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Home > Past Conferences > Dynamic Structures in DNA Damage Responses and Cancer

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Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Synopsis

Key sessions will include:

  1. DNA and RNA complexes
  2. Chromatin Remodeling
  3. Post-translational modifications - Ub,  SUMO kinases
  4. The repair interface with Replication
  5. Transcription, and Recombination
  6. Hybrid methods for dynamic structures
  7. Damage signaling and processing
  8. DNA repair and disease

Confirmed Invited Speakers:

Dr. Stephen J. Smerdon
National Institute for Medical Research

Dr Jessica Anne Downs
University of Sussex

Prof. Dr. Caroline Kisker
Rudolf Virchow Center DFG Research Center for Experimental Biomedicine

Prof. Tom Ellenberger
Washington University

Prof. Dorothy Erie
University of North Carolina at Chapel Hill, NC

Prof. Lorena Beese
Duke University Medical Center

Dr. Christopher D. Lima
Memorial Sloan-Kettering Cancer Center

Professor Walter J. Chazin
Vanderbilt University

Dr. Mark Glover
University of Alberta

Sponsors

No Sponsors info available

Programme

Wednesday 12th February 2014

07:30 – 08:30

Registration & Reception

 

08:30 -08:45

Opening  Comments

 

Session Title From DNA Complexes to Chromatin Session
Session Chair John Tainer

08:45 – 09:15

Walter Chazin

Dynamic hubs in multi-protein machinery

09:15 – 09:35

Gloria Borgstahl

Hyper-phosphorylation in RPA:RAD52 complex function

09:35 – 09:55

Franz Klein

Smc5/6-Mms21 in DHJ formation and resolution

09:55 – 10:25

Karl-Peter Hopfner

Integrative methods for a mega-Dalton chromatin remodeler

10:25 – 10:45

Anna Chambers

 

 

RSC2 BAH domain and SRC complex function

 

10:45 – 11:15

Refreshments

11:15 – 11:45

Jessica Downs

PBAF remodeling complex & transcription repression

11:45 – 12:05

Evi Soutoglou

Compartmentalization of repair at nuclear lamina & pores

12:05 – 12:25

Li Lan

Recruitment of repair proteins to heterochromatin and euchromatin

12:25 – 12:45

Terence Strick

Single Molecule DNA repair pathway reconstruction

12:45 – 12:55

Discussion

12:55 – 16:25

Welcome Lunch and Free Time

Session Title Hybird Methods for Dynamic Structures
Session Chair Walter Chazin

16:25 – 16:30

Tom Blundell

Announcements

16:30 – 17:00

Dorothee Kern

Using ancient kinases to unravel cancer drug mechanism

17:00 – 17:20

Ivaylo Ivanov

Integrative modeling of complex nucleic acid assemblies

17:20 – 17:40

Susan Tsutakawa

PCNA with SUMO and Ub by combined methods

17:40 – 18:10

 

Refreshments

18:10 – 18:30

Qian Wu

Abraxas phosphorylation and BRCA1 dimerization

18:30 – 18:50

Susan Lees-Miller

New roles of DNA-PK in mitosis

18:50 – 19:10

 

Greg Hura

 

Comprehensive DNA conformations in mismatch repair

 

19:10 – 19:30

Angela Eggleston

Nature and DNA repair structural biology

19:30 – 19:40

Discussion

19:40 – 00:00

Dinner at Leisure and Free Time

Thursday 13th February 2014

Session Title Mismatch Responses and DNA Replication
Session Chair Tom Ellenberger

08:15 – 08:20

08:20 – 08:50

John Tainer

Lorena Beese

Announcements

Mismatch and fidelity

08:50 - 09:10

Jean-Baptist Charbonnier

MutL homologs and cancer

09:10 – 09:30

09:30 – 10:00

10:00 – 10:20

10:20 – 10:45

10:45 – 11:15

Alba Guarne

Dorothy Erie

Cynthia McMurray

 

Luca Pellegrini

Transient MMR interactions

MMR initiation by single-molecule methods

MSH2-MSH3 plus OGG1 in trinucleotide expansion

Refreshments

Helicase-polymerase coupling in the eukaryotic replisome

11:15 – 11:35

Brandt Eichman

DNA junction recognition

11:35 – 11:55

Samir Hamdan

Dynamics of 5’ nucleases by single molecule imaging

11:55 – 12:15

Piero Bianco

SSB interactome partners and targeting repair

12:15 – 12:35

Murray Junop

Single-stranded annealing shown by DNA complex structure

12:35 – 12:45

 

Discussion

12:45 – 16:15

Lunch at Leisure and Free Time

Session Title From Structure and Chemistry to Cancer Session
Session Chair Dorothee Kern

16:15 – 16:20

16:20 – 16:50

Tom Blundell

Wei Yang

Announcements

Human polymerase to cancer biology

16:50 – 17:10

Sylvie Doublie

NEIL glycosylases, repair polymorphisms and cancer

17:10 – 17:30

Arne Klungland

Dynamics and disease role of 6-methhyladenine in mRNA

17:30 – 17:50

Herwig Schuler

PARP inhibitors : structures, selectivity and pharmacology

17:50 – 18:10

 

Refreshments

18:10 – 18:25

18:25 – 18:40

18:40 – 19:00

19:00 – 19:30

Luxin Sun

Eva Barkauskaite

Hideki Aihara

Tom Ellenberger

BRCA1 BRCT inhibitors for cancer therapy

Poly(ADP-ribose) glycohydrolase structure and activity

Novel TDP2 interaction with ubiquitin by NMR

Targeting poly-(ADP-ribose) Glycohydrolase for Apoptosis

19:30 – 19:40

19:40 – 21:00

21:00 – 00:00

Discussion

Cocktails and General Discussion
Dinner at Restaurant with Optional Mentor Tables

Friday 14th February 2014

Session Title Dynamic machines & signaling
Session Chair Caroline Kisker

08:15 – 08:20

08:20 – 08:50

John Tainer

Christopher Lima

Announcements

RNA processing by the Eukaryotic RNA exosome

08:50 – 09:10

Mihaly Kovacs

Switching DNA-bound RecQ Helicase for repair

09:10 – 09:30

Opher Gileadi

Crystal structure of human Bloom helicase

09:30 – 09:50

Shunichi Takeda

CtlP and Dna2 nucleases form 3’ ends for recombination

09:50 – 10:10

Penny Jeggo

Regulating DSB repair pathway choice

10:10 – 10:35

Refreshments

10:35 – 10:55

Anthony Davis

DNA-PK and DSBR

10:55 – 11:15

Valerie Garcia

Tel1(ATM) suppresses meiotic DSB formation in chromatin

11:15 – 11:35

David O Ferguson

Control of ATM and CDK2/cyclin A kinases by MRN complex

11:35 – 11:55

11:55 – 12:25

Takashi Ochi

Tom Blundell

PAXX Paralog of XRCC4 and XLF

Spatial-Temporal Organisation of DSBR & cancer

12:25 – 12:35

Discussion

12:35 – 16:15

Lunch at Leisure and Free Time

Session Title Junctions and switches
Session Chair Magnar Bjoras

16:15 – 16:20

16:20 – 16:50

Tom Blundell

R. Scott Williams

Announcements

Aprataxin resolves adenylated RNA-DNA junctions

16:50 – 17:10

Bjorn Dalhus

EndoV eukaryotic structure & DNA/RNA specificity

17:10 – 17:40

Mark Glover

Flipping the switch on Ubc13 in the DNA damage response

17:40 – 18:00

Jeff Perry

RNF4 repair functions and telomeres

18:00 – 18:25

 

Refreshments

18:25 – 18:55

18:55 – 19:15

19:15 – 19:35

Steve Smerdon
Anthony Oliver

Dong Wang

Nbs1 structures, functions and break signaling

Rad4TopBP1 & DNA Damage Checkpoint Apparatus

Transcriptional fidelity control and lesion recognition

19:35 – 19:45

Discussion

21:00 – 00:00

*Gala Night & Group Photo*

Free Time

Saturday 15th February 2014

Session Title Bulky lesions, signaling and conformations in damage responses
Session Chair Karl-Peter Hopfner

08:15 – 08:20

Tom Blundell

Announcements

08:20 – 08:50

Caroline Kisker

Two faces of XPD by single molecule analyses

08:50 – 09:10

Li Fan

XPD and XP helicases

09:10 – 09:30

09:30 – 10:00

10:00 – 10:20

Jill Fuss

Dale Wigley

Joanne I. Yeh

DNA-mediated redox signaling & charge transfer by XPD

FeS enzyme AddAB CHI recognition & mechanism

UV-DDB binding to Damaged DNA induces oligomerization

10:20 – 10:45

Refreshments

10:45 – 11:05

Fernando Gomez-Herreros

TDP2 Protects Transcription

11:05 – 11:25

Xiaochun Yu

Novel functions of ribosylation & PAR-binding domains

11:25 – 11:45

Kristina Lakomek

Heteromeric Rvb1-Rvb2 complex for molecular machines

11:45 – 12:15

John Tainer

Conformations controlling repair responses

12:15 – 12:25

Discussion

12:25 – 12:40

Closing remarks & Farewell: John Tainer and Tom Blundell

Speakers

Invited Speakers

  • Dr Steve Smerdon
    Programme Leader, The Francis Crick Institute, UK
  • Prof. Dr. Caroline Kisker
    Professor, University of W├╝rzburg
  • Professor Jessica Downs
    Professor, Genome Damage and Stability Centre
  • Dr Curtis Hodge
    Dr, University of Alberta
  • Professor Dorothy Erie
    Professor, University of North Carolina
  • Dr. Wei Yang
    Section Chief, National Institutes of Health
  • Professor Walter Chazin
    Director- Center for Structural Biology, Vanderbilt University
  • Professor Dale Wigley
    , Imperial College London
  • Dr. Luca Pellegrini
    Senior Lecturer, University of Cambridge
  • Principal Investigator Scott Williams
    Principal Investigator, NIH/NIEHS
  • Dr. Christopher Lima
    Professor and Member, Sloan-Kettering Institute, HHMI
  • Prof. Dorothee Kern
    Prof. of Biochemistry, HHMI Investigator, Brandeis University/HHMI
  • Prof Karl-Peter Hopfner
    Professor, Gene Center
  • Professor Tom Ellenberger
    Professor, Washington University School of Medicine
  • Professor Lorena Beese
    Professor, Duke University Medical Center

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