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Home > Past Conferences > Musculoskeletal Development and Regeneration

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Musculoskeletal Development and Regeneration

06 Feb 2015 - 09 Feb 2015

Cancun, Mexico

Synopsis

The 2015 Fusion Conference on "Musculoskeletal Development and Regeneration", a premier scientific forum for the scientific investigation of the musculoskeletal system, will cover a wide range of topics to encompass basic to translational aspects of the biology and pathology of musculoskeletal tissues, including cartilage, bone, tendon, ligament, and muscle. These topics will include morphogenesis, development, evolutionary specification of tissue types, cellular organization, production and assembly of extracellular matrix, biological and biomechanical functions, functional modeling, genetic basis of musculoskeletal diseases, cellular and molecular mechanisms of degeneration, and therapeutic strategies to regenerate, repair and functionally restore damaged or diseased tissues and organs. Special emphasis will be on the application of contemporary approaches to address epigenetic, molecular, cellular, and tissue biology of musculoskeletal tissues, including a session featuring new directions and technologies, and challenges and opportunities in musculoskeletal research. The conference will be interdisciplinary and multidisciplinary, merging concepts and approaches from the sciences, engineering, medicine and more.

We expect the 2015 Musculoskeletal Development and Regeneration Fusion Conference to be an exciting and stimulating meeting for both established and new investigators in the field, and provide ample opportunities for interaction and networking.

2015 Musculoskeletal Poster Prize

The conference chairs will be awarding 3 poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 21 November 2014. The winners will be selected shortly after the Poster Session and each winner will receive a $250 cheque! 

Confirmed Plenary Speakers

Dr. Stuart Goodman      
Stanford School of Medicine
Prof. Farshid Guilak                
Duke University School of Medicine
Dr. Robert Guldberg 
Georgia Institute of Technology 
Dr. Johnny Huard            
University of Pittsburgh
Prof. Catherine K. Kuo
Tufts University
Dr. Suzanne Maher        
Hospital for Special Surgery
Prof. Maurizio Pacifici 
The Children's Hospital of Philadelphia
Dr. Vicki Rosen 
Harvard School of Dental Medicine
Dr. Linda Sandell              
Washington University Orthopedics
Dr. Maria Siemionow
University of Illinois College of Medicine at Chicago
Prof. Rocky Tuan
University of Pittsburgh 

Sponsors

Sponsors

Report

Overview

Professors Rocky S. Tuan and Catherine K. Kuo co-chaired the first Fusion Conference on Musculoskeletal Development and Regeneration (MDR) in Cancun, Mexico. The conference began the afternoon of February 6, and concluded mid-day on February 9, 2015. Special events for the conference included a group tour to Tulum one afternoon (not included in registration), and also a gala dinner (and live band) for all registered attendees. A particularly unique aspect of the conference was a merged session the morning of February 7, 2015, with the Fusion Conference on Fibroblast Growth Factor (chaired by Professors David Ornitz and Saverio Bellusci) in the same venue.

Conference Theme

The theme of the conference was Musculoskeletal Development and Regeneration (MDR), indicated by the conference title. Seven sessions included (by order of first to last): Injury and Healing; Repair and Reconstruction Strategies; Skeletal Development (joint session with FGF conference); Developmental and Degenerative Diseases; Experimental Models; Stem Cells: Biology and Engineering 1 and 2. One or two plenary speakers were invited for each session, followed by invited and submitted shorter abstract talks. (Please see attached for the conference program and abstracts.)

Plenary Speakers

Stuart Goodman, Stanford University
Robert Guldberg, Georgia Institute of Technology
Suzanne Maher, Hospital for Special Surgery
Maria Siemionow, University of Illinois
Vicki Rosen, Harvard School of Dental Medicine
Maurizio Pacifici, University of Pennsylvania
Veronique Lefebvre, Cleveland Clinic
Linda Sandell, Washington University
Jennifer Westendorf, May Clinic
Catherine K. Kuo, Tufts University
Johnny Huard, University of Pittsburgh
Farshid Guilak, Duke University
Rocky S. Tuan, University of Pittsburgh

Conference Format

The conference was held at the Fiesta Americana Condesa in Cancun, Mexico. Lodging and all meals were included with the registration fee at the all-inclusive resort. The format of the conference was morning and afternoon sessions, with lunch and leisure time between the two sessions. Out of 45 registered attendees, 36 talks including plenary (45 min) and invited (30 min) and submitted (15 min) abstract talks were delivered. Additionally, more than 30 posters were presented on abstracts accepted for podium or poster presentations. Poster sessions were ongoing during refreshment breaks and two different hour-long scheduled sessions. Poster awards with cash prizes funded by the Fusion Conference were given for the top three posters, judged by the conference co-chairs. Invited plenary speakers were asked to chair various sessions throughout the conference. The organizers and attendees found the Fusion Conference staff to be highly professional, organized and attentive. Jack Peters was excellent throughout the entire process.

Attendee Feedback

Feedback regarding the conference was outstanding, regarding the speakers, selected topics, quality of talks and venue. Attendees have explicitly stated that continued interactions in the form of collaborations and university exchanges have resulted from attending this conference. Numerous attendees and non-attendees that have heard by word-of-mouth have expressed interest in attending a future MDR conference. Notably, this conference was held a little more than a month before the Annual Conference of the Orthopaedic Research Society (ORS) and also the Cartilage Gordon Research Conference (GRC), each of which many of the MDR attendees also attended this year or previously. Multiple attendees stated that, even after attending all three (MDR, ORS and Cartilage GRC), they will definitely attend a future MDR conference.

The feedback from attendees has been compiled at the end of this document. Some notable feedback has been included here. 

Professor Veronique Lefebvre, who chaired the Cartilage Gordon Conference shortly after attending the MDR conference: “…I came back home knowing that I would definitely attend the next conference and recommend it to many people…I most importantly appreciated the breadth of cutting-edge topics in the musculoskeletal field and the gathering of scientists working on basic processes and translational questions from development to late adulthood and on various tissues in the musculoskeletal system. This integration of scientific and translational topics, broad range of tissues and broad range of disease questions was made very successfully and was very instructive. I learned a lot! The shared session with the FGF conference was a brilliant idea too and it worked out extremely well, adding another dimension to the conference. As important as the scientific content of the conference, I truly enjoyed the very friendly and collegial atmosphere that was spearheaded by both of you and that was happily embraced and amplified by all participants. This helped generate lots of interesting discussions. I made new friends and started new scientific collaborations with them.”

Professor Farshid Guilak, ORS 1st Vice President and Editor-in-Chief of the Journal of Biomechanics: “Overall, one of the best meetings of its kind, and I would certainly come back to it again.”

Professor Vicki Rosen: “…After attending both the Cartilage GRC and the ORS, I think the greatest benefit of the Fusion Meeting was the combination of small size and diversity of topics within musculoskeletal biology… I would definitely attend a future meeting.”

In addition to extremely positive feedback from well established and senior investigators, it is important to highlight how valuable this conference was for junior investigators.

Postdoctoral fellow Dr. Thomas Lozito:“…It was definitely one of the most rewarding meetings I’ve ever been to, both personally and professionally. Not only did I get the chance to meet and interact with leaders in the field, but I was also invited to give several talks by faculty who found my research interesting, which is huge for someone at my stage in career development. All these opportunities were made possible by this Fusion Conference, and I would definitely like to attend similar conferences in the future.”

Assistant Professor Rhima Coleman: “This was an excellently organized conference... I learned so much in so little time. It was also community building, especially for junior investigators; a good mix of fun and science. The opportunity to interact with experts in the field at that level is very rare, but quite fulfilling. I would go every year to get critical feedback on my own research.”

Sponsors

The generous donation provided by the Arthritis Foundation enabled the registration of 12 attendees (students, postdoctoral fellows and PIs) that delivered either abstract talks or posters. Travel grants were disbursed in dollar amounts of $500, id="mce_marker"000, or full registration, based on need.

Programme

Friday 6th February 20

12:00 – 15:00

Registration

13:00 -14:15

Welcome Lunch
*Kalmia Buffet Restaurant*

14:45 – 15:00

Opening Speech

Injury and Healing
Session Chair: Stuart Goodman

15:00 – 15:45

Stuart Goodman
Stanford University

CROSSTALK BETWEEN MACROPHAGES AND OSTEOPROGENITORS AFFECTS BONE FORMATION

15:45 – 16:30

Robert Guldberg
Georgia Institute of Technology

INTRA-ARTICULAR DELIVERY OF MICRONIZED ECM FOR TREATMENT OF JOINT DEGENERATION

16:30 – 17:00

Thomas Lozito
University of Pittsburgh

LIZARD TAIL SKELETAL REGENERATION COMBINES ASPECTS OF FRACTURE HEALING AND BLASTEMA-BASED REGENERATION

17:00 – 17:15

Ronald Kwon
University of Washington

ZEBRAFISH FIN REGENERATION AS A TRANSLATIONAL MODEL FOR BONE BIOMEDICAL RESEARCH

17:15 – 17:45

Refreshments

Repair and Reconstruction Strategies
Session Chair: Suzanne Maher

17:45 – 18:30

Suzanne Maher
Hospital for Special Surgery

FROM CONCEPT TO IN-VIVO EVALUATION: A MULTI-DISCIPLINARY APPROACH TO THE DEVELOPMENT OF IMPLANTS FOR SOFT TISSUE REPAIR

18:30 – 19:15

Maria Siemionow
University of Illinois

RECONSTRUCTIVE TRANSPLANTATION- A NEW CONCEPT IN MUSCULOSKELETAL REGENERATION

19:15 – 19:30

Stephen Andrews
University of Alberta

MENISCAL SURFACES ARE ANALAGOUS TO ARTICULAR CARTILAGE IN BOTH STRUCTURE AND CELLULARITY

19:30 – 20:15

Poster Session 1

20:15

Dinner at Leisure & Free Time

Saturday 7th February 2015

07:00 -08:30

Breakfast

Skeletal Development (Joint Session with FGF Conference)
Session Chairs: Rocky Tuan & David Ornitz

08:30 – 09:05

Lin Chen
Center of Bone Metabolism and Repair

THE ROLE OF FGFR3 IN CARTILAGE DISEASES

09:05 -09:45

Vicki Rosen
Harvard School of Dental Medicine

DEVELOPMENTAL REGULATION OF BONE WIDTH BY BMP SIGNALING IS KEY FOR CREATING STRONG BONES

09:45 -10:25

Maurizio Pacifici
University of Pennsylvania

DEVELOPMENTAL INSIGHTS INTO THE PATHOGENESIS OF HEREDITARY MULTIPLE EXOSTOSES

10:25 – 10:40

Refreshments

10:40 – 11:10

Veronique Lefebvre

Cleveland Clinic

GENOME-WIDE COOPERATIVITY BETWEEN SOX5/6 AND SOX9 DRIVES CHONDROGENESIS

11:10 – 11:45

David Ornitz
Washington University

REGULATION OF SKELETAL GROWTH AND CHONDROGENESIS BY FGFR1 AND FGFR2 SIGNALING IN THE OSTEOPROGENITOR LINEAGE

11:45 – 12:05

Peter Hurlin
Shriners Hospitals for Children

MUTANT ACTIVATED FGFR3 IMPAIRS ENDOCHONDRAL BONE GROWTH BY PREVENTING SOX9 DOWNREGULATION IN DIFFERENTIATING CHONDROCYTES

12:05 – 12:40

Laurence Legeai-Mallet
Imagine Institute-Inserm

FROM FUNCTIONAL STUDIES TO THERAPEUTIC APPROACHES FOR FGFR3-RELATED DISORDERS

12:40 – 12:50

Closing Remarks (for FGF Conference)

12:50 – 16:00

Lunch at Leisure & Free Time

Developmental and Degenerative Diseases
Session Chairs: Jennifer Westendorf & Rulang Jiang

16:00 – 16:45

Linda Sandell
Washington University

GENETIC ASPECTS OF ADULT CARTILAGE REPAIR AND DEGENERATION

16:45 – 17:30

Jennifer Westendorf
Mayo Clinic

HISTONE DEACETYLASE 3 (HDAC3) REGULATES SKELETAL DEVELOPMENT, METABOLISM AND AGING

17:30 – 17:45

Pallavi Bhattaram

Cleveland Clinic

ROLES OF SOXC GENES IN JOINT DEVELOPMENT AND DISEASE

17:45 – 18:00

Fayez F. Safadi
Northeast Ohio Medical University

THE ROLE OF OSTEOACTIVIN IN BONE HOMEOSTASIS-POSITIVE REGULATOR OF OSTEOBLASTOGENESIS AND NEGATIVE REGULATOR OF OSTEOCLASTOGENESIS 

18:00: – 18:30

Jamie Fitzgerald Henry Ford Hospital

ARTICULAR CARTILAGE DEGRADATION FOLLOWING EXPOSURE TO MICROGRAVITY

18:30 – 19:00

Refreshments

19:00 – 19:15

Nidhi Bhutani
Stanford University

A CRITICAL ROLE FOR TET1 AND DNA HYDROXYMETHYLATION IN CHONDROGENIC DIFFERENTIATION

19:15 – 19:30

Rulang Jiang
Cincinnati Children’s Hospital

NEW RESOURCES FOR INVESTIGATION OF MOLECULAR MECHANISMS OF TENDON DEVELOPMENT

19:30

Dinner at Leisure & Free Time

Sunday 8th February 2015

07:00 – 08:30

Breakfast

Experimental Models
Session Chairs: Catherine K. Kuo & Johnny Huard

08:30 – 09:15

Catherine K. Kuo
Tufts University

TENDON REGENERATION AND SCARLESS HEALING: INSTRUCTIONS FROM THE EMBRYO

09:15 – 10:00

Johnny Huard
University of Pittsburgh

THE ROLE OF STEM CELL EXHAUSTION IN AGING AND DISEASE

10:00 – 10:15

Mark Langhans
University of Pittsburgh

WDPCP SUPPRESSES HEDGEHOG SIGNALING TO FACILITATE CARTILAGE CONDENSATION IN THE LIMB BUD

10:15 – 10:30

Rhima Coleman
University of Michigan

THE EFFECTS OF MATRIX STIFFNESS ON THE RESPONSE OF CHONDROPROGENITOR CELLS IN A 3D PRECONDENSATION MICROENVIRONMENT

10:30 – 11:00

Refreshments

11:00 – 11:30

Wan-ju Li
University of Wisconsin

PRIMING HUMAN MESENCHYMAL STEM CELLS FOR ENHANCED LINEAGE-SPECIFIC DIFFERENTIATION

11:30 – 12:00

Simon Tang
Washington University

EXPOSURE TO EXTRACELLULAR SUGARS AND ADVANCED GLYCATION END-PRODUCTS ALTER CHONDROCYTE MORPHOLOGY VIA CYTOSKELETAL REARRANGEMENT AND SUBSEQUENT WHOLE-CELL BIOMECHANICAL BEHAVIOR

12:00 – 12:15

Chitra Dahia

Hospital for Special Surgery

SHH AND WNT SIGNALING PATHWAYS CONTROL POSTNATAL INTERVERTEBRAL DISC GROWTH, DIFFERENTIATION AND AGING

12:15 – 16:00

Lunch at Leisure & Free Time

Stem Cells: Biology and Engineering 1
Session Chair: Robert Guldberg

16:00 – 16:45

Farshid Guilak
Duke University

SMART CELLS AND SCAFFOLDS FOR REGENERATIVE MEDICINE

16:45 - 17:15

Cato Laurencin
University of Connecticut

REGENERATIVE ENGINEERING: THE THEORY AND PRACTICE OF A NEXT GENERATION FIELD

17:15 – 17:30

Di Chen
Rush University Medical Center

MIR-204 SUPPRESSES SKELETAL NEOPLASIA THROUGH INHIBITION OF RUNX2-ACTIVATED AKT SIGNALING IN MESENCHYMAL STEM CELLS

17:30 – 19:30

Poster Session 2 & Cocktails

20:00 – 23:00

Gala Night & Group Photo
*Lower Pool Deck*

Speakers

Plenary Speakers

  • Dr. Johnny Huard
    Director and Chief Scientific Officer, Steadman Philippon Research Institute
  • Prof. Maurizio Pacifici
    Director of Orthopaedic Research, The Children's Hospital of Philadelphia
  • Prof. Farshid Guilak
    Professor, Washington University
  • Prof. Dr. Maria Siemionow
    Professor of Orthopaedics, University of Illinois at Chicago
  • Dr. Suzanne Maher
    Associate Scientist, Hospital for Special Surgery
  • Dr. Stuart Goodman
    Professor, Stanford University School of Medicine, Department of Orthopaedic Surgery
  • Prof. Vicki Rosen
    Professor and Chair, Department of Developmental Biology, Harvard School of Dental Medicine
  • Prof. Linda Sandell
    Director of Research, Washington University School of Medicine
  • Dr. Robert Guldberg
    Director & Professor, Georgia Insititute of Technology

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