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Home > Past Conferences > Personalized Medicine Conference

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Personalized Medicine Conference

30 Sep 2015 - 03 Oct 2015

Tucson, Arizona, USA

Synopsis

The first in the series of the Personalized Medicine Fusion conference.

New technologies and therapeutic approaches are being developed and implemented which could transform patient management in the near future.

This Personalized Medicine conference will address several of these key areas:
- Overviews of Personalized Medicine
- Cardiovascular Health
- Stem Cells and Regenerative Medicine
- Gene Therapy
- Cancer Immunotherapy
- Ethics in Personalized Medicine 
- The Diagnostics-Pharma Convergence
- Cancer genomics
- Bioinformatics

Learning Objectives

Develop a deeper understanding of key research questions, challenges, approaches and results in each of the topics. The conference participant will hear key findings and future directions for research in each topic.

Target Audience

Scientists and physician-scientists in academia, biotech and pharmaceutical companies who would like to gain a better understanding in any of the above areas or engage in discussions on state of the art in each of these areas. Specifically, researchers working in clinical research or clinical development, biomarkers, translational research and computational biology will find this conference very appealing.

Confirmed Plenary Speakers

Dr Matthew Porteus (Stanford School of Medicine)
THERAPEUTIC GENOME EDITING  

Dr. Gary Schroth (Illumina)
NEXT GENERATION RNA-SEQ ANALYSIS 

Dr. Bruce Levine (University of Pennsylvania)
CREATING EXCEPTIONAL IMMUNITY: ENGINEERED PATIENT CELLS TO TREAT THEIR UNTREATABLE CANCERS

Dr. Gunaretnam Rajagopal (Johnson & Johnson)
BIG DATA IN PRECISION MEDICINE – CHALLENGES & OPPORTUNITIES 

Dr. Carlo Maley (University of California, San Francisco)
IMPLICATIONS OF THE EVOLUTION OF CANCER FOR PERSONALIZED MEDICINE

Dr. Jessica Mozersky (University of Pennsylvania)
THE ETHICS OF PERSONALIZED MEDICINE 

Dr. Omar Perez (Pfizer)

Dr. Gerard Schellenberg (University of Pennsylvania)
PERSONALIZED MEDICINE AND NEURODEGENERATIVE DISORDERS. WHAT DOES THE FUTURE HOLD?

Dr. Megan Lim (University of Pennsylvania)
MOLECULAR MARKERS FOR TARGETED THERAPY IN LYMPHOMA

Dr. Kojo S. Elenitoba-Johnson (University of Pennsylvania)
PROSPECTS, IMPACT, OPPORTUNITIES AND CHALLENGES OF CLINICAL NEXT GENERATION SEQUENCING

Dr. Athena Aktipis (Arizona State University)
CANCER AS CHEATING IN MULTICELLULAR COOPERATION

Dr. Lanny Kirsch (Adaptive Biotechnologies)
IMMUNOSEQUENCING IN THE SERVICE OF CLINICAL MANAGEMENT AND THERAPEUTIC GUIDANCE

Dr. Shyamala Maheswaran (Harvard University)
MOLECULAR EVOLUTION OF CIRCULATING TUMOR CELLS

Professor David Whitcomb (University of Pittsburgh)
WHAT IS PERSONALIZED MEDICINE, AND WHAT SHOULD IT REPLACE?

Professor Dan Rader (University of Pennsylvania)
PERSONALIZED PREVENTIVE MEDICINE: CARDIOVASCULAR DISEASE AS A PARADIGM

Prof. Dr. Seth Crosby (Washington University)
NEW TOOLS IN THE SEARCH FOR RARE ALLELES 

Dr. Daryl Pritchard (Personalized Medicine Coalition)
INTEGRATING PERSONALIZED MEDICINE INTO HEALTHCARE PRACTICE: COMMON CHALLENGES AND POTENTIAL SOLUTIONS

Dr. Paul R. Billings (Life Technologies)
REAL PRECISION MEDICINE 

Dr. Rong Chen (Mount Sinai Hospital)

USING BIG DATA TO INTERPRET PERSONAL GENOMES FOR DRIVE MUTATIONS, PROTECTIVE ALLELES, AND PRECISION MEDICINE

Dr. Dena Davis (Lehigh University)

Dr. Jennifer Wagner (Geisinger Health System)

Professor Robert Cook-Deegan (Duke University)
DATA ACCESS AND TRANSPARENT ANALYSIS: FROM BERMUDA PRINCIPLES TO THE GLOBAL ALLIANCE

Sponsors

Sponsors

Report

This inaugural Personalized Medicine conference covered topics such as biomarkers and companion diagnostics, big data, next generation sequencing, gene editing, cancer immunotherapy and ethics. A diverse group of scientists, physicians and physician-scientists from academia and industry attended and participated in oral and poster presentations and lively panel discussions.

Day 1 focused on biomarkers, with an opening presentation from Dr. Ron Mazumder of Johnson and Johnson who gave an industry perspective on developing companion diagnostics for targeted therapies. Dr. Shyamala Maheswaran from the Massachusetts General Hospital Cancer Center then discussed how circulating tumor cells can be used to understand patients’ disease progression and to gain insights into metastasis. Dr. Lynn Wang of The University of Chicago then presented data on resistance mutations arising after treatment with ibrutinib. Professor Michael Heller of The University of California at San Diego presented a technology to characterize cell free biomarkers. Dr. Minoli Perera of The University of Chicago presented data on warfarin pharmacogenomics in minority populations. Dr. Kojo Elenitoba-Johnson of The University of Pennsylvania discussed challenges and progress in the implementation of next generation sequencing in a large academic medical center. Dr. Erdam Bangi of The Icahn School of Medicine at Mount Sinai discussed the use of flies to understand pathway biology. Dr. Megan Lim of The University of Pennsylvania discussed various molecular markers she is investigating in lymphoma targeted therapies. Dr. Rong Fan of Yale University presented an exciting new multiplex technology to study cytokines in immunity and hematopoietic malignancy. The last speaker of the day was  Daryl Pritchard who discussed challenges facing the implementation of personalized medicine from a policy and regulatory perspective.

Day 2 focused on personalized medicine in areas other than oncology, evolutionary biology and ethics. Dr. Daniel Rader of The University of Pennsylvania discussed the use of personalized medicine in prevention of cardiovascular disease. Dr. Gerard Schellenberg of The University of Pennsylvania discussed personalized medicine in Alzheimer’s disease and other neurological disorders. Dr. Seth Crosby of Washington University presented data on new molecular tools in the search for rare alleles. Dr. Paul Billings discussed broad perspectives in implementation of precision medicine. Dr. David Whitcomb of The University of Pittsburgh discussed the use of personalized medicine in gastrointestinal disorders. Dr. Carlo Maley of Arizona State University discussed evolutionary paths in cancer and implications for personalized medicine. Dr. Athena Aktipis of Arizona State University discussed multicellular organisms and implications for cancer evolution. These discussions were followed by a session on ethics. Dr. Jessica Mosersky of The University of Pennsylvania discussed ethical considerations in fetus characterization. Dr. Dena Davis of Lehigh University gave a compelling and emotional talk on suicide in patients with dementia. Dr. Bob Cook Deegan of Duke University discussed data access in the new digital age. Lastly, Jennifer Wagner discussed disruptive concepts from the perspective of a large health care system.

Day 3 focused on data analysis, next generation sequencing, gene editing and cancer immunotherapy. Dr. Gunaretnam Rajagopal from Johnson and Johnson discussed challenges and progress in analyzing big data. Dr. Peter Nagy of Columbia University discussed optimizing exome sequencing data analysis. Dr. Rong Chen of The Icahn School of Medicine at Mount Sinai discussed big data and identification of driver mutations. Dr. James Broach of The Penn State College of Medicine presented genomic analyses in amyotrophic lateral sclerosis. Dr. Mira Marcus-Kalish of Tel Aviv University discussed her work in data analysis of small and large datasets. Dr. Gary Schroth of Illumina discussed RNA sequencing methodologies for formalin fixed paraffin embedded samples in cancer and gave a nice overview of next generation sequencing. Dr. Ilan Kirsch discussed the use of sequencing of T cell receptors to guide therapeutic regimens. Dr. David Roth of The University of Pennsylvania discussed progress and challenges over the last three years in setting up a clinical diagnostic sequencing service at a large patient-oriented institution. Dr. Matthew Porteus of Stanford University discussed progress and challenges in genome editing for therapeutic purposes. Lastly, Dr. Bruce Levin of The University of Pennsylvania gave an inspirational talk on the benefits of immunotherapy for difficult to treat cancers.

All of the meeting participants were highly engaged and had numerous active discussions during and after the sessions. Positive feedback was also given on the high quality posters that were presented throughout the meeting. Several potential collaboration discussions and follow up meetings were scheduled amongst the participants. This conference was and will continue to be a fantastic networking and knowledge gathering forum for personalized medicine researchers.

Johnson and Johnson was a Diamond sponsor of the event while The University of Pennsylvania and Foundation Medicine were each Silver sponsors. The Personalized Medicine Coalition, The Journal of Personalized Medicine, BMC Medicine, and Applied and Translational Genomics were media partners.

Programme

Wednesday 30th September 2015

14:00 – 15:00

Registration & Reception

14:00 – 14:45

Group Welcome Lunch

BIOMARKERS A&B

Session Chair:  Ron Mazumder

14:45 – 15:00

Opening Comments

 

15:00 – 15:35

Ron Mazumder
Johnson and Johnson

EXECUTING ON PERSONALIZED MEDICINE: CURRENT CHALLENGES AND THOUGHTS FOR THE FUTURE

15:35 – 16:00

Shyamala Maheswaran
Massachusetts General Hospital

MOLECULAR EVOLUTION OF CIRCULATING TUMOR CELLS

16:00 –16:15

Y.Lynn Wang
The University of Chicago

PRECISION MEDICINE IN LYMPHOMA: MUTATIONS AND PATHWAY ANOMALIES LEADING TO IBRUTINIB RESISTANCE IN CLL AND NON-HODGKIN LYMPHOMAS

16:15 –16:30

Michael Heller
University of California San Diego

CELL FREE DNA/RNA BIOMARKERS FROM HEMATOLOGICAL CANCER, SOLID TUMORS AND TBI PATIENTS AND ROLE IN PERSONALIZED MEDICINE

16:30 – 17:00

Refreshments

17:00 – 17:15

Minoli Perera
University of Chicago

WARFARIN PHARACOGENOMICS IN MINORITY POPULATIONS

17:15 – 17:50

Kojo Elenitoba-Johnson University of Pennsylvania

PROSPECTS, IMPACT, OPPORTUNITIES AND CHALLENGES OF CLINICAL NEXT GENERATION SEQUENCING

17:50 – 18:05

Erdem Bangi
Icahn School of Medicine at Mount Sinai

PERSONALIZED CANCER THERAPEUTICS USING FLIES

18:05 – 18:30

Megan Lim
University of Pennsylvania

MOLECULAR MARKERS FOR TARGETED THERAPY IN LYMPHOMA

18:30 – 18:45

Rong Fan
Yale University

SINGLE CELL, 42-PLEX CYTOKINE ANALYSIS OF IMMUNE DEFENSE AND HEMATOPOIETIC MALIGNACY

18:45 – 19:10

Daryl Pritchard
Personalized Medicine Coalition

INTEGRATING PERSONALIZED MEDICINE INTO HEALTHCARE PRACTICE: COMMON CHALLENGES AND POTENTIAL SOLUTIONS

19:10

Group Dinner

 

 

Thursday 1st October 2015

07:00 – 08:30

Group Breakfast

EVOLUTIONARY BIOLOGY AND PERSONALIZED CANCER DIAGNOSTICS AND GENETICS

Session Chair: Paul Billings

08:30 – 09:05

Daniel Rader

University of Pennsylvania

PERSONALIZED PREVENTIVE MEDICINE: CARDIOVASCULAR DISEASE AS A PARADIGM

09:05 – 09:30

Gerard Schellenberg
University of Pennsylvania

PERSONALIZED MEDICINE AND NEURODEGENERATIVE DISORDERS.  WHAT DOES THE FUTURE HOLD?

09:30 – 10:05

Seth Crosby
Washington University

NEW TOOLS IN THE SEARCH FOR RARE ALLELES

10:05 – 10:40

Paul Billings
Johnson and Johnson

REAL PRECISION MEDICINE

10:40 – 11:10

Refreshments

11:10 – 11:35

David Whitcomb
University of Pittsburgh

WHAT IS PERSONALIZED MEDICINE AND WHAT SHOULD IT REPLACE?

11:35 – 12:00

Carlo Maley
Arizona State University

IMPLICATIONS OF THE EVOLUTION OF CANCER FOR PERSONALIZED MEDICINE

12:00 –12:25

Athena Aktipis
Arizona State University

CANCER ACROSS THE TREE OF LIFE: MULTICELLULAR COOPERATION AND CHEATING

 

12:25 – 18:00

Group Lunch & Free Time

13:35 – 17:40

Group Activity-  ARIZONA-SONORA DESERT MUSEUM

ETHICS

Session Chair: Jessica Mozersky

17:30 – 18:00

Refreshments

18:00 –18:15

Jessica Mozersky
University of Pennsylvania

FETAL PERSONALIZED MEDICINE? UNEXPECTED COMPLEXITIES AND BLURRED BOUNDARIES

 

18:15 –18:30

Dena Davis
Lehigh University

USING BIOMARKERS TO PLAN PREEMPTIVE SUICIDE IN THE FACE OF DEMENTIA

18:30 –18:45

Bob Cook Deegan
Duke University

DATA ACCESS AND TRANSPARENT ANALYSIS: FROM BERMUDA PRINCIPLES TO THE GLOBAL ALLIANCE

18:45 – 19:00

Jennifer Wagner
Geisinger Health System

PROGRESS IN PERSONALIZED MEDICINE: EMBRACING THE DISRUPTIVE

19:00 – 20:00

Panel Discussion

20:00

Group Dinner

Friday 2nd October 2015

07:00 – 08:30

Group Breakfast

DATA ANALYSIS

Session Chair: Gunaretnam Rajagopal

08:30 – 09:05

Gunaretnam Rajagopal
Johnson & Johnson

BIG DATA IN PRECISION MEDICINE – CHALLENGES & OPPORTUNITIES

09:05 – 09:20

Peter Nagy
Columbia University

OPTIMIZATION OF CLINICAL EXOME SEQUENCING DATA ANALYSIS

09:20 – 9:45

Rong Chen
Icahn School of Medicine at Mount Sinai

USING BIG DATA TO INTERPRET PERSONAL GENOMES FOR DRIVE MUTATIONS, PROTECTIVE ALLELES, AND PRECISION MEDICINE

09:45 – 10:00

James Broach
Penn State College of Medicine

GENOMIC ANALYSIS OF SPORADIC AMYOTROPHIC LATERAL SCLEROSIS

10:00 – 10:15

Mira Marcus-Kalish
Tel Aviv University Ramat Aviv

BIG VERSUS SMALL DATA ANALYSIS
3C STRATEGY TARGETING PERSONALIZED HEALTHCARE

10:15 – 11:30

Refreshments & Poster Session

12:00 – 14:00

Group Activity - HIKE

14:00 – 15:30

Group Lunch & Free Time

NGS CANCER DIAGNOSTICS AND GENE AND CELL THERAPIES

Session Chair: David Roth

15:30 – 16:05

Gary Schroth
Illumina

SENSITIVE CANCER FUSION DETECTION AND DISCOVERY IN FFPE SAMPLES BY RNA-SEQ

16:05 – 16:30

Ilan Kirsch
Adaptive Biotechnologies

IMMUNOSEQUENCING IN THE SERVICE OF CLINICAL MANAGEMENT AND THERAPEUTIC GUIDANCE

16:30 – 17:05

David Roth 
University of Pennsylvania

CLINICAL NGS CANCER DIAGNOSTICS IN AN ACADEMIC MEDICAL CENTER: LESSONS LEARNED FROM THE FIRST 2.5 YEARS

17:05 – 17:30

Refreshments

17:30 – 18:05

Matthew Porteus
Stanford University

THERAPEUTIC GENOME EDITING

18:05 – 18:40

Bruce Levine
University of Pennsylvania

CREATING EXCEPTIONAL IMMUNITY: ENGINEERED PATIENT CELLS TO TREAT THEIR UNTREATABLE CANCERS

19:00 – 22:00

*Gala Dinner, Group Photo & Poster Awards*

 

Speakers

Plenary Speakers

Invited Speakers

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