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The past ten years have seen an explosion of information regarding intestinal stem cells (ISCs), due to an improved ability to identify ISCs, follow their fates, and manipulate ISCs in vitro. The next frontier in the ISC field is understanding the role that dysregulated ISC behavior plays in the etiology of disease, and conversely, the impact of intestinal disease on proper ISC function. This meeting will bring together a diverse group of investigators to discuss topics such as how the environment of the small intestine and colon impacts ISC behavior in healthy and diseased states, how ISC behavior and the niche differ along the proximal-distal axis of the intestine, and the strengths of various models for investigating the relationship between ISCs, the niche, and the onset and propagation of disease states.
- Inflammation: causes and consequence
- Metabolism and Aging
- Modeling the intestine in vitro
- Intestinal diseases and ISCs
- Plasticity in the intestine
- Regulation of ISC behavior
Take advantage of this fantastic opportunity for students! Register an academic at the earlybird rate and bring a student for only €820. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 20,21,22 November 2020 (on a shared basis for students) and a food and beverage package for the conference period.Once registered, please contact Amy Johnson to obtain a special registration link for your student.
Confirmed Keynote Speakers
Frederic de Sauvage (Genentech)
James Wells (Cincinnati Children's Hospital)
HUMAN PLURIPOTENT STEM CELL-DERIVED GASTROINTESTINAL ORGANOIDS AS NEW MODELS TO STUDY HUMAN ORGAN DEVELOPMENT, DIGESTIVE DISEASES AND DIABETES
Confirmed Invited Speakers
Helen Abud (Monash Biomedicine Discovery Institute)
ROLE OF THE EGF FAMILY OF LIGANDS IN MEDIATING STEM CELL IDENTITY AND REGENERATION
Nicolas Buchon (Cornell College)
FROM HOMEOSTASIS TO PLASTICITY: HOW THE DIALOGUE BETWEEN ISCS, NUTRIENTS AND MICROBES SHAPES GUT STRUCTURE AND FUNCTION
Tracy Grikscheit (Keck School of Medicine)
ACCESSING THE NICHE IN ENTERIC NEUROPATHY: INTESTINAL STEM CELL THERAPIES
Holly Ingraham (UCSF)
Shalev Itzkovitz (Weizmann Institute of Science)
SPATIAL TRANSCRIPTOMICS OF THE SMALL INTESTINE
Heinrich Jasper (Genentech)
Klaus Kaestner (Perelman School of Medicine)
FOXL1-POSITIVE TELOCYTES IN THE INTESTINAL STEM CELL NICHE
Pekka Katajisto (University of Helsinki)
STEM CELL NICHE INTERACTIONS DURING AGING
Prisca Liberali (Friedrich Miescher Institute for Biomedical Research)
REGENERATIVE LANDSCAPE OF INTESTINAL ORGANOIDS
Maria Mihaylova (Ohio State University)
NUTRIENT SENSING AND UTILIZATION IN THE INTESTINAL CRYPT
Jason Mills (Washington University School of Medicine)
PALIGENOSIS: A CONSERVED CELLULAR PROGRAM FOR RECRUITING STEM CELLS IN REGENERATION AND CANCER
Alessandro Ori (Leibniz Institute on Aging- Fritz Lipmann Institute)
REGION-SPECIFIC EFFECTS OF AGING AND DIETARY RESTRICTION ON THE INTESTINAL EPITHELIUM
Jason Spence (University of Michigan)
DISSECTING THE ROLE OF EGF FAMILY MEMBERS IN THE HUMAN INTESTINAL STEM CELL NICHE.
Jerrold Turner (Harvard Medical School)
Jeff Wrana (Lunenfeld-Tanenbaum Research Institute)
REVIVAL STEM CELLS IN INTESTINAL REGENERATION AND INFLAMMATORY BOWEL DISEASE.
Kelley Yan (Columbia University Medical Center)
SINGLE-CELL STUDIES OF INTESTINAL STEM CELLS AND THEIR NICHE
Ömer Yilmaz (Koch Institute for Integrative Cancer Research)
DIETARY CONTROL OF INTESTINAL STEM CELLS IN PHYSIOLOGY AND DISEASE
Matthias Zilbauer (University of Cambridge)
ROLE OF DNA METHYLATION IN THE HUMAN INTESTINAL EPITHELIUM DURING DEVELOPMENT, HEALTH AND INFLAMMATORY BOWEL DISEASES
Scientists and physicians from the fields of stem cell biology, gastrointestinal disease, metabolic disorders, or immunology who are interested in integrating concepts across these areas to improve understanding of mechanisms underlying intestinal homeostasis, disease, and disease treatment.
There does not appear to be any other conference which focuses entirely on intestinal stem cell biology in the context of multiple disease states and in a variety of organisms. In the conference, we will discuss topics such as:
- Novel methods for assessing stem cell growth and differentiation capabilities from along the intestinal tract
- Discussing the extent to which mouse studies can faithfully model human disease, and what are the limits
- The impact of inflammation (disease, infection) on ISC proliferation and differentiation capacity
- The impact of diet and metabolism on ISC behaviour from different regions of the small and large intestine
- The impact of aging on ISCs from different regions of the small and large intestine
If you're interested in sponsoring this conference please contact us.