Registration deadlines

Early Bird - 10 Feb 2020

Talk Submission - 17 Feb 2020

Poster Submission - 01 Jun 2020

Registration Deadline - 05 Jun 2020

Register

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Synopsis

We have reached a fascinating point in our research on the ubiquitin system’s function, physiology and roles in disease. The attachment of ubiquitin to a protein in the cytosol was first identified as a means to enable degradation of proteins in the cytosol by the proteasome. It was much later that it was discovered that the ubiquitin system fulfils another crucial cellular function: through the dynamics offered by ubiquitination and subsequent deubiquitination it gives a multitude of signalling pathways the required plasticity to initiate but also to limit their signalling output in an exquisitely controlled manner. Whereas certain signalling-related functions employ ubiquitin’s proteasome-targeting function, e.g. the activation of NF-kB following degradation of I-kB, most signalling-related functions of the ubiquitin system are mediated by different types of ubiquitin chains acting as scaffolds for the recruitment of signalling modules to protein complexes which serve as platforms for the triggering of specific signalling complexes.

Rather than discussing mainly structural aspects of the ubiquitin system, this conference is dedicated to the study of functional roles of the ubiquitin system, how it works to ensure normal signal transduction, what are the pathological consequences when it is perturbed and how can we harness our knowledge of the ubiquitin system therapeutically for more efficacious treatment of diseases with high unmet clinical need, including cancer, chronic inflammatory and autoimmune disorders as well as neurodegenerative diseases.

Importantly, this conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues that emerge from the study of the ubiquitin system will be presented and discussed.

Vishva Dixit says 'The field of ubiquitin biology and applications to clinical medicine is one of the most exciting topics in Biomedicine. With the realization that widely prescribed powerful immunomodulatory drugs (IMIDs) including thalidomide and its analogues lenalidomide and pomalidomide work by engaging ubiquitin mediated degradation of critical targets, the field has exploded. A PROTAC strategy (Proteolysis targeting chimera) is now underway at all major Biopharma enterprises to extend the lessons from the IMID field to specifically target unwanted proteins. The impact of the field is far reaching. Indeed, the Nobel Prize this year was given to researchers who worked out how hypoxia engages the ubiquitin system to regulate oxygen availability. The future for the field has never been brighter. Clear your calendars and come join what should be a most exciting conference. It will focus on the myriad ways ubiquitin controls the signaling circuitry of life. If the regulation exerted by ubiquitin goes awry the consequences are devastating: it promulgates the pathology associated with inflammatory disease states, cancer and neurodegeneration.'

Student Offer

Take advantage of this fantastic opportunity for students! Academics can bring a student for only €820 (must have paid the academic registration fee in full). Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 26, 27, 28 July 2020 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Laura Trundle to obtain a special registration link for your student. 

Confirmed Speakers

Alessandro Annibaldi (Center for Molecular Medicine Cologne)
MECHANISMS OF cFLIP-MEDIATED REGULATION OF CELL DEATH
Eric Baehrecke (UMass Medical School)
A NOVEL RELATIONSHIP BETWEEN UBIQUITIN, MITOCHONDRIA AND AUTOPHAGY
Petra Beli (Institute of Molecular Biology)
UBIQUITIN SIGNALING IN PROTEIN QUALITY CONTROL
Nicolas Bidere (University of Nantes)
CYLD REGULATES CENTRIOLAR SATELLITES PROTEOSTASIS BY COUNTERACTING THE E3 LIGASE MIB1
Anja Bremm (Goethe University Frankfurt)
Tim Clausen (IMP)
Heran Darwin (NYU Langone Health)
PROTEASOMAL REGULATION OF MYCOBACTERIUM TUBERCULOSIS PATHOGENESIS
Anne Dejean (Institut Pasteur)
ROLE OF SUMO ON CHROMATIN
Ivan Dikic (Goethe University Frankfurt)
UBIQUITIN SYSTEM IN BACTERIAL INFECTIONS
Wayne Fairbrother (Genentech)
Brian Ferguson (University of Cambridge)
ANTI-VIRAL FUNCTIONS OF LINEAR UBIQUITIN CHAINS
Adolfo Garcia-Sastre (Icahn School of Medicine at Mount Sinai)
REGULATION OF PATHOGEN SENSING BY TRIM UBIQUITIN LIGASES
Thorsten Hoppe (CECAD)
ORGANISMAL REGULATION OF UBIQUITIN-MEDIATED QUALITY CONTROL
Philipp Jost (TU Munich)
MUCOSAL IMMUNITY BY THE E3 LIGASE XIAP
Rachel Klevit (University of Washington)
BRCA1/BARD1, TWENTY YEARS LATER
Sascha Martens (Max Perutz Labs, Vienna)
THE ROLE OF UBIQUITIN AND UBIQUITIN-LIKE CONJUGATION SYSTEMS IN SELECTIVE AUTOPHAGY
Pascal Meier (ICR London)
UBIQUITIN-MEDIATED REGULATION OF NECROPTOSIS
Yifat Merbl (Weizmann Institute)
Kim Newton (Genentech)
REGULATION OF CELL DEATH AND INFLAMMATION BY DUBs OTULIN AND CYLD
Michele Pagano (NYU)
UNCOVERING THE POWER OF PROTEIN DEGRADATION: MECHANISMS TO THERAPEUTIC STRATEGIES
Nieves Peltzer (University of Cologne)
LUBAC AT THE CROSSROAD OF CELL DEATH AND INFLAMMATION
Simona Polo (IFOM)
RIBONUCLEOPROTEIN GRANULES IN NEURONS AND OVARIES: DYNAMIC SENSORS MODULATED BY UBIQUITIN
Katrin Rittinger (Francis Crick Institute)
THE ROLE OF TRIM FAMILY PROTEINS IN SIGNALLING
Marc Schmidt-Supprian (TU Munich)
Michal Sharon (Weizmann Institute of Science)
SPECIFIC REGULATION OF THE 20S PROTEASOME COMPLEX
John Silke (The Walter and Eliza Hall Institute of Medical Research)
UBIQUITIN AND DEAD BODIES, A DEGRADING BUSINESS
Adrian Ting (Mayo Clinic)
UBIQUITIN, CELL DEATH AND TRANSPLANTATION
Sylvie Urbe (University of Liverpool)
DEUBIQUITINASES (DUBS): DRUGGABLE REGULATORS OF PROTEIN AND ORGANELLE HOMEOSTASIS
Domagoj Vucic (Genentech)
UBIQUITINATION REGULATES INFLAMMATORY SIGNALING BY RIP KINASES
Georg Winter (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences)
TARGETED PROTEIN DEGRADATION: CHEMICAL REWIRING OF UBIQUITIN LIGASES

Target Audience

This conference will appeal to researchers who are particularly interested in the diverse functions of the ubiquitin system, rather than structural aspects of it, as well the way this system is involved in normal physiology in a whole range of pathologies that have been shown to be associated with abnormal ubiquitin signalling. Naturally this target profile will bring together researchers from both academia and the biotech/pharma industries who want to be on top of the most recent developments in this fascinating and fast developing field.

Learning Objectives

  • To be on top of the field with regards to the diverse functions of the ubiquitin system
  • To comprehend how the ubiquitin system affects health and disease
  • To understand the therapeutic opportunities provided through our increased knowledge of ubiquitin’s functions 
  • To learn which ubiquitin-related drug candidates are presently in preclinical and clinical development and in which clinical entities they are tested
  • To develop a sense for fruitful future research directions and therapeutic opportunities offered by the study of ubiquitin function

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Speakers

Speakers to be confirmed.

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Programme

Although the programme has not yet been released, we are able to confirm that the conference should begin no earlier than 14:00 with opening comments on 26th July 2020. The conference will conclude no later than 12:30 on 29th July 2020.


Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Prices

Early Bird Full Price Additional Adult Additional Child Extra Night Adult Extra Night Child
Academic €1628 €1728 €622 €426 €158 €41
Industry €1628 €1728 €622 €426 €158 €41
Student €1425 €1475 €622 €426 €158 €41

All registration fees include 3 nights accomodation and meals during the conference period. Exact inclusions are detailed below.

What's Included in our Registration Fees?

Our registration fees are inclusive of the following during the conference period only:

- Conference registration 
- 3 Nights’ fixed accommodation (26, 27, 28 July 2020) on a single basis for academics and industry, on a shared basis for students
- Buffet breakfast in the Manjapão restaurant
- Buffet lunch in the Manjapão restaurant, with soft drinks beer and wine
- Buffet dinner in the Manjapão restaurant, with soft drinks, beer and wine
- Private outdoor Gala Dinner, with a selection of soft drinks, beer and wine
- Complimentary WIFI in both conference rooms and your guest room 

What's Included in our Accompanying Adult Fees?

Our accompanying adult fees are inclusive of the following during the conference period only:

- 3 Nights’ fixed accommodation (26, 27, 28 July 2020) on a shared basis with a conference participant  
- Buffet breakfast in the Manjapão restaurant
- Buffet lunch in the Manjapão restaurant, with soft drinks beer and wine
- Buffet dinner in the Manjapão restaurant, with soft drinks, beer and wine
- Private outdoor Gala Dinner, with soft drinks, beer and wine
- Complimentary WIFI in your guest room

Important Notes: 
- Accompanying persons are not permitted access to the conference
- Meals are only available during the times listed in the conference programme

What's Included in our Accompanying Child Fees?

Our accompanying child fees are inclusive of the following during the conference period only:

- 3 Nights’ fixed accommodation (26, 27, 28 July 2020) on a shared basis with parents 
- Buffet breakfast in the Manjapão restaurant
- Buffet lunch in the Manjapão restaurant with soft drinks
- Buffet dinner in the Manjapão restaurant with soft drink
- Complimentary WIFI in your guest room
- A cot (0-3 years old) or roll out bed (4-17 years old)

Important Notes: Accompanying child fees are applicable for children aged 12-17 years. Children aged 0-3 years stay free of charge and children aged 4-11 years will be charged a rate of €147.00, inclusive of the above package. If your child is aged 0-11 years, please contact us so we can adjust the invoices relating to your child/children. Please kindly ensure your child / children are supervised at all times during conference and related events. Childcare services are available at the hotel, please contact Laura for further information.

What's Included in our Extra Night Fees?

- 1 night’s accommodation for 1 person
- Buffet breakfast in the Manjapão restaurant
- Complimentary WIFI in your guest room

Important Note: Accompanying child extra night fees are applicable for children aged 12-17 years. Children aged 0-11 years stay free of charge, inclusive of the above package. If your child is aged 0-11 years, please contact us so we can adjust the invoices relating to your child/children.

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

LinkedIn forum

Bringing together the global community of researchers and scientists interested in Ubiquitin, Cell Death and Metabolism. Relevant specialties are wide-ranging, reflecting the importance of Ubiquitin, Cell and Metabolism research in many aspects of health and disease.

The group is open to all and is intended as a networking forum for past, present and future participants of Fusion Conferences as well as those interested in the related topics.

Join our group

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Venue

Dolce CampoReal Lisboa

Venue Rating
Currency
Euro (EUR)
Address
R. do Campo (Campo Real ) 2565-770 Portugal
Nearest Airport
Lisbon Portela Airport

Located in Torres Vedras, just a 30-minute drive from Lisbon, Dolce CampoReal Lisboa offers unique tranquillity, as a result of its idyllic environment. The hotel offers stunning views over the golf course, vineyards and the extraordinary landscape of Socorro and Archeira Mountains.

The hotel has three restaurants to provide a variety of gastronomic choices, and two bars including one beside the outdoor pool.

Hotel Facilities

  • Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
  • Indoor heated swimming pool
  • Outdoor swimming pool with Jacuzzi
  • Spa
  • Gym
  • Golf course
  • 2 Tennis courts

Location

The Dolce CampoReal Lisboa is nestled between the vineyards and the extraordinary landscape of the Socorro and Archeira Mountains.

Lisbon is only a short 30-minute drive away. The Portuguese capital is constantly recognised as one of the greatest cities in the world, a claim confirmed by the “Lonely Planet Guides", who named Lisbon one of the world’s top 10 cities. Lisbon in one of the world’s oldest cities, predating the likes of London, Rome and Paris by hundreds of years. Hillsides covered in tumbledown houses and a mix of baroque and neoclassical buildings, including cathedrals and palaces, make up Lisbon’s skyline. The city is a combination of old and new, with beautiful modern buildings constructed near renovated historical landmarks and ruins.

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Transportation

Dolce CampoReal Lisboa, Torres Vedras is approximately a 30-minute journey from Lisbon Portela Airport.

Taxis

Taxis are available outside the airport, but we would strongly recommend you pre-book your airport transfer with one of the many private transfer companies that are available. The Dolce CampoReal Lisboa is located outside of the city zone and a pre-booked transfer will be a cheaper option than a taxi taken from the airport taxi rank.

Uber also operate in and around Lisbon and there are other Portuguese taxi-hailing apps such as MyTaxi, TaxisLisboa and Coop Taxis, all offering reasonable rates.

Pre-booked Airport Transfers

Further information of local taxi services will be available shortly

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Local Activities

There are various on-site activities available. These include:

- Indoor and 2 outdoor swimming pools
- Fitness centre, available 24h
- Tennis courts
- Donald Steel designed Golf Course – 18 holes Par 72
- Miguel Athayde Equestrian Centre 
- Mandalay Wellness & Spa with 7 treatment rooms
- Kids Club – The hotel will provide details of daily activities for children
- Center “Clube Aventura” for outdoor activities such as Giant Balls, Aquaball, Stand Up Paddle, Archery, Slackline, Water Slide   

**Please note, there may be a charge to participate in some of the above activities.

Should you have time to venture off-site, the Oeste Region and Torres Vedras have a distinctive cultural heritage, rich history, 20 km of coastal area, and a commitment to environmental awareness, accessibility and biodiversity. Below are a few suggestions:

- Monastery of Alcobaça, a UNESCO World Heritage site
- Historical route of the lines of Torres Vedras
- Day trip to Óbidos
- Royal Palace and Convent of Mafra
- Tapada Nacional de Mafra
- Mountain biking along the Santa Cruz to Torres Vedras Loop
- Birdwatching at the Tajus Estuary Nature Reserve
- Jeep tours in and around Torres Verdras

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Group Activities

Lisbon City Walking and Tuk Tuk Tour – 27th July 2020

We have arranged an exciting group activity for our Ubiquitin participants (accompanying guests welcome). Please find the details, timings and price for the activity below. Please note you are required to sign up by the 26th June 2020 and unfortunately, we cannot accept sign ups after this date nor onsite. Our apologies for any inconvenience this may cause.

We have organised an exclusive tour for participants and accompanying guests to visit Portugal’s Capital, to see some of Lisbon’s most beautiful sights and experience Portuguese culture.

Transportation will be provided from the hotel to Lisbon City Centre, where the tour will begin. Starting in Restauradores square, participants will visit and ride the Gloria Funicular, a famous funicular railway which will take the group up sloping terrain to see magnificent views of Lisbon, including St George’s Castle. This viewpoint will give a unique insight into the city that has successfully merged the old and the new. Tuk Tuks will be waiting to take the group on an exciting journey through Portuguese streets with local tour guides taking the group to the best places and views in Lisbon, including sampling a taste of Ginjinha in the Chiado Quarter, visiting Praça do Comércio and the Castle Quarter. Participants will have the opportunity to stop in the areas to take in the culture and views, before returning to the coach to travel back to the hotel.

The final cost will be dependent upon final numbers; therefore, we can only provide a guide at this stage. The cost will range from EUR€70 – EUR€100 per person. Payment will be required in advance of the trip and reservation and payment information will follow once we have confirmed numbers.

Tour Includes:
Private Air-Conditioned Coach
Official English Guide Assistance
Translation Radio Guides 
Funicular Ride
Ginginha Drink
Tuk Tuks
Taxes and Services

Itinerary:
12h45 – Departure from Dolce 
13h30 – Arrival in Lisbon (Restauradores Square)
Then walking from Restauradores and taking the Gloria Funicular, visiting São Pedro de Alcântara Belvedere to admire the magnificent view over Lisbon
15h00 – Start of Tuk Tuk tour in Principe Real Square
17h00 – Depart from Lisbon
17h45 – Arrival at Dolce

*Minimum of 19 people required / Maximum capacity of 49*

Sign-ups are required by the 26th June 2020 should you wish to participate. To sign up, please email Laura Trundle noting the names of any accompanying guests joining you on the activity. Once you have confirmed your participation, you are financially committed. Should you decide after this time to no longer participate or not show up at the time of the trip, no refunds will be given. We do apologise.

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Childcare

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Oral Presenters

We have several oral opportunities available at this meeting. To be considered for a talk, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

If you are accepted for a talk, we recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference website.

Your Presentation

On the day of your presentation please make yourself known to our AV technician who will be present in the conference room. We advise running through your presentation at least 30minutes prior to your session commencing to ensure your slides and any videos or animations appear as expected. We prefer our speakers to run their presentation from the master PC or Mac, however, if you prefer to use your own laptop then please notify us prior to the session. A HDMI or VGA cable is usually available on the podium.

Our AV technician will apply your microphone and provide a combined slide advancer and laser pointer.

We ask all speakers to adhere to their time slots and respect their fellow presenters. A visual traffic light aide will be available to warn presenters as their time decreases.

Please make sure your presentation adheres to the following guidelines.

Aspect Ratio: On Screen Show (16:9)
File Type: Please save your presentation in PPT, PPTS or Keynote format.

Download Abstract Template

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.

2nd Fusion Conference on Ubiquitin Function in Health and Disease

#Ubiq20


26 Jul 2020 - 29 Jul 2020

Lisbon, Portugal

Chairs

Henning Walczak
University of Cologne / University College London
Vishva Dixit
Genentech, Inc.
Florian Bassermann
Technical University of Munich

Posters

We have several poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

Please bring your poster to registration and hand this to a member of the Fusion team. They will advise of your poster number and display your poster for you. 

Your poster will remain on display for the duration of the conference, allowing presenters to take advantage of the refreshment breaks and free time for valuable networking opportunities, in addition to the official poster session.

Please check the programme and note the date and time of the poster session(s). Your poster will be judged during the poster session and prizes will be awarded at the Gala Dinner.

Posters will be taken down by the Fusion team and will be ready for collection at the Fusion desk on the final day of the conference.

Download Abstract Template

Supported By

Media Partners
If you're interested in sponsoring this conference please contact us.