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Home > Past Conferences > Fibroblast Growth Factors in Development and Repair

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Fibroblast Growth Factors in Development and Repair

04 Feb 2015 - 07 Feb 2015

Cancun, Mexico

Synopsis

The first in the series of the Fibroblast Growth Factors in Development and Repair Fusion conference.

The major goal of this Fusion Conference is to bring together in a single forum the diverse group of researchers who study fibroblast growth factor (FGF) signaling. This will provide a unique opportunity to discuss new results and to target future research areas.

Key Sessions

  1. The mechanisms by which FGF signaling governs organogenesis and tissue patterning during embryonic development.
  2. The role of FGF signaling in adult tissue homeostasis, repair, regeneration, and angiogenesis.
  3. Aberrant FGF signaling in developmental/hereditary diseases including including skeletal, cardiovascular, neurological, respiratory, digestive, genitourinary, and endocrine disorders.

Target Audience

Reflecting the pleiotropic functions of FGF signaling in human biology, FGF researchers encompass a wide range of scientific disciplines, including structural biologists, biochemists, cell biologists, endocrinologists, developmental biologists, geneticists, pharmacologists and clinicians. 

2015 Fibroblast Growth Factors Poster Prize

The conference chairs will be awarding 3 poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 21 November 2014. The winners will be selected shortly after the Poster Session and each winner will receive a $250 cheque!

Confirmed Plenary speakers

Prof. Dr. Lin Chen
Center of Bone Metabolism and Repair
THE ROLE OF FGFR3 IN CARTILAGE DISEASES

Dr. Richard Grose
The Barts Cancer Institute
MECHANISMS OF FGFR INHIBITOR RESISTANCE IN FGFR-DRIVEN CANCER

Dr. Mohammad Hajihosseini
University of East Anglia
FGF10 FUNCTION IN THE ADULT BRAIN – FROM NEURAL STEM CELLS TO THE CONTROL OF APPETITE/ ENERGY BALANCE

Prof. Lynn E. Heasley
University of Colorado Denver
AUTOCRINE SIGNALING THROUGH NON-MUTATED FGFR1 IN HUMAN CANCERS

Prof. Matthew Hoffman
National Institutes of Health
FGF-DEPENDENT WNT SIGNALS REGULATE EPITHELIAL PROGENITOR-NEURONAL INTERACTIONS DURING DEVELOPMENT

Dr. Laurence Legeai-Mallet
Hôpital Necker-Enfants Malades
FROM FUNCTIONAL STUDIES TO THERAPEUTIC APPROACHES FOR FGFR3-RELATED DISORDERS

Prof. Xiaokun Li
Wenzhou Medical University

Prof. Suzanne Mansour
University of Utah
FGF SIGNALING IN INNER EAR DEVELOPMENT

Prof. Philippe Soriano
The Mount Sinai Hospital
FGF SIGNALING PATHWAYS IN DEVELOPMENT

Prof. Dr. Sabine Werner 
ETH Zürich 
FGF SIGNALING IN EPITHELIAL HOMEOSTASIS, INJURY AND REPAIR 

Confirmed Invited Speakers

Dr. Alvaro Ingles Prieto
Institute of Science and Technology Austria
LIGHT-CONTROLLED RTKS ALLOW CELL-BASED EXPLORATION OF MAPK/ERK PATHWAY INHIBITORS

Prof. David Warburton
Childrens Hospital Los Angeles
FGF SIGNALING: PUSH ME PULL YOU? 

Sponsors

Sponsors

Report

This first Fusion conference on Fibroblasts Growth Factors in Development and Repair took place in Cancun Mexico, from February 04 through February 07, 2015. The meeting was chaired by Prof. David Ornitz (Washington University, St Louis, USA) and Prof. Saverio Bellusci (Justus Liebig University, Giessen, Germany).

The invited Faculty included Prof. Dr. Lin Chen (Center of Bone Metabolism and Repair, China), Dr. Richard Grose (The Barts Cancer Institute, UK), Dr. Mohammad Hajihosseini (University of East Anglia, UK), Prof. Lynn E. Heasley (University of Colorado Denver, USA), Dr. Laurence Legeai-Maillet (Hopital Necker-Enfants Malades, France), Prof .Xiokun Li (Wenzhou Medical University, China), Prof. Susanne Mansour (University of Utah, USA), Prof. Philippe Soriano (The Mount Sinai Hospital, USA) and Prof. Dr. Sabine Werner (ERTH, Zurich, Switzerland).

In addition, other speakers, both junior, mid-level, and senior scientists were selected from the submitted abstracts. We had a good ratio of speakers both in terms of gender and seniority, with the priority given to junior to mid level scientists.

This meeting was organized on a relatively short notice but we were successful both in attracting high level faculty speakers and a diverse repertoire of participants from multiple nationalities. We were also able to attract substantial funding allowing travel awards to be given to all attending students, postdocs, and junior faculty. The participants at this meeting primarily work in the field of FGFs in cancer, neurobiology, regeneration and disease, and organogenesis. In addition, a joint session was organized with the fusion conference on Musculoskeletal Development and Regeneration taking place at the same time as the FGF conference. This was a wonderful opportunity to allow additional networking and cross fertilization of ideas between two overlapping but related fields of research.

The conference venue allowed for a very relaxed atmosphere for discussion, networking, and setting up collaborations. Participation of most of the attendees to the discussions following the talks was outstanding and these often continued into the free time in the afternoons and evenings. Overall, high quality speakers presented state of the art data and the posters were thoroughly discussed.

The fusion conference staff was outstanding and very professional. Participants were generally very impressed with the quality of the venue and the organization of the meeting. There was considerable enthusiasm from the participants to hold another Fusion meeting in 2017 on the same topic and in a location that remains to be defined.

 

Programme

Wednesday 4th February 2015

12:00 – 15:00

Registration

13:00 -14:30

Welcome Lunch
*Kalmia Buffet Restaurant*

Cancer Session
Session Chair: Philippe Soriano

14:45 – 15:00

Opening Comments

 

15:00 – 15:35

Lynn Heasley
University of Colorado Anschutz Medical Campus

AUTOCRINE SIGNALING THROUGH NON-MUTATED FGFR1 IN HUMAN CANCERS

15:35 – 15:55

Debbie Cunningham
University of Birmingham

CHARACTERISATION OF PHOSPHORYLATION EVENTS DOWNSTREAM OF AMPLIFIED FGFR2 IN THE BREAST CANCER CELL LINES SUM52 AND MFM223

15:55 – 16:30

Dina Ron
Technion, Israel Instititute of Technology

THE TUMOR SUPPRESSOR, SEF, REGULATES HUMAN EPIDERMIS HOMEOSTASIS THROUGH MULTIPLE MECHANISMS INVOLVING FGF AND PRO-INFLAMMATORY CYTOKINES

16:30 – 17:00

Refreshments

17:00 – 17:20

Regina Irschick
Medical University of Innsbruck

MODULATION OF FGFR1 AND FGF2 TRAFFICKING IN HUMAN GLIOMA CELLS

17:20 – 17:55

Fen Wang
Texas A&M

TYPE 2 FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING IS REQUIRED FOR PRESERVING STEMNESS AND PREVENTING DIFFERENTIATION OF PROSTATE STEM CELLS

18:00 – 19:30

Dinner at Leisure

Cancer Session
Session Chair: Denise Al Alam

19:30 – 20:05

Richard Grose
Queen Mary, University of London

MECHANISMS OF FGFR INHIBITOR RESISTANCE IN FGFR-DRIVEN CANCER

20:05 – 20:25

Alvaro Ingles-Prieto
Institute of Science and Technology Austria

LIGHT-CONTROLLED RTKS PERMIT CELL-BASED SCREEN OF SMALL MOLECULES

20:25

Poster Viewing

Thursday 5th February 2015

07:00 -08:30

Breakfast

Brain Session
Session Chair: Helen Makarenkova

08:30 – 09:05

Ivor Mason
King's College London

FGF REGULATION OF CONNECTIVITY IN THE DEVELOPING VERTEBRATE BRAIN

09:05 -09:40

Lars Klimaschewski
Medical University of Innsbruck

NOVEL APPROACHES TO SPEED UP LONG-DISTANCE AXON REGENERATION BY ENHANCED FGFR1 SIGNALLING

09:40 – 10:15

Mohammad Hajihosseini
University of East Anglia

FGF10 FUNCTION IN THE ADULT BRAIN – FROM NEURAL STEM CELLS TO THE CONTROL OF APPETITE/ ENERGY BALANCE

10:15 – 10:45

Refreshments

Brain Session
Session Chair: Richard Grose

10:45 – 11:20

Rajesh Ladher
RIKEN CDB

FGFR1 ROUTES PROTOCADHERIN-15 TO THE CILIUM OF THE INNER EAR HAIR CELLS

11:20 – 11:55

Suzanne Mansour
University of Utah

FGF SIGNALING IN INNER EAR DEVELOPMENT: HEARING LOST AND FOUND

12:00 – 15:30

Lunch at Leisure & Free Time

Regeneration and Disease Session
Session Chair: Ivor Mason

15:30 – 16:05

Sabine Werner
ETH Zurich Institute of Molecular Health Sciences

ROLES AND MECHANISMS OF ACTION OF FGFS IN SKIN HOMEOSTASIS AND DISEASE

16:05 – 16:40

Saverio Bellusci
Justus Liebig University Giessen

A BREATH OF FRESH AIR ON THE LUNG MESENCHYME DURING DEVELOPMENT AND DISEASE: LESSONS LEARNT FROM THE FGF AND WNT  SIGNALLING

16:40 – 17:15

Xiaokun Li
Wenzhou Medical University

 

17:15 – 17:50

Anne-Karina Perl
Cincinnati Children's Hospital

INTERSTITIAL RESIDENT FIBROBLASTS UNDERGO FUNCTIONAL CHANGES DURING ALVEOLAR REGENERATION

18:00 – 19:30

Dinner at Leisure

Regeneration and Disease Session
Session Chair: Anne-Karina Perl

19:30 – 20:05

David Warburton
Children's Hospital Los Angeles

FGF SIGNALING: PUSH ME PULL YOU?

20:05 – 20:25

Robert Guzy
Washington University School of Medicine

FIBROBLAST-SPECIFIC FGF SIGNALING IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS

20:25 – 20:45

Chiko Shimbori
McMaster University

FIBROBLAST GROWTH FACTOR-1 ATTENUATES TGF-β1-INDUCED LUNG FIBROSIS BY REGULATING TGF-β1 SIGNALING

20:45

Poster Viewing

Friday 6th February 2015

07:00 – 08:30

Breakfast

Regeneration and Disease Session
Session Chair: Dina Ron

08:30 – 08:50

Stacey House
Washington University in St. Louis

CARDIOMYOCYTE-SPECIFIC FIBROBLAST GROWTH FACTOR RECEPTOR SIGNALING PROVIDES ACUTE CARDIOPROTECTION IN A CLOSED-CHEST MODEL OF ACUTE MYOCARDIAL INFARCTION

08:50 – 09:10

Jo El Schultz
University of Cincinnati College of Medicine

DIFFERENTIAL CARDIOVASCULAR FUNCTIONS OF FIBROBLAST GROWTH FACTOR-2 PROTEIN ISOFORMS IN ISCHEMIA

09:10 – 09:30

Yoshikazu Takada
UC Davis School of Medicine

FGF-INTEGRIN CROSSTALK THROUGH DIRECT INTEGRIN BINDING TO FGF: DEVELOPMENT OF A DOMINANT-NEGATIVE FGF MUTANT (FGF DECOY)

09:30 – 09:50

Chao Jiang
Wenzhou Medical University

DEVELOPMENT OF OLIOSEN-FGF FUSIONS FOR TOPICAL APPLICATIONS

09:50 – 10:20

    Refreshments

Development Session
Session Chair: Mohammad Hajihosseini

10:20 – 10:55

Matthew Hoffman
National Institutes of Health

FGF-DEPENDENT WNT SIGNALS REGULATE EPITHELIAL PROGENITOR-NEURONAL INTERACTIONS DURING DEVELOPMENT

10:55 – 11:30

Helen Makarenkova
The Scripps Research Institute

FGF SIGNALING IN LACRIMAL GLAND DEVELOPMENT, HOMEOSTASIS AND DISEASE              

11:30 – 11:50

Vincent Harley
MIMR-PHI

CRANIOSYNOSTOSIS WITH XY SEX REVERSAL

11:50 – 17:30

Lunch at Leisure & Free Time

Development Session
Session Chair: Suzanne Mansour

17:30 – 17:50

Ing-Ming Chiu
National Health Research Institutes

EXPRESSION PATTERN OF REPORTER GENES DRIVEN BY HUMAN FGF1 PROMOTER IN TRANSGENIC MICE

17:50 – 18:25

Philippe Soriano
Icahn School of Medicine at Mt. Sinai

FGF SIGNALING PATHWAYS IN DEVELOPMENT

18:25 – 18:45

Denise Al Alam
Children's Hospital Los Angeles

FGF10 IN SMALL INTESTINAL HOMEOSTASIS AND REPAIR

18:45 – 20:00

  Poster Session & Cocktails

20:15- 23:00

Gala Night, Group Photo & Poster Awards
*Lower Pool Deck*

Saturday 7th February 2015

07:00 -08:30

Breakfast

Joint session with the Fusion conference on Musculoskeletal Development and Regeneration
Session Chair: David Ornitz

08:30 – 09:05

Lin Chen
Center of Bone Metabolism and Repair

DELETION OF FGFR3 IN CARTILAGE LEADS TO CHONDROMA-LIKE LESION

09:05 - 09:45

Vicki Rosen
Harvard School of Dental Medicine

DEVELOPMENTAL REGULATION OF BONE WIDTH BY BMP SIGNALING IS KEY FOR CREATING STRONG BONES

09:45 – 10:25

Maurizio Pacifici
University of Pennsylvania

DEVELOPMENTAL INSIGHTS INTO THE PATHOGENESIS OF HEREDITARY MULTIPLE EXOSTOSES

10:25 – 10:40

Refreshments

10:40 – 11:10

Veronique Lefebvre
Cleveland Clinic

GENOME-WIDE COOPERATIVITY BETWEEN SOX5/6 AND SOX9 DRIVES CHONDROGENESIS

11:10 – 11:45

David Ornitz
Washington University

REGULATION OF SKELETAL GROWTH AND CHONDROGENESIS BY FGFR1 AND FGFR2 SIGNALING IN THE OSTEOPROGENITOR LINEAGE

11:45 – 12:05

Peter Hurlin
Shriners Hospitals for Children

MUTANT ACTIVATED FGFR3 IMPAIRS ENDOCHONDRAL BONE GROWTH BY PREVENTING SOX9 DOWNREGULATION IN DIFFERENTIATING CHONDROCYTES

12:05 – 12:40

Laurence Legeai-Mallet
Imagine Institute-Inserm

FROM FUNCTIONAL STUDIES TO THERAPEUTIC APPROACHES FOR FGFR3-RELATED DISORDERS

12:40 – 12:50

Closing Remarks

Speakers

Plenary Speakers

  • Dr. Mohammad K Hajihosseini
    Senior Lecturer in Neuroscience, University of East Anglia
  • Prof. Philippe Soriano
    Professor, Icahn School of Medicine at Mt. Sinai
  • Dr. Suzanne Mansour
    Professor, University of Utah
  • Prof. Dr. Sabine Werner
    Prof. Dr., ETH Zurich Institute of Molecular Health Sciences
  • Dr. Richard Grose
    Senior Lecturer, Queen Mary, University of London
  • Dr. Laurence Legeai-Mallet
    Director of Research, Imagine Institute-Inserm U1163
  • Dr. Matthew Hoffman
    Senior Investigator, National Institutes of Health
  • Prof. Lynn Heasley
    Professor, University of Colorado Anschutz Medical Campus
  • Prof. Dr. Lin Chen
    Professor, Trauma Center,Daping Hospital,Third Military Medical University
  • Prof. Xiaokun Li
    Vice president , Wenzhou Medical University

Invited Speakers

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