Extracellular vesicles (EVs), which are generated by almost all living cells, are now considered to be an important system of cell–cell communication. A large volume of data has been published on EVs in different fields of biology and medicine, from immunology to marine biology. These data are discussed at large international meetings that gather thousands of researchers.
However, there is still a need for more-focused meetings at which the importance and reliability of the data should be evaluated by a narrow circle of experts. Here, we propose to organize a small conference that will focus on one of the most important aspects of EVs, their role in infectious human diseases. The aim of the proposed conference is to improve our understanding of the mechanisms of this involvement and to evaluate EVs as potential therapeutic targets.
Key Sessions to include:
- Extracellular vesicles generated by human cells: a diverse population of vesicles formed by diverse biogenesis and having diverse composition.
- Extracellular vesicles as mediators of communications between human cells in vitro and in vivo: proved cases vs. unproved hypotheses.
- Extracellular vesicles in retroviral pathogenesis: human retroviruses as close relatives of extracellular vesicles.
- Extracellular vesicles as carriers of viral proteins and infectious viruses.
- Extracellular vesicles in bacterial pathogenesis: effects of bacterial vesicles on human tissues.
- Extracellular vesicles in complicated pregnancies: EVs as mediators of disruption of mother-to-child dialogue in infections.
- Extracellular vesicles as vehicles carrying RNA and soluble factors between cells.
- Isolation and characterization of different vesicles generated by human cells in vivo and in vitro: Is this mission possible?
Take advantage of this fantastic opportunity for students! Register an academic at the earlybird rate and bring a student for only $850. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 5,6,7 th March 2020 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 19th December 2019. Once registered, please contact Amy Johnson to obtain a special registration link for your student.
Confirmed Keynote Speaker
Yoel Sadovsky (Magee-Womens Research Institute)
PLACENTAL EXOSOMES IN VIRAL RESISTANCE AND FETAL-MATERNAL COMMUNICATION
Confirmed Plenary Speakers
Genoveffa Franchini (NIH)
RISK OF SIVmac251 ACQUISITION IN MACAQUES AND EXTRACELLULAR VESICLE MIRNAS ELICITED BY HIV VACCINE CANDIDATES
Stephen Gould (Johns Hopkins University)
MECHANISMS OF PROTEIN AND VIRUS BUDDING
Clotilde Thery (Institute Curie)
HETEROGENEITY OF EXTRACELLULAR VESICLES: WAYS OF DEFINING EV SUBTYPES
Guillaume van Niel (INSERM)
LIVE TRACKING OF EXOSOMES IN VIVO
Philip Stahl (Washington University in St. Louis)
Confirmed Invited Speakers
Igor Almeida (University of Texas)
ALPHA-GAL-CONTAINING EXTRACELLULAR VESICLES FROM TRYPANOSOMA CRUZI AS BIOMARKERS OF CHAGAS DISEASE
Shilpa Buch (Nebraska Medical Center)
Michael Bukrinsky (District of Columbia Center)
EXTRACELLULAR VESICLES CARRYING HIV NEF ARE THE KEY PLAYERS IN PATHOGENESIS OF HIV-ASSOCIATED CO-MORBIDITIES
Hernando Del Portillo (Barcelona Insititute for Global Health)
CIRCULATING PLASMA VESICLES FROM MALARIA PATIENTS FACILITATE PARASITE SEQUESTRATION IN THE HUMAN SPLEEN
Dirk Dittmer (UNC Lineberger)
FUNCTION OF EXOSOMES IN VIRAL LYMPHOMA
Susanne Gabrielsson (Karolinska University)
EXOSOMES IN LUNG DISEASES; ASTHMA, SARCOIDOSIS AND COPD.
Ramin Hakami (George Mason University)
MECHANISMS OF INNATE IMMUNE REGULATION BY EXOSOMES RELEASED DURING GRAM-NEGATIVE BACTERIAL INFECTIONS
David Meckes (Florida State University)
MODULATION OF HOST CELL EXTRACELLULAR VESICLE CARGO AND FUNCTIONS DURING VIRAL INFECTION
Jan Münch (Ulm University)
EVS IN SEMEN PREVENT ZIKV INFECTION – A NOVEL ANTIVIRAL INNATE IMMUNE DEFENSE MECHANISM?
Esther Nolte-'t Hoen (Universiteit Utrecht)
PATHWAYS UNDERLYING THE RELEASE OF PICORNAVIRUSES INSIDE SUBPOPULATIONS OF EXTRACELLULAR VESICLES
Rogers Palomino (NIH)
VAGINAL LACTOBACILLUS-DERIVED EXTRACELLULAR VESICLES IN PROTECTING FROM HIV-1 TRANSMISSION
Eva Povedra (Galicia Sur Health Research Institute)
EXTRACELLULAR VESICLES AND MITOCHONDRIAL DNA, NEW BIOMARKERS OF HIV PATHOGENESIS?
Ratna Ray (Doisy Research Center)
COMMUNICATION AMONG HCV INFECTED HEPATOCYTES AND OTHER LIVER CELLS VIA EXOSOMES
Hermann Schatzl (University of Calgary)
AUTOPHAGY AND EXOSOMAL RELEASE OF PRIONS
Yong Song Gho (Postech)
BACTERIAL EXOSOMES AS NEXT-GENERATION CANCER IMMUNOTHERAPY
The specific audience that will attend this conference will consist of the leading experts in extracellular vesicles, post-doctoral fellows, and possibly PhD students who plan to investigate the relevance and involvement of extracellular vesicles in their scientific projects, as well as physicians who have read about extracellular vesicle involvement in human diseases and who want to learn about this topic from the experts. The field of extracellular vesicles is relatively new, and the ideas so far developed are rather simple. Therefore, to understand the field at this stage of its development does not require prior knowledge or skills beyond general university courses in microbiology.
The field of extracellular vesicles has undergone extensive growth over the last several years; it has attracted significant funding and a diverse circle of researchers. As the result, the field benefits from excellent new data but is also held back by less-than-convincing results and unproved hypotheses. A relatively small conference focused on only one aspect of extracellular vesicles, namely their role in human infectious disease, may provide for the scientific community a consensus view of the leading experts on the validity of different data and may develop new lines of research necessary for the progress of basic knowledge of EVs and their potentials in translational medicine.
International Women's Day
International Women's Day is a global day celebrating the social, economic, cultural and political achievements of women across the world. The day also marks a call to action for accelerating gender parity. To mark the day we aim to dedicate the programme to an all-female speaker line up on Sunday 08 March 2020.
If you're interested in sponsoring this conference please contact us.