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Home > Past Conferences > Biology and Treatment of Metastatic Cancers

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Biology and Treatment of Metastatic Cancers

23 Sep 2014 - 26 Sep 2014

El Jadida, Morocco

Synopsis

The first in the series of Biology and Treatment of Metastatic Cancers Fusion conferences. 

Key Sessions

  • The processes involved in tumor dissemination
  • The role of circulating tumor cells and cancer stem cells
  • The tumor microenvironment
  • Metastatic dormancy
  • Tumor cell plasticity
  • Chemoresistance
  • Novel targeted therapies for the treatment of established metastases

As many as 90% of all cancer deaths can be attributed to metastatic disease.   Cells from the primary tumor, after travel to regional or distant sites, cause failure of essential organs including the lungs, liver, brain and bone marrow.  Significant advances in the field make this an exciting time for the study of metastasis.  Genetic signatures in primary tumors as well as circulating tumor cells and oligonucleotide or protein biomarkers hold the promise of predicting cancer outcomes and allowing selection of optimal drug candidates.  The isolation of circulating tumor cells has further improved our ability to analyze the tumor genotype.  The ability to metastasize is influenced by the invasive potential of cells in the primary tumor and particularly by self-renewing tumor cells that have properties of cancer stem cells.  New results highlight the plasticity of tumor cells.  Genetic and epigenetic changes take place over time both in the primary site and in the secondary metastatic sites.  Tumor cells can take on the properties of mesenchymal cells or epithelial cells and transition back and forth between these two states.  Furthermore, cells that occupy metastatic sites and primary sites may be so different that they respond to completely different drugs.  An important current goal is the identification of agents that selectively target the cells in established tumor metastases.

Target Audience

Scientists working in either academic centers or in a pharmaceutical/drug development laboratories will benefit from this meeting.

Keynote Speaker

Dr. David Lyden
Weill Cornell Medical College

Plenary Speakers

Professor Dr. Thomas Brabletz
University of Freiburg
Dr. Janine Erler
University of Copenhagen
Professor Dr. Jonathan Sleeman
University of Heidelberg

Invited Speakers:

Dr. Catherine Alix-Panabières
Laboratory of Rare Human Circulating Cells Montpellier
Dr. Roger Gomis
Institute for Research in Biomedicine of Barcelona
Dr. Sonja Loges
University Hospital Hamburg-Eppendorf
Professor Massimiliano Mazzone
KU Leuven
Professor Andrei Thomas-Tikhonenko
Children's Hospital of Philadelphia  

Contributing Speakers

Dr. Amina Zoubedi 
Vancouver Prostate Centre
Professor Dario Marchetti
Baylor College of Medicine
Dr. Khalid Sossey-Alaoui
Cleveland Clinic Lerner Research Institute
Dr. Vivek M. Rangnekar
University of Kentucky College of Medicine
Professor Menashe Bar-Eli
UT M.D. Anderson Cancer Center
Dr. Gabri van der Pluijm 
Leiden University
Professor Susan L Bellis
University of Alabama at Birmingham 
Professor Stuart S. Martin
University of Maryland School of Medicine 
Professor James Lorens
University of Bergen
Dr. Adriana Albini
Arcispedale S. Maria Nuova
Dr. Frank Rauscher
The Wistar Institute 
Dr. Arijit Chakravarty
Takeda 
Shiladit Sengupta
Brigham and Women's Hospital 

Short Talks

Dr. Andreas Möller
QIMR Berghofer Medical Research Institute
Dr. Alex Chenchik
Cellecta, Inc.
Dr. William Schiemann 
Case Western Reserve University
Mme Yu-Ting Huang
University of Fribourg 
Dr. Madeline Oudin 
Massachusetts Institute of Technology
Mme Sarah Knuchel
University of Fribourg
Dr. Klaus Luecke
GILUPI GmbH

Sponsors

No Sponsors info available

Programme

Tuesday 23rd September 2014

08:00 – 11:00

Registration & Reception

 

10:00 -10:15

Opening  Comments

 

Tumor Evolution and Heterogeneity
Session Chair: Arijit Chakravarty

10:15 – 10:40

Massimiliano Mazzone

TUMOR-ASSOCIATED NEUTROPHILS, A TWO EDGED SWORD IN CANCER

10:40 – 11:05

Arijit Chakravarty

AN EVOLVING VIEW OF CANCER: TUMOR RESISTANCE AND TREATMENT STRATEGIES

11:05 – 11:20

Alex Chenchik

MOLECULAR PROFILING OF HETEROGENOUS CIRCULATING TUMOR CELLS

11:20 – 12:00

Panel Discussion

12:00 – 16:30

Group Welcome Lunch & Free Time

The Metastatic Microenvironment
Session Chair: Jonathan Sleeman

16:30 – 17:15

Jonathan Sleeman

MICROENVIRONMENTAL DETERMINANTS OF METASTASIS FORMATION

17:15 – 17:40

Gabri van der Pluijm

TUMOR-STROMA INTERACTIONS AND NEW THERAPY DEVELOPMENT IN BONE METASTASIS

17:40 – 18:05

Adriana Albini

ROLE OF TUMOR INFILTRATING NATURAL KILLER CELLS ("TINK") IN ANGIOGENESIS AND TUMOR PROGRESSION

18:05 – 18:30

Refreshments

18:30 – 18:45

Sarah Knuchel

ROLE OF FIBROBLASTS IN PROMOTING COLON CANCER CELL INVASION

18:45 – 19:00

Madeline Oudin

HAPTOTAXIS: NEW MECHANISTIC INSIGHT INTO HOW CELLS MIGRATE ON FIBRONECTIN GRADIENTS AND WHY THIS MATTERS FOR TUMOR METASTASIS

19:00 – 19:30

Panel Discussion

19:30

Group Dinner & Free Time

Wednesday 24th September 2014

Stem Cells and the Metastatic Niche – Key Note Presentation
Introduced by: Bruce Zetter

08:30 – 09:15

David Lyden

 

Stem Cells and the Metastatic Niche
Session Chair: Sonja Loges

09:15 – 09:40

Sonja Loges

THE BONE MARROW (STROMA) – A KEY PLACE FOR MALIGNANT INTERACTION

09:40 – 10:10

Panel Discussion

10:10 – 10:30

Refreshments

10:30 – 13:30

Group Tour to El Jadida (optional)

10:30 – 17:30

Group Lunch & Free Time

Circulating Tumor Cells
Session Chair: Bruce Zetter

17:30 – 17:55

Dario Marchetti

MECHANISMS AND BIOMARKERS OF BRAIN-COLONIZING BREAST CANCER CTCS

17:55 – 18:20

Stuart Martin

TARGETING THE CYTOSKELETAL PHYSICS OF CIRCULATING BREAST TUMOR CELLS TO REDUCE METASTASIS

18:20 – 18:35

Emanuela Fina

MOLECULAR CHARACTERIZATION AND BIOLOGICAL ROLE OF CIRCULATING TUMOR CELLS IN BREAST CANCER PATIENTS AND XENOGRAFT MODELS

18:35 – 18:50

Klaus Luecke

DETERMINATION OF IN VIVO CAPTURED CIRCULATING TUMOR CELLS IN NON-SMALL CELL LUNG CANCER PATIENTS USING A NOVEL CELLCOLLECTOR

18:50 – 19:20

Panel Discussion

19:20 – 20:20

Poster Session & Cocktail Reception

   

20:20

Group Dinner & Free Time

Thursday 25th September 2014

Tumor Cell Plasticity
Session Chair: Thomas Brabletz

08:30 – 09:15

Thomas Brabletz

METASTASIS: EMT, MICRORNAS AND CANCER STEM CELLS

09:15 – 09:30

Simone Ragusa

PROX1 PROMOTES METABOLIC ADAPTION AND FUELS OUTGROWTH OF WNTHIGH METASTATIC COLON CANCER CELLS

09:30 – 10:00

Panel Discussion

10:00 – 10:30

Refreshments

Treatment  of Metastatic/Resistant Disease
Session Chair: Bruce Zetter

10:30 – 11:15

Bruce Zetter

NOVEL MECHANISMS OF CHEMORESISTANCE IN METASTATIC CELLS

11:15 – 11:40

Khalid Sossey-Alaoui

NOVEL WAVE3-DIRECTED BIOMARKERS AND THERAPEUTIC OPTIONS FOR TRIPLE-NEGATIVE BREAST CANCER

11:40 – 12:10

Panel Discussion

12:10 – 16:30

Group Lunch & Free Time

Signals and Pathways Leading to Metastatis I
Session Chair: Janine Erler

16:30 – 17:15

Janine Erler

NEW APPROACHES TO TARGETING METASTASIS

17:15 – 17:40

Roger Gomis

COLON CANCER METASTASIS TO THE LUNG IS MEDIATED BY MAPK SIGNALING THROUGH CYTOKINE MEDIATED ACTIONS

17:40 – 18:05

Andrei Thomas-Tikhonenko

THE ROLE OF TGFBETA IN COLON CANCER PROGRESSION

18:05 – 18:35

Panel Discussion

18:35 – 19:00

Refreshments

20:00 – 23:00

*Gala Night & Group Photo*

Speakers

Plenary Speakers

  • Prof. Dr. Jonathan Sleeman
    Professor, University of Heidelberg
  • Dr. Janine Erler
    Group Leader/Associate Professor, BRIC, University of Copenhagen
  • Professor David Lyden
    Professor, Weill Cornell Medical College
  • Prof. Dr. Thomas Brabletz
    Scientific Director,Dept. of Visceral Surgery, University of Freiburg Medical Center

Invited Speakers

  • Prof. Massimiliano Mazzone
    Group Leader , VIB Vesalius Research Center
  • M.D., Ph.D. Sonja Loges
    Group Leader, University Hospital Hamburg-Eppendorf
  • Prof Roger Gomis
    Professor, IRB Barcelona
  • Professor Andrei Thomas-Tikhonenko
    Division Chief, Children's Hospital of Philadelphia

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