The germline provides an eternal cellular link between generations and is the source of genetic diversity and evolution of animal populations. In addition, perturbations in the epigenome or genome of a parental germline that arise during development could be underlying causes of many disease states in offspring. In males, sperm are the conduit for transmission of genetic and epigenetic information to the next generation and are formed by the complex process of spermatogenesis, which involves undifferentiated stem cell, differentiating, meiotic, and morphogenesis phases. This workshop will explore recent advances in understanding the biology of these different phases in a variety of animal models as well as how epigenetic and genetic abnormalities may underlie transmission of diseases and fertility disorder in humans. Invited talks that focus on cutting edge findings along with vibrant discussions and debates about controversies in the field will provide a rich intellectual atmosphere that is sure to have an important impact on how the biology of spermatogenesis is investigated for years to come.
 

Key Sessions

• Origins of the spermatogenic lineage
• Mechanisms of spermatogenic differentiation
• Genetic anomalies of the male germline
• Metabolics of spermatogenesis
• Environmental influences on spermatogenesis
• Novel genetic discovery in spermatogenesis
• Late breaking science  

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying ‘single’ or ‘shared’ registrants can bring a student for only €882. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 08, 09, 10 October 2023 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Amy Johnson to obtain a special registration link for your student. 

Confirmed Invited Speakers

Ramiro Alberio (University of Nottingham)
SPECIFICATION AND EPIGENETIC REPROGRAMMING OF PIG PRIMORDIAL GERM CELLS  
Christophe Arnoult (CNRS)
UNDERSTANDING SPERMIOGENESIS THANKS TO TERATOZOOSPERMIA
Guylain Boissonneault (Université de Sherbrooke)
NEW INSIGHTS INTO THE SPERMATIDS BREAKOME ANALYSIS
Jo Bowles (University of Queensland)
CRIPTO PROMOTES PLURIPOTENCY AND MALIGNANCY OF THE MALE GERMLINE IN MICE
Jochen Buck (Weill Cornell University)
ON-DEMAND MALE CONTRACEPTION VIA ACUTE INHIBITION OF SOLUBLE ADENYLYL CYCLASE
Geraldine Delbes (Institut national de la recherche scientifique)
DNA METHYLATION PROGRAMMING DURING RAT SPERMATOGENESIS AND ENVIRONMENTAL INFLUENCES
Klementina Fon Tacer (Texas Tech University)
FROM SINGLE-CELL ANALYSIS TO PHYSIOLOGY: PROTECTING SPERMATOGENESIS IN FOOD SCARCITY
Kanako Hayashi (Washington State University)
SINGLE-CELL MULTI-OMICS REVEALS TRANSCRIPTOMIC AND EPIGENETIC CHANGES IN MURINE GERM CELLS EXPOSED TO BISPHENOL A AND S AT THE PRENATAL STAGE
Katsuhiko Hayashi (Osaka University)
RECONSTITUTION OF REPRODUCTIVE ORGANS FROM MOUSE PLURIPOTENT STEM CELLS
Masahito Ikawa (Research Institute for Microbial Diseases)
TESTIS-ENRICHED GENES AND THEIR FUNCTIONS DURING SPERMATOGENESIS AND SPERM FUNCTIONS
Kei-Ichiro Ishiguro (Kumamoto University)
THE SEXUALLY DIFFERENT MECHANISM OF MEIOSIS INITIATION IN MOUSE GERM CELLS
Leanne Jones (University of California, San Francisco)
METABOLIC REGULATION OF MALE GERMLINE STEM CELL BEHAVIOR
Noora Kotaja (University of Turku)
GERM GRANULE-MEDIATED RNA REGULATION DURING SPERMATOGENESIS
Diana Laird (University of California, San Francisco)
HOW DO ENVIRONMENTAL INPUTS ALTER MALE GERM CELL DEVELOPMENT? A STUDY OF NUCLEAR HORMONE RECEPTORS
Tessa Lord (University of Newcastle)
EXPLORING THE INTERSECTION BETWEEN METABOLISM, HYPOXIA, AND SPERMATOGONIAL STEM CELL FUNCTION
John McCarrey (The University of Texas at San Antonio)
EPIGENETIC REGULATION OF SPERMATOGONIAL STEM CELL FATE
Marcos Morgan (NIH)
ROLE OF MRNA POLY(A) TAIL DYNAMICS IN SPERMATOGENESIS
Ignasi Roig (Universitat Autonoma de Barcelona)
TRIP13 PREVENTS PRECOCIOUS DESYNAPSIS DURING MEIOTIC PROPHASE
Kotaro Sasaki (University of Pennsylvania)
RECONSTITUTION OF HUMAN MALE GERM CELLS USING PLURIPOTENT STEM CELLS
Monika Ward (University of Hawaii)
DO WE NEED Y CHROMOSOME FOR SUCCESSFUL REPRODUCTION?
Jeremy Wang (University of Pennsylvania)
EPIGENETIC CONTROL OF SPERMATOGONIAL STEM CELL SELF-RENEWAL AND SPERMIOGENESIS
Joy Winuthayanon (University of Missouri)
INHIBITION OF SEMEN LIQUEFACTION TO PREVENT SPERM TRANSPORT PROCESS AS A NON-HORMONAL CONTRACEPTIVE METHOD
Wei Yan (The Lundquist Institute)
THINKING OUTSIDE THE BOX: WHAT IS NEW WITH NONHORMONAL MALE CONTRACEPTIVE DEVELOPMENT?
Humphrey Yao (NIH)
DECIPHER GERM CELL SEX DIFFERENTIATION WITH SINGLE CELL MULTIOMICS AND BLASTOCYST COMPLEMENTATION

Target Audience

The target audience will be scientists working on the field of male reproduction, especially on germ cells.
It must "regroup" people working on stem cell biology, genetics (meiosis), epigenetic processes, aspects of transgenerational transmission of diseases; cancer and scientists working on environmental diseases.
We would like to have recognized scientists and new researchers in the field to refresh the community.
We would like clinicians, basic scientists and people involved in the evolution of technologies.
One objective will also be to attract doctoral and post-doctoral students.