Registration deadlines

Early Bird - 09 Sep 2019

Talk Submission - 16 Sep 2019

Poster Submission - 20 Dec 2019

Registration Deadline - 20 Dec 2019

Register

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Synopsis

Nuclear Receptors are, physiologically and pharmacologically, a critical superfamily of transcription factors. They drive key processes at every stage from development and reproduction to ageing and cancer. They are critical determinants of everyday health via their roles in metabolism and circadian rhythms. Nuclear receptors allow external factors to influence cellular pathways and the fact that many bind and are activated by small molecules means they represent highly druggable targets; currently, 13% of FDA-approved drugs target nuclear receptors.

This meeting will address the new roles and novel crosstalk mechanisms that are emerging for many of the 48 human nuclear receptors, in health and disease. For example, it has long been known that the estrogen receptor drives progression of breast cancer, and patients with estrogen receptor-positive disease are treated using antiestrogens or aromatase inhibitors to inhibit estrogen signalling. Now however, it is apparent that the androgen receptor can in some cases drive breast cancer progression and is a therapeutic target, resulting in clinical trials for androgen receptor-targeting therapies in advanced breast cancer. The androgen receptor, itself long the main therapeutic target in prostate cancer, is emerging as a key player in metabolic disease, while conversely other nuclear receptor including the glucocorticoid receptor and several orphan nuclear receptors are implicated in prostate cancer progression. Meanwhile, given the impact of many nuclear receptors on the central nervous system, it is unsurprising that they are being explored in the context of neurological disorders and depression. Thus there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases.

Crosstalk between nuclear receptors and other fundamental processes is another exciting expanding area that will also be covered. DNA damage repair pathways are inextricably linked to steroid signalling via transcriptional processes, with implications for drug combinations in several diseases. Hitherto unsuspected roles of nuclear receptors in epigenetic control and the processing and function of non-coding RNAs opens up to capacity of this superfamily to further means of impacting on development and normal functioning, but also on disease development.

This unique meeting will bring together many of the leading figures in nuclear receptor research from across the globe, to discuss emerging roles and their implications for health and disease – and both human and drug development – in an intimate meeting that will generate meaningful idea exchange and interaction that will help to further shape this influential field.

 Key Sessions 

  • Further emerging roles for nuclear receptors in cancer
  • Structural insights into nuclear receptor function and crosstalk
  • Nuclear receptors’ role in epigenetic regulation and non coding RNA
  • Nuclear receptors and DNA damage
  • Nuclear receptors and cell cycle
  • Nuclear receptors in metabolism/metabolic disease
  • Nuclear receptors in the CNS

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the earlybird rate of $1,835 and bring a student for only $850. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 24, 25, 26 February 2020 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 20 December 2019. Once registered, please contact Amy Johnson to obtain a special registration link for your student. 

Confirmed Invited Speakers:

Mohamed Bentires (University Hospital, Basel)
Jason Carroll (University of Cambridge)
John Cidlowski (National Insitute of Enviromental Health Sciences)
Edwin Cheung (University of Macau)
Geoffrey Greene (University of Chicago)
Gary Hammer (University of Michigan)
Benita Katzenellenbogen (University of Illinois and College of Medicine)
Anastasia Kralli (Johns Hopkins Medical School)
David Mangelsdorf (University of Texas)
Susanne Mandrup (University of Southern Denmark)
Ciara Metcalfe (Genentech) 
David Moore (Baylor College of Medicine)
Donald Patrick McDonnell (Duke University)
Carol Sartorius (University of Colorado)

Target Audience 

Scientists and Clinician Scientists at a range of levels from postdoctoral and up: Principal Investigators, Junior Team Leaders, Research Fellows. Ambitious postgraduate students in the field will also be encouraged to attend.

Relevant specialties are wide-ranging, reflecting the importance of nuclear receptors in many aspects of health and disease. These include Endocrinology, Oncology, Paediatrics, Urology, Gynaecology, Obstetric Medicine, Neuroscience, Cardiology.

Educational Need 

Since the first cloning of the nuclear receptors in the 1980s, they have been the subject of detailed molecular investigation due to their critical roles in every aspect of cellular and physiological functioning. This has led to enormous progress in our understanding of how external factors can act via nuclear receptors to drive processes such as development, metabolism, reproduction, sexual function, and influence diseases such as metabolic syndrome, depression and cancer. Currently, around 13% of FDA-approved drugs target nuclear receptors, reflecting their unique druggability among transcription factors and pharmacological importance. Although we have known for some time that growth factor signalling can influence nuclear receptor signalling and vice versa, over the last few years, some hitherto unsuspected roles for nuclear receptors have emerged. Notable among these is the crosstalk between steroid receptors and DNA damage repair pathways, and more recently the mutual regulation between nuclear receptor signalling and microRNA action, which has far-reaching implications. Further, it is increasingly apparent that nuclear receptors have influence and action outside of the roles we have traditionally ascribed to them, and can drive processes and diseases either in normal function or in as a consequence of advanced disease (e.g. androgen receptor driving some forms of breast cancer, or glucocorticoid receptor “hijacking” androgen receptor-driven transcription in some advanced prostate tumours). There is an urgent need for integration of this knowledge across the many disciplines which nuclear receptors impact – although endocrinology meetings can combine many of these they do not encompass al. Further, as nuclear receptor research is frequently marginalised at these meetings, they are not traditionally well attended by, for examples, those in the hormone-dependent cancer field or neuroscientists. This meeting will bring together the scientists and clinicians who have made these surprising discoveries, those who are further delineating the novel mechanisms and those who are applying the new knowledge in clinical development, to discuss the ramifications and implication, the common ground and the idiosyncrasies. There is an urgent need to use this knowledge to drive both drug repurposing for existing nuclear receptor-targeted therapies, and new drug development. The intimate venue and small size will provide a unique platform for new collaborations to be formed and existing ones cemented, and meaningful knowledge and idea exchange, to really drive the next decade of research in this important area.

Supported By

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If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Speakers

Invited Speakers

Gary Hammer

Clinician/Researcher, University of Michigan

Mohamed Bentires-Alj

Professor of Experimental Surgical Oncology, University of Basel

Donald McDonnell

Professor and Chairman, Department of Pharmacology and Cancer Biology, Duke University School of Medicine

John Cidlowski

Chief, NIH/NIEHS

David Mangelsdorf

Professor, University of Texas Southwestern Medical Center

Jason Carroll

Professor, University of Cambridge

Carol Sartorius

Professor, University of Colorado Anschutz Medical Center

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Programme

Although the programme has not yet been released, we are able to confirm that the conference should begin no earlier than 14:45 with opening comments on 24th February 2020. Registration and a welcome reception should be available from 14:00. The conference will conclude no later than 12:30 on 27th February 2020.


Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Prices

Early Bird Full Price Additional Adult Additional Child Extra Night Adult Extra Night Child
Academic $1845 $1945 $684 $350 $321 $88
Industry $1845 $1945 $684 $350 $321 $88
Student $1556 $1656 $684 $350 $321 $88

All registration fees include 3 nights accomodation and meals during the conference period. Exact inclusions are details below.

What's Included in our Registration Fees?

Our registration fees are inclusive of the following during the conference period only:

- Conference registration 
- 3 Nights’ fixed accommodation (24, 25, 26 Feb 2020) on a single basis for academics and industry, on a shared basis for students/Postdocs
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited select brand liquors, wines by the glass, local domestic beer, bottled water and soft drinks
- Gala Dinner (includes an open bar)
- Room service
- Guest room mini bar
- Non motorized water sports equipment
- Complimentary WIFI in both conference rooms and your guest room

What's Included in our Accompanying Adult Fees?

Our accompanying adult fees are inclusive of the following during the conference period only:

- 3 Nights’ fixed accommodation (24, 25, 26 Feb 2020) on a shared basis with a conference participant 
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited select brand liquors, wines by the glass, local domestic beer, bottled water and soft drinks
- Gala Dinner (includes an open bar)
- Room service
- Guest room mini bar
- Non motorized water sports equipment
- Complimentary WIFI in your guest room

Important Note: Accompanying persons are not permitted access to the conference.

What's Included in our Accompanying Child Fees?

Our accompanying child fees are inclusive of the following during the conference period only:

- 3 Nights’ fixed accommodation (24, 25, 26 Feb 2020) on a shared basis with the parent/s
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited bottled water and soft drinks
- Gala Dinner 
- Room service 
- Non motorized water sports equipment
- Complimentary WIFI in your guest room

Important Note: Accompanying child fees are applicable for children aged 2-12 years. Children younger than 2 years stay free of charge with a parent. Children aged 13-17 years will be charged $366 per child. 18 years + will be classified as an adult at this venue (Melia Nassau Beach, Bahamas).

What's Included in our Extra Night Fees?

- 1 night’s accommodation for 1 person
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited select brand liquors, wines by the glass, local domestic beer, bottled water and soft drinks
- Room service 
- Guest room mini bar
- Non motorized water sports equipment
- Complimentary WIFI in your guest room

Important Note: Extra night child fees are applicable for children aged 2-12 years. Children younger than 2 years stay free of charge with a parent. Children aged 13-17 years will be charged $122 per night, per child. 18 years + will be classified as an adult at this venue (Melia Nassau Beach, Bahamas).

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

LinkedIn forum

The Nuclear Receptors Research Network is an excellent platform to bring together the global community of researchers and scientists interested Nuclear Receptors. To join, please follow the link below
 

Join our group

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Venue

Melia Nassau Beach All Inclusive

Venue Rating
Currency
US Dollar (USD)
Address
Nassau W Bay St. Nassau Bahamas
Nearest Airport
Lynden Pindling International Airport

Overlooking one of the finest beaches in the world the Meliá Nassau Beach is surrounded by crystal blue waters and white sandy beaches. Located on the stunning Cable Beach, you are just a few minutes walk from the center, shops and restaurants. The beautiful Nassau Botanical Gardens are within easy reach (7km) and Lynden Pindling International Airport is situated only 9km away.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from Cilantro where you can experience the natural textures, aromas and flavors of Mexico, Nikkei, celebrated for its exquisite fusion of Japanese, Cantonese and Peruvian cuisine featuring a sushi bar and Teppanyaki tables, Estavida, an upbeat tapas lounge located in the hotel lobby serving innovative tapas and a wide selection of cocktails, Aqua, an A la carte restaurant specializing in exquisite, rustic Italian cuisine, The Market Place, where you will find an International buffet serving an array of exquisite dishes, O'Grille, an open air restaurant with fabulous views of the sea and pool serving casual beach fare and light bites and finally The Black Angus, a steakhouse featuring hip, contemporary jazz and modern decor, offering guests the finest quality prime cuts and the freshest ingredients.(This restaurant is not included in the all inclusive package, additional charges apply). The Gala Night takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment.  We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

  • 24 hour reception
  • Room service
  • 3 heated outdoor pools
  • Complimentary resort wide Wi-Fi (guest rooms, throughout hotel, beach and conference areas)   
  • 24-hour Fitness Center
  • 7 dining venues
  • 4 bars.
  • non-motorised water sports

The Bahamas is formed by over 700 islands, keys and islets located in the Atlantic Ocean and renowned for its warm sunshine, mild climate, fine, white sandy beaches, turquoise, crystal clear water and friendly people, making this the perfect environment to relax and unwind in your free time during the conference.

Location

The Melia Nassau Beach All-Inclusive is located right on the stunning Cable Beach just a few minutes away from the airport and city center; Nearby in Downtown Nassau you can experience the flavours of new foods at local restaurants, shop 'til you drop at Straw market or take a trip through time at the Pirates Museum. The beautiful Nassau Botanical Gardens are close by and water enthusiasts can enjoy non-motorized water sports right on property.

Nassau is the capital of the Bahamas. It lies on the island of New Providence, with neighboring Paradise Island accessible via Nassau Harbor bridges. The city has a hilly landscape and is known for it's fabulous beaches as well as its offshore coral reefs, popular for diving and snorkeling. It retains many of its typical pastel-colored British colonial buildings, like the pink-hued Government House.

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Transportation

Local  Airport

The Melia Nassau Beach Resort is located just 9km from Lynden Pindling International Airport, approximately 10-15 minutes journey time. Formerly known as Nassau International Airport, it is the largest airport in the Bahamas and provides an international gateway into the country.

We will be partnering with a local reputable company that will provide transportation services for our attendees. Further information will be available nearer the time.

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Local Activities

Several free activities are available within the resort and include:

  • Trip to Balmoral Island during your stay; a taxi boat to and from Balmoral Island and access to the VIP Balmoral Beachside is included.
  • Daily fitness activities: gym classes, yoga, zumba, pool aerobics, etc.
  • In the water: paddleboards, glass-bottom kayaks, ocean duo kayaks, reef-board zayaks, cabana floating mats, water hammocks, etc.
  • Workshops: jewellery making, henna tattoo, scent creation, Bahamian crafts, etc.
  • Classes: mixology, scuba diving, dancing, etc.
  • Friendly competitions: beach volleyball, beach soccer, ping pong, darts, water balloon toss, deep dive contest, etc.
  • Free shuttle to Baha Mar and direct access to its spectacular 100,000 sq. ft. casino, Royal Blue™ tournament player’s golf course with special rates for Meliá guests, tennis court, spa, retail outlets and over 30 dining venues and lounges

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Group Activities

To be announced.

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Childcare

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Oral Presenters

We have several oral opportunities available at this meeting. To be considered for a talk, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

If you are accepted for a talk, we recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference website.

Your Presentation

On the day of your presentation please make yourself known to our AV technician who will be present in the conference room. We advise running through your presentation at least 30minutes prior to your session commencing to ensure your slides and any videos or animations appear as expected. We prefer our speakers to run their presentation from the master PC or Mac, however, if you prefer to use your own laptop then please notify us prior to the session. A HDMI or VGA cable is usually available on the podium.

Our AV technician will apply your microphone and provide a combined slide advancer and laser pointer.

We ask all speakers to adhere to their time slots and respect their fellow presenters. A visual traffic light aide will be available to warn presenters as their time decreases.

Please make sure your presentation adheres to the following guidelines.

Aspect Ratio: On Screen Show 16:9 (we can also accommodate 4:3 presentations) 
File Type: Please save your presentation in PPT, PPTS or Keynote format.

Download Abstract Template

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease                                                  #NR2020


24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Posters

We have several poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

Please bring your poster to registration and hand this to a member of the Fusion team. They will advise of your poster number and display your poster for you. 

Your poster will remain on display for the duration of the conference, allowing presenters to take advantage of the refreshment breaks and free time for valuable networking opportunities, in addition to the official poster session.

Please check the programme and note the date and time of the poster session(s). Your poster will be judged during the poster session and prizes will be awarded at the Gala Dinner.

Posters will be taken down by the Fusion team and will be ready for collection at the Fusion desk on the final day of the conference.

Download Abstract Template

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.