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Home > Past Conferences > DNA Replication as a Source of DNA Damage

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DNA Replication as a Source of DNA Damage

From Molecules to Human Health

30 Sep 2014 - 03 Oct 2014

El Jadida, Morocco

Synopsis

This conference has now ended. The 2nd DNA Replication as a Source of DNA Damage conference in 2017 is now open for registration. You can find out more information here

The maintenance of genome integrity is critical for the suppression of cancer and premature ageing. Only recently has it become appreciated that DNA replication stress is a crucial driver of genomic instability. The timely progression of replisomes can be disrupted by lesions and secondary structures in the template, by bound proteins and by conflicts with the transcription machinery. A prolonged pause of the replisome then exposes single stranded DNA, which, due to its recombinogenic nature, can lead to genome rearrangements, fragile site expression and cell death. Importantly, some cancers present excessive endogenous levels of replication stress, which can be exploited for their clearance. In this conference, we aim to bring together scientists studying DNA replication and repair, with those interested in how DNA damage can influence cancer and ageing. 

Key Sessions

  • Pathways for repair of damaged replication forks
  • Systems for site-specific perturbation of replication
  • Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins
  • Replication perturbation as a driver of tumorigenesis and ageing
  • Exploitation of replication defects in cancer treatment

Sponsors

Sponsors

Programme

Tuesday 30th September 2014

08:00 – 12:00

Registration & Reception

 

11:00 – 11:15

Opening  Comments

 

Session Chair: Stephen West

11:15 – 11:40

Virginia Zakian
Princeton University, New Jersey, USA

PROTEOMICS OF BUDDING YEAST TELOMERASE: THE TELOMERASE ASSOCIATED CDC48-NPL4-UFD1 COMPLEX REGULATES EST1 ABUNDANCE AND TELOMERE LENGTH

11:40 – 12:05

John Rouse
University of Dundee, UK

DISSECTING THE ROLES AND REGULATION OF NUCLEASES INVOLVED IN ICL REPAIR

12:05 – 12:20

Andres Lopez-Contreras
CNIO, Spain

A CONSERVED ROLE FOR NUCLEOTIDE BIOSYNTHESIS ON ATR BIOLOGY IN MAMMALS

12:20 – 12:45

Michelle Debatisse
Institut Curie, Paris, France

RESPECTIVE ROLES OF REPLICATION AND TRANSCRIPTION IN COMMON FRAGILE SITE INSTABILITY

12:45 – 13:10

Xiaolan Zhao
Memorial Sloan-Kettering Cancer Center, USA

REGULATION OF GENOME DUPLICATION

13:10 – 16:30

Group Welcome Lunch & Free Time

Session Chair: Virginia A. Zakian

16:30 – 16:55

Junjie Chen
The University of Texas M.D. Anderson Cancer Center, USA

BALANCE BRCA1 AND 53BP1 AT DSB SITES

16:55 – 17:20

Aidan Doherty
University of Sussex, UK

PRIMPOL, A EUKARYOTIC PRIMASE-POLYMERASE INVOLVED IN LESION BYPASS DURING DNA REPLICATION

17:20 – 17:35

Jennifer Cobb
University of Calgary, Canada

THE NUA4 COMPLEX FUNCTIONS ON THE TRANSLESION SYNTHESIS (TLS) PATHWAY DURING DNA POST REPLICATION REPAIR

17:35 – 18:00

Stephen West
London Research Institute, UK

STRUCTURE AND FUNCTION OF THE BRCA2 TUMOUR SUPPRESSOR

18:00 – 18:25

George Garinis
Institute of Molecular Biology and Biotechnology-FORT, Heraklion, Greece

NUCLEOTIDE EXCISION REPAIR: LESSONS FROM THE MOUSE

18:25 – 19:00

Refreshments

Session Chair: John Rouse

19:00 – 19:25

Juan Méndez
Spanish National Cancer Research Centre (CNIO), Madrid, Spain

CONTROL OF DNA RE-REPLICATION IN VIVO: MOUSE MODELS FOR CDC6 AND CDT1 DEREGULATED EXPRESSION

19:25 – 19:50

Ivan Ahel
University of Oxford, UK

STRUCTURE AND CATALYTIC MECHANISM OF ADP-RIBOSYLGLYCOHYDROLASES

19:50 – 20:15

Hocine Mankouri
University of Copenhagen, Denmark

ANALYSIS OF SITE-SPECIFIC REPLICATION PERTURBATION IN YEAST

20:15 – 20:30

Grant Brown
University of Toronto, Canada

SLX4 PROMOTES MEC1 SIGNALING BEHIND DAMAGED DNA REPLICATION FORKS

20:30 – 21:30

Welcome Buffet Dinner Hosted in Pre-function Area

Wednesday 1st October 2014

Session Chair: Simon Boulton

09:00 – 09:25

Noel Lowndes
National University of Ireland Galway, Ireland

ATR ACTIVATES THE S-M CHECKPOINT DURING UNPERTURBED GROWTH TO ENSURE SUFFICIENT REPLICATION PRIOR TO MITOTIC ONSET

09:25 – 09:50

Andre Nussenzweig
National Institutes of Health, Maryland, USA

DNA-DAMAGE INDUCED DIFFERENTIATION OF LEUKEMIC CELLS AS AN ANTI-CANCER BARRIER

09:50 – 10:05

Makoto Nakanishi
Nagoya City University, Japan

NECESSARY AND SUFFICIENT ROLE FOR A MITOSIS SKIP IN SENESCENCE INDUCTION

10:05 – 10:30

Filippo Rosselli
CNRS - Gustave Roussy Institute, France

 

10:30 – 11:00

Refreshments

Session Chair: Antony Carr

11:00 – 11:25

Sophie Polo
Paris Diderot University, France

CHROMATIN LICENSING FOR TRANSCRIPTION RESTART AFTER DNA DAMAGE

11:25 – 11:50

Massimo Lopes
University of Zurich, Switzerland

REMODELLING OF REPLICATION INTERMEDIATES IN FACE OF REPLICATION STRESS

11:50 – 12:05

Vincent Geli
CRCM, France

RPA AND PIF1 HELICASE PREVENT SECONDARY STRUCTURES FORMATION DURING TELOMERE AND HUMAN SUBTELOMERIC MINISATELLITE REPLICATION

12:05 – 12:30

Alessandro Vindigni
Saint Louis University School of Medicine, USA

DNA2 AND WRN COORDINATE REPLICATION RESTART BY PROCESSING REVERSED REPLICATION FORKS

12:30 – 16:30

Group Lunch & Free Time

14:00 – 17:00

Group Tour to El Jadida (optional)

Session Chair: Josef Jiricny

17:00 – 17:25

Karlene Cimprich
Stanford University, USA

MECHANISMS FOR RNA-INDUCED GENOME INSTABILITY

17:25 – 17:50

Madalena Tarsounas
The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK

HIGHLY SPECIFIC KINASE INHIBITORS ENABLE SELECTIVE TARGETING OF BRCA2- DEFICIENT CELLS

17:50 – 18:05

Kara Bernstein
University of Pittsburgh School of Medicine, USA

SUMO-TARGETED UBIQUITIN LIGASES SLX5-SLX8/RNF4 REGULATE RECQ-LIKE HELICASE SGS1/BLM LOCALIZATION IN YEAST AND HUMAN CELLS

18:05 – 18:30

Ana Rojas Mendoza
Institute of Biomedicine of Seville (IBIS), Sevilla, Spain

COMPARATIVE GENOMICS OF DDR: IMPLICATIONS IN DOWSTREAM ANALYSES

18:30 – 18:55

Thanos Halazonetis
University of Geneva, Switzerland

BREAK-INDUCED REPLICATION MEDIATES REPAIR OF COLLAPSED DNA REPLICATION FORKS AND TANDEM DUPLICATIONS IN CANCER CELLS

18:55 – 20:30

Poster Session I & Cocktail Reception

20:30

Beach BBQ Dinner & Free Time

Thursday 2nd October 2014

Session Chair: Ian Hickson

09:00 – 09:25

Cynthia McMurray
Lawrence Berkeley National Laboratory, California, USA

FXS: REPLICATION DEPENDENT BREAKS AT RNA-DNA HYBRIDS

09:25 – 09:50

Simon Boulton
London Research Institute, UK

DNA REPLICATION AND TELOMERE FUNCTIONS OF RTEL1

09:50 – 10:05

Zuzana Storchova
Max Planck Institute of Biochemistry, Germany

ANEUPLOIDY DRIVES GENOMIC INSTABILITY BY GENERATING REPLICATION STRESS

10:05 – 10:30

Claus Sørensen
University of Copenhagen, Denmark

FBH1 HELICASE: PROMOTING DNA DAMAGE CHECKPOINT SIGNALING FROM STALLED REPLICATION FORKS

10:30 – 11:00

Refreshments

Session Chair: Karlene Cimprich

11:00 – 11:25

Philippe Pasero
IGH, CNRS UPR 1142, Montpellier, France

SAMHD1 PROCESSES STALLED FORKS AND PROMOTES REPLICATION RESTART

11:25 – 11:50

Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre (CNIO), Madrid, Spain

TARGETING ONCOGENE-INDUCED REPLICATION STRESS FOR CANCER THERAPY

11:50 – 12:05

Angelos Constantinou
IGH-Institute of Human Genetics, France

EARLY RESPONDERS TO DNA REPLICATION IMPEDIMENTS

12:05 – 12:30

Jiri Lukas
Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark

POLY(ADP-RIBOSE)-DEPENDENT ASSEMBLY OF LOW-COMPLEXITY PROTEINS FUNCTIONS AS A ‘MOLECULAR SIEVE’ DURING THE EARLIEST STAGES OF DNA DAMAGE RESPONSE

12:30 – 16:30

Group Lunch & Free Time

Session Chair: Oscar Fernandez-Capetillo

16:30 – 16:55

Antony Carr
Genome Damage and Stability Centre, UK

MECHANISMS OF REPLICATION-ASSOCIATED GENOME REARRANGEMENT

16:55 – 17:20

Anja Groth
BRIC, University of Copenhagen, Denmark

CHROMATIN REPLICATION AND EPIGENOME MAINTENANCE

17:20 – 17:35

Eric Brown
University of Pennsylvania, USA

GENOME-WIDE IDENTIFICATION OF REPLICATION FORK COLLAPSE SITES THROUGH ATR-DEFICIENCY

17:35 – 19:05

Poster Session II

19:05 – 19:30

Meeting of Poster Jury

21:00 – 00:00

*Gala Night, Group Photo & Poster Awards*

Friday 3rd October 2014

Session Chair: Jiri Lukas

09:35 – 10:00

Dana Branzei
Fondazione Ifom, Milan, Italy

VISUALIZATION OF RECOMBINATION–MEDIATED DAMAGE-BYPASS BY TEMPLATE SWITCHING

10:00 – 10:25

Oliver Mortusewicz
Science for Life Laboratory, Stockholm, Sweden

PC4 PROMOTES GENOME STABILITY AND DNA REPAIR THROUGH BINDING OF SSDNA AT DNA DAMAGE SITES

10:25 – 10:50

Camilla Sjögren
Karolinska Institutet, Stockholm, Sweden

CONNECTING CHROMOSOME REPLICATION AND SEGREGATION: DNA TOPOLOGY AND SMC COMPLEXES

10:50 – 11:15

Evi Soutoglou
IGBMC, Illkirch, France

NUCLEAR COMPARTMENTALIZATION AND GENOME INTEGRITY: DIFFERENTIAL REGULATION OF DNA REPAIR AND DNA DAMAGE RESPONSE AT NUCLEAR LAMINA AND NUCLEAR PORES

11:15 – 11:30

Refreshments

11:30 – 11:55

Ian Hickson
University of Copenhagen, Denmark

HOW UNFINISHED BUSINESS FROM S-PHASE IMPACTS ON MITOSIS

11:55 – 12:20

Josef Jiricny
Institute of Molecular Cancer Research, Zurich, Switzerland

A NOVEL INSIGHT INTO THE CONTRIBUTIONS OF PROOFREADING AND MISMATCH REPAIR TO REPLICATION FIDELITY

12:20 – 12:45

Raimundo Freire
Unidad de Investigacion, Hospital Universitario de Canarias, Spain

UBIQUITIN HYDROLASES AS NOVEL REGULATORS OF DNA REPLICATION

12:45

Closing Remarks (Chairs)

13:00

Farewell & Goodbye

Speakers

Plenary Speakers

  • Professor Josef Jiricny
    Professor and Director, Institute of Molecular Cancer Research
  • Dr. Andre Nussenzweig
    Branch Chief, LGI, National Institutes of Health
  • Dr. Stephen West
    Senior Group Leader, Francis Crick Institute
  • Professor Antony Carr
    Director, Genome Damage and Stability Centre
  • Professor Karlene Cimprich
    Professor, Stanford University
  • Dr. Philippe Pasero
    Dr, IGH, CNRS UPR 1142
  • Professor Thanos Halazonetis
    Professor, University of Geneva
  • Professor Camilla Sjögren
    Professor, PI, Karolinska Institutet
  • Professor Michelle Debatisse
    Head of department UMR3244, Institut Curie
  • Professor Jiri Lukas
    Managing Director, Novo Nordisk Foundation Center for Protein Research
  • Dr. Simon Boulton
    Senior Principle Investigator , London Research Institute
  • PhD Anja Groth
    Associate professor, BRIC, University of Copenhagen
  • Professor Virginia Zakian
    Harry C. Wiess Professor in the Life Sciences, Princeton University
  • Dr George Garinis
    Group leader, Institute of Molecular Biology and Biotechnology-FORTH
  • Dr. Madalena Tarsounas
    CR-UK Senior Group Leader, The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford
  • PhD. Evi Soutoglou
    Group leader, IGBMC
  • Professor Junjie Chen
    Professor and Chair, The University of Texas MD Anderson Cancer Center
  • Prof. Massimo Lopes
    Assistant Professor, University of Zurich

Invited Speakers

  • PhD Ana Rojas
    Head of the Computational Biology and Bioinformatics Group, Institute of Biomedicine of Seville (IBIS)
  • Dr. Claus Sørensen
    Dr., University of Copenhagen
  • Prof. Alessandro Vindigni
    Associate Professor, Saint Louis University School of Medicine
  • Dr. Dana Branzei
    GROUP LEADER, FONDAZIONE IFOM
  • Dr. Oliver Mortusewicz
    Postdoctoral Researcher, Science for Life Laboratory / Karolinska Institutet
  • Associate Professor Xiaolan Zhao
    Associate Professor, Memorial Sloan-Kettering Cancer Center
  • Dr Sophie Polo
    PI, Paris Diderot University
  • Professor Aidan Doherty
    Professor of Biochemistry, University of Sussex
  • Dr Hocine Mankouri
    Research Associate Professor, Nordea Center for Healthy Aging
  • Dr. Raimundo Freire
    Researcher, Unidad de Investigacion, Hospital Universitario de Canarias
  • Professor Noel Lowndes
    Professor, National University of Ireland Galway
  • Dr. Juan Méndez
    Lab Head, Spanish National Cancer Research Centre (CNIO)
  • Dr. Cynthia McMurray
    Senior Scientist, Lawrence Berkeley National Laboratory

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