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Home > Past Conferences > DNA Replication as a Source of DNA Damage

DNA Replication as a Source of DNA Damage

From Molecules to Human Health

30 Sep 14 - 03 Oct 14

Ian Hickson
Prof Ian Hickson
Professor of Molecular Aging, University of Copenhagen
Oscar Fernandez-Capetillo
Dr Oscar Fernandez-Capetillo
Group Leader, Spanish National Cancer Research Centre (CNIO)

**If you are looking to arrive the night before the conference starts (29th September) and you do not wish to pay the extra night rate of $209 for the conference venue, we recommend using a renowned travel website such as Expedia or Trip Advisor to help source an alternative hotel that offers lower rates in the local area.**

The maintenance of genome integrity is critical for the suppression of cancer and premature ageing. Only recently has it become appreciated that DNA replication stress is a crucial driver of genomic instability. The timely progression of replisomes can be disrupted by lesions and secondary structures in the template, by bound proteins and by conflicts with the transcription machinery. A prolonged pause of the replisome then exposes single stranded DNA, which, due to its recombinogenic nature, can lead to genome rearrangements, fragile site expression and cell death. Importantly, some cancers present excessive endogenous levels of replication stress, which can be exploited for their clearance. In this conference, we aim to bring together scientists studying DNA replication and repair, with those interested in how DNA damage can influence cancer and ageing. 

Key Sessions

  • Pathways for repair of damaged replication forks
  • Systems for site-specific perturbation of replication
  • Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins
  • Replication perturbation as a driver of tumorigenesis and ageing
  • Exploitation of replication defects in cancer treatment
08:00 - 20:25 TUESDAY 30TH SEPTEMBER
08:00 - 12:00 Registration & Reception
11:00 - 11:15 Opening Comments
11:15 - 11:40 Virginia Zakian
Princeton University, New Jersey, USA
PROTEOMICS OF BUDDING YEAST TELOMERASE: THE TELOMERASE ASSOCIATED CDC48-NPL4-UFD1 COMPLEX REGULATES EST1 ABUNDANCE AND TELOMERE LENGTH
11:40 - 12:05 John Rouse
University of Dundee, UK
DISSECTING THE ROLES AND REGULATION OF NUCLEASES INVOLVED IN ICL REPAIR
12:05 - 12:20 Andres Lopez-Contreras
CNIO, Spain
A CONSERVED ROLE FOR NUCLEOTIDE BIOSYNTHESIS ON ATR BIOLOGY IN MAMMALS
12:20 - 12:45 Michelle Debatisse
Institut Curie, Paris, France
RESPECTIVE ROLES OF REPLICATION AND TRANSCRIPTION IN COMMON FRAGILE SITE INSTABILITY
12:45 - 13:10 Xiaolan Zhao
Memorial Sloan-Kettering Cancer Center, USA
REGULATION OF GENOME DUPLICATION
13:10 - 16:30 Welcome Lunch & Free Time
16:30 - 16:55 Junjie Chen
The University of Texas M.D. Anderson Cancer Center, USA
BALANCE BRCA1 AND 53BP1 AT DSB SITES
16:55 - 17:20 Aiden Doherty
University of Sussex, UK
PRIMPOL, A EUKARYOTIC PRIMASE-POLYMERASE INVOLVED IN LESION BYPASS DURING DNA REPLICATION
17:20 - 17:35 Jennifer Cobb
University of Calgary, Canada
THE NUA4 COMPLEX FUNCTIONS ON THE TRANSLESION SYNTHESIS (TLS) PATHWAY DURING DNA POST REPLICATION REPAIR
17:35 - 18:00 Stephen West
London Research Institute, UK
STRUCTURE AND FUNCTION OF THE BRCA2 TUMOUR SUPPRESSOR
18:00 - 18:25 George Garinis
Institute of Molecular Biology and Biotechnology-FORT, Heraklion, Greece
NUCLEOTIDE EXCISION REPAIR: LESSONS FROM THE MOUSE
18:25 - 19:00 Refreshments
19:00 - 19:25 Juan Méndez
Spanish National Cancer Research Centre (CNIO), Madrid, Spain
CONTROL OF DNA RE-REPLICATION IN VIVO: MOUSE MODELS FOR CDC6 AND CDT1 DEREGULATED EXPRESSION
19:25 - 19:50 Ivan Ahel
Paterson Institute for Cancer Research, Manchester, UK
STRUCTURE AND CATALYTIC MECHANISM OF ADP-RIBOSYLGLYCOHYDROLASES
19:50 - 20:15 Hocine Mankouri
University of Copenhagen, Denmark
ANALYSIS OF SITE-SPECIFIC REPLICATION PERTURBATION IN YEAST
20:15 - 20:30 Grant Brown
University of Toronto, Canada
SLX4 PROMOTES MEC1 SIGNALING BEHIND DAMAGED DNA REPLICATION FORKS
20:30 - 21:30 Welcome Buffet Dinner Hosted in Pre-Function Area
08:50 - 20:45 WEDNESDAY 1ST OCTOBER
09:00 - 09:25 Noel Lowndes
National University of Ireland Galway, Ireland
ATR ACTIVATES THE S-M CHECKPOINT DURING UNPERTURBED GROWTH TO ENSURE SUFFICIENT REPLICATION PRIOR TO MITOTIC ONSET
09:25 - 09:50 Andre Nussenzweig
National Institutes of Health, Maryland, USA
DNA-DAMAGE INDUCED DIFFERENTIATION OF LEUKEMIC CELLS AS AN ANTI-CANCER BARRIER
09:50 - 10:05 Makoto Nakanishi
Nagoya City University, Japan
NECESSARY AND SUFFICIENT ROLE FOR A MITOSIS SKIP IN SENESCENCE INDUCTION
10:05 - 10:30 Filipo Rosselli
CNRS - Gustave Roussy Institute, France
10:30 - 11:00 Refreshments
11:00 - 11:25 Sophie Polo
Paris Diderot University, France
CHROMATIN LICENSING FOR TRANSCRIPTION RESTART AFTER DNA DAMAGE
11:25 - 11:50 Massimo Lopes
University of Zurich, Switzerland
REMODELLING OF REPLICATION INTERMEDIATES IN FACE OF REPLICATION STRESS
11:50 - 12:05 Vincent Geli
CRCM, France
RPA AND PIF1 HELICASE PREVENT SECONDARY STRUCTURES FORMATION DURING TELOMERE AND HUMAN SUBTELOMERIC MINISATELLITE REPLICATION
12:05 - 12:30 Alessandro Vindigni
Saint Louis University School of Medicine, USA
DNA2 AND WRN COORDINATE REPLICATION RESTART BY PROCESSING REVERSED REPLICATION FORKS
12:30 - 16:30 Group Lunch & Free Time
17:00 - 17:25 Karlene Cimprich
Stanford University, USA
MECHANISMS FOR RNA-INDUCED GENOME INSTABILITY
17:25 - 17:50 Madalena Tarsounas
The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK
HIGHLY SPECIFIC KINASE INHIBITORS ENABLE SELECTIVE TARGETING OF BRCA2-DEFICIENT CELLS
17:50 - 18:05 Kara Bernstein
University of Pittsburgh School of Medicine, USA
SUMO-TARGETED UBIQUITIN LIGASES SLX5-SLX8/RNF4 REGULATE RECQ-LIKE HELICASE SGS1/BLM LOCALIZATION IN YEAST AND HUMAN CELLS
18:05 - 18:30 Ana Rojas Mendoza
Institute of Biomedicine of Seville (IBIS), Sevilla, Spain
COMPARATIVE GENOMICS OF DDR: IMPLICATIONS IN DOWSTREAM ANALYSES
18:30 - 18:55 Thanos Halazonetis
University of Geneva, Switzerland
BREAK-INDUCED REPLICATION MEDIATES REPAIR OF COLLAPSED DNA REPLICATION FORKS AND TANDEM DUPLICATIONS IN CANCER CELLS
18:55 - 20:30 Poster Session I & Cocktail Reception
20:30 - 00:00 Beach BBQ Dinner & Free Time
08:50 - 20:45 THURSDAY 2ND OCTOBER
09:00 - 09:25 Cynthia McMurray
Lawrence Berkeley National Laboratory, California, USA
FXS: REPLICATION DEPENDENT BREAKS AT RNA-DNA HYBRIDS
09:25 - 09:50 Simon Boulton
London Research Institute, UK
DNA REPLICATION AND TELOMERE FUNCTIONS OF RTEL1
09:50 - 10:05 Zuzana Storchova
Max Planck Institute of Biochemistry, Germany
ANEUPLOIDY DRIVES GENOMIC INSTABILITY BY GENERATING REPLICATION STRESS
10:05 - 10:30 Claus Sorensen
Max Planck Institute of Biochemistry, Germany
FBH1 HELICASE: PROMOTING DNA DAMAGE CHECKPOINT SIGNALING FROM STALLED REPLICATION FORKS
10:30 - 11:00 Refreshments
11:00 - 11:25 Philippe Pasero
IGH, CNRS UPR 1142, Montpellier, France
SAMHD1 PROCESSES STALLED FORKS AND PROMOTES REPLICATION RESTART
11:25 - 11:50 Oscar Fernandes-Capetillo
Spanish National Cancer Research Centre (CNIO), Madrid, Spain
TARGETING ONCOGENE-INDUCED REPLICATION STRESS FOR CANCER THERAPY
11:50 - 12:05 Angelos Constantinou
IGH-Institute of Human Genetics, France
EARLY RESPONDERS TO DNA REPLICATION IMPEDIMENTS
12:05 - 12:30 Jiri Lukas
Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark
POLY(ADP-RIBOSE)-DEPENDENT ASSEMBLY OF LOW-COMPLEXITY PROTEINS FUNCTIONS AS A ‘MOLECULAR SIEVE’ DURING THE EARLIEST STAGES OF DNA DAMAGE RESPONSE
12:30 - 16:30 Lunch at Leisure & Free Time
16:30 - 16:55 Antony Carr
Genome Damage and Stability Centre, UK
MECHANISMS OF REPLICATION-ASSOCIATED GENOME REARRANGEMENT
16:55 - 17:20 Anja Groth
BRIC, University of Copenhagen, Denmark
CHROMATIN REPLICATION AND EPIGENOME MAINTENANCE
17:20 - 17:35 Eric Brown
University of Pennsylvania, USA
GENOME-WIDE IDENTIFICATION OF REPLICATION FORK COLLAPSE SITES THROUGH ATR-DEFICIENCY
17:35 - 19:05 Poster Session II
19:05 - 19:30 Meeting of Poster Jury
21:00 - 00:00 *Gala Night, Group Photo & Poster Awards*
09:30 - 13:00 FRIDAY 3RD OCTOBER
09:35 - 10:00 Dana Branzei
Fondazione Ifom, Milan, Italy
VISUALIZATION OF RECOMBINATION–MEDIATED DAMAGE-BYPASS BY TEMPLATE SWITCHING
10:00 - 10:25 Oliver Mortusewicz
Science for Life Laboratory, Stockholm, Sweden
PC4 PROMOTES GENOME STABILITY AND DNA REPAIR THROUGH BINDING OF SSDNA AT DNA DAMAGE SITES
10:25 - 10:50 Camilla Sjogren
Karolinska Institutet, Stockholm, Sweden
CONNECTING CHROMOSOME REPLICATION AND SEGREGATION: DNA TOPOLOGY AND SMC COMPLEXES
10:50 - 11:15 Evi Soutoglou
IGBMC, Illkirch, France
NUCLEAR COMPARTMENTALIZATION AND GENOME INTEGRITY: DIFFERENTIAL REGULATION OF DNA REPAIR AND DNA DAMAGE RESPONSE AT NUCLEAR LAMINA AND NUCLEAR PORES
11:15 - 11:30 Refreshments
11:30 - 11:55 Ian Hickson
University of Copenhagen, Denmark
HOW UNFINISHED BUSINESS FROM S-PHASE IMPACTS ON MITOSIS
11:55 - 12:20 Josef Jiricny
Institute of Molecular Cancer Research, Zurich, Switzerland
A NOVEL INSIGHT INTO THE CONTRIBUTIONS OF PROOFREADING AND MISMATCH REPAIR TO REPLICATION FIDELITY
12:20 - 12:45 Raimundo Freire
Unidad de Investigacion, Hospital Universitario de Canarias, Spain
UBIQUITIN HYDROLASES AS NOVEL REGULATORS OF DNA REPLICATION
12:45 - 13:00 Closing Remarks (Chairs)
13:00 - 13:05 Farewell & Goodbye

Plenary Speakers

  • Professor Josef Jiricny
    Professor and Director, Institute of Molecular Cancer Research
  • Dr. Andre Nussenzweig
    Branch Chief, LGI, National Institutes of Health
  • Dr. Stephen West
    Senior Group Leader, London Research Institute
  • Professor Antony Carr
    Director, Genome Damage and Stability Centre
  • Professor Karlene Cimprich
    Professor, Stanford University
  • Dr. Philippe Pasero
    Dr, IGH, CNRS UPR 1142
  • Professor Thanos Halazonetis
    Professor, University of Geneva
  • Professor Camilla Sjögren
    Professor, PI, Karolinska Institutet
  • Professor Michelle Debatisse
    Head of department UMR3244, Institut Curie
  • Professor Jiri Lukas
    Managing Director, Novo Nordisk Foundation Center for Protein Research
  • Dr. Simon Boulton
    Senior Principle Investigator , London Research Institute
  • PhD Anja Groth
    Associate professor, BRIC, University of Copenhagen
  • Professor Virginia Zakian
    Harry C. Wiess Professor in the Life Sciences, Princeton University
  • Dr George Garinis
    Group leader, Institute of Molecular Biology and Biotechnology-FORTH
  • Dr. Madalena Tarsounas
    CR-UK Senior Group Leader, The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford
  • PhD. Evi Soutoglou
    Group leader, IGBMC
  • Professor Junjie Chen
    Professor and Chair, The University of Texas MD Anderson Cancer Center
  • Prof. Massimo Lopes
    Assistant Professor, University of Zurich

Invited Speakers

  • PhD Ana Rojas
    Head of the Computational Biology and Bioinformatics Group, Institute of Biomedicine of Seville (IBIS)
  • Dr. Claus Sørensen
    Dr., University of Copenhagen
  • Prof. Alessandro Vindigni
    Associate Professor, Saint Louis University School of Medicine
  • Dr. Dana Branzei
    GROUP LEADER, FONDAZIONE IFOM
  • Dr. Oliver Mortusewicz
    Postdoctoral Researcher, Science for Life Laboratory / Karolinska Institutet
  • Associate Professor Xiaolan Zhao
    Associate Professor, Memorial Sloan-Kettering Cancer Center
  • Dr Sophie Polo
    PI, Paris Diderot University
  • Professor Aidan Doherty
    Professor of Biochemistry, University of Sussex
  • Dr Hocine Mankouri
    Research Associate Professor, Nordea Center for Healthy Aging
  • Dr. Raimundo Freire
    Researcher, Unidad de Investigacion, Hospital Universitario de Canarias
  • Professor Noel Lowndes
    Professor, National University of Ireland Galway
  • Dr. Juan Méndez
    Lab Head, Spanish National Cancer Research Centre (CNIO)
  • Dr. Cynthia McMurray
    Senior Scientist, Lawrence Berkeley National Laboratory

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