Professor, University of Washington
  • Dr. Mark O'Connor
    Chief Scientist, AstraZeneca
  • Prof. Zhenkun Lou
    Professor, Mayo Clinic
  • Dr. Brendan Price
    Professor, Dana-Farber Cancer Institute
  • Prof. Richard Wood
    Professor, The University of Texas MD Anderson Cancer Center
  • Dr. Shridar Ganesan
    Associate Professor, Rutgers Cancer Institute of New Jersey
  • Dr. Yi Fan
    Assistant Professor, University of Pennsylvania
  • Dr. Michelle Barton
    Dean, UT MD Anderson Cancer Center
  • Dr. Jean Gautier
    Professor, Columbia University Medical Center
  • Dr. Akihiro Ohashi
    Group Head, Takeda Pharmaceutical Company Limited
  • Dr. Guang Peng
    Assistant Professor, MD Anderson Cancer Center
  • Dr. Matthew Weitzman
    Associate Professor, Children's Hospital of Philadelphia
  • Prof. Chuan-Yuan Li
    Professor, Duke University Medical Center
  • Prof. Mien-Chie Hung
    Vice President for Basic Research, MD Anderson Cancer Center
  • Dr. Yinsheng Wang
    Professor, University of California Riverside
  • Dr. Fen Xia
    Professor and Chair, University of Arkansas for Medical Sciences
  • Prof. Jos Jonkers
    Division Head, Netherlands Cancer Institute
  • Prof. Philip Hinds
    Professor and Chair, Tufts University School of Medicine
  • Prof. Kyungjae Myung
    Director, Institute of Basic Science
  • Dr. Ranjit Bindra
    Assistant Professor, Yale Medical School
  • Prof. Christopher Bakkenist
    Associate Professor, University of Pittsburgh School of Medicine
  • Prof. Eric Hendrickson
    Professor, University of Minnesota

Feedback

Sign In

Your feedback has been received.